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Soumalee Basu, Assistant Professor


Research Interests

The research group is involved in molecular modelling and dynamics besides in silico protein-protein interaction study of plant and animal Leucine-rich Repeat (LRR) proteins (PGIP & TLR respectively) involved in innate immunity. The aim is to address issues of hampered crop yield due to fungal infection and therapeutics against human diseases respectively, in addition to building up knowledge of how and why this unique repeat fold has been popularly used.

Identification of flavonoids with antiamyloidogenic properties and or with properties to inhibit beta-secretase using in vitro studies is a parallel research interest of the group. In future the laboratory plans to design lead compounds for therapeutics in not only Alzheimer's disease but other neurodegenrative diseases as well.

Recent Publications

  1. Sucharita Das & Soumalee Basu, Multi-targeting Strategies for Alzheimer's Disease Therapeutics: Pros and Cons. Current Topics in Medicinal Chemistry (2017) 17(27) 3017-3061.
  2. Sandipan Chakraborty & Soumalee Basu, Multi-functional activities  of citrus flavonoid narirutin in Alzheimer’s disease therapeutics: An integrated screening approach and in vitro validation. International Journal of Biological Macromolecules (2017) Oct:103: 733-743.
  3. Sandipan Chakraborty & Soumalee Basu, Dual inhibition of BACE1 and Aβ aggregation by β-ecdysone: Application of a phytoecdysteroid scaffold in Alzheimer’s disease therapeutics. International Journal of Biological Macromolecules (2017) Feb;95:281-287.
  4. Ananya Marik, Haraprasad Naiya, Madhumanti Das, Gairik Mukherjee, Soumalee Basu, Chinmay Saha, Rajdeep Chowdhury, Kankan Bhattacharya & Anindita Seal, Split-ubiquitin yeast two-hybrid interaction reveals a novel interaction between a natural resistance associated macrophage protein and a membrane bound thioredoxin in Brassica junceaPlant Molecular Biology (2016) Nov.92(4-5):519-537.
  5. Sandipan Chakraborty, Jaya Bandyopadhyay, Sourav Chakraborty & Soumalee Basu, Multi-target screening mines hesperidin as a multi-potent inhibitor : implications in Alzheimer's Disease therapeutics. European Journal of Medicinal Chemistry. (2016)  Oct4;121:810-22.

  6. Sandipan Chakraborty & Soumalee Basu, Structural insight into the mechanism of amyloid precursor protein recognition by β-secretase 1: A molecular dynamics study. Biophysical Chemistry. (2015) 202: 1-12.
  7. Sucharita Das, Sandipan Chakraborty & Soumalee Basu, Fragment-based designing for the generation of novel leads against BACE1. Central Nervous System Agents in Medicinal Chemistry. (2015) 15:1 52-64.
  8. Sandipan Chakraborty, Balaji Ramachandran & Soumalee Basu, Encompassing receptor flexibility in virtual screening using ensemble docking-based hybrid QSAR model: discovery of novel phytochemicals for BACE1 inhibition. Molecular Biosystems (2014) 10:2684-2692.
  9. Sandipan Chakraborty & Soumalee Basu, Mechanistic insight into the radical scavenging activity of polyphenols and its application in virtual screening of phytochemical library: an in silico approach. European Food Research Technology (2014) DOI 10.1007/s00217-014-2285-x
  10. Sandipan Chakraborty & Soumalee Basu, Insight into the anti-amyloidogenic activity of polyphenols and its application in virtual screening of phytochemical database. Medicinal Chemistry Research (2014) DOI 10.1007/s00044-014-1081-2.
  11. Sandipan Chakraborty, Soumalee Basu & Soumen Basak, Effect of β-cyclodextrin on the molecular properties of myrecetin upon nano-encapsulation: Insight from optical spectroscopy and quantum chemical studies. Carbohydrate Polymers (2014) 99(2) 116-125.
  12. Sandipan Chakraborty, Barnali Chatterjee & Soumalee Basu, Pinpointing proline substitution to be responsible for the loss of amyloidogenesis in IAPP. Chemical Biology & Drug Design (2013) 82(4) 446-452.
  13. Aditi Maulik & Soumalee Basu, Study of Q224K, V152G double mutation in bean PGIP2, an LRR protein for plant defence- an in silico approach. PROTEINS: Structure Function & Bioinformatics 2013 81(5) 852-862.
  14. Sandipan Chaktaborty, Barnali Chatterjee & Soumalee Basu, A mechanistic insight into the amyloidogenic structure of hIAPP peptide revealed from sequence analysis and molecular dynamics simulations. Biophysical Chemistry (2012) 168-169:1.
  15. Aditi Maulik, Asif Sarkar, Suneeta Devi & Soumalee Basu, Study of polygalacturonase-inhibiting proteins (PGIP) – a leucine-rich repeat (LRR) protein in plant defense. Plant Biology (2012) 14(1) :22{Special Issue on plant pathogen interaction of February}
  16. Sandipan Chakraborty. Sanjay Kumar and Soumalee Basu, Conformational transition in the substrate binding domain of β-secretase exploited by NMA and its implication in inhibitor recognition: BACE1-myricetin a case study. Neurochemistry International 58(8):914 (2011).
  17. Sumana Banerjee, Soumalee Basu and Srimonti Sarkar, Comparative genomics reveals preferential distribution and domain organization of FYVE and PX domain proteins across eukaryotic lineages. BMC Genomics 11:83 (2010).
  18. Sandipan Chakraborty, Soumalee Basu, Ansuman Lahiri and Soumen Basak, Inclusion of chrysin in β-cyclodextrin nanocavity and its effect on antioxidant potential of chrysin: A spectroscopic and molecular modeling approach. Journal of Molecular Structure 977:180 (2010).
  19. Aditi Maulik, Hiren Ghosh and Soumalee Basu, Comparative study of protein-protein interaction observed in PolyGalacturonase-Inhibiting Proteins from Phaseolus vulgaris and Glycine max and PolyGalacturonase from Fusarium moniliforme. BMC Genomics, 10: S19 (2009).

Group Members

    Madhusudan Dutta, SRF     

    Sucharita Das, SRF

Ph.D. awarded

Dr. Aditi Maulik
Dr. Sandipan Chakraborty