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David J. E. Callaway, PhD
Professor and Laboratory Director
大卫★凯乐威
david dot callaway at nyu dot edu
Looking for a WELL-COMPENSATED job? Click HERE! to see opportunities
"There's plenty of room at the bottom: An invitation to enter a new field of PHYSICS."
-- Richard Feynman, 1959
Biological NanoPhysics
"The Future of Medicine "
Neutron Spin Echo spectroscopy! Protein nanomachines are far more complex than any molecular machines yet constructed.
Their skillful utilization likely represents the future of medicine.
★Easy introduction to NSE HERE:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374024/
Nanoscale protein dynamics: A new frontier for Neutron Spin Echo spectroscopy
Neutron spin echo spectroscopy (NSE) is the only experimental technique that can determine protein motion on nano length and time scales. Such motions have long been hypothesized to be the most significant modes for protein function. We have developed a theoretical framework that allows one to interpret the NSE data. Our theoretical framework uses simple concepts from nonequilibrium statistical mechanics, and does not require elaborate molecular dynamics simulations, complex fits to rotational motion, or elastic network models. In combination with our experimental methodology of selective deuterium labeling, our work clears significant hurdles to the understanding of this very important problem.
Read all about it HERE! Interdisciplinary nanoscale biophysical approaches to the cure of disease were once thought revolutionary, but are now rapidly becoming a standard part of the repertoire. We have instituted a new multidisciplinary program of research in this area, headed by Professor David Callaway.
Dr Callaway has worked extensively in the field of Alzheimer's disease, specifically in understanding and controlling amyloid formation. His Alzheimer's program has developed and patented several potential therapeutics for Alzheimer's disease, based upon apomorphine, which are reviewed in a Wikipedia article.
Trained as a theoretical physicist, Dr. Callaway has published research on topics ranging from elementary particles, black holes, semiconductors and superconductors to protein dynamics and structure-based drug design. Presently he works on probing protein domain dynamics by neutron spin-echo spectroscopy, allowing us to observe protein nanomachines in motion.
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Bu Z, Callaway DJE. Adv Protein Chem Struct Biol. 2011;83:163-221.
PMID: 21570668
DOI: 10.1016/B978-0-12-381262-9.00005-7
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Farago B, Li J, Cornilescu G, Callaway D.J.E. (co-corresponding), Bu Z.
Biophys J. 2010 Nov 17;99(10):3473-82.
DOI: 10.1016/j.bpj.2010.09.058
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Callaway, DJ, Farago, B, Bu, Z.
The European Physical Journal E-Soft Matter & Biological Physics
Eur. Phys. J. E (2013) 36: 76
DOI: 10.1140/epje/i2013-13076-1
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Bu Z, Biehl R, Monkenbusch M, Richter D, D.J.E. Callaway
Proc Natl Acad Sci USA 2005 Dec 6;102(49):17646-17651.
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Z. Bu, J. Cook, D.J.E. Callaway. J. Mol. Biol. (2001) 312, 865-873.
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Jianquan Li, David J.E. Callaway,and Zimei Bu. J Mol Biol. Sep 11, 2009; 392(1): 166180.
DOI: 10.1016/j.jmb.2009.07.005
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Another recent publication and HERE! and HERE!
Structure-specific DNA induced conformational changes in Taq polymerase revealed by small angle neutron scattering.
D. L. Ho, W. M. Byrnes, W. P. Ma, Y. Shi, D.J.E. Callaway (co-corresponding), Zimei Bu. J. Biol. Chem., 2004 Sep 10;279(37):39146-54.
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Bhattacharya S, Dai Z, Li J, Baxter S, D.J.E. Callaway (co-corresponding), Cowburn D, Bu Z. J Biol Chem. 2010 Mar 26;285(13):9981-94.
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Li J, Dai Z, Jana D, Callaway DJ, Bu Z. J Biol Chem. 2005 Nov 11;280(45):37634-43.
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Callaway DJE, Bu Z. Biophys Rev. 2015 Jun;7(2):165-174.
Biophysical Reviews ISSN 1867-2450
DOI: 10.1007/s12551-015-0162-x
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Callaway DJE, Bu Z. Methods in Enzymology.
Isotope Labeling of Biomolecules - Applications. Volume 566, 2016, Pages 253 -270.
