Dr. Wood, B.

Brent Wood obtained his MD and PhD from Loma Linda University followed by a residency in Anatomic and Clinical Pathology at the University of Washington in Seattle. After a fellowship in Hematopathology at the University of Washington, Dr. Wood accepted a faculty position in the Department of Laboratory Medicine at the University of Washington where he is currently Professor and Director of the Hematopathology Laboratory. His responsibilities include extensive clinical service work and teaching Hematopathology to medical technology students, medical students, residents and fellows. Flow cytometry is an area of particular interest for Dr. Wood and he is responsible for implementing the first use of 9 and 10 color flow cytometry in the clinical laboratory and exploiting its potential for the identification of minimal residual disease in acute lymphoid and myeloid leukemia. His laboratory serves as one of two national reference laboratories for the identification of minimal residual disease in childhood acute lymphoblastic leukemia for the Children's Oncology Group and is involved in similar protocols with the Southwest Oncology Group. Dr. Wood lectures both nationally and internationally on clinical applications of flow cytometry and is President of the International Clinical Cytometry Society.
Lecture and Wet Lab

Flow cytometry has become an important methodology in the clinical laboratory for the enumeration of cell populations and the diagnosis of hematopoietic neoplasia. Dr. Wood will discuss the optimization of instrument and reagents, quality control of instrumentation, reagents and process, principles of data interpretation, and the application of flow cytometry to the detection of minimal residual disease. The objective is that the participant will obtain a sufficient understanding of the technology to allow the generation of high-quality flow cytometry data and understand the principles of data analysis relative to the diagnosis of hematopoietic neoplasia.


Relevant Literature

Wood BL 9 and 10 color flow cytometry in the clinical laboratory. Archives of Path. and Lab. Med. 130: 680-690, 2006.

Wood, BL Myeloid neoplasms: Myelodysplasia, myeloproliferative disorders, and acute myeloid leukemia. Clinics in Lab Medicine 27: 551-575. 2007.

Roshal M, Fromm JR, Winter S, Dunsmore K and Wood BL (2009) Immaturity associated antigens are lost during induction for T cell lymphoblastic leukemia: implications for minimal residual disease detection. Cytometry Part B 78:139-46.

Walter RB, Gooley TA, Wood BL, Milano F, Fang M, Sorror ML, Estey EH, Salter AI Lansverk E, Chien JW, Gopal AK, Appelbaum FR, and Pagel JM. (2011) Impact of Pre- Transplant Minimal Residual Disease, as Detected by Multiparametric Flow Cytometry, on Outcome of Myeloablative Hematopoietic Cell Transplantation for Acute Myeloid Leukemia. JCO 29:1190-7.

Wood BL and Borowitz M. Flow Cytometry. Clinical Diagnosis and Management by Laboratory Methods (Henry), W.B. Saunders, 2011.