The mechanism of mRNA transport and
localised translation in Drosophila. We are elucidating the cis-acting RNA
signals and transacting factors that dictate the intracellular
destination of mRNA and its localised translation in oocytes and neuromuscular junctions.
Keywords: RNA, Development, Drosophila, live cell imaging, synaptic plasticity, neuromuscular junction
We welcome informal enquiries from prospective Post-Doc (email darragh.ennis@bioch.ox.ac.uk) and PhD students (go here)
Cells are the fundamental unit of all life on earth. Understanding how cells function is a major goal of modern biology and is of major importance in medicine. Our lab is using flies as a model system to understand how molecules are actively sorted and distributed within cells. Furthermore, flies are an excellent model for many human diseases, including genetic disorders and infections.
Major Funding Sources Wellcome Trust Senior Fellowship Until 2017Wellcome Trust Strategic Award: Advanced Imaging for Chromosome and RNA Dynamics (Micron) Until 2016
__________________________________________________________ David Ish-Horowicz science family at the 2013 RNA Localisation Meeting in Toronto | DPhil Opportunities in Advanced Imaging
We currently have openings for a doctoral programme in advanced imaging, with a focus on biomedical imaging, starting in October 2014. For more information please contact darragh.ennis@bioch.ox.ac.uk
Selected Recent Publications -
Weil TT, Parton RM, Herpers B, Soetaert J, Veenendaal T, Xanthakis D, Dobbie IM, Halstead JM, Hayashi R, Rabouille C, Davis I. (2012). Drosophila patterning is established by differential association of mRNAs with P bodies. Nat Cell Biol. 1305-13. pdf - McDermott SM, Meignin C, Rappsilber J, Davis I. (2012). Drosophila Syncrip binds the gurken mRNA localisation signal and regulates localised transcripts during axis specification. Biology Open 1, 488-497.pdf
- Weil TT, Parton RM, Davis I. (2012) .Preparing Individual Drosophila Egg Chambers for Live Imaging. J. Vis. Exp. (60), e3679. video
- Parton RM, Hamilton RS, Ball G, Yang L, Cullen CF, Lu W, Ohkura H, Davis I. (2011). PAR-1-dependent orientation gradient of dynamic microtubules directs posterior cargo transport in the Drosophila oocyte. J Cell Biol. 194, 21-35. pdf Podcast
- Brown A., Oddos, S., Dobbie, I., Alakoskela, J., Parton, R., Eissmann, P., Neil, M., Dunsby, C., French, P., Davis, I., Davis, D.. (2011) Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy. Plos Biol. 9: 31001152. free pdf
- Oliveira, R., Hamilton, R., Pauli, A., Davis, I., Nasmyth,
K. (2010) Cohesin cleavage and Cdk inhibition trigger formation of
daughter nuclei. Nature Cell Biol, 12:185-92 pdf
- Weil, TT., Xanthakis,
D., Parton, R., Dobbie, I., Rabouille, C., Gavis, E. and Davis, I.
(2010). Distinguishing direct from indirect roles for bicoid mRNA
localization factors. Development 13: 169-176 free pdf
- Meignin C, and Davis I. (2010) Transmitting the message: intracellular mRNA localization. Curr Opin Cell Biol 22:112-9
- Weil, T, Parton, R. and Davis I. (2010) Making the message clear: Visualizing mRNA localization Trends in Cell Biology
- Zimyanin VL, Belaya K, Pecreaux J, Gilchrist MJ, Clark A, Davis I, St Johnston D. (2008). In vivo imaging of oskar mRNA transport reveals the mechanism of posterior localization. Cell 134, 843-53 free pdf
- Weil TT, Parton R, Davis I, Gavis ER. (2008). Changes in bicoid mRNA anchoring highlight conserved mechanisms during the oocyte-to-embryo transition. Current Biology 18, 1055-61 free pd
Research Projects mRNA localisation and localised translation and their roles in establishing the body plan in the oocytes and embryos
mRNA transport and localised translation and its role in synaptic plasticity at the Neuromuscular junction (Ben Bleasdale and Ilan Davis)
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