ISBN: 978-0-12-803049-3
DOI: 10.1016/bs.mie.2015.05.011
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Jayasundar JJ, Ju JH, He L, Liu D, Meilleur F, Zhao J, Callaway DJ, Bu Z. J Biol Chem. 2012 Oct 26;287(44):37119-33.
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Li J, Poulikakos PI, Dai Z, Testa JR, Callaway DJ, Bu Z. J Biol Chem. 2007 Sep 14;282(37):27086-99
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Callaway DJE, Bu Z. Current Opinion in Structural Biology 2017,42:1-5.
DOI: 10.1016/j.sbi.2016.10.001
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David J E Callaway (co-corresponding), Tsutomu Matsui, Thomas Weiss, Laura R Stingaciu, Christopher B Stanley, William T Heller, Zimei Bu.
Journal of Molecular Biology 429 (2017) pp. 987-998
DOI: 10.1016/j.jmb.2017.03.003
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Iain D Nicholl, Tsutomu Matsui, Thomas M Weiss, Christopher B Stanley, William T Heller, Anne Martel, Bela Farago,
David J E Callaway (co-corresponding), Zimei Bu
Biophys. J. 115(4), 642-654, August 21, 2018
DOI: 10.1016/j.bpj.2018.07.005
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Xiaodong Chen, Jahan Ali Khajeh, Jeong Ho Ju, Yogesh K. Gupta, Christopher B. Stanley, Changwoo Do, William T. Heller, Aneel K. Aggarwal,
David J. E. Callaway and Zimei Bu
J Biol Chem. 2015 Mar 6;290(10):6639-52
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Ashkar, R., Bilheux, H., Bordallo, H., Briber, R., Callaway, D.J.E., et al.
Acta Cryst. (2018). D74, 1129-1168
DOI: 10.1107/S2059798318017503
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Bush M, Alhanshali BM, Qian S, Stanley C, Heller W, Matsui T, Weiss T, Nicholl ID, Walz T, Callaway DJE (co-corresponding), Bu Z.
Proc Natl Acad Sci USA October 22, 2019 116 (43) 21545-21555
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Proc Natl Acad Sci USA
March 30, 2021 118 (13) e2025012118
Farago B, Nicholl ID, Wang S, Cheng X, Callaway DJE (co-corresponding), Bu Z
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New horizons: unanticipated ultrafast dynamics in cytoskeletal signaling
欢迎访问学者客座教授
Alzheimer's program HERE! with my
million dollar baby.
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★★★★
Potential therapeutics for Alzheimer's disease
HERE! and HERE! and HERE! and HERE! and HERE! Solvent-induced organization: a physical model of folding myoglobin. Proteins. 1994 Oct;20(2):124-38. D.J.E. Callaway. cond-mat 9406071
HERE! and HERE! Shi Y, Stouten PF, Pillalamarri N, Barile L, Rosal RV, Teichberg S, Bu Z, D.J.E. Callaway, Quantitative determination of the topological propensities of amyloidogenic peptides. Biophys Chem. 120 (2006), 55-61.
discovered in our laboratory
HERE! and HERE! and HERE! and HERE! and HERE! and HERE!
New class of beta-amyloid aggregation inhibitors: Implications for the mechanism of pathogenesis in Alzheimer's disease.
H. A. Lashuel, D. M. Hartley, D. Balakhaneh, A. Aggarwal, S. Teichberg, D.J.E. Callaway. J. Biol. Chem., (2002) 277,42881-42890.
HERE! and HERE! and HERE! Bu Z, Shi Y, D.J.E. Callaway, {co-corresponding}, and Tycko R. Molecular alignments within beta-sheets in Abeta(14-23) fibrils: solid-state NMR experiments and theoretical predictions. Biophys J. 2007 92: p. 594-602.
HERE! and HERE! Controlling amyloid beta-peptide fibril formation with protease stable ligands. J. Biol. Chem. 1997 272 (19): 12601-12605; 272 (28): 17894.
HERE! and HERE! A molecular model of Alzheimer amyloid beta-peptide fibril formation. J. Biol. Chem. 1999 274, 12619-12625.
HERE! The amyloid beta peptide (Abeta(1-40)) is thermodynamically soluble at physiological concentrations. Biochemistry. 2003 Sep 9;42(35):10506-13.
