Our group focuses on the development of new catalysts and catalyzed reactions within the areas of asymmetric organocatalysis and transition metal catalysis. Since 2000, we have concentrated on palladium catalyzed carbon-carbon and carbon-heteroatom bond forming reactions as well as enantioselective organocatalysis. We have a profound interest in developing new palladium catalysts to work with nonreactive substrates using very low catalyst loadings and, if possible, water as solvent. On the other hand, the design of new and highly enantioselective chiral organocatalysts as well as the study of their mechanism by which they activate the substrates is also an important research topic in the group.
Congratulations to Dr. FRANCISCO CÍVICOS for his Award to the best PhD Thesis ("MICROWAVE-ASSISTED OXIME PALLADACYCLE-CATALYZED CROSS-COUPLING REACTIONS OF ARYL CHLORIDES AND ARYL IMIDAZOLYLSULFONATES" in the Organic Synthesis Doctoral Program of Alicante University.
Congratulations to Dr. EDUARDO BUXADERAS for his PhD Dissertation and Defense "ALKYNE CROSS-COUPLING REACTIONS CATALYZED BY OXIME PALLADACYCLES"
ALICANTE UNIVERSITY 2014
Congratulations to MELANIA GÓMEZ MARTÍNEZ for her MSc dissertation and Defense
ALICANTE UNIVERSITY 2014
Asymmetric Catalysis new journal recently launched by De Gruyter Open
covers quite well known and capital fields such as organometallic and
bioorganic catalyses as well as the emerging and growing
fast research area of organocatalysis. The journal reflects the full breadth of
research in these fields, from methodologies to synthetic applications or
mechanistic studies. Asymmetric Catalysis is an open access, electronic
only publication platform employing world's top publishing
technologies, and is published within Emerging Science Journals, unprecedented
publishing program dedicated to young and rapidly developing research areas. The Journal Advisory Board has gathered
a number of key and expert academics, who are working in this field and guarantee a high profile to our publications: Yujiro Hayashi, Svetlana B.
Tsogoeva, Petri Pihko, Peter I. Dalko, Pher Andersson, Jan H. van Maarseveen,
Andrei V. Malkov, Olga García Mancheño, José Alemán, Fernando López Garcia,
Thavendran Govender, Babak Karimi, Antonio Massa, Mikel Oiarbide, Oscar Pàmies,
Gabriel Radivoy, Rita Ventura, Jan Veselý, and Jung Woon Yang.
Asymmetric Organocatalysis Meeting and Training School (COST ORCA Action
The 5th ORCAMeeting and 1st Training School, will be held October 17-19, 2013, at Alicante University in Alicante, Spain. We are glad to bring the 5th ORCA meeting to Alicante which will attractparticipants from all over Europe to discuss on the latest advancements about asymmetric organocatalysis. Some key topics will include the design and applications of new organocatalysts; mechanistic studies; development of new organocatalyzed reactions; and other interesting topics related with industrial applications, and other interdisciplinary aspects. The intention is to emphasize on the multidisciplinary character of the asymmetric organocatalysis and, accordingly, to put together academics, industrials and students from different branches of the field.
Palladium nanoparticles supported on graphene and reduced graphene oxide as efficient recyclable catalyst for the Suzuki-Miyaura reaction of potassium aryltrifluoroborates
Microwave-assisted Palladium-catalyzed Highly Regio- and Stereoselective Head to Head Dimerization of Terminal Aryl Alkynes in Water
Diego A. Alonso and Carmen Nájera RSC Advances 2014, 4, 46508-46512.
Dihydroisobenzofurans via Palladium-catalyzed Sequential Alkynylation/Annulation
of 2-Bromobenzyl and 2-Chlorobenzyl Alcohols under Microwave Irradiation
Eduardo Buxaderas, Diego A. Alonso and Carmen Nájera Adv. Synth. Catal. 2014, 356, 3415-3421.
Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis
Recent Advances in the Catalytic Enantioselective Reformatsky Reaction
Enantioselective Synthesis of Succinimides by Michael Addition of 1,3-Dicarbonyl Compounds to Maleimides Catalyzed by a Chiral Bis(2-aminobenzimidazole) Organocatalyst
Gómez-Torres, E.; Alonso, D. A.; Gómez-Bengoa, E.; Nájera, C. Eur. J. Org. Chem. 2013, 1434-1440. DOI: 10.1002/ejoc.201201046
Microwave-Promoted Copper-free Sonogashira-Hagihara Couplings of Aryl Imidazolylsulfonates in water
Cívicos, J. F.; Alonso, D. A.; Nájera, C. Adv. Synth. Catal. 2013, 355, 203-205. DOI: 10.1002/adsc.201200629
Microwave-Promoted Suzuki-Miyaura Cross-Coupling of Aryl Imidazolylsulfonates in water
Cívicos, J. F.; Alonso, D. A.; Nájera, C. Adv. Synth. Catal. 2012, 354, 2771-2776. DOI: 10.1002/adsc.201200364
Oxime Palladacycle-Catalyzed Suzuki-Miyaura Arylation and Alkenylation of Aryl Imidazolylsulfonates under Aqueous and Phosphane-free Conditions
Cívicos, J. F.; Alonso, D. A.; Nájera, C. Eur. J. Org. Chem. 2012, 3670-3676. DOI: 10.1002/ejoc.201200368
Monge, A.; Pleixats, R.; Cattoën, X.; Chi Man, M. W.; Alonso, D. A.; Nájera, C Green Chem. 2012, 14, 1601-1610. DOI: 10.1039/C2GC35227C
Oxime Palladacycle-Catalyzed Suzuki-Miyaura Alkenylation of Aryl-, Heteroaryl-, Benzyl-, and Allyl Chlorides under Microwave Irradiation Conditions
Cívicos, J. F.; Alonso, D. A.; Nájera, C. Adv. Synth. Catal. 2011, 353, 1683-1687.DOI: 10.1002/adsc.201100019
Phosphane-Free Suzuki-Miyaura Coupling of Aryl Imidazolylsulfonates with Arylboronic Acids and Potassium Aryltrifluoroborates under Aqueous Conditions
Cívicos, J. F.; Gholinejad, M.; Alonso, D. A.; Nájera, C. Chem. Lett. 2011, 40, 907-909. DOI: 10.1246/cl.2011.
Prolinamide bridged silsesquioxane as an efficient and eco-compatible asymmetric organocatalyst
Monge, A.; Pleixats, R.; Cattoën, X.; Man, M. W. C.; Alonso, D. A.; Almasi, D.; Nájera, C. New. J. Chem. 2011, 35, 2766-2772. DOI: 10.1039/C1NJ20516A
Conjugate Addition of 1,3-Dicarbonyl Compounds to Maleimides Using a Chiral C2-Symmetric Bis(2-aminobenzimidazole) as Recyclable Organocatalyst
Gómez-Torres, E.; Alonso, D. A.; Gómez-Bengoa, E.; Nájera, C. Org. Lett. 2011, 13, 6106-6109. DOI: 10.1021/ol202599h
Oxime-derived Palladacycles as Source of Palladium Nanoparticles
Alonso, D. A.; Nájera, C. Chem. Soc. Rev. 2010, 39, 2891-2902. DOI: 10.1039/B821314N
Transition Metal-Catalyzed Synthesis of Hydroxylated Arenes
Alonso, D. A.; Nájera, C.; Pastor, I.; Yus, M. Chem. Eur. J. 2010, 316, 5274-5284. DOI: 10.1002/chem.201000470