Uric acid, a metabolic waste product, is generally excreted from the body in the urine.
When the body fails to properly eliminate uric or overproduces it (a condition known as hyperuriccemia).
Tiny needle-like uric acid crystals collect in the joints, causing the extreme pain associated with gout.
Gout attacks usually occur in the joint of the big toe, but may also affect other foot joints, the ankle, knee, elbows, and wrists.
Attacks often start during the night, and as the pain worsens, even the slightest pressure is excruciating.
If left untreated, the attacks become more frequent, increase in duration, and may cause permanent damage to the affected joints, in addition, uric acid crystal deposits, may collect in the joint or the ear, break through the skin, and cause infection.
Kidney stones are another danger associated with gout.