Gleevec (imatinib) is a biological treatment that has been approved for the treatment of metastatic or recurrent DFSP and DFSP-FS. It was first marketed for Chronic Myelogenous Leukemia (CML). a disease to which I lost a dear friend back before it was treatable. Here is a quote from a site on DFSP and Gleevec. "Before starting imatinib therapy, cytogenetic studies to confirm PDGFB gene rearrangement may be necessary for predicting the clinical response. Chromosome translocation t(17,22) is detected in more than 90% of DFSP tumors." " Although medical therapy is not a first-line treatment for localized dermatofibrosarcoma protuberans (DFSP), the approved molecular-targeted drug, imatinib mesylate, is an effective oral medication for unresectable, recurrent, and/or metastatic DFSP." I will post a link to the site the above quotes were respectfully snipped from. I hope this info helps anyone wanting to know more about gleevec and it's use in DFSP treatment.