Disuse is a common clinical condition associated with long-term bed resting and disuse induces bone loss by increasing bone resorption and decreasing bone formation. Disuse also affects millions of patients with postmenopausal osteoporosis. Results of Scl-Ab on increasing bone mass through stimulating bone formation and inhibiting bone resorption has been observed in previous animal study conducted by Amgen. Sclerostin deficiency in humans and together with data from sclerostin-knockout mice suggested that sclerostin inhibition might be an attractive approach for the development of a novel bone anabolic agent.
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