Gitler Lab

Lab News

June 8, 2017: Maya is awarded the EMBO Long-Term Fellowship!

May 17, 2017: Article about ALS with Len Petrucelli published in Scientific American. Click here to read the article. 

May 4, 2017: A special collection focused on neurodegeneration published in Disease Models and Mechanisms. Click here to see the collection of articles and here to read the introductory Editorial with Paraminder Dhillon and Jim Shorter.

April 12, 2017: Lindsay's paper on ataxin-2 and TDP-43 published in Nature. Click here to read the paper. Click here to read a related paper on ataxin-2 and SCA2. Click here to read a News & Views article on both papers by Ke Zhang and Jeff Rothstein.

March 17, 2017: Perspective article with Dan Jarosz on yeast aging and Whi3 published in Science. Click here to read the article.

March 16, 2017: Greg and Michel's review article on alpha-synuclein published in Neurobiology of Disease. Click here to read the article. 

February 2, 2017: Ana's paper on exosomal miRNAs from astrocytes published in PLoS One. Click here to read the article.

January 4, 2017: Preview article with Nick published in Neuron. Click here to read the article.

November 30, 2016: Remembering Susan Lindquist.

November 9, 2016: Review article with Asa Abeliovich on intracellular trafficking and Parkinson's Disease published in Nature. Click here to read the article. 

October 13, 2016: Nick wins the 2016 Sammy Kuo Prize in Neuroscience!

October 13, 2016: Jacob is awarded a four year graduate fellowship from the Blavatnik Family Foundation!

August 19, 2016: Noori passes her qualifying exam!

August 12, 2016: Nick's paper on targeting Spt4 in ALS caused by C9orf72 mutations is published in Science. Click here to read the article. Click here to read a Perspective article on the work by Sarah Mizielinska and Adrian Isaacs. Click here to read a Neuron Spotlight article on Spt4 by Jie Jiang and Don Cleveland. 

July 15, 2016: Insight article with Nick published in eLife. Click here to read the article.

April 17, 2016: Review article with Ana and Joseph on nuclear transport in ALS and FTD published in Journal of NeurochemistryClick here to read the paper.

April 5, 2016: Review article with Hitomi Tsuiji on mechanisms of C9orf72 mutations published in Brain Research. Click here to read the paper.

February 12, 2016: Collaborative paper on nucleocytoplasmic transport and C9orf72 in a fly model published in Scientific Reports. Click here to read the paper.

January 28, 2016: Greg and Michel's paper on alpha-synuclein, Htt, and Abeta axonal transport published in Acta Neuropathologica. Click here to read the paper. 

October 30, 2015: Shizuka passes her qualifying exam!

August 26, 2015: Ana's paper on C9orf72 mutations and nucleocytoplasmic transport in ALS published in Nature Neuroscience. Click here to read the article. Click here to read a Nature News & Views article on the work by Bennett Fox and Randall Tibbetts and here for a Science news story on the work and related findings. 

August 17, 2015: Dispatch article with Matt published in Current Biology. Click here to read the article.

August 5, 2015: Insight article with Lindsay published in eLife. Click here to read the article.

July 21, 2015: Matt defends his Ph.D. thesis!

July 7, 2015: Lindsay passes her qualifying exam!

June 25, 2015: Nick passes his qualifying exam!

February 19, 2015: Collaborative paper on exome sequencing in sporadic ALS published in Science. Click here to read the paper. 

January 22, 2015: Ana wins prize for her talk at the Unstable Microsatellites & Human Diseases Conference in Guanacaste, Costa Rica

January 15, 2015: Target ALS funds new research consortium: "Validating ataxin 2 as a therapeutic target in ALS". Consortium members include: Aaron Gitler (Stanford; team leader), Nancy Bonini (University of Pennsylvania), Stefan Pulst (University of Utah), Robert Baloh (Cedars-Sinai), and Frank Rigo (Isis Pharmaceuticals).

