The Choluteca Transcrisur ministry was started in early 1999 as a response to the Hurricane Mitch disaster the previous October. A pastoral family, the Mejias, from the Honduras Holiness Church moved to Choluteca and began the ministry by holding services in their home.  They also helped distribute relief aid that had been generously donated through World Gospel Mission.

The regional ministry quickly grew to include several churches, a clinic, a vocational school and other community development projects. Transcrisur ("Christian Holistic Transformation of the South") is the name of the regional ministry that is based in Choluteca in southern Honduras, a city of 180,000 people. World Gospel Mission (WGM) and the Honduras Holiness Church (IESH) have worked together to establish church congregations in the southern region of Honduras.