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Laboratory of Fungal Chemistry & Biology
School of Chemistry & Biochemistry, University of Western Australia
Bridging genes, molecules and functions...

Welcome to the Chooi lab homepage!

The work in our lab focuses on understanding the biosynthesis of secondary metabolites (natural products) in fungi and uncovering the bio-ecological roles of these molecules. 

Fungal secondary metabolites have been the source of medicines, including important clinical drugs, such as the antibiotic penicillin, the cholesterol-lowering statins and the immunosuppressive cyclosporine. On the other hand, some fungal secondary metabolites are mycotoxins that are harmful to humans, while some have been implicated as the virulence factors that enable fungi to cause disease in plants and animal, including human. 

We employ a combination of tools in functional genomics, synthetic biology, biochemistry and chemical ecology to bridge the gaps between genes, molecules and functions. 

Research

  Our research aims to expand the enzymatic tool-box for synthesizing diverse small molecules, contribute to the understanding of the roles of secondary metabolites in ecological interactions, and advance the discovery of bioactive molecules for medicinal and agricultural applications.


News

  • Accepted Manuscript: Bridge-forming aldolase involved in biosynthesis of fungal phytotoxins Manuscript titled "Biosynthesis of a Tricyclo[6.2.2.02,7]dodecaneSystem by a Berberine Bridge Enzyme-like Aldolase" from our talented PhD student Hang Li accepted in Chemistry ...
    Posted Sep 26, 2019, 9:02 PM by Yit Heng Chooi
  • Welcome Marianne! Our lab welcome Marianne Costa this week. Dr Costa won a CSIRO FSP SynBio Fellowship and is joining the Chooi lab to start his research on engineering bacterial PKSs. Marianne ...
    Posted Sep 25, 2019, 6:36 AM by Yit Heng Chooi
  • Our lab 1st independent JACS publication! Congratulations to Jinyu, the 1st PhD student of Chooi lab, for his paper published in the prestigious Journal of American Chemical Society. Hang Li, another PhD student, is also a ...
    Posted May 8, 2019, 9:41 PM by Yit Heng Chooi
  • Welcome Thom Booth! Dr Thom Booth has joined the Chooi lab and started his research on a project funded by CRC-P in collaboration with Microbial Screening Technologies (microbialscreening.com), Dr Andrew Piggott ...
    Posted May 8, 2019, 9:43 PM by Yit Heng Chooi
  • 2019 Update! Finally, get to update the Members page of the website (procrastinating from doing what I supposed to do).At the end of 2018, we farewell Nico who have been with ...
    Posted Jan 24, 2019, 8:51 AM by Yit Heng Chooi
Showing posts 1 - 5 of 44. View more »





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