Welcome to the Cognitive Neuroscience of Aging Lab. The CNA lab is part of the Department of Neuroscience, within the University of Kentucky's College of Medicine. Dr. Brian Gold, Professor, is the principal investigator of the CNA lab. We study neurocognitive systems and how those systems change with aging.


Age-related changes in brain networks contribute to cognitive changes seen in older adults such as reductions in executive function and memory. There appear to be many contributing factors to disruption of brain networks in aging including accumulation of Alzheimer's pathology and disruption of white matter connections associated with cerebrovascular disease (CVD). We seek to better understand the interplay of these factors on brain network changes. Toward that end, we use functional magnetic resonance imaging (fMRI) to characterize the brain networks engaged during cognitive processes. To assess the influence of CVD on brain networks, we use a variety of MRI techniques such as FLAIR imaging and diffusion tensor imaging.


In addition to studying how brain pathways are affected by negative modifiers such as early-stage Alzheimer’s pathology and CVD, we also explore the effects of positive modifiers such as cognitive stimulation and aerobic fitness on neurocognitive functions in aging.

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