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NAME : GOBIND SINGH BISHT

EDUCATION                                                                                                                                                                                                    

Degree/ Board or Branch

Year

Institute

CGPA /Percentage

Bachelor Of Technology (B.Tech.)/ Biotechnology & Biochemical Engineering 1

2008

Indian Institute of Technology (IIT) Kharagpur

8.34  2

 

AISSE(XII Standard)/ Central Board of Secondary Education (CBSE)

2003

Army Public School, Lucknow

84%

AISSCE (X Standard)/ Central Board of Secondary Education (CBSE)

2001

Army Public School, Lucknow

81%

1 Ranked 4th in a batch of 23 students of Department of Biotechnology, IIT Kharagpur

2 CGPA is calculated out of 10, on the basis of an absolute scale of grading

 

SCHOLASTIC ACHIEVEMENTS                                                                                                              

 

  • Awarded “Bal Vigyanik Samman” in 2004 by Department of Science of Technology, Government of Uttar Pradesh, as the highest honor for scientific achievement in the state of Uttar Pradesh, India.
  • Represented India at 6th International Astronomy Olympiad (2001) at Crimean Astrophysical Observatory, Crimea, Ukraine and won Rank 2nd among all the participating countries.
  • Awarded the MCM scholarship by the IIT Kharagpur, covering the entire tuition fee and monthly allowances, during the academic year 2004-2007.
  •  Awarded ‘Ex’ (highest grade) in Programming & Data Structures and Introduction to Physical Metallurgy , and ‘A’ grade in Microbiology, Genetics, Cell & Molecular Biology, University Physics, Methods in Experimental Physics, Mathematics-II and, Chemical Thermodynamics during course work.
  • Won 1st prize at District level & 2nd prize at State level, consecutively in the year 1998 and 1999 at National Children Science Congress (NCSC) organized by Department of Science and Technology India, and Science & Technology Division UNICEF for my work on “Therapeutic effects of common medicinal plants for reducing public health cost”
  • Created Animation Film depicting “Bane of Social Disharmony in Indian Scenario”, rated the Best project in the course Visual Communication, in a batch of 35 students.

 

KEY ACADEMIC PROJECTS                                                                                                                      

 

Biocompatibility of Carbon-MEMS for implantable biosensing                                             (2007-Present)

Advisors : Prof. Marc Madou, Dep. of Mechanical and Aerospace Engg., UC Irvine; Dr. T.K. Maiti, Dep. of Biotechnology, IIT Kharagpur; Dr. T.K. Bhattacharya, Dep. of Electronics & ECE, IIT Kharagpur, India

·          Carbon-MEMS are microstructures formed by pyrolysis of patterned photoresist. Electrochemistry studies show that these structures exhibit anisotropic conductivity. This coupled with their ability to form exotic fractal structures has been already been put to use in enhancing performance of Li ion batteries. Ideas for fabrication of potentiostats for implantable biosensing or on chip bioassaying have been proposed in the present project.

·         Biocompatibility tests have been undertaken to study the interaction of biomolecules and cells with C-MEMS and study its effects on the performance of C-MEMS based implantable biosensing device.

 

Diamond-like Nanocomposites (DLN) for Biomaterial and Bioimplant applications      (2006-Present)

Advisors : Dr. T.K. Maiti, Dep. of Biotechnology, IIT Kharagpur; Dr. T.K. Bhattacharya, Dep. of Electronics & ECE, IIT Kharagpur, India

·      Diamond-like nanocomposites (DLN) posses’ novel properties like excellent adhesion to a wide array of substrate materials (i.e., metals, plastics, ceramics, semiconductors, etc.), high hardness, low internal residual stress, excellent thermal stability, and excellent wear resistance.

·         The material characteristic and interaction of the Diamond-like Nanocomposite thin films with proteins and cells were studied using different techniques and the role of its material characteristics in modulating its biocompatible properties was established. Several patents and a journal paper are in the pipeline.

