Our research focuses on two inter-related areas: sexual selection and the nature of genetic variance in natural populations. Sexual preferences for elaborate sexual displays and ornaments are thought to evolve because they benefit the choosing sex (usually females) genetically. For the genetic benefits to be possible there must be additive genetic variation (VA) for sexual ornaments, such that highly ornamented individuals can pass fitter genes on to the progeny of choosy individuals.
Mutations and genes interacting with parasites, such as genes of the major histocompatibility complex (MHC) are important sources of genetic variation for fitness, and are therefore an important focus of our research.
Sexual selection can also affect the amount of genetic variance in natural populations, for example by purging deleterious mutations from populations, which can decrease the cost of sexual reproduction and decrease the risk of population extinction. However, sexual selection also leads to divergent selection on sexes, which can increase sexually antagonistic genetic variation within populations.
Sexual selection often leads to the maintenance of alternative reproductive phenotypes (ARPs) within sexes. Evolution of ARPs, including its genetic aspects, is another area of our research.
Currently, our main study species include acarid mites, guppies and bank voles. See our current projects for more details.
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News & jobs
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T-cell receptor (TCR) repertoire profiling in non-model species using high-throughput sequencing
High-throughput sequencing (HTS) prompted development of novel, refined methods of analyzing immunological repertoires (e.g. immunoglobulins, TCRs). So far, despite a decade of progress, these techniques were mainly used in research involving model species and humans.Recently, our group published an article in Scientific Reports describing first use of HTS in TCR repertoire sequencing in a non-model mammal (the bank vole, Myodes glareolusI). The article also presents our newly developed software: AmpliTCR and AmpliCDR3. Programs allow detailed quantitative and qualitative description of TCR repertoires without reference sequences. These tools should become particularly useful in the fields of comparative immunology, ecology and evolutionary biology, which often focus on non-model species.
Posted Aug 21, 2018, 4:10 AM by Magdalena Migalska
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PhD position starting 1st October 2018
PhD
position in evolutionary biology is available for four years starting from 1st
October 2018 in NCN-funded project aiming to investigate the effect of sexual
selection on genome-wide genetic variation using a powerful approach of
experimental evolution coupled with genome re-sequencing. The student will receive stipend of 4500
PLN/month and, in addition to carrying our research, will have opportunity to attend
specialized courses for PhD students in English. The candidate should hold MSc
degree in biological sciences or bioinformatics.
Further information
about the project and application procedure can be obtained from the project
leader via email: jradwan@amu.edu.pl
Brief
summary of the project:
Genetic
variation is a fuel of evolution, therefore assessing the ...
Posted May 22, 2018, 4:01 AM by Jacek Radwan
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Novel MHC alleles give their guppy hosts advantage in dealing with ectoparasites
In our recent article "Immunogenetic novelty confers a selective advantage in host–pathogen coevolution" published in PNAS (read informal story behind the paper here), we demonstrate that MHC alleles to which Gyrodactylus flukes had no opportunity to adapt are associated with less severe infection in hosts. The major histocompatibility complex (MHC) is one of the most polymorphic gene families in the vertebrate genome, with natural selection actively promoting and maintaining variability. The exact mechanism/mechanisms responsible for these characteristics remain unclear, but identifying them is fundamental to our understanding of host–pathogen dynamics. Using targeted crosses of the model Trinidadian guppy, a tractable parasite, and exposure-controlled infection trials, we show that novel MHC variants are associated with less severe ...
Posted Jun 15, 2018, 5:33 AM by Jacek Radwan
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