About Us

Our founding scientist, Leslie Crews Robertson, PhD received her undergraduate training at the University of California, Los Angeles, where she majored in Microbiology, Immunology and Molecular Genetics and graduated with Magna cum laude honors. She has laboratory experience in both industry and academic research, and obtained her graduate degree at the University of California, San Diego.

Credentials and writing experience:

  • Laboratory-trained scientist (PhD in Molecular Pathology, UCSD)
  • Over 10 years of extensive writing experience in large academic research labs
  • Assisted in writing and preparing over 15 successfully-funded grant applications
  • Co-author of over 50 original research articles, reviews, and book chapters
  • Strong track record of publication in basic science and clinical research studies

Selected publications:

  1. Jiang Q, Crews LA, Barrett CL, Chun H-J, Court AC, Isquith JM, Zipeto MA, Goff DJ, Minden M, Sadarangani A, Rusert J, Dao KH, Morris SR, Goldstein LSB, Marra MA, Frazer KA & Jamieson CH (2012) ADAR1 Drives Malignant Progenitor Reprogramming in Chronic Myeloid Leukemia. Proc Natl Acad Sci U S A Epub 28 Dec 2012.

  2. Crews L, Spencer B, Desplats P, Patrick C, Paulino A, Rockenstein E, Hansen L, Adame A, Galasko D, Masliah E: Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy, PLoS ONE 2010, 5:e9313
  3. Crews L, Rockenstein E, Masliah E: APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesis, Brain Struct Funct 2010, 214:111-126
  4. Crews L, Adame A, Patrick C, Delaney A, Pham E, Rockenstein E, Hansen L, Masliah E: Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis, J Neurosci 2010, 30:12252-12262
  5. Pham E, Crews L, Ubhi K, Hansen L, Adame A, Cartier A, Salmon D, Galasko D, Michael S, Savas JN, Yates JR, Glabe C, Masliah E: Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins, Febs J 2010, 277:3051-3067
  6. Rose JB, Crews L, Rockenstein E, Adame A, Mante M, Hersh LB, Gage FH, Spencer B, Potkar R, Marr RA, Masliah E: Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease, J Neurosci 2009, 29:1115-1125
  7. Crews L, Patrick C, Achim CL, Everall IP, Masliah E: Molecular pathology of neuro-AIDS (CNS-HIV), Int J Mol Sci 2009, 10:1045-1063
  8. Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, Spencer B, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E: Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases, PLoS ONE 2008, 3:e3135
  9. Crews L, Mizuno H, Desplats P, Rockenstein E, Adame A, Patrick C, Winner B, Winkler J, Masliah E: Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice, J Neurosci 2008, 28:4250-4260
  10. Bar-On P, Crews L, Koob AO, Mizuno H, Adame A, Spencer B, Masliah E: Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease, J Neurochem 2008, 105:1656-1667
  11. Spencer B, Crews L, Masliah E: Climbing the scaffolds of Parkinson's disease pathogenesis, Neuron 2007, 53:469-470
  12. Singer O, Marr RA, Rockenstein E, Crews L, Coufal NG, Gage FH, Verma IM, Masliah E: Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model, Nat Neurosci 2005, 8:1343-1349
  13. Shults CW, Rockenstein E, Crews L, Adame A, Mante M, Larrea G, Hashimoto M, Song D, Iwatsubo T, Tsuboi K, Masliah E: Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy, J Neurosci 2005, 25:10689-10699
  14. Rockenstein E, Mante M, Alford M, Adame A, Crews L, Hashimoto M, Esposito L, Mucke L, Masliah E: High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease, J Biol Chem 2005, 280:32957-32967
  15. Masliah E, Rockenstein E, Adame A, Alford M, Crews L, Hashimoto M, Seubert P, Lee M, Goldstein J, Chilcote T, Games D, Schenk D: Effects of alpha-Synuclein Immunization in a Mouse Model of Parkinson's Disease, Neuron 2005, 46:857-868