 

Microcontact Printing of Protein arrays                                                                                        (2005-2006)

Advisors : Dr. T.K. Maiti, Dep. of Biotechnology, IIT Kharagpur; Dr. T.K. Bhattacharya, Dep. of Electronics & ECE, IIT Kharagpur, India

·       This involved the printing of a major lectin protein Concanavalin A micro-arrays on glass substrate (modulated by polylysine and APTES – Aminopropyltriethoxysilane) by using Microcontact Printing.

·         Retention of protein-protein interactions was observed. This technique can therefore be used for the fabrication of lectin micro-arrays with specific cellular membrane-glycosylation pattern recognition capabilities in diseased conditions and control of cellular shape-functionality on-chip.

 

Pasteurization of liquid foods using Pulse Field Electroporation                                          (2006-2007)

Advisors : Dr. T.K. Maiti, Dep. of Biotechnology, IIT Kharagpur; Prof. N.N. Kishore, Dep. of Electrical Engineering, IIT Kharagpur, India

·         Supervised the development of a prototype for Pulsed Electric Field based pasteurization of liquid foods in collaboration with the Department of Electrical Engineering. Manufactured a treatment chamber and carried out all the biological analysis for the experiments. A business plan was worked out under my lead that won prizes and incubation at several National and International Business Plan competitions.

 

SUMMER INTERNSHIPS                                                                                                                                            

 

University of Southern California, Los Angeles, USA                                                (May 2007- July 2007)

Advisor :  Dr. Chongwu Zhou, Associate Professor, Department of Electrical Engg., USC, Los Angeles, USA

·         Selected through the USC-IIT InfoUSA Junior Summer Fellowship program, among total 14 students from IIT Kharagpur.

·         Developed a Soft Lithography technique for the Patterned transfer of Ferritin on quartz to achieve an aligned growth of Carbon Nanotubes during the synthesis process using Chemical Vapor Deposition.

·         This technique has potential applications in reducing the time and cost requirements in fabricating CNT based miniaturized devices for high throughput bio/chemical sensing. Such devices have been proven very effective in early diagnosis of lethal diseases like Cancer due to their high sensitivity.

 

Indian Institute of Science, Bangalore, India                                                               (May 2006- July 2006)

Advisor : Dr. Manju Bansal, Professor, Molecular Biophysics Unit, India Institute of Sciences, Bangalore, India

·         Selected through the IAS Summer Fellowship program among total 70 students (including undergraduate and postgraduate) from all across the country in the Life Sciences stream.

·         Proposed and implemented a computational technique for understanding Mg-ADP inhibition of F1-ATPase: a biological nanomotor. Paper communicated at International Symposium on Computational Biology and Bioinformatics 2006, Bhubaneshwar, India.

 

PAPERS

 

      G S Bisht, T Das, D Mishra, S K Mallick, T K Bhattacharya, T K Maiti; Material and Biological characterization of Diamond-like Nanocomposite (DLN) thin films. Presented at the International Conference on Design of Biomaterials: BIND-06 & XVII Annual Meeting of SBAOI (Society of Biomaterials and Artificial Organs, India) held at IIT Kanpur, on December 8-11, 2006.

·          T Das, D Pal, G S Bisht, T K Bhattacharya, T K Maiti; Retention of Protein-Protein interactions in Microcontact Printing. Proceedings of International Symposium On Nano-Bio Interface, 1-3 March 2006, Saha Institute of Nuclear Physics, Kolkata, India.

·      G S Bisht, Manju Bansal; A Computational Investigation of Mg ADP Inhibition of F1-ATPase , presented at the International Symposium on Computational Biology and Bioinformatics-2006 held in Bhubaneshwar, India from Dec 15-17 2006.

