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Drugs to Avoid on LDN

Drugs To Avoid When Taking Low Dose Naltrexone

For many years, it was thought that LDN should not be taken concurrently with immunosuppressants because their actions would conflict. As a result of time and experience, however, it is now believed that the short-term use of immunosuppressants is alright. It was also thought that LDN should not be taken concurrently with opioid-containing drugs because the LDN would nullify the effect of the opioid. It is now believed, however, that if the opioid is administered far enough apart from the LDN, there would be no conflict (do not attempt this, however, without medical supervision).

To quote Dr. David Gluck, a life-long friend and colleague of Dr. Bihari:
There are only two substantial contraindications to LDN’s use. The first is that the potential user must not be dependent on daily narcotic-containing pain medications. Remember that naltrexone is a pure opioid antagonist, so even one little capsule of LDN taken by such a person might well lead to a prompt and dangerous withdrawal reaction. The other contraindication is based on a supposition: we believe that anyone who has had an organ transplant, and thus must take daily immunosuppressant medications, ought not start using LDN, which reliably strengthens one’s immune system.

Use of LDN is generally compatible with all other treatments or medications, with these few caveats:

Use of any narcotic-containing pain medication during the same few hours (about 5 hours) of LDN’s activity is unwise because LDN will block that drug’s effect.
To read the entire article from which the above quote is taken, visit


Patients who have become dependant on daily use of narcotic-containing pain medication require at least ten days to two weeks of slowly weaning off of such drugs entirely (while substituting full doses of non-narcotic pain medications such as Tramadol) before being able to begin LDN safely.

If you are already taking immunosuppressives and want to take LDN, you may do so. However, it is advisable to gradually wean yourself off them (with medical supervision) when you are doing well on LDN.

With regard to the question of whether LDN should be taken concurrently with chemotherapy, a number of physicians are prescribing it that way. In addition, many patients claim that LDN helps offset the adverse effects of the chemo. LDN may also be beneficial in reducing the duration of myelosuppression following chemotherapy.

Any cough suppressant that says "DM" on the label may interfere with the action of LDN.

Do not take Naltrexone with any of the following without first consulting your doctor:

• disulfiram (Antabuse®);

• thioridazine (Mellaril®);

• buprenorphine (Buprenex®, Subutrex®);

• codeine (Tylenol with Codeine®, and other brand names);

• hydrocodone (Lorcet®, Lortab®, Vicodin®, Vicoprofen®, and other brand names);

• hydromorphone (Dilaudid®);

• levorphanol (Levo-Dromoran®);

• meperidine (Demerol®);

• methadone (Dolophine®, Methadose®);

• morphine (Kadian®, MS Contin®, MSIR®, OMS®, Roxanol®, Oramorph SR®, and other brand names);

• oxycodone (M-Oxy®, OxyContin®, OxyIR®, Roxicodone®, Percocet®, Percodan®, and other brand names);

• oxymorphone (Numorphan®);

• propoxyphene (Darvon®, and other brand names).

Painkillers approved for use with LDN include earthing/grounding, Moxxor, medical marijuana, Ultram® (tramadol) [should be taken six hours apart from LDN and in doses of no more than 50 mg two or three times a day], aspirin, Tylenol®, Advil®, Motrin®, Aleve®, Naprosyn®, Ansaid®, Dolobid®, Orudis®, Voltaren®, Feldene®, Mobic®, and the food supplement, DL-Phenylalanine (DLPA).

DLPA, which is also said to enhance the effectiveness of LDN, should be taken twice a day on an empty stomach in doses of 500 mg. It should not, however, be used by people with high blood pressure, pregnant or lactating women (breast feeding), in cases of phenylketonuria (a rare medical condition), by patients taking MAOI’s (monamineoxidase inhibitor drugs for mental illness), and by children under the age of 14 years.

Click here to read about three herbal painkillers that are also compatible with LDN.

In regard to alcohol consumption concurrent with taking LDN, Dr. Lenz has this to say:
One of the uses of LDN is to help alcoholics get off the juice. You should never use alcohol and LDN at the same time. Now, there will be folks who say they always have had a drink with no problems; on the other side of the coin, I know of several dozen cases where the patient has had projectile vomiting.
Alcohol is also a neurotoxin, even in small amounts. It also has other drawbacks, as indicated by this quote from an article by Dr. Joseph Mercola about the link between alcohol and cancer:
Alcohol consumption not only drives up your net carbohydrate intake, and thus glucose, but also releases toxic acetaldehyde as a first metabolite. Even light use of alcohol is linked to cancers of the mouth, pharynx, larynx, esophagus, liver, colon and, in women, breast. Carbohydrates in alcohol contribute to an increased amount of blood sugar, also linked to the development and progression of cancer.
Naltrexone is deemed compatible with marijuana (cannabis), and some doctors are now prescribing them concurrently with good results. This site gives examples of numerous diseases and conditions helped by cannabis: