Catalysis

Our group focuses on the development of new catalysts and catalyzed reactions within the areas of asymmetric organocatalysis and transition metal catalysis. Since 2000, we have concentrated on palladium catalyzed carbon-carbon and carbon-heteroatom bond forming reactions as well as enantioselective organocatalysis. We have a profound interest in developing new palladium catalysts to work with nonreactive substrates using very low catalyst loadings and, if possible, water as solvent. On the other hand, the design of new and highly enantioselective chiral organocatalysts as well as the study of their mechanism by which they activate the substrates is also an important research topic in the group.




News


15-07-21

Dr. Khoshnood is leaving our group. We wish you good luck in your new adventure Abbas!


15-05-19

Special Issue of Molecules "Phase-Transfer catalysis". Deadline for manuscript submissions: 15 January 2016. Editors: Dr. Isidro M. Pastor (Alicante University) and Dr. Diego A. Alonso (Alicante University).



14-12-01

Congratulations to Dr. FRANCISCO CÍVICOS for his Award to the best PhD Thesis ("MICROWAVE-ASSISTED OXIME PALLADACYCLE-CATALYZED CROSS-COUPLING REACTIONS OF ARYL CHLORIDES AND ARYL IMIDAZOLYLSULFONATES" in the Organic Synthesis Doctoral Program of Alicante University.


14-07-25

Congratulations to Dr. EDUARDO BUXADERAS for his PhD Dissertation and Defense "ALKYNE CROSS-COUPLING REACTIONS CATALYZED BY OXIME PALLADACYCLES"

ALICANTE UNIVERSITY 2014


14-07-11

Congratulations to MELANIA GÓMEZ MARTÍNEZ for her MSc dissertation and Defense

ALICANTE UNIVERSITY 2014


Asymmetric Catalysis new journal recently launched by De Gruyter Open


Asymmetric Catalysis covers quite well known and capital fields such as organometallic and bioorganic catalyses as well as the emerging and growing fast research area of organocatalysis. The journal reflects the full breadth of research in these fields, from methodologies to synthetic applications or mechanistic studies. Asymmetric Catalysis is an open access, electronic only publication platform employing world's top publishing technologies, and is published within Emerging Science Journals, unprecedented publishing program dedicated to young and rapidly developing research areas. The Journal Advisory Board has gathered a number of key and expert academics, who are working in this field and guarantee a high profile to our publications: Yujiro Hayashi, Svetlana B. Tsogoeva, Petri Pihko, Peter I. Dalko, Pher Andersson, Jan H. van Maarseveen, Andrei V. Malkov, Olga García Mancheño, José Alemán, Fernando López Garcia, Thavendran Govender, Babak Karimi, Antonio Massa, Mikel Oiarbide, Oscar Pàmies, Gabriel Radivoy, Rita Ventura, Jan Veselý, and Jung Woon Yang.


Asymmetric Organocatalysis Meeting and Training School (COST ORCA Action CM0905)

The 5th ORCAMeeting and 1st Training School, will be held October 17-19, 2013, at Alicante University in Alicante, Spain. We are glad to bring the 5th ORCA meeting to Alicante which will attractparticipants from all over Europe to discuss on the latest advancements about asymmetric organocatalysis. Some key topics will include the design and applications of new organocatalysts; mechanistic studies; development of new organocatalyzed reactions; and other interesting topics related with industrial applications, and other interdisciplinary aspects. The intention is to emphasize on the multidisciplinary character of the asymmetric organocatalysis and, accordingly, to put together academics, industrials and students from different branches of the field.




Recent publications


2015

Palladium nanoparticles supported on graphene and reduced graphene oxide as efficient recyclable catalyst for the Suzuki-Miyaura reaction of potassium aryltrifluoroborates

Melania Gómez-Martínez, Eduardo Buxaderas, Isidro M. Pastor and Diego A. Alonso J. Mol. Catal. A-Chem 2015, 404-405, 1-7.

doi:10.1016/j.molcata.2015.03.022




2014

Microwave-assisted Palladium-catalyzed Highly Regio- and Stereoselective Head to Head Dimerization of Terminal Aryl Alkynes in Water

Eduardo Buxaderas, Diego A. Alonso and Carmen Nájera RSC Advances 2014, 4, 46508-46512.


Synthesis of Dihydroisobenzofurans via Palladium-catalyzed Sequential Alkynylation/Annulation of 2-Bromobenzyl and 2-Chlorobenzyl Alcohols under Microwave Irradiation

Eduardo Buxaderas, Diego A. Alonso and Carmen Nájera Adv. Synth. Catal. 2014, 356, 3415-3421.

DOI: 10.1002/adsc.201400457



2013


Copper-Free Oxime–Palladacycle-Catalyzed Sonogashira Alkynylation of Deactivated Aryl Bromides and Chlorides in Water under Microwave Irradiation
Eduardo Buxaderas, Diego A. Alonso and Carmen Nájera Eur. J. Org. Chem. 2013, 5864-5870 . DOI: 10.1002/ejoc.201300785


Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis
M. Ángeles Fernández-Ibáñez, Beatriz Maciá, Diego A. Alonso and Isidro M. Pastor. Molecules 2013, 18, 10108-10121. DOI: 10.3390/molecules180910108


Recent Advances in the Catalytic Enantioselective Reformatsky Reaction
M. Ángeles Fernández-Ibáñez, Beatriz Maciá, Diego A. Alonso and Isidro M. Pastor. Eur. J. Org. Chem. 2013, 7028-7034. DOI: 10.1002/ejoc.201300571


Enantioselective Synthesis of Succinimides by Michael Addition of 1,3-Dicarbonyl Compounds to Maleimides Catalyzed by a Chiral Bis(2-aminobenzimidazole) Organocatalyst  

 Gómez-Torres, E.; Alonso, D. A.; Gómez-Bengoa, E.; Nájera, C. Eur. J. Org. Chem. 2013, 1434-1440. DOI: 10.1002/ejoc.201201046


Microwave-Promoted Copper-free Sonogashira-Hagihara Couplings of Aryl Imidazolylsulfonates in water

Cívicos, J. F.; Alonso, D. A.; Nájera, C. Adv. Synth. Catal. 2013, 355, 203-205. DOI: 10.1002/adsc.201200629


2012

Microwave-Promoted Suzuki-Miyaura Cross-Coupling of Aryl Imidazolylsulfonates in water
Cívicos, J. F.; Alonso, D. A.; Nájera, C. Adv. Synth. Catal. 2012, 354, 2771-2776DOI: 10.1002/adsc.201200364



Oxime Palladacycle-Catalyzed Suzuki-Miyaura Arylation and Alkenylation of Aryl Imidazolylsulfonates under Aqueous and Phosphane-free Conditions
Cívicos, J. F.; Alonso, D. A.; Nájera, C. Eur. J. Org. Chem. 2012, 3670-3676DOI: 10.1002/ejoc.201200368



Recyclable silica-supported prolinamide organocatalysts for direct asymmetric aldol reaction in water
Monge, A.; Pleixats, R.; Cattoën, X.; Chi Man, M. W.; Alonso, D. A.; Nájera, C Green Chem. 2012, 14, 1601-1610DOI: 10.1039/C2GC35227C




2011

Oxime Palladacycle-Catalyzed Suzuki-Miyaura Alkenylation of Aryl-, Heteroaryl-, Benzyl-, and Allyl Chlorides under Microwave Irradiation Conditions
Cívicos, J. F.; Alonso, D. A.; Nájera, C. Adv. Synth. Catal. 2011, 353, 1683-1687.DOI: 10.1002/adsc.201100019



Phosphane-Free Suzuki-Miyaura Coupling of Aryl Imidazolylsulfonates with Arylboronic Acids and Potassium Aryltrifluoroborates under Aqueous Conditions
Cívicos, J. F.; Gholinejad, M.; Alonso, D. A.; Nájera, C. Chem. Lett. 2011, 40, 907-909. DOI: 10.1246/cl.2011.


Prolinamide bridged silsesquioxane as an efficient and eco-compatible asymmetric organocatalyst
Monge, A.; Pleixats, R.; Cattoën, X.; Man, M. W. C.; Alonso, D. A.; Almasi, D.; Nájera, C. New. J. Chem. 2011, 35, 2766-2772. DOI: 10.1039/C1NJ20516A


Conjugate Addition of 1,3-Dicarbonyl Compounds to Maleimides Using a Chiral C2-Symmetric Bis(2-aminobenzimidazole) as Recyclable Organocatalyst
Gómez-Torres, E.; Alonso, D. A.; Gómez-Bengoa, E.; Nájera, C. Org. Lett. 2011, 13, 6106-6109. DOI: 10.1021/ol202599h




2010

Oxime-derived Palladacycles as Source of Palladium Nanoparticles
Alonso, D. A.; Nájera, C. Chem. Soc. Rev. 2010, 39, 2891-2902. DOI: 10.1039/B821314N



Transition Metal-Catalyzed Synthesis of Hydroxylated Arenes
Alonso, D. A.; Nájera, C.; Pastor, I.; Yus, M. Chem. Eur. J. 2010, 316, 5274-5284. DOI: 10.1002/chem.201000470