Welcome to the crablab at Illinois State University

One of the fundamental questions in Neuroscience is understanding how sensory pathways control neural circuit function to produce adequate behavioral responses in varying environmental conditions. The Stein lab uses experimental and theoretical approaches to study the neuromodulation of sensory pathways and motor circuits, exploiting the advantages of the central pattern generating circuits in the crustacean stomatogastric ganglion. Central pattern generators are sets of neurons that exist in most animals and control rhythmic behaviors, including walking, swimming, breathing and swallowing. In the stomatogastric ganglion, these neurons are easy to record from, they continue to function even if isolated from the animal, and their connectivity is known. Methods used in the lab are manifold, including current and voltage clamp recordings, optical imaging, RNA and DNA extraction, and computer modeling.
The photo above shows a fluorescence staining of the stomatogastric ganglion and its 26 motor neurons. For details click here to read Goldsmith et al., 2014.


  • Nature Eco Evo paper out Our marbled crayfish genome paper is out. Congrats to our collaborators for making this such a nice story!In this study we sequenced the genome of a parthenogenetic species of ...
    Posted Feb 9, 2018, 5:34 PM by Wolfgang Stein
  • Travelling from around the world to tour our lab! Science knows no borders. We hosted a lab tour for a group of Chinese students from Southwest University yesterday. We had a blast. Come again!
    Posted Jan 26, 2018, 4:32 PM by Wolfgang Stein
  • Recruiting new graduate students The Stein lab is looking for new graduate students to join our lab. We are particularly interested in students with a keen interest in using neurophysiology and optical imaging to ...
    Posted Jan 18, 2018, 7:09 PM by Wolfgang Stein
  • Society for Neuroscience meeting We had four posters at this year's annual meeting of the Society for Neuroscience, three of which were related to our current NSF-funded project. Click here to see ...
    Posted Nov 24, 2017, 2:13 PM by Wolfgang Stein
  • New YouTube videos uploaded I finally had time to finish and upload the newest videos from my MotoVlog series. There are a total of six new videos: 1. What are scientific theories?2. Why ...
    Posted Nov 4, 2017, 9:40 PM by Wolfgang Stein
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