Research program

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The mission of the Translational Exercise Biology Laboratory is to elucidate cellular and molecular mechanisms underlying cardiovascular and skeletal muscle adaptations by conducting innovative translational research with genomics being the common theme. We are particularly interested in studying cellular adaptations to exercise-induced mechanical / biochemical stimulations in cardiovascular and skeletal muscle systems through which potentially druggable targets can be discovered.
 
Our current research focuses are:
1) Shear stress-induced mitochondrial remodeling in vascular endothelium; and physiological role of mitochondrial fission/fusion events in exercise-induced muscle adaptation
2) To conceptualize the effect of exercise on multi-directional crosstalk among cells in different organ systems including vessels, muscles, liver, and brain.
3) To discover blood biomarker for the repetitive subconcussive head injury.

Our Innovative approaches including research techniques in bioinformatics, physiology, cell biology, molecular genetics and epigenomics. Our research models include mechanical shear stress, primary cell culture, transgenic mice, mitochondrial functional assays, site-directed mutagenesis, random DNA mutation capture, microvescicle/exosomal markers discovery,  gain- and loss-of-function studies, microarray, NGS, and other -omics combining with acute and chronic exercise.

 
 
MITOCHONDRIAL REMODELINGMULTI-DIRECTIONAL CROSSTALKSBIOMARKER DISCOVERYCARDIOVASCULAR PATHOPHYSIO-GENOMICS

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