January 7, 2015: Vps35, EIF4G1, and α-Synuclein  paper highlighted in a Preview article by Owen Ross, Casey Cook, and Leonard Petrucelli in Neuron. Click here to read the Preview article. And check out the cover art designed by Lili Guo! Click here to watch a video abstract about the paper. 

December 18, 2014: Nripesh's paper on interactions between Parkinson's disease genes VPS35, EIF4G1, and α-Synuclein published in Neuron. Click here to read the paper.  

November 23, 2014: Target ALS funds new research consortium: "Exploiting yeast to uncover small molecule drugs for ALS caused by aberrant TDP-43 and FUS proteostasis". Consortium members include: Jim Shorter (UPenn; team leader), Aaron Gitler (Stanford), and Nick Brandon and John Dunlop at AstraZeneca.

October 10, 2014: Matt Figley wins the 2014 Sammy Kuo Prize in Neuroscience!

October 9, 2014: Julien and Alya's paper on targeted exon capture and sequencing in sporadic ALS published in PLoS Genetics. Click here to read the paper. 

October 2, 2014: The Stanford Neurosciences Institute funds our NeuroHealth initiative Stanford Brain Rejuvenation Project, which will create a center for neurodegeneration research focusing on brain maintenance and regeneration, and the role of the immune system in these processes. Click here to read about the new neuroscience projects at Stanford.

September 11, 2014: Collaborative project with Dr. Jin Hyung Lee, "Innovating High-Resolution Novel Imaging Approaches to Elucidate Mechanisms of Prion-Like Spreading of Neurodegenerative Disease", funded by Bio-X Seed Grants Interdisciplinary Initiatives Program.

September 4, 2014: Perspective article with Joseph on C9orf72 dipeptide repeat proteins published in Science. Click here to read the article.

August 26, 2014: Gregor passes his qualifying exam!

August 8, 2014: Packard Center for ALS Research features Matt's paper on profilin 1 and stress granules. Click here to read the story.

July 29, 2014: Gregor is selected as a 2014 HHMI International Predoctoral Fellow. Click here to read about the award. 

June 11, 2014: Matt's paper on profilin 1 and stress granules in ALS published in the Journal of Neuroscience. Click here to read the article. 

May 29, 2014: Collaborative paper with Lili Guo and Xiaolu Yang at PENN on PML and misfolded proteins published in Molecular Cell. Click here to read the article. And check out the cover art designed by Lili Guo!

May 1, 2014: Alya and Julien's paper on exome sequencing to identify GMPPB 
mutations in muscular dystrophy and generalized epilepsy published in Brain Research. Click here to read the article. 

April 28, 2014: Gitler lab receives a three year grant from the Muscular Dystrophy Association to study a novel role of the ALS disease protein profilin 1 in stress granules. 

February 10, 2014: Julien and Alya's paper on exome sequencing to identify a DNAJB6 mutation in limb-girdle muscular dystrophy published in Neuromuscular Disorders. Click here to read the article. 

February 5, 2014: Preview article with Ana published in Neuron. Click here to read the article. 

December 20, 2013: Ana is awarded the Stanford School of Medicine Dean's Postdoctoral Fellowship

December 15, 2013: Collaborative paper with Nancy Bonini (PENN) on therapeutic modulation of stress granules in ALS models published in Nature Genetics. Click here to read the article. 

November 25, 2013: Matt wins best poster prize at the Bay Area Aging Meeting.

October 25, 2013: Matt and Anna's paper on evaluating non-coding nucleotide repeats in ALS published in Neurobiology of Aging. Click here to read the article. 

September 12, 2013: Preview article with Adriano Aguzzi published in Cell. Click here to read the article. 

July 8, 2013: Gitler lab research funded by NIH Director's New Innovator Award highlighted on NIH Common Fund website. 

June 28, 2013: Aaron participates in Team Gleason ALS Summit in New Orleans, LA.

June 24, 2013: Alessandra's ALS trios paper highlighted in a News & Views article by Alan Renton and Bryan Traynor in Nature Neuroscience. Click here to read the article.

