The folding of the triple helix of collagen




This project concern the folding of the triple helix of collagen. Collagen is a major component of bone, skin, and other organs. It is in fact the most abundant protein in humans, taking a quarter of the protein mass. Collagen has a unique structure consisting of three chains wrapped around each other, hence the name triple helix. Mutations in collagen cause misfolding of the triple helix, leading to diseases such as Osteogenesis imperfecta and Ehlers-Danlos syndrome. We are studying the folding mechanism and how mutations affect it. (see all projects)


p1808 - 153 points, 44 days; p1809 - 153 points, 44 days;


Project NumberWork Unit NameNumber of AtomsPreferred (days)Final deadline (days) CreditFramesCode



1808p1808_Collagen_Brodsky_refolding1125 30.00 44.00 153.00100AMBER


1809p1809_Collagen_POG10new_refolding1116 30.00 44.00 153.00100AMBER