Lupus (Systemic Lupus Erythematosus) 系統性紅斑狼瘡


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Most of scholars hold the view that it may be related to autoimmunity and genetic factors.

Many organs and connective tissues of the body may be involved.

The disease is often accompanied with many serological and immunological changes. It is seen more often in young females.

Main points of diagnosis:

1 the onset of disease is slow, early symptoms include fatigue, anorexia, emaciation, arthralgia, low fever, skin rash, photosensitization, etc.

The initial symptoms are usually atypical, and diagnosis is difficult.

2 Functional damages of multiple organs: As the disease progresses, there appear functional damages of the liver, kidney, cardiovascular, digestive and nervous systems.

Cardiovascular and renal damages are predominant features and renal failure is the major cause of death.

Accessory examinations:

1 Blood picture shows anemia, decreased numbers of white blood cells and platelets. ESR may be increased.

2 Serum albumin is reduced, with elevated globulin. IgG (Immune globulin G)is elevated markedly. Some of the patients are positive for rheumatoid factor (RF).

3 Lupus cells are positive in 70-80% of the patients, ANA(antinuclear antibody) is positive, up to 95%; sensitivity to anti-DNA_antibody is high in some cases.


多數學者認為與自身免疫和遺傳因素有關.病变可累及多個機體器官及結締組織,并伴有多種血清學和免疫學上的變化,以青年女性為多者.

診斷要點:

1 起病多緩慢,早期可有乏力,納差,消瘦,關節痛,低燒,皮疹,畏光,症狀多不典型,診斷較困難.

2 多器官功損害;病程進展后,可出現肝,腎,心血管,消化,神經等系統損害的表現,但以心,腎損害為最常見,晚期腎

功能衰竭常是死亡原因.

輔助檢查:

1 血象多數有貧血,白細胞,血小板亦有下降,血沉增快.

2 血白蛋白下降,球蛋白升高;免疫球蛋白G升高明顯,部分患者類風濕因子陽性.

3 狼瘡細胞多次檢查有70-80%陽性;抗核抗體95%以上陽性.


多数学者认为与自身免疫和遗传因素有关.病变可累及多个机体器官及结缔组织,并伴有多种血清学和免疫学上的变化,以青年女性为多者.

诊断要点:

1起病多缓慢,早期可有乏力,纳差,消瘦,关节痛,低烧,皮疹,畏光,症状多不典型,诊断较困难.

2多器官功损害;病程进展后,可出现肝,肾,心血管,消化,神经等系统损害的表现,但以心,肾损害为最常见,晚期肾

功能衰竭常是死亡原因.

辅助检查:

1血象多数有贫血,白细胞,血小板亦有下降,血沉增快.

2血白蛋白下降,球蛋白升高;免疫球蛋白G升高明显,部分患者类风湿因子阳性.

3狼疮细胞多次检查有70-80%阳性;抗核抗体95%以上阳性.


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