positions open

Postdoctoral position in synaptic physiology
. The goal of our research is to understand the basic mechanisms underlying synaptic function. We have recently developed new optical methods for stimulating single GABA receptors in brain slices (Nature Methods (2010) 7, 123-127. and Nature Chemical Biology (2010) 39, 255-7.), and want to extend this work to detail the distribution of functional receptors and the balance of excitation and inhibition in pyramidal cells. We are looking for a highly motivated and independent candidate with strong background and publication record in neuroscience and expertise in patch-clamp in brain slices. The lab is well-equipped for this type of science, having three two-photon microscopes of our own. Interested candidates should e-mail a cover letter describing research experience, and the webpages of 3 references to graham.ellis-davies at mssm.edu.

Postdoctoral fellowships in chemical biology. The Ellis-Davies lab is well known for work at the interface of chemistry and biology (e.g. photosensitive, or caged, neurotransmitters for the stimulation of nerve cells). Two postdoctoral positions are available in our new labs at Mount Sinai School of Medicine to do make novel chromophores for photochemical uncaging in living animals using modern synthetic organic chemistry. The successful candidates will have the opportunity to interact with biologists, and learn about pharmacology and neuroscience. Our papers appear in high profile journals (eg. Nature Chemical Biology, Nature Methods, Nature Protocols, JACS, etc.). Candidates MUST HAVE a Ph.D. in synthetic organic chemistry for consideration. Please send these important details: 1. education history; 2. webpages of three references; and 3. list of publications. Ideally you live in the USA or Europe, as you will have to come to New York City for an interview.

Rotations for prospective PhD students in neuroscience. I am very excited to be a member of the Department of Neuroscience at Mount Sinai, not least because of the high quality of the graduate students! The core technique my lab uses is 2-photon imaging of living mice. Thus, a lab rotation involves, at a minimum, mastering this technique (see below example by Yael Grossman from a rotation in the Autumn of 2011) and showing some real interest in collaboration with the "other half" of the Ellis-Davies lab (the chemical biologists).

The possibilities of applying the longitudinal in vivo imaging technique seem almost limitless. We are currently collaborating with our colleague Hiro Hirofumi to use 2-photon imaging to help understand neuroplasticity in the visual cortex.