The field of Developmental Biology asks the fundamental question of how the simple and uniform early embryo is programmed to give rise to an astonishing variety of tissues and functions in the adult. Our lab is mostly interested in these topics during the development of the nervous system, by studying two distinct, although related, embryonic tissues; hindbrain and cranial neural crest. Chicken and mouse embryos serve as model systems to answer central questions such as which genes coordinate hindbrain development from early embryonic stages of neural progenitor/stem cells to later processes of neural differentiation, axonal navigation,  and connectivity formation, as well as how matrix metalloproteases promote neural crest migration and ECM modulation in the developing embryo. In addition, a more applicable research in the lab aims to develop the chick embryo as a proof of concept model to test for environmental contaminants. The lab combines state of the art technologies, such as Crisper/Cas and Cre-Lox-based methodologies in chick embryos in vivo, NSC isolation and manipulation, mutant mice lines and advanced microscopy with classical developmental biology  strategies.