When it comes to miniature size machinery, nature by far outcompetes human-made devices on both scale and robustness. Consider for example the DNA polymerase (DNAp), the molecular machine that copies the genetic information from mother cell to daughter cell. The DNAp has a size of a few nanometers, but can work at speeds approaching 1000 nucleotides copied per second, while making less than an error 10 million nucleotides---all while operating inside a crowded and highly thermal environment of the cell. Understanding how such feats are achieved by various molecular machines forms the primary focus of our group, as we aim to build theoretical models that explain how complex biological function arises from simple molecular interactions. For more information on current research directions, please see the research page.
Our theoretical group enjoys the luxury of being integrated into the largely experimental department of Bionanoscience at TU Delft. Though the work we perform is theoretical, we often work closely with experimental collaborators.