During his 42-year career in the Department of Chemistry of Washington University in St Louis (1947-1989), he rose through the ranks to become Professor in 1959, Department Chairman 1970-76 and Professor Emeritus in 1989, at which time he joined Texas Christian University in Fort Worth as the Robert A. Welch Professor of Chemistry (1989 -2002).
His research covered a variety of fields of organic chemistry, including Diazoalkane-Carbonyl Reactions, Carbene Chemistry, Photochemistry, Boroxazolidines, Polylfunctional Catalysis, Enzyme Mimics, Micellar Catalysis, and Calixarenes. It is the last of these for which he is most noted, having pioneered the field of calixarene chemistry that has expanded to involve many scientists in a variety of disciplines around the world.
His publications include 165 journal articles, 6 books (including a major text book  on Organic Chemistry) and numerous chapters in books. He has been awarded several honors including inter alia Guggenheim Fellowship (1981) and the Alumni Award of Washington University (1976) given for excellence in teaching, based on recommendations from alumni 5-10 years beyond their baccalaureate degree.
He has been married to Alice Carr Gutsche since 1944, and they are the parents of Clara Jean, Betha Lynn and Christopher Glen and grandparents of Sarah Johanna Gutsche-Miller, Alice Jemima Gutsche-Smith, and Oliver Ogden Gutsche-Smith.