Treating Cancer With LDN

Treating Cancer With Low Dose Naltrexone (LDN)


Naltrexone is an inexpensive generic pharmaceutical approved by the U.S. Food and Drug Administration for the treatment of drug and alcohol addiction. In very low doses, it appears to be amazingly effective in treating the cancers listed here:

Low Dose Naltrexone (LDN) is inexpensive, readily available, and taken by mouth between 9 pm and 3 am (to control for changes between Daylight Savings and Standard time, some individuals take it between 10 pm and 2 am).

The recommended dosage of LDN for the average adult is 4.5 mg (higher amounts are generally considered counterproductive). At one time, however, Dr. Bihari thought that 3 mg was the optimal daily dose for the average adult. One of Dr. Bihari's MS patients (let's call her Sally) was on 3 mg of LDN for MS and not doing particularly well. She inadvertently took 4.5 mg one night, and the next day had a dramatic improvement in her condition. This occurrence is mentioned in this video interview with his widow:

In time, most of Dr. Bihari's patients ended up on either 3 or 4.5 mg. He mentions this fact in this video documentary:

There is a great deal of misinformation on the Internet regarding LDN. Much of it derives from animal studies that have never been replicated by independent investigators, nor validated by comparable studies with humans. One of the most dangerous and irresponsible concepts is that people with cancer should not exceed a dosage of 3 mg daily.

Let's say Sally eventually developed cancer. That dictum would lower Sally's dose to 3 mg. Unfortunately, it totally ignores individual differences (does everyone have the same number of opioid receptors? does everyone metabolize LDN the same?, etc.). It is based solely on speculation and is not backed up by any clinical studies. The result of imposing this dictum on Sally would be that, not only would her MS regress, but she would not be getting the best that LDN could do for her cancer, which in this particular case would be 4.5 mg.

When it comes to LDN, one size definitely does NOT fit all. Some people will do fine on 3 mg, like a patient Dr. Berkson (mentioned later) had who suffered from B-cell lymphoma. But some need 4.5 mg to achieve the maximum therapeutic benefit, as in Sally's case. Eventually, Dr. Bihari came to believe that 4.5 mg was the optimal dose for the average adult, and most of the LDN studies involving humans used that dose. We each have to find the dose that works best for us and then stick to it religiously.

In regard to the 3 mg rule, Dr. Berkson (who has treated a great many cancer patients with LDN) has this to say: "From my experience, most cancer patients eventually receive 4.5 mg."

The following is an hour-long video documentary, "The Game Changer," produced for the LDN Research Trust. It presents the encouraging experience of numerous researchers, physicians, and patients using LDN in the treatment of various cancers, including melanoma, bladder, uterus, colon, ovarian, liver, and tongue:

Several patients mentioned using a dose of 4.5 mg to successfully treat their cancer, and one patient mentioned a using a starting dose of 1.5 mg. No patient mentioned using 3 mg as their optimal dose.

For more information about LDN dosing, visit

LDN has none of the terrible side effects often associated with chemotherapeutic agents, such as nausea, vomiting, hair loss, overwhelming fatigue, painful mouth sores, and intestinal malabsorption problems. Instead of suppressing your immune system, it enhances it. Instead of working against your body, it works with it. LDN may not be a cancer cure-all, but, in my opinion, it should at least be tried in every case of this dreaded disease.

Given its low cost and minimal side effects, some people at risk for developing cancer take LDN as a preventative measure.

In 1999, one of my half-brothers lost a four year battle with multiple myeloma (MM), a type of cancer that affects the bone marrow and which is almost always fatal. He left a wife, four young children, and a successful business. I wish to God I had known about LDN back then, because this is a video clip about a case in which LDN halted the progression of MM:

In this site, a woman claims to have used LDN to defeat not only terminal lung cancer, but a host of other conditions as well:

Here is another lung cancer testimonial:

In this site, a man gains ground against chronic lymphocytic leukemia with LDN:

This site features video interviews with a number of people who defeated cancer using LDN:

Here is a case report describing the the oral use of LDN with the intravenous administration of alpha lipoic acid (a powerful antioxidant) to successfully treat terminal pancreatic cancer:

The lead investigator in this report, Dr. Burton M. Berkson, believes alpha lipoic acid is an important adjunct to LDN in the treatment of cancer.