June 1, 2013: Target ALS consortium funds new collaborative project "Unraveling mechanisms in RNA-binding protein-mediated ALS". Team members include Aaron Gitler (Stanford), Jim Shorter (Penn), J. Paul Taylor (St. Jude), Clotilde Lagier-Tourenne (UCSD), Steve Finkbeiner (UCSF), and Don Cleveland (UCSD).

May 26, 2013: Alessandra's paper on exome sequencing of ALS trios is published in Nature Neuroscience. Click here to read the article. Click here to read a press release on the study from Stanford, here to read a story about the paper on Alzforum, and here for a story about the paper by the Packard Center for ALS Research.

April 29, 2013: Rose's review article, with Oliver King and Jim Shorter, on a role for stress granules in ALS pathogenesis is published in the Journal of Cell Biology. Click here to read the article. 

March 31, 2013: Matt's addendum about Dbr1 published in Rare Diseases and featured on the cover. Click here to read the article and here to view the cover in our cover gallery. 

March 3, 2013: The iceberg emerges! Collaborative paper with Paul Taylor (St. Jude) and Jim Shorter (UPENN) on two new RNA-binding proteins with prion-like domains associated with ALS and related neurodegenerative diseases published in Nature. Click here to read the article. 

February 6, 2013: Preview article with Rosalind Chuang published in Neuron. Click here to read the article. 

January 24, 2013: Aaron selected to receive International Society for Neurochemistry Young Scientist Lectureship Award.

December 27, 2012: Maria's Dbr1 paper featured in Packard Center for ALS Research December Newsletter. Click here to read the article.

December 6, 2012: All Eyes on RNA. Science highlights Gitler lab research. Click here to read the story.

December 1, 2012: Maria's Dbr1 paper highlighted in a News & Views article by Shuying Sun and Don Cleveland in Nature Genetics. Click here to read the article.

November 16, 2012: Maria Armakola defends her Ph.D. thesis!

November 8, 2012: Mike Hart wins the 2012 Flexner Award for the best Neuroscience Ph.D. dissertation! 

October 28, 2012Maria's paper on Dbr1 and TDP-43 published in Nature Genetics. Click here to read the article. Click here to read a press release about the work from Stanford and here for a story on Alzforum. Click here for a feature article on the paper on SGD.

October 26, 2012Aaron's News and Views article published in Nature Neuroscience. Click here to read the article. 

October 3, 2012: Matt passes his qualifying exam!

July 19, 2012: Editorial with Dr. Ruth Lehmann on model organisms and human disease research published in Science. Click here to read the editorial. 

July 17, 2012: Gitler lab joins Biogen Idec-sponsored research consortium to help sequence genomes of ALS patients. Read press release about the consortium here

July 10, 2012: Alya Raphael is awarded a two-year Alzheimer's Disease Research Fellowship from the American Health Assistance Foundation. Click here to read more details about Alya's research project. 

July 5, 2012: Mike's paper on ataxin 2 polyQ, caspase activation and TDP-43 published in the Journal of Neuroscience. Click here to read the paper and here to read a feature on this work by Alzforum.

June 20, 2012: Mike Hart defends his Ph.D. thesis!

June 11, 2012: Rose Li is awarded the Paul and Daisy Soros Fellowship for New Americans.

May 14, 2012: Teresa Lee is selected to participate in the HHMI Medical Research Fellows Program.

April 21, 2012: Mike's paper on distinct TDP-43 pathological features in ALS cases with ataxin 2 intermediate-length polyQ expansions is published in Acta Neuropathologica. Click here to read the paper.

March 27, 2012: Julien's paper on evaluating a role for the EWSR1 gene in ALS is published in Human Molecular Genetics. Click here to read the paper.

March 23, 2012: Alessandra's paper on Ypk9 and manganese toxicity in yeast published in PLoS One. Click here to read the paper.

January 21, 2012: Review article with Oliver King and Jim Shorter on the expanding role of  RNA-binding proteins with prion-like domains in neurodegenerative diseases is published in Brain Research. Click here to read the paper.

January 1, 2012: Gitler Lab moves to Stanford!

