Kinetics and Catalysis I-IV

September 27, 2018

Outline

1. Chllin' with Uri.
2. Discussion of class projects and proposals.
3. Setup of the EGFR binding problem.
4. One more binding problem....
5. Review and extension of chemical kinetics.

Reading

PBOC2, chapter 15.1.-15.2.

Lecture notes

October 2, 2018

Chemical kinetics

1. Elementary reactions
2. Linear model (1D)
3. Building blocks and simple motifs

Lecture notes

October 9, 2018

1. Enzyme catalysis
2. Mixed inhibition

Lecture notes

October 11, 2018

1. Phosphorylation cascades
   1. Single site
   2. Multisite (distributive)
   3. Zero order ultrasensitivity
2. Autophosphorylating kinase

Lecture notes