In December of 2009, Dr. Berkson published a report describing his successful treatment of three more cases of pancreatic cancer with the same combination of oral LDN and intravenous alpha lipoic acid. This site presents an abstract of the study:

Dr. Berkson has a website at

For detailed information about Dr. Berkson's cancer treatment protocol, please contact him at

For an informative video interview with Dr. Berkson in which he discusses LDN as a treatment for cancer, visit

Dr. Bernard Bihari recommended the nutritional supplement known as DL-Phenylalanine (DLPA) to enhance the effectiveness of LDN. It also acts as a mild antidepressant and pain-killer. The recommended dose is 500 mg in the morning and 500 mg in the afternoon, both on an empty stomach. However, it should not be used by pregnant or lactating women, in cases of phenylketonuria, by patients who are hypertensive or taking MAOI’s, or by children under 14.

Here is an online discussion group for people interested in LDN as a treatment for cancer:

For more information about the efficacy of LDN in treating cancer, visit

A very important book to read when considering the use of LDN as a treatment for cancer is

There's More To Life Than Just Living: A Personal Story About Cancer Survival

The author was diagnosed with terminal renal cancer in 2004 and given six months to live. The book tells how he overcame his condition with LDN, nutrition, and other natural means.

Another LDN-related book you may wish to read is

How To Be Free Of Alcoholism, Cancer, and Many Other Diseases

Dr. Michael B. Schachter, a physician skilled in complementary medicine, suggests a protocol for the use of LDN in the treatment of cancer at

This is the website of a Canadian clinic that employs LDN in the treatment of cancer:

With regard to the question of whether LDN should be taken concurrently with chemotherapy drugs, a number of physicians are prescribing it that way. In addition, many patients claim that LDN helps offset the adverse effects of the chemo. LDN may also be beneficial in reducing the duration of myelosuppression following chemotherapy.

It is my personal opinion that if a cancer victim can get by without chemotherapy--with its high cost and terrible side effects--he or she is much better off.

When the combination of LDN and chemotherapy is deemed desirable, there are a number of measures one can implement to counteract the side effects of chemotherapy.

This site discusses the use of acupuncture, massage, and herbs to help alleviate the side effects of chemotherapy:

This video features the successful use of medical marijuana in the treatment of chemotherapy side effects:

This site features an FDA-approved device that may be of help in treating chemo-related neuropathy:

This site discusses nutritional supplements as an aid to cancer patients:

This site discusses general nutritional considerations and cancer:

This site presents an interesting article about chemo-related cognitive impairment (also known as "chemo brain"):

It is possible that the combination of Ginkgo Biloba and colloidal gold (CG) might be of help in preventing and/or treating chemo brain. For information about CG, visit

For an enlightening article about the numerous drawbacks and limitations of chemotherapy, visit

This article presents three tonics that are said to help clear the body of chemotherapy drugs:

This article gives seven reasons why natural cancer treatments sometimes fail:

Pain medications deemed compatible with LDN include Moxxor, medical marijuana, Tramadol, aspirin, Tylenol, Advil, Aleve, Motrin, Mobic, Naprosyn, Voltaren, Feldene, Dolobid, Orudis, and DL-Phenylalanine (which has already been alluded to above).

In the absence of definitive clinical trials to the contrary, prudence would dictate that you not depend solely on LDN in the treatment of your cancer. I believe, for example, that 35% Food Grade Hydrogen Peroxide, diet, exercise, medical marijuana, colloidal silver, alpha lipoic acid, vitamin D3, Laetrile, and other treatment options are well worth considering. For more information, visit

Alternative Treatments for Cancer

For best results when dealing with cancer, I strongly suggest that you avoid dairy and gluten (see, genetically modified food (see, fried food (see, and the foods discussed here: Some people have found it also helps to avoid nightshades, e.g., tomatoes, potatoes, peppers, and eggplant (see

Some have found that physically connecting to the earth (a process called earthing/grounding) has significantly helped in terms of pain reduction. The advantage of this approach is that it does not require a doctor's prescription, has no side effects, helps many other health issues, and, after a small outlay, is absolutely FREE. For more information, visit

If you are afflicted with any condition and are not a praying person, now would be an excellent time to start. Prayer changes things, and there are a number of scientific studies that show it can hasten healing, both mental and physical. For more information, visit:

If you have questions comments, or suggestions, please feel free to contact me at

Very sincerely,

Dudley Delany, R.N., M.A., D.C.