High energy, nuclear, statistical, condensed matter and computational physics
HERE! and HERE and HERE and HERE Triviality pursuit: Can elementary scalar particles exist? D.J.E. Callaway, Phys. Reports 167 (1988), 241.
HERE! and HERE and HERE and HERE and HERE On the remarkable structure of the superconducting intermediate state. D.J.E. Callaway, Nucl. Phys. B344 [FS] (1990) 627.
HERE! and HERE and HERE Langevin simulations in Minkowski space. D.J.E. Callaway, F. Cooper, J. R. Klauder, H. Rose. Nucl.Phys.B262:19,1985
(PDF format) and HERE and HERE Can Elementary Scalar Particles Exist? D.J.E. Callaway, R. Petronzio. Nuclear Physics B267(1986),253-265
HERE Can Elementary Scalar Particles Exist? 2. Scalar Electrodynamics D.J.E. Callaway, R. Petronzio. Nucl.Phys. B277 (1986) 50 CERN-TH-4369/86, RU86/B/151 DOI: 10.1016/0550-3213(86)90431-1
HERE! and arxiv and HERE and HERE and HERE Surface tension, hydrophobicity, and black holes: The entropic connection. D.J.E. Callaway, Phys. Rev. E53 (1996), 3738.
HERE! and HERE and HERE and HERE and HERE. Random matrices, fractional statistics, and the quantum Hall effect. D.J.E. Callaway, Phys. Rev. B43 (1991) 8641.
HERE! and HERE and HERE and HERE Microcanonical ensemble formulation of lattice gauge theory. D.J.E. Callaway and A. Rahman, Phys. Rev. Lett. 49 (1982), 613.
HERE and HERE and HERE David J. E. Callaway and Aneesur Rahman (1983). Lattice gauge theory in the microcanonical ensemble. Physical Review. D28 (6): 1506–1514. Bibcode:1983PhRvD..28.1506C. doi:10.1103/PhysRevD.28.1506.
HERE! and HERE and HERE and HERE and HERE Non-triviality of gauge theories with elementary scalars and upper bounds on Higgs masses. D.J.E. Callaway, Nucl. Phys. B233 (1984), 189.
HERE! and HERE and HERE and HERE and HERE Is the standard model Higgs mass predictable? D.J.E. Callaway and R. Petronzio, Nuclear Physics B, Volume 292, p. 497-526 (1987).
HERE! and HERE and HERE and HERE and HERE Determination of critical points and flow diagrams by Monte Carlo renormalization group methods. D.J.E. Callaway and R. Petronzio, Phys. Lett. 139B (1984), 189.
HERE! HERE and HERE Spin structure of the nucleon. D.J.E. Callaway and S.D. Ellis Phys. Rev. D 29 (1984), 567.
HERE! and HERE and HERE and HERE Effective potential of lattice phi^4 theory. D.J.E. Callaway and D.J. Maloof, Phys. Rev. D27 (1983), 406.
HERE! and HERE and HERE and HERE and HERE Abelian Higgs model: A Monte Carlo study. D.J.E. Callaway and L.J. Carson, Phys. Rev. D25 (1982), 531.
HERE! Topics in Lattice Gauge Theory. Lectures for Non-Particle Theorists given to the Materials Science and Technology Division at Argonne National Laboratory. D.J.E. Callaway, Argonne Report ANL-HEP-82-57, November 1982.
HERE! and (PDF format) and HERE and HERE and HERE and HERE Landau, Abrikosov, Hofstadter: Magnetic Flux Penetration in a Lattice Superconductor David J.E. Callaway Annals Phys. 224 (1993) 210-224 DOI: 10.1006/aphy.1993.1045 arXiv:hep-lat/9301013
Protein nanomachines are far
more complex than any molecular machines yet constructed.
Their skillful utilization likely
represents the future of medicine.
Looking for a WELL-PAID job? Want to get a PhD? Want a summer internship? Click HERE!
See research on ResearchGate, research on Academia●edu, research in high energy, nuclear, condensed matter and computational physics, research in biological nanophysics, research on Google Scholar, research on Mendeley, research on Scopus, research at CERN library, research at INSPIRE-HEP, profile on LinkedIn, profile on Facebook, profile on Instagram, profile on Wikipedia, mobility site, and Net Worth.
Biophysical Society poster 2019
Biophysical Society poster 2018
Climbing in the Alps, Himalaya, Karakoram, assorted greater ranges, other adventures, and other stuff.