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The paranasal sinuses are mucosal lined and air-filled spaces in the bones around your nose. There are typically four pairs of sinuses. The frontal sinuses are located in the forehead region, the maxillary sinuses are located the cheek region, the ethmoid sinuses are located between your eyes along the roof of your nasal cavity, and the sphenoid sinuses are located behind your nasal cavity.
Under normal conditions, air enters the sinuses and mucous are drained from the sinuses into the nasal cavity through small openings called ostium. The lining of the sinuses has microscopic cilia (hair-like structure) that move the mucous towards the ostium, called mucociliary clearance. In order for the sinuses to drain appropriately, the ostium of the paranasal sinuses must be open and the mucosa must have functional and healthy cilia.
The air-filled spaces in the facial bones have a theoretical benefit of decreasing the weight of the head. In addition, the sinuses may act as a crumble zone, protecting the eyes and brain in unfortunate cases of head and facial trauma. The sinuses also help humidifies the air and increase the resonance speech.
Natural sinus drainage pathway. Source: Ludman et. al. ABC of Ear, Nose & Throat & enttech.com.au
Rhinosinusitis, or commonly known as sinusitis, is inflammation and infection of the paranasal sinuses. This typically occurs when the channels (ostiums) of the sinuses are blocked and the sinuses and nasal cavities are filled with mucous and pus. The underlying cause may be anatomical abnormalities (deviated septum, enlarge turbinate, narrow ostium), nasal polyps, allergy, a viral infection (cold/flu), a bacterial infection, or a fungal infection. It affects 1 in 8 adults yearly and can cause significant quality of life impairment with loss of productivity in work and school.
Graphic illustration of a patient's left sinusitis
CT scan of a patient with a left sinus infection
CT scan of a patient with chronic sinusitis .
A patient with maxillary sinus cancer .
Nasal polyposis is typically the end result of chronic sinus infections and can present in a small subset of patients with sinus infections. Nasal polyps develop from the lining (mucosa) of the nasal cavity and the sinuses. They are typically benign semi-transparent grape-like lesions that originate from the sinuses and the nose. The exact pathophysiology leading to the development of nasal polyposis is not well known. It is linked to chronic inflammation and genetic pre-disposition. Patients with underlying sinus infections, allergy, allergic fungal sinusitis, aspirin sensitivity, alcohol intolerance, non-allergic rhinitis, cystic fibrosis and autoimmune conditions are more likely to develop nasal polyps.
Animation explaining sinusitis. Source: Free Medical Education
The common signs and symptoms of a sinus infection may include nasal congestion, thick and discolored nasal discharge, a decreased sense of smell or taste, facial pressure or fullness and fatigue. Other less common features include headaches, bad breath, fever, upper dental pain, cough, sore throat, and ear pressure. In rare cases, sinusitis can spread to the eyes or the brain.
In patients with nasal polyps, the symptoms may present much more insidiously. Common initial symptoms may include nasal congestion, runny nose, loss of smell, and chronic cough. With flare-up of the disease, classic symptoms of sinus infections will develop.
There are many types of nasal and sinus conditions with overlapping signs and symptoms. As a result, the timing, specific combination of symptoms, and other tests such as laboratory culture, allergy testing, fiberoptic nasal endoscopy and radiographic imaging can often help to find the correct diagnosis for your problem.
Source: JAMA.com
A sinus infection is considered acute if it lasts up to 4 weeks and considered chronic if it lasts more than 12 weeks. Acute sinusitis often reflects a viral or bacterial etiology whereas chronic sinusitis often reflects a prolonged inflammatory state. Chronic sinusitis may have periodic infectious flare-ups with worsening of sinus symptoms.
Healthy hair cells. Source: American Rhinologic Society
Hair cell loss in a patient with sinusitis. Source: American Rhinologic Society
Acute Viral Sinusitis
Symptoms typically presents during an upper respiratory infection such as the common cold and usually do not last more than 7-10 days.
Acute Bacterial Sinusitis
Symptoms usually do not improve within 10 days or the symptoms gets worse after a short period of improvement. The symptoms may last up to 4 weeks.
Chronic Sinusitis
May presents with or without nasal polyps. The symptoms last more than 12 weeks with possible intermittent flare-ups.
Allergic Fungal Sinusitis
Symptoms resemble chronic sinusitis and typically do not improve with antibiotics. It is characterized by non-invasive fungal element and secretion of allergic cells (eosinophils).
Invasive Fungal Sinusitis
Includes fungal ball, allergic fungal sinusitis, acute invasive fungal sinusitis, and chronic invasive fungal sinusitis.
There are multiple causes sinus infection and sinus symptoms. During your visit, your ENT doctor will perform a complete history and physical exam to determine the exact cause of your sinusitis. A procedure called a nasal endoscopy with a fiberoptic endoscope may be performed to further evaluate the nasal anatomy and sinus pathology deep inside your nose. Depending on your history and examination, your physician may refer you to obtain additional studies including blood testing, allergy testing, a sleep study, and radiographic exams.
In-office Nasal Endoscopy. Source: JAMA.com
Rigid nasal endoscope
Nasal endoscopy of a patient with a headache and post-nasal drip without other sinus symptoms. The endoscopic evaluation showed a frank sinus infection.
The treatment for sinus infections depends on the underlying cause. In general watchful waiting with supportive treatment such as nasal saline irrigation (sinus rinse or neti pot), topical nasal steroid spray, short-term nasal decongestant and oral decongestants can alleviate symptoms with most types of sinusitis.
In cases of chronic sinus infections or acute bacterial sinus infection that is not improving with watchful waiting (after 7 days), antibiotics and possible oral steroid can be considered.
Antifungal therapy has a role in the treatment of invasive fungal sinus infection, but not allergic fungal sinusitis and a fungal ball.
Sinus infection with purulent drainage. Drainage pathway is blocked, with swollen turbinate.
Sinus infection with trapped pus, bulging sinus wall from pressure build up.
Fungal debris with a "peanut butter" consistency after a sinus is surgically opened.
Sinus infections can have a significant impact on quality of life with loss of productivity at work and school. In general, the decision to proceed with sinus surgery is one that the patient and ENT surgeon makes together given the complexity of various types of sinus infections and their presentation to the individual patient. Sinus surgery is usually reserved for patients who are symptomatic and do not respond to medical therapy or for patients who develop frequent recurrent infections. In rare cases of severe orbital or intracranial complications, sinus surgery may be the first line of treatment in addition to medical management.
The most common type of surgery on the sinus is functional endoscopic sinus surgery (FESS). The goal of sinus surgery is to open up the natural drainage pathways of the paranasal sinuses for better mucous clearance and aeration of the sinuses. With wider openings, topical treatments are more feasible and reduce the need for oral and systemic antibiotics.
Functional endoscopic sinus surgery is performed through the nostrils using a fiberoptic endoscope. There is typically NO external incision and no external facial changes are anticipated. Depending on your surgery center and the extent of your surgery, your surgeon may use neuronavigation to achieve a safer and more thorough surgery. Learn more about sinus surgery or post-operative surgical care.
Source: uptodate.com
Sinus surgically opened, completely filled with pus.
Sinus cavity suctioned and the pus is rinsed out during surgery.
Endoscopy of the sinuses after surgery
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