About Us

The research of the Smart Imaging Laboratory, lead by Prof. Guoan Zheng @ UConn, is focused on the development of novel imaging/sensing tools to tackle measurement problems in biology, medicine, and metrology. The major techniques that are under development in the laboratory include angular light modulatorsingle-pixel 3D fluorescence imagingwhole slide imaging system (InstantScope), multiplexed structured illuminationLCD-based digital eyeglassgigapixel imaging using flatbed scannergigapixel Fourier ptychography, super-resolution imaging approaches, 3D tomography imagingePetri dish and related lab-on-a-chip platforms, surface-plasmon-enabled imaging devices, and other novel imaging techniques. Our lab is currently supported by NSF, NIH and CT innovations.

The Fourier Ptychographic imaging approach represents a new way of tackling microscopy by transforming a physical optical problem to a computational problem. Through this reduction, we can push the performance of standard imaging systems beyond their physical limitations. We have demonstrated the use of Fourier ptychography for 

For more information, refer to our publicationsSome of our gigapixel images can be found on Gigapan, for example, human brain section with Alzheimer disease, breast cancer slide 

Featured Publications (* corresponding)

(Book) Guoan Zheng, “Fourier Ptychographic Imaging: a MATLAB Tutorial”, IOP Press, May 2016. 

Kaikai Guo, Shaowei Jiang, and Guoan Zheng*, “Multilayer fluorescence imaging on a single-pixel detector,” Biomedical Optics Express, 7, 7, 2425 (2016). 

Kaikai Guo, Jun Liao, Zichao Bian, Xin Heng, and Guoan Zheng*, "InstantScope: a low-cost whole slide imaging system with instant focal plane detection," Biomedical Optics Express, 6, 9, 3210 (2015).

Guoan Zheng*, Roarke Horstmeyer and Changhuei Yang, “Wide-field, high-resolution Fourier ptychographic microscopy,” Nature Photonics, 7, 739–745 (2013). (Featured by Naturepdf download
Guoan Zheng*, Seung Ah Lee, Yaron Antebi, Micheal B. Elowitz, and Changhuei Yang, “The ePetri dish, an on-chip cellimaging platform based on subpixel perspective sweeping microscopy (SPSM),” Proceedings of the National Academy of Sciences, 108, 16889-94 (2011). (Highlighted by Nature Methods)

Guoan Zheng*, Xiquan Cui, and Changhuei Yang, “Surface-wave-enabled darkfield aperture for background suppression during weaksignal detection,” Proceedings of the National Academy of Science, 107 (60), 9043-8 (2010).


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