December 27, 2011: Paper on yeast screen for new ALS disease genes featured on the cover of PNAS (Volume 108, issue 52). Click here to see the cover photo in the PNAS cover archive and here to see our lab cover gallery. Paper also featured in a Research Highlight in Disease Models and Mechanisms. Click here to read the highlight. 

December 6, 2011: Nature Reviews Neurology highlights Julien's paper on yeast screen for new candidate ALS disease genes. Click here to read the article.

November 9, 2011: Mini-symposium article with Benjamin Wolozin on local RNA translation at the synapse published in the Journal of Neuroscience. Click here to read the article.

November 7, 2011: Julien's paper (with the Summer high school students) on yeast screen to predict new candidate ALS disease genes published in PNAS. Click here to read the article. Click here to read a highlight of the work on the PNAS website and here to read a story about this work on the Packard Center for ALS Research website. Click here to read a press release from PENN. Click here to read a feature on this work by Alzforum.

November 3, 2011Aaron's Perspectives article published in Science. Click here to read the article. 

November 3, 2011Aaron is selected as a Finalist in the 2011 Eppendorf and Science Prize for Neurobiology. Click here to see the announcement on the Science website and here to read Aaron's essay, "A Simple Yeast Model Provides New Insight into a Complicated Human Neurodegenerative Disease." 

August 17, 2011Aaron wins the 2011 International Paulo Contijo Young Investigator Award from the Instituto Paulo Gontijo. Click here to see the announcement from the IPG and here to see a press release from PENN. 

August 1, 2011: Julien Couthouis awarded a postdoctoral fellowship from the Ellison Medical Foundation/American Federation for Aging Research.

July 27, 2011: Mike Fleming's yeast high-throughput plasmid overexpression screen video protocol published in Journal of Visualized Experiments. Click here to watch the video.

July 19, 2011: Extra-Views article with Jim Shorter on RNA-binding proteins in ALS and FTLD-U accepted in Prion and featured on the cover. Click here to read the article and here to see the cover design in our cover gallery

: Teresa's paper (with the Summer high school students) on polyQ disease genes in ALS published in . Click to read the paper and to read an accompanying editorial by Kenneth Fischbeck and Stefan Pulst. May 11, 2011Neurologyherehere

: Alzforum covers our recent  paper on FUS. Click to read the story. May 10, 2011PLoS Biologyhere

April 26, 2011: Zhihui's paper with Zamia from the Shorter lab on the ALS disease protein FUS/TLS published in . Click to read the article, for a related article by Greg Petsko and colleagues, for a synopsis of the work by and for a press release of the work from PENN.PLoS BiologyherehereherePLoS Biologyhere

April 5, 2011: Mike Hart is awarded a National Research Service Award (NRSA) from the National Institute of Neurological Disorders and Stroke (NINDS).

March 29, 2011: Ataxin-2 CAG vs. CAA repeat paper with Nancy Bonini's group published in PLoS One. Click here to read the paper.

February 4, 2011: Gitler lab collaborative project with Nancy Bonini's group to use yeast and fly models to study ALS featured in the February issue of HHMI Bulletin. Click here to read the story.

February 3, 2011: Teresa and Rose's paper on Ataxin-2 polyQ expansions in ALS published in Human Molecular Genetics and featured on the cover!. Click here to see the cover design in our cover gallery and here to read the article.

January 3, 2011: Teresa's paper (with the Summer high school students) on polyQ disease genes in ALS accepted in Neurology.

December 11, 2010: Gitler Lab awarded an Addgene Challenge Award as part of the Addgene Innovation Awards Program.

November 27, 2010: Maria and Mike's paper on TDP-43 toxicity in yeast published in Methods. Click here to read the article.

November 2, 2010: Rose Li awarded scholarship to attend Keystone Symposium on Neurodegenerative Diseases: The Molecular Basis for Neurodegeneration in Taos, NM.

October 8, 2010: The Packard Center for ALS Research at Johns Hopkins funds our collaboration with Jim Shorter's group to study the ALS disease protein FUS/TLS.

