Corresponding Address:
Dr. Gautam Panda
Scientist E-II, Principal Scientist from 22.02.2010
Scientist F, Sr. Principal Scientist due from 22.02.15
 
Medicinal and Process Ch
emistry Division
CSIR-CDRI (Central Drug Research Institute )
Sector-10, Jankipuram Extension, Sitapur Road, Lucknow-226031
Phone (Office) : 0522-2772450, 2772550, Ext. 4661, 4662
Phone (Mob) : 09450657049; 7355768581; Fax : 0522-2771941
Email : gautam.panda@gmail.com, gautam_panda@cdri.res.in
http://www.cdri.res.in/1547.aspx?id=1547
https://sites.google.com/view/apiatcdri/home
https://scholar.google.co.in/citations?user=YwJvoiIAAAAJ&hl=en
http://oasis.csir.res.in/gum/gumhome.aspx

http://www.ncbi.nlm.nih.gov/pubmed/?term=gautam+panda

          All    Since  2013

Citations   1768      1060

h-index       24          19

i10-index    51          41

Permanent Address: Athilagari, H. P. Sarani, P.O. Contai, Dt. Midnapore (East), West Bengal
Date of Birth: 30.11.1969

Academic Background :

 Ph.D. University of Hyderabad, with Professor Goverdhan Mehta (1999)
 M. Sc. Indian Institute of Technology (IIT) Kharagpur (1993)
 B. Sc.
 Ramakrishna Mission Residential College, Narendrapur of Calcutta University 
Madhyamik & Higher Secondary
 Contai Kshetramohan Vidyabhaban, Contai, East Midnapore, West Bengal

Current Broad Area of Research

  • Synthetic Organic, Bioorganic and Medicinal Chemistry, Chemical Biology, Chemo and Bioinformatics, Advanced Pharmaceutical Ingredients (API), Innovative Process for Blockbuster Drugs

Sub Area of Research

  • i) Ligand and structure-based screening of designed and synthesized chemical library based on Psammaplin A and Plinabulin against different kinds of DNA methyltransferase enzyme

    ii) Chemistry around Tri and Tetrasubstituted Methanes (TRSMs) as M tb ATP Synthase inhibitors; Asymmetric Synthesis of 9-substituted Xanthenes as constrained TRSMs having anti-TB properties 

    iii) Applications of Bucky-Bowls as biomaterials and carriers for selective drugs

    iv) Disruptive Innovative Process Research for Blockbuster Drugs like Bedaquiline, Paliperidone, Iloperidone and Quetiapine             

    v) Target and diversity oriented Synthesis of Bioactive natural products and designed chiral molecules from Amino Acids through identification of new synthetic methods

  • vi) Quest for Steroidomimetics: Amino acids Derived Chiral Steroidal and non-steroidal architectures as anti breast cancer agents

Postdoctoral Research: I was involved in Solid Phase Synthesis (SPS) of heterogeneous catalysts and their development as new catalytic systems for exhibiting enhanced reactivity. A bio-mimetic approach in designing Rh-based heterogenized catalysts that exhibited prolonged activity during hydroformylation reactions was developed

Doctoral Research: I was involved in multi-step organic transformations for total synthesis of Buckminsterfullerene (C60). Several new and conceptually simple approaches to fullerene fragments (bucky-bowls) that can be applied to fullerenes (bucky-balls) have been conceived and explored


Research Experience :

 Academic Title Institution Year
 Scientist  CDRISince Feb. 2002
JSPS Invitation Fellowship Program National Centre for Molecular Scale Nanoscience, Institute for Molecular Science Myodaiji, Okazaki, Japan (with Prof. Hidehiro Sakurai) Sept2011-
 July    2012
INSA, India - DFG, Germany     Exchange Fellowship  University of Duesseldorf (with Prof. Matthias Kassack )2007 (3 Months)
 Visiting FellowNational Chiao Tung Univ., Hsinchu, Taiwan (with Prof. Tse Lok Ho) ; NSERC Visiting Postdoctoral Fellow, Department of Chemistry, Univ. of Ottawa (with Prof. Howard Alper and National Research Council, Ottawa, Canada (with Prof. Prabhat Arya ) Aug. 1999- 
June 2001

Awards/Fellowships/Recognitions :


Member of Indian JSPS Alumni Association (IJAA)

Member of Evaluation committee of MEXT fellowships, Japan

Appointed as a member of “ADVISORY BOARD” for “JOURNAL OF ADVANCED LABORATORY RESEARCH IN BIOLOGY (ISSN 0976-7614)” published by “WE-Together to Save Yourself Society”

Editorship: SM Online Scientific Resources LLC, # 160 Greentree Drive,  Suite 101, Dover, DE 19904, USA.  +1-469-647-3601  info@smjournals.org

Membership of National Academy of Sciences (MNASc), Allahabad, 2014

JSPS  Invitation Fellowship Program for Research in Japan (2011-2012)
Chemical Research Society of India Bronze Medal in Chemistry (2012)
CDRI Incentive Award in Chemical sciences from CDRI, Lucknow
Visited Heinerich Heine University, Duesseldorf, Germany for three months under Indian National Science Academy, India - DFG, Germany Exchange Fellowship Programme.

