Week 7: Applications of Binding, Kinetics, and Catalysis
Lectures 13&14: Mixed enzyme inhibition, multisite phosphorylation, and ultrasensitivity
Lectures 13&14: Mixed enzyme inhibition, multisite phosphorylation, and ultrasensitivity
Outline
Outline
- Mixed inhibition
- General derivation
- Limiting cases: "competitive," "uncompetitive," and "noncompetitive"
- Reversible phosphorylation ("Push-pull" systems)
- Single site
- Multisite
- Zeroth order ultrasensitivity
- Ultrasensitivity through bistability
Reading
Reading
- (optional) A. Goldbeter and D. E. Koshland, Jr., “An amplified sensitivity arising from covalent modification in biological systems,” Proc. Natl. Acad. Sci. USA, vol. 78, no. 11, pp. 6840–6844, 1981. (pdf)
- (optional) J. E. Lisman, “A mechanism for memory storage insensitive to molecular turnover: a bistable autophosphorylating kinase.,” Proc. Natl. Acad. Sci. U. S. A., vol. 82, no. 9, pp. 3055–7, May 1985. (pdf)
Notes
Notes