Dr. Borowitz, M.

Michael J Borowitz is a Professor of Pathology and Oncology, Johns Hopkins Medical Institutions. He received his MD PhD from Duke University and completed residency training in Anatomic and Clinical Pathology from Duke. He has been on the faculty at Johns Hopkins since 1993. His area of interest includes diagnosis and classification of hematologic malignancies, and in the application of ancillary diagnostic testing, particularly flow cytometry, in their characterization. He has a particular interest in childhood acute lymphocytic leukemia, and for the past 25 years has been active in laboratory studies in support of clinical trials in this disease. He has long been involved in training courses in flow cytometry of leukemia. He has been President of the International Clinical Cytometry Society. 
Lectures and Labs

Lectures and Labs: Dr. Borowitz will present lectures on minimal residual disease in childhood ALL and flow cytometric testing for paroxysmal nocturnal hemoglobinuria. In the former, he will compare and contrast methodologic aspects of testing, and discuss the clinical significance of MRD detection in a variety of clinical trials. In the PNH lecture, he will describe the development of consensus guidelines for PNH testing, and discuss features that characterize high quality testing of PNH. 

In conjunction with Dr. Wood, Dr. Borowitz will present illustrative case studies in leukemia and lymphoma, emphasizing interpretation of patterns of antigen expression in a variety of leukemias that can be used to diagnose and classify leukemias. He will also present examples of MRD detection in ALL, emphasizing analysis strategies and pitfalls in the interpretation of these cases. 

Relevant Literature

Borowitz MJ, Devidas M, Hunger SP, Bowman WP, Carroll AJ, Carroll WL, Linda S, Martin PL, Pullen DJ, Viswanatha D, Willman CL, Winick N, Camitta BM. (2008) Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: A Children's Oncology Group study. Blood. 111:5477-85. [Epub 2008 Apr 3] 

Bowman WP, Larsen EL, Devidas M, Linda SB, Blach L, Carroll AJ, Carroll WL,Pullen DJ, Shuster J, Willman CL, Winick N, Camitta BM, Hunger SP, Borowitz MJ(2011).Augmented therapy improves outcome for pediatric high risk acute lymphocytic leukemia: Results of Children's Oncology Group trial P9906. Pediatr Blood Cancer.2011 57:569-77 [Epub 2011 Feb 25] 

Borowitz MJ, Craig FE, Digiuseppe JA, Illingworth AJ, Rosse W, Sutherland DR,Wittwer CT, Richards SJ; Clinical Cytometry Society. Guidelines for the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria and related disorders by flow cytometry. Cytometry B Clin Cytom. 2010 Jul;78(4):211-30.