Salk Institute for Biological Research









new website at www.bardylab.com

























Cedric Bardy, PhD
Laboratory of Genetics - Fred H Gage 
The Salk Institute for Biological Research
Sanford Consortium for Regenerative Medicine
San Diego, California - USA

Marie Curie FP7 International Fellow 2011-2015
Nationality: French

cbardy@salk.edu




Current Research


There is no need to be a scientist to be amazed how powerful the human brain may be. The way it lets us learn, perceive or feel is simply fascinating. 

I like to see the brain as a complex network of wires. Any thought or action our brain performs is achieved through orchestrated biological mechanisms which aim to modulate the electrical and chemical information travelling in different areas of our brain.

Despite its remarkable plasticity, the brain itself sometimes fails to compensate some genetic defects and/or to adapt to some external trauma. Neurological disorders such as Parkinson and Alzheimer can be devastating. A better understanding of the biology of the human brain as well as the pathophysiology of neurological disorders is desperately needed to find new therapies for patients. 

The Gage Lab at the Salk Institute and Sanford Consortium for Regenerative Medicine is providing one of the best research environments in the world to study those issues. The broad scientific expertise of people here allows me to try to tackle those problems from an innovative multidisciplinary approach. My current efforts are focused on developing new strategies to understand the dysfunctions of neurons from patients affected by neurological disorders.







Salk Institute (Gage Lab) 2011-current

Evaluating cell reprogramming differentiation and conversion technologies in neuroscience
Mertens J, Marchetto C, Bardy C and Gage FH. 
Nature Reviews Neuroscience (2016) 

Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency
van den Hurk M, Kenis G, Bardy C, van den Hove DLA, Gage FH, Steinbusch HWM and Rutten BPF 
Epigenomics (2016) 

Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration
Zheng X, Boyer L, Jim M, Kim Y, Fan W, Bardy C, Berggren T, Evans RM, Gage FH, Hunter T. 
Elife (2016)

Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro
Bardy, C., Van den Hurk, M., Eames, T., Marchand, C., Hernandez, R.V., Kellogg, M., Gorris, M., Galet, B., Palomares, V., Brown, J., Bang, A.G., Mertens, J., Bohnke, L., Boyer, L., Simon, S., Gage, F.H. 
PNAS (2015)

Generation of functional human serotonergic neurons from fibroblasts
Krishna C. Vadodaria*, Jerome Mertens*, Apua Paquola, Cedric Bardy, Roberto Jappelli, Lianna Fung, Michael Hamm, Marc Gorris, and Fred H. Gage 
Molecular Psychiatry (2015)

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells
C., Reyna, S. M., Mu, Y., Herrera, C., Hefferan, M. P., Van Gorp, S., Nazor, K.L, Boscolo, F.S, Carson, C.T., Laurent, L.C., Marsala, M., Gage, F.H., Remes, A.M., Koo, E.H. & Goldstein, L.S.B. 
Nature (2012)

Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc
Giorgetti, A. et al. 
PNAS (2012)

Institut Pasteur (Lledo's Lab) 2008-2010:

Activation of adult-born neurons facilitates learning and memory. 
Alonso, M., Lepousez, G., Wagner, S., Bardy, C., Gabellec, MM., Torquet, N. & Lledo, PM. 
Nature Neuroscience (2012).

How, when, and where new inhibitory neurons release neurotransmitters in the adult olfactory bulb. 
Bardy, C., Alonso, M., Bouthour, W., & Lledo, PM.  
The Journal of Neuroscience (2010).

What happens to olfaction without adult neurogenesis. 
Bardy, C., & Pallotto, M. 
Frontiers in Neuroscience (2010).

Adult neurogenesis promotes synaptic plasticity in the olfactory bulb. 
Nissant, A., Bardy, C., Katagiri, H., Murray, K., & Lledo, PM.  
Nature Neuroscience (2009).

Early synapse formation in developing interneurons of the adult olfactory bulb. Panzanelli, P., Bardy, C., Nissant, A., Pallotto, M., Sassoe-Pognetto, M., Lledo, PM., & Fritschy, J. 
The Journal of Neuroscience (2009).

PhD - University of Sydney (Dreher's Lab) 2004-2008:

Malleable Functional Properties of Single Neurones in the Cat Striate Cortex
Bardy, C.
PhD Thesis, University of Sydney, (2008)

'Simplification' of responses of complex cells in cat striate cortex: suppressive surrounds and “feedback” inactivation. 
Bardy, C., Huang, J. Y., Wang, C., FitzGibbon, T., & Dreher, B. 
The Journal of Physiology  (2006).

'Top-down‘ influences of ipsilateral or contralateral postero-temporal visual cortices on the extra-classical receptive fields of neurons in cat’s striate cortex. 
Bardy, C., Huang, J. Y., Wang, C., FitzGibbon, T., & Dreher, B. 
Neuroscience (2009). 

Contrast dependence of center and surround integration in primary visual cortex of the cat. 
Wang, C., Bardy, C., Huang, J. Y., FitzGibbon, T., & Dreher, B.  
Journal of Vision (2009).

Influence of “feedback” signals on spatial integration in receptive fields of cat area 17 neurons.
Wang, C., Huang, J. Y., Bardy, C., FitzGibbon, T., & Dreher, B.
Brain Research (2010).

Undergraduate Research - Universite of Montreal (Dubuc's Lab):

Modulatory effect of substance P to the brain stem locomotor command in lampreys.
Brocard, F., Bardy, C., & Dubuc, R.
Journal of Neurophysiology (2005).


Education

2008    PhD (Neurosciences) - School of Medical Sciences, University of Sydney, Australia

2005    Master (Neurosciences) - School of Medical Sciences, University of Sydney, Australia

2003    CREPUQ International exchange program (Neurosciences) - Univ. of Montreal, Canada

2002    DEUG 2 Life science (Physiology and biochemistry) - Univ. des Sciences Montpellier, France

2001    DEUG 1 Life science (Physiology and biochemistry) - Univ. Paul Sabatier Toulouse, France