The mechanism of mRNA transport and localised translation in Drosophila. We are elucidating the cis-acting RNA signals and transacting factors that dictate the intracellular destination of mRNA and its localised translation in oocytes and neuromuscular junctions.
Keywords: RNA, Development, Drosophila, live cell imaging, synaptic plasticity, neuromuscular junction
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Cells are the fundamental unit of all life on earth. Understanding how cells function is a major goal of modern biology and is of major importance in medicine. Our lab is using flies as a model system to understand how molecules are actively sorted and distributed within cells. We are working to better understand how the growth and development of nerves is regulated. Furthermore, flies are an excellent model for many human diseases, including genetic disorders and infections.
mRNA localisation and localised translation and their roles in establishing the body plan in the oocytes and embryos
mRNA transport and localised translation and its role in synaptic plasticity at the Neuromuscular junction
Construction of the Deep SIM microscope (in collaboration with Micron Oxford)
Video by Kirsty Gill & Richard Parton
We use fluorescent proteins to track the movement of RNA through Drosophila, the animal system that we use in the lab. This video shows in-vitro transcribed gurken RNA localising to the dorsal-anterior corner of a stage 8 Drosophila egg chamber after injection.
Video by Lu Yang
This is a 3-dimensional image of a Drosophila larva, showing the muscle wall and its associated neurons. The red part of the image is a neuron while the blue circular structures are muscle cell nuclei.
Selected Recent Publications