        G S Bisht, D Mishra, T Das, T K Bhattacharya, T K Maiti; Role of Material Characteristics of DLN thin films in
tailoring its biocompatible properties; Prepared: To be submitted for Journal

        G Teixidor, R Gorkin, G S Bisht, M Kulkarni, P Tripathi, J Subramaniam, T Maiti, T Battacharyya, A Sharma, B Y
Park, Marc Madou; Carbon micro-arrays as a substrate for patterned cell growth: In preparation
 

PRESENTATIONS AND WORKSHOPS:

 

·         Delivered a talk on “Soft Lithography: Marvels of polymer science” at the Indo-German Summer School on Frontiers in Polymer Chemistry 2006, held at Indian Institute of Science, Bangalore, India.

·         My work on “Designer Diamond-like Nanocomposite thin films for application in BioMEMS and Bioimplants” presented at the International Workshop on Micro/ Nano Systems Technology for Bio-Implants and Bio Applications-2006 held at Indian Institute of Technology, Kharagpur.

 

LAB EXPERIENCE

 

1.        Basic Techniques in Biochemistry, Microbiology, and Cell and Molecular Biology including PCR, Gel documentation, Cell culture techniques, Protein purification, characterization and functional analysis etc.

2.        Bioinformatics:

·         Gene analysis (worked on “DNA star” analysis software by LaserGene) and using BLAST for designing PCR primers.

·         Structural Bioinformatics: Reading and Interpreting protein databases using software and algorithms, Structure prediction using homology modeling and Molecular Dynamics simulations (worked on AMBER, SPDBV, and VMD etc.)

·         Molecular Modeling and simulations using AMBER and TINKER.

·         Structural Bioinformatics in drug design.

3.        Material and Biophysical techniques:

  • Circular Dichroism Study of proteins and DNA.
  • FTIR techniques for studying Biomaterials and biomolecules as thin films.
  • UV spectroscopy and melting studies of proteins and DNA.
  • AFM imaging for analysis of Biomaterials, biomolecules and their interactions.
  • HPLC and GLC purification techniques for various samples.
  • Mass Spectroscopic analysis of biomolecules.
  • XRD analysis of ordinary samples as well as thin films.

·         Transmission Electron Microscopy for Biomaterials

 

EXTRA CURRICULARS: POSITIONS OF RESPONSIBILITY                                                         

 

Position/Org./Resp.

Period

Key Achievements

 

Team Leader, Product and Technology Biopure / Supervising the development of a prototype for non thermal pasteurization of liquid foods using Pulsed Electric Fields.

 

 

 

2006-Present

·         Semi finalists in the Rice Business Plan Competition (RBPC) 2007, among the top 36 teams around the world and won 2nd prize in the Challenge Round

·         Won 1st prize at National Business Plan Competitions of Kshitij 2007 at IIT Kharagpur and of Empresario, National at National Institute of Industrial Engg.  (NITIE), Mumbai

·         Won 2nd prize at National Business Plan competition of IIM Lucknow (Nirvaan) and that of All India Technical Symposium on Industrial Engg. 2007 at IIT Kharagpur

·         Awarded INR 6.5 Lakhs worth of Incubation by IndiaCo

Team Leader, Product and Technology / DIAMAS-COATS / Supervising development of biocompatible Diamond-Like Nanocomposite (DLN) based coating technology

 

 

2007- Present

·         National Finalists (among top 6) at Business Plan Competitions organized by Mudra Institute for Communication Ahmedabad(MICA), India; TAPMI Manipal, India and NMIMS Delhi, India respectively.

·         Filing several patents on the core technologies of DIAMAS COATS.

 

OTHER EXTRACURRICULAR ACTIVITIES                                                                                                        

·         Delivered a public lecture at Kshitij 2008 Kolkata Workshop on “Business Planning for technology Ideas” attended by 700 students from different parts of the country.

·         Selected Undergraduate Research Associate to Saha Institute of Nuclear Physics in 2004, among the top 14 science students in the country. Addressed technology problems related to scientific research.

·         Won II prize in 2001 and Finalist  in 2002 at the Science Quiz in Macfair International Competition

·        Won I prize (out of 300 participants), at International Astronomy School in 2001.