Teaching and Coordinating Experience :

Teaching for the course work under Chemical Science for the candidates working at CDRI, Lucknow and registered for Ph.D. either in Jawaharlal Nehru University (JNU), New Delhi or Academy of Scientific and Innovative Research (AcSIR), New Delhi as part of the Ph.D. program.

Courses being taught: a) Conformational Analysis b) Reactive Intermediates c) Chemistry and Biology of Heterocycles d) Selected reagents for organic synthesis e) Methods for stereoselective synthesis f) Selected name reactions g) structure based drug design h) Introduction and Advances in Chemical Biology i) Green and Sustainable Chemistry j) Natural products and drug discovery

Taught for the course work on “Logic in Organic Synthesis-I (MC-520, 3 credits) in Semester-I and “Logic in Organic Synthesis-II (MC-620, 3 credits) in Semester-II at NIPER, Raebareli from 2010 to 2014

Course Coordinator from 2002 to 2009 for candidates registered for Ph.D. in JNU

Coordinator of Tuberculosis and Microbial Infection in CDRI from 2009 to 2015

Professional Society Involvement: (active membership in bold face)

       2004                            Chemical Research Society of India (CRSI), Life member

2003                            UP Science and Technology, Life member

2014                            Member of National Academy of Sciences, Allahabad

Ongoing/Completed Project Title:

a)         “Diversity Oriented Organic Synthesis of Small but Smart Molecules in Drug Discovery Research” of Rs. twenty lakhs, DST, New Delhi (2006-2009).

b)         Project Coordinator from CDRI on “Synthetic Biology (Metabolic Engineering of Vinca Alkaloid Pathway (Rs 81 lakhs) and Metabolic Engineering of Azadirachtin biosynthetic pathway (Rs 35 lakhs)” (2010-2013).

c)       “Design and Synthesis of Novel SERMs (Selective Estrogen Receptor Modulators) for the management of Osteoporosis and other estrogen related disorders” of Rs. seventeen lakhs, ICMR, New Delhi (2003-2006).

d)        “Design and Development of Tissue Selective Antiestrogens” of worth Rs. eleven lakhs, DST, New Delhi (2003- 2006).   

e)        “Amino Acids as chiral Synthons: Development of new synthetic protocols for creating Natural Products and related diversity in quest for anticancer agent” of Rs. 35 lakhs, DST, New Delhi (2010-2013).

f)       “Design, synthesis and evaluation of new chemical entities against atypical mycobacterium, Mycobacterium fortuitumof Rs. 40 lakhs, ICMR, New Delhi (2011-2013).             

g)        “Quest for Corannulene based Polyfunctional Molecules in Nanobiotechnology and Nanomedicine: Transporting and Translocating properties of Corannulene derived carrier systems” of Rs 53 lakhs, DST, New Delhi (2015-todate).

h)    Ligand and structure-based screening of designed and synthesized chemical library around Psammaplin A against DNA methyltransferase 1 (DNMT1) and Diversity oriented synthesis of Halimide & Phenylahistin related analogs as anticancer agents, of Rs 45 lakhs from MoES, New Delhi.

i)            Amino acids derived steroidal and non-steroidal Ligands as inhibitors of steroid 5-α-reductase in cancer, from BRNS, Mumbai has been approved

j)           Research Collaboration with Professor Hidehiro Sakurai, Research Center for Molecular Scale Nanoscience, Institute for Molecular Science Myodaiji, Okazaki 444-8787, JAPAN on “Design, Synthesis and functional evaluation of Bucky-Bowls and related diversity” 

Group News:

Congrats Srinivas, Sudipta and Saroj for OBC paper on alkylideneoxindoles

Congrats for Tiash, Srinivas, Saurav and Bidhu for their paper in RSC Advances

Congrats Priyanka et al for their work on TB in SAR and QSAR in Environmental Research 

Welcome Manoj, Indranil and Deblina and Amit Kumar in the group

MoES project (GAP 0195) on DNMT has been approved

BRNS Project on 5-alpha reductase has been approved

List of Past Doctoral (Ph.D.) students:

