Most cases developing more frequently in men after 50, about 90% of pancreatic cancers develop in the exocrine part of the pancreas, which makes and secretes digestive enzymes.
Most of the remaining cancers are called islet cell carcinomas because they develop in the cells that produce insulin and glucagons, the hormones that regulate blood sugar (glucose).
The cancer often spreads to the liver and other abdominal organs.
The early symptoms are vague and often attributed to indigestion,
especially after eating fatty foods, gas, bloating, and alternation
diarrhea and constipation, nausea, vomiting, unexplained loss of
appetite and weight, possible onset or worsening of diabetes,
increasingly intense pain that seems to bore through the abdomen and
into the back, pain worsens at night and is aggravated by lying flat on
the back or stomach.