本實驗室近期利用許多天然材料開發許多具抗菌與抗病毒之奈米碳點。我們發現生物多胺(bio-polyamine)如亞精胺(spermidine),經高溫處理後能生成有高表面正電之碳點(Spermidine carbon dots, CQDSpds),並利用其高表面電荷破壞細菌有效抑制並毒殺MRSA,並由於其具有打開細胞之緊密連接(tight junction)可有效應用於細菌性角膜炎(Bacterial Keratitis)的治療。與多巴胺(polydopamine)一同燒製可製備出高黏附性的亞精胺/多巴胺碳點(SPM/DA-CQDs),能有效的吸附於隱形眼鏡上做到同時殺菌與防止細菌生物膜的生成。此CQDs亦可應用於水產,Polyamine CQDs可作為蝦飼料的佐料,能有效的保護蝦苗防止其受到白點症病毒(White spot syndrome virus, WSSV)的毒害。此外,生物胺基酸製備之碳奈米膠(Carbonized Lysine-Nanogels)也證明能治療禽冠狀病毒(Bronchitis Virus)。然而不只是含氮之天然物質能有效型形成奈米碳材,薑黃素經高溫燒製後形成之薑黃素奈米粒子(Curcumin carbon dots, Cur-CQDs),能在表面形成vanillin, ferulic acid 及 4-vinyl guaiacol等由薑黃素裂解出之生物活性物質,並藉由調節Nrf2或對氧磷酶(paraoxonase)增加細胞抗氧化能力,並透過IL-6路徑達到抑制發炎的效果,搭配上這些裂解物質本身的抗氧化效能,做到有效抑制腸病毒71型(enterovirus 71, EV71)的能力。
(1) Y.-J. Li, S. G. Harroun, Y.-C. Su, C.-F. Huang, B. Unnikrishnan, H.-J. Lin*, C.-H. Lin and C.-C. Huang*, Adv. Healthcare Mater., 2016, 5, 2545–2554.
(2) H.-J. Jian, R.-S. Wu, T.-Y. Lin, Y.-J. Li, H.-J. Lin, S. G. Harroun, J.-Y. Lai* and C.-C. Huang*, ACS Nano, 2017, 11, 6703–6716.
(3) C.-J. Lin, L. Chang, H.-W. Chu, H.-J. Lin, P.-C. Chang, R. Y. L. Wang,* B. Unnikrishnan, J.-Y. Mao, S.-Y. Chen* and C.-C. Huang*, Small, 2019, 15, 1902641
(4) H.-J. Jian, J, Yu, Y.-J. Li, B. Unnikrishnan, Y.-F. Huang, L.-J. Luo, D, H.-K. Ma, S. G. Harroun, H.-T. Chang, H.-J. Lin, J.-Y. Lai* and C.-C. Huang*, Chem. Eng. J. 2020, 386, 123913.
(5) H.-T. Huang, H.-J. Lin, H.-J. Huang, C.-C. Huang, J. H.-Y. Lin* and L.-L. Chen*, Sci. Rep., 2020, 10, 1–11.
(6) D.-L. Chou, J.-Y. Mao, A. Anand, H.-J. Lin, J. H.-Y. Lin*, C.-P. Tseng, C.-C. Huang and H.-Y. Wang*, Int. J. Mol. Sci., 2021, 22, 5415.
(7) H.-Y. Lin, S.-W. Wang, J.-Y. Mao, H.-T. Chang, S. G. Harroun, H.-J. Lin*, C.-C. Huang and J.-Y. Lai*, Chem. Eng. J., 2021, 411, 128469.