Welcome to the crablab at Illinois State University

One of the fundamental questions in Neuroscience is understanding how sensory pathways control neural circuit function to produce adequate behavioral responses in varying environmental conditions. The Stein lab uses experimental and theoretical approaches to study the neuromodulation of sensory pathways and motor circuits, exploiting the advantages of the central pattern generating circuits in the crustacean stomatogastric ganglion. Central pattern generators are sets of neurons that exist in most animals and control rhythmic behaviors, including walking, swimming, breathing and swallowing. In the stomatogastric ganglion, these neurons are easy to record from, they continue to function even if isolated from the animal, and their connectivity is known. Methods used in the lab are manifold, including current and voltage clamp recordings, optical imaging, RNA and DNA extraction, and computer modeling.
The photo above shows a fluorescence staining of the stomatogastric ganglion and its 26 motor neurons. For details click here to read Goldsmith et al., 2014.

Messages

  • Phi Sigma Research Symposium Congrats to everyone in the lab for another successful Phi Sigma Research Symposium and great presentations! Special shout-out to our three prize winners Josselyn Gonzalez (best oral presentation), Maisam ...
    Posted Apr 13, 2019, 10:16 AM by Wolfgang Stein
  • University Research Symposium Our students presented at this year's University research symposium. With four posters from graduate students and one undergraduate poster we were among the most productive labs. The photos below ...
    Posted Apr 5, 2019, 4:12 PM by Wolfgang Stein
  • ScienceTrend article about our PloS Biology paper Great article on ScienceTrend about our @PLOSBiology paper on how multisensory information is encoded in the nervous system: http://buff.ly/2HGN4ga
    Posted Mar 19, 2019, 10:52 AM by Wolfgang Stein
  • Confocal imaging of pyloric axons with distinct properties Our lab is interested in temperature effects on neurons and their function. Most long distance communication in the nervous system is carried our by long neuronal processes called axons. These ...
    Posted Dec 27, 2018, 11:04 AM by Wolfgang Stein
  • New PLoS Biology paper Our newest paper is out in PLoS Biology: Follmann, R., Goldsmith, C.J. & Stein, W.* (2018). Multimodal sensory information is represented by a combinatorial code in a sensorimotor system. PLoS ...
    Posted Nov 21, 2018, 9:15 PM by Wolfgang Stein
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