Dynamics in Transcriptional Networks - III
Tuesday, September 26, 2017
Tuesday, September 26, 2017
Outline
Outline
1) Review network motifs
•Diversity & robustness
•Network motif dynamics
2) Perception
•Psychophysics
•Cellular perception
3) Heterogeneity and dynamics in single cells
•Nuclear localization of NFkB encodes transcriptional signals
•Fold change detection
•NFkB redux
•Dynamics in other signaling systems
Optional Reading and References
Optional Reading and References
- An Introduction to Systems Biology: Design Principles of Biological Networks; Chapters 4-5
- Milo et al. Network Motifs: Simple building blocks of complex networks, Science, 2002
- Goentoro et al. The incoherent Feedforward Loop Can Provide Fold-Change Detection in Gene Regulation, Molecular Cell, 2009
- Shoval et al. Fold-change detection and scalar symmetry of sensory input fields, PNAS, 2010
- Purvis, et al. p53 Dynamics Control Cell Fate, Science, 2012
- Purvis, and Lahav. Encoding and Decoding Cellular Information through Signaling Dynamics, Cell, 2013
- Lee, et al. Fold change of nuclear NF-κB determines TNF-induced transcription in single cells, Molecular Cell, 2014
- Ryu et al. Frequency modulation of ERK activation dynamics rewires cell fate, Molecular Systems Biology, 2015
- Adler et al. Optimal regulatory circuit topologies for fold-change detection, Cell Systems, 2017
Notes
Transcription Networks III notes
Slides