Welcome to Virus Research Lab

Rajeev Kaul, BVSc&AH, MVSc, PhD
Department of Microbiology ,
University of Delhi South Campus,
Benito Juarez Road,
New Delhi-110021, INDIA
Homepage on Department Website: Click here

From left to right: Juhi Jain, Nivedita Gaur, Catherine Paul, Dr.Rajeev Kaul,Tanvi Tikla, Sunil Kumar

Department Homepage on University of Delhi website : Click here
Alumni Homepage on University of Pennsylvania website : Click here

One of the major focus of our lab presently is to study biology of cancers mediated by viruses. Tumor viruses have provided relatively simple genetic systems, which can be manipulated for understanding the molecular mechanisms of the cellular transformation process. A growing body of information in the tumor virology field provides several prospects for rationally targeted therapies. However, further research is needed to better understand the multiple mechanisms utilized by these viruses in cancer progression in order to develop therapeutic strategies. The major focus of our lab is to investigate virus host interactions using various tools including cell culture system and mice models. Primarily, we study two human tumor associated viruses, one Epstein Barr Virus (EBV) and other Hepatitis C Virus (HCV). In particular, we are using genetic, genomic, proteomic and biochemical approaches to identify viral pathways involved in these cellular events to develop mechanistic models for transformation by viruses.Tumor associated viruses provide a unique opportunity to understand the role played by viral proteins in transformation and to identify pathways critical for tumorigenesis and metastasis. A clear understanding of the pathways most critically involved in tumor formation and progression and the consequences of altered cell behavior in the tissue micro-environments will provide nuggets of information which will help us in formulating better therapeutic approaches. It is likely that a combination of therapeutic agents targeting multiple signal transduction pathways will be needed for maximum therapeutic benefits.

In addition, We have recently initiated work on understanding the molecular basis of peste-des-petits ruminants (PPRV) mediated host immune modulation for the development of next generation vaccine. Immunosuppression and innate immunity control by morbilliviruses such as PPRV in small ruminants and measles in humans remains a leading cause of death among infected host because it suppresses immune function, facilitating secondary infections. The basic mechanisms underlying PPRV-induced immunosuppression are poorly understood. The extent of viral replication documented in immune cells implies that it can directly cause immunosuppression. Our central hypothesis is that these viruses have evolved a multi-pronged host cell control strategy that allow them to replicate to high levels in host cells and induce generalized immunosuppression by interfering in cellular immune signaling pathways.The work will be important for more comprehensive understanding of basic cellular processes, in addition to providing us with targets to focus for development of anti-viral therapeutics and better safer non-immunosuppressive vaccines. The implications of the generated knowledge will extend beyond the morbillivirus field to include immunology, and cell biology. Small genome, simple organization and life cycle of morbilliviruses permits their use as a tool to dissect complex cellular pathways and to determine basic aspects of immune response induction. The research will lead to generation of information which can be used for development of approaches resulting in improvement of animal health and herd immunity

Whats' New !

New Publications from lab (2017)

Lohit Khera, Catherine Paul, Rajeev Kaul. Hepatitis C Virus E1 protein promotes cell migration and invasion by modulating cellular metastasis suppressor Nm23-H1. Virology

Jaya Gandhi, Lohit Khera, Nivedita Gaur, Catherine Paul, Rajeev Kaul. Role of Modulator of Inflammation Cyclooxygenase-2 in Gammaherpesvirus Mediated Tumorigenesis. Front. Microbiol.

Catherine Paul wins first prize for best poster in NSD-2017
Catherine Paul won first prize for her Poster presentation in National Science Day Symposium 2017 at South Campus.

Nivedita Gaur wins first prize for best oral presentation in Molecular Virology meeting 2017
Nivedita Gaur won first prize for best oral presentation at Molecular Virology Meeting 2017 organized by THSTI Faridabad. 

Academic calender
for year 2016-17 at University of Delhi

Rate Contract
List of Companies in rate contract with University of Delhi for purchase of research reagents