1. Shagufta (2002-2007), Thesis Title: Design and Synthesis of Antiestrogens for Contraception, Osteoporosis and management of other estrogen related disorders

PDF, Donna Nelson, University of Oklahoma, USA; PDF, A. IJzerman, Leiden/Amsterdam Centre for Drug Research, University of Leiden, Netherland;

Now as Assistant Professor –Chemistry, American University of Ras Al khaimah, Ras Al Khaimah, UAE (http://aurak.ac.ae/en/dr-shagufta-waseem/)

2. Jitendra Kumar Mishra (2002-2007)Thesis Title: Quest for Potential Bio-dynamic Agents

PDF, Peter Wipf, Department of Chemistry, University of Pittsburgh, USA, PDF, William R Roush, The Scripps Florida, USA,

Now as Staff Scientist, St. Jude Children's Research Hospital, Memphis, TN (https://www.linkedin.com/in/jitendra-mishra-5446ba11/)

3. Ajay Kumar Srivastava (2003-2008), Thesis Title: An Approach to Target and Diversity Oriented Synthesis in Drug Discovery

PDF, S. B. Park, Department of Chemistry, Seoul National University, Korea

Scientist C, IICT Hyderabad, currently as Scientist C, CSIR-Central Drug Research Institute, Lucknow (http://www.cdri.res.in/Profile_all.aspx?fid=4&id=1868)

4. Sajal Kumar Das (2003-2008), Thesis Title: Diversity Oriented Organic Synthesis of Biologically Important Molecules

PDF, Bong Rae Cho, Department of Chemistry, Korea University, Korea; PDF, Alfred Hassner, Department of Chemistry, Bar-Ilan University, Israel;

Now Assistant Prof, Tezpur Central University, Assam (http://www.tezu.ernet.in/dcs/people/faculty/~sajal/)

5. Maloy Kumar Parai (2004-2009), Thesis Title: Design, Synthesis and Evaluation of Bio-active Privileged Structures for Drug Discovery

Postdoc with Tariq M. Rana, Birmingham Institute, California, USA;

Now as postdoc with Prof. James Sacchettini, Department of Biochemistry and Biophysics, Texas A & M University, 300 Olsen Boulevard, College Station, TX 77843-2128 (http://www.sacclab.com/#!leadership/c1ab0)  

6. Krishnananda Samanta (2006-2011), Thesis Title: Synthesis of Bioactive Natural Products and Chiral Heterocycles from α-Amino Acids

Postdoc, Professor Jean-Francois Hernandez, CNRS UMR5247, Faculté de Pharmacie, 34093 Montpellier cedex 5, France;

Now Postdoc, Prof. Carsten Schmuck, Institute of Organic Chemistry, University Duisburg-Essen, Universitätsstraße 7, 45117 Essen, Room: S07 S04 C46, Germany (https://www.uni-due.de/akschmuck/group_members.shtml); joined as assistant professor in Balurghat College, West Bengal

7. Sanjit Kumar Das (2006-2011), Thesis Title: α-Amino Acids Based Stereoselective Synthesis of Biologically Important Natural Products and Natural Product-like Molecules

Working in Department of Chemistry 7.32 H3D Lab Suite, PD Hahn Building, Level 7 North Lane off Ring Road Upper Campus, University of Cape Town Rondebosch, 7700, South Africa (http://www.h3d.uct.ac.za/hd3/about-h3d/our-team)

8. Subal Kumar Dinda (2006-2011), Thesis Title: Design, Synthesis and Pharmacological Evaluation of Small Organic Molecules for Therapeutic Agent

Working in a company

9. Ritesh Singh (2007-2012)Thesis Title: Quest for Heteropolycycles as Therapeutic Agents

Postdoc with Prof. Rudi Fasan, Department of Chemistry, 416 Hutchison Hall, RC Box 270216, University of Rochester, NY 14627-0216

Postdoc, Chi-Moen Park, Korea,

Joined as DST Inspire Faculty, Indian Institute of Chemical Technology (IICT), Hyderabad

Now as JSPS fellow at Kyoto Prefectural university of Medicine Department of chemistry, Japan (http://www.f.kpu-m.ac.jp/y/chemistry/English/members.html)

10. Priyanka Singh (2008-2013)Thesis Title: Carbohydrate and Amino Acid as Chiral Synthons: Approach towards Natural Product and Natural Product like Designer Synthetic Molecules

Postdoc, Professor Jean-Francois Hernandez, Institut des Biomolécules Max Mousseron, CNRS UMR5247, Faculté de Pharmacie, 34093 Montpellier cedex 5, France

11. Saurav Bera (2009-2014)Thesis Title: Quest for Target and Diversity Oriented Synthesis of Medicinally Important Natural Product and Natural Product-like Molecules from Amino Acids

Worked in Dr. KPC life Sciences, Kolkata as research scientist

Now  joined as a postdoctoral researcher in Zhejiang University, Hangzhou, China from 1st February 2018. 