September 23, 2010: Gitler lab research mentioned by PENN president Dr. Amy Gutmann during her White House meeting with Vice President Joe Biden. Click here to watch the video clip (video is ~25 minutes and lab mention is at 24m04s). 

August 25, 2010: Our paper on TDP-43 and Ataxin-2 published in Nature. Click here to read the article, here to read the accompanying News & Views article by Clotilde Lagier-Tourenne and Don Cleveland. Click here for a press release of the work from PENN and here for a press release from the Packard Center for ALS Research at Johns Hopkins.

August 1, 2010: Aaron selected as Scientist to Watch by The Scientist Magazine. Click here to link to the article (subscription required). Click here to watch the YouTube video associated with the article.

June 1, 2010: Maria passes her prelim exam!

May 18, 2010: Mike passes his prelim exam!

April 23, 2010: Mike selected as a 2010 predoctoral trainee for Dr. Meera Sundaram's T32 Predoctoral Training Grant: Genetics Training Program

April 15, 2010: Brian's review with Mimi from Jim Shorter's lab on prion-like properties of neurodegenerative disease proteins published in The Journal of Cell Science. Click here to read the article.

October 16, 2009: Mike Hart wins 1st prize in the Center for Neurodegenerative Disease Research Retreat Poster Contest.

May 22, 2009: Brian and Jon's paper with David and Jim in the Shorter lab on ALS-linked TDP-43 mutations published in JBC. Click here to read the paper and here for a story on the paper featured on Alzforum.

May 4, 2009:  Alessandra Chesi awarded another year of postdoctoral fellowship funding from the Parkinson's Disease Foundation to continue investigating the PARK9/ATP13A2 gene.

February 1, 2009: Alessandra and Aaron's paper on a connection between genetic and environmental causes of Parkinson's disease published in Nature Genetics. Click here to read the paper and here for press release on the work.

November 20, 2008: Alessandra Chesi wins 2nd prize in the Center for Neurodegenerative Disease Research Retreat Poster Contest for her poster entitled, "Investigating the function of YPK9, the yeast orthologue of the human Parkinson's disease gene PARK9 / ATP13A2".

September 22, 2008:  Aaron is awarded 2008 NIH Director's New Innovator Award. Click here to see the NIH announcement and here for press release from Penn.

July 17, 2008: Aaron selected as a 2008 Rita Allen Foundation Scholar. Click here for press release from Penn.

July 1, 2008: Aaron selected as a 2008 Pew Scholar in the Biomedical Sciences. Click here to see the Pew announcement and here for press release from Penn. 

June 15, 2008: Zhihui Sun awarded postdoctoral fellowship from the American Parkinson's Disease Association. Click here to see APDA fellowship announcement online.

June 3, 2008: Zhihui Sun's paper on zebrafish synuclein genes is published in Developmental Dynamics. Click here to read the paper online.

April 29, 2008: Brian Johnson's paper on yeast TDP-43 model is published in PNAS. Click here to read the paper and here for press release on Brian's work.

April 16, 2008: Alessandra Chesi awarded postdoctoral fellowship from the Parkinson's Disease Foundation.

November 12, 2007: Zhihui Sun wins 1st prize in the Center for Neurodegenerative Disease Research Retreat Poster Contest for her poster entitled, "Discovery and Characterization of Three Novel Synuclein Genes in Zebrafish".

July 1, 2007: The Gitler Lab officially opens!


Gitler Lab in the news

Philadelphia Inquirer
Daily Intelligencer
http://www.sciencedaily.com/releases/2009/02/090201141559.htm
http://www.the-scientist.com/2008/11/1/59/1/
http://www.upenn.edu/pennnews/current/research/050808.html

Popular Science 
http://www.sciencedaily.com/releases/2008/04/080417163854.htm
http://www.genengnews.com/news/bnitem.aspx?name=33975594
http://www.cba-news.com/issues/5_17/features/146541-1.html
http://www.alzforum.org/new/detail.asp?id=1804