Lab projects

We study birth defects and regeneration

Organogenesis is regulated by several inductive factors, such as Wnts. Incorrect activity and timing of these signaling pathways during early development frequently result in embryonic death or severe birth defects. We are investigating the mechanism and prevention of birth defects mainly using Wnt signaling mutant mice as the research model. We are also investigating the role of Wnt signaling in stem cell/progenitor renewal and regeneration processes in order to enhance their therapeutic potential.

* From the aspect of congenital disease, we are investigating the mechanism and prevention of several major birth defects related to tissue patterning and closure processes in Wnt signaling mutant animal models, which include:

orofacial clefts
(defective tissue closure in the upper lip, palate, and related orofacial structures), such as cleft lip with or without cleft palate (CLP) and isolated cleft palate,

neural tube closure defects (NTDs), such as spina bifida (open spine) and exencephaly (open skull/brain),

and o
ther common congenital disorders in major organs.

* From the aspect of stem cell biology, we are addressing the role of Wnt signaling in tissue/organ-specific stem cells during development and regeneration.