The research of the Smart Imaging Laboratory, lead by Prof. Guoan Zheng @ UConn, is focused on the development of novel imaging/sensing tools to tackle measurement problems in biology, medicine, and metrology. The major techniques that are under development in the laboratory include angular light modulator, single-pixel 3D fluorescence imaging, whole slide imaging system (InstantScope), multiplexed structured illumination, LCD-based digital eyeglass, gigapixel imaging using flatbed scanner, gigapixel Fourier ptychography, super-resolution imaging approaches, 3D tomography imaging, ePetri dish and related lab-on-a-chip platforms, surface-plasmon-enabled imaging devices, and other novel imaging techniques. Our lab is currently supported by NSF, NIH and CT innovations.
The Fourier Ptychographic imaging approach represents a new way of tackling microscopy by transforming a physical optical problem to a computational problem. Through this reduction, we can push the performance of standard imaging systems beyond their physical limitations. We have demonstrated the use of Fourier ptychography for
- High-resolution, high-throughput gigapixel imaging
- Quantitative phase imaging
- Field-portable high-resolution microscope using a cellphone lens
- Spectral multiplexing
- Adaptive imaging
- Super-resolution fluorescence imaging
- 3D imaging
- Incoherent photographic imaging
- Resolution doubling with 4 frames
- Multiplexed structured illumination
- Macroscopic imaging beyond the diffraction limit of the photographic lens
Featured Publications (* corresponding)
(Book) Guoan Zheng, “Fourier Ptychographic Imaging: a MATLAB Tutorial”, IOP Press, May 2016.
Kaikai Guo, Shaowei Jiang, and Guoan Zheng*, “Multilayer fluorescence imaging on a single-pixel detector,” Biomedical Optics Express, 7, 7, 2425 (2016).
Kaikai Guo, Jun Liao, Zichao Bian, Xin Heng, and Guoan Zheng*, "InstantScope: a low-cost whole slide imaging system with instant focal plane detection," Biomedical Optics Express, 6, 9, 3210 (2015).
oan Zheng*, Roarke Horstmeyer and Changhuei Yang, “Wide-field, high-resolution Fourier ptychographic microscopy,” Nature Photonics, 7, 739–745 (2013). (Featured by Nature) pdf download
Guoan Zheng*, Seung Ah Lee, Yaron Antebi, Micheal B. Elowitz, and Changhuei Yang, “The ePetri dish, an on-chip cellimaging platform based on subpixel perspective sweeping microscopy (SPSM),” Proceedings of the National Academy of Sciences, 108, 16889-94 (2011). (Highlighted by Nature Methods)
Guoan Zheng*, Xiquan Cui, and Changhuei Yang, “Surface-wave-enabled darkfield aperture for background suppression during weaksignal detection,” Proceedings of the National Academy of Science, 107 (60), 9043-8 (2010).