12. Amit Kumar Jana (2009-2014)Thesis Title: Synthetic Approach towards Alkaloids using Amino Acids as Building Blocks

Working in TCG Life Sciences, Kolkata

13. Sudipta Kumar Manna (2009-2014), Thesis Title: Synthetic Approach towards Amino Acid and Benzopyran Based Tetracyclic Architectures of Biological Importance

Worked in TCG Life Sciences, Kolkata

Now as postdoc in Prof. Masato Kitamura’s group, University of Nagoya, Japan as JSPS fellow

14. Sankalan Mondal (2009-2015), Thesis Title: Design, Synthesis, Molecular Modeling Studies and Bioevaluation of Trisubstituted Methanes and Amino Acids Derived Heterocycles 

Joined as DST National Postdoctoral Fellow in BHU, Varanasi 

List of Past Postdocs (minimum one year):

1. Dr. Preeti Gupta

PDF & DST-Inspire Faculty, Gautam Panda, CDRI, Lucknow 

Assistant Professor, Dr. Bhimrao Ambedkar University, Lucknow (http://www.bbau.ac.in/S%20Physics/D%20Applied%20Chemistry/Faculty_Chemistry.aspx)

 

List of Past Project Assistants (minimum one year):

1. Sailaja Ireddy, Project Assistant, OSDD (Open Source Drug Discovery)

2. Pankaj Mishra, Project Assistant, OSDD (Open Source Drug Discovery)

Now as research student (http://www.pharmaceutical-bioinformatics.org/main/member_details/Mishra,Pankaj/)

3. Mangeram MangyanProject Assistant, OSDD (Open Source Drug Discovery)

Now as research scholar, Delhi Technological University, (DTU), New Delhi

4. Tiash Saha, Project Assistant, CSIR-Network project.

Editor, Medgenera (http://medgenera.com/about)

List of Past Master’s dissertation (minimum six months):

1. Ms. Deepshikha, M.Sc. Pharmaceutical Chemistry, Banasthali University, Banasthali, Rajasthan

2. Mr. Manish Sinha, M. Pharm. Birla Institute of Technology, Mesra, Ranchi

3. Monica, M. Pharm

4. Ms. Nancy Gupta, M.Sc. in Pharmaceutical Chemistry, Banasthali University, Banasthali, Rajasthan

5. Sarpate Nikhil Datta, M. Pharm, Department of Medicinal Chemistry, NIPER, Raebareli

6. Prerna Ganwir, M. Pharm, Department of Medicinal Chemistry, NIPER, Raebareli

7. Raginee Niranjan, M.Sc. Applied Chemistry, Bundelkhand University, Jhansi

8. Mr.  Sandip Chakraborty, M. Tech, Vellore Institute of Technology-University, Vellore, Tamil Nadu,

9. Sonia Khurana, M. Pharm, Uttar Pradesh Technical University, Lucknow

10. Amit Kumar, M. Pharm, Department of Medicinal Chemistry, NIPER, Raebareli

11. Rajesh Pawar, M. Pharm, Department of Medicinal Chemistry, NIPER, Raebareli

12. Aakrusta Charana Panigrahy, M. Pharm, Department of Medicinal Chemistry, NIPER, Raebareli

13. Shashank Shekhar Mishra, M. Pharm,  Rajasthan University of Health Sciences, Jaipur.

14. Rahul KumarDepartment of Medicinal Chemistry, NIPER, Raebareli

15. Surabhi Jain, Skill Development Trainee, Ph.D. GTU, Ahmedabad pursuing

16. Vijeta Sah, M.Sc., Integral University, Lucknow

17. Priya Kalluri, M. Pharm, Department of Medicinal Chemistry, NIPER, Raebareli

For position of JRF/Project Assistant/Postdoc etc. contact me at gautam.panda@gmail.com; gautam_panda@cdri.res.in or call me at 9450657049
For Postdoc fellowships one can also go through CSIR (http://www.csirhrdg.res.in/npdf.htm) or http://csirhrdg.res.in/ra.htm
/DBT (http://www.dbtindia.nic.in/funding-mechanism-2/fellowships-for-students), DST (http://www.serb.gov.in/npdf.php), http://www.inspire-dst.gov.in/faculty_scheme.html)
/ICMR (http://icmr.nic.in/jrf.htm) websites 



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