2017


Durrant TN, van den Bosch MT, Hers I.
Blood. 2017 Aug 9. pii: blood-2017-03-773614. doi: 10.1182/blood-2017-03-773614. [Epub ahead of print]

Agbani EO, Williams CM, Hers I and Poole AW. 
Sci Reports. 2017 Jun 5;7(1):2770.

Durrant TN, Hutchinson JL, Heesom KJ, Anderson KE, Stephens LR, Hawkins PT, Marshall AJ, Moore SF and Hers I.
Blood Adv. 2017; 1:918-932

Battram AM, Durrant TN, Agbani EO, Heesom KJ, Paul DS, Piatt R, Poole AW, Cullen PJ, Bergmeier W, Moore SF, Hers I.

J Biol Chem. 2017 Feb 3;292(5):1691-1704.


2016


Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage.

Mattheij NJ, Braun A, van Kruchten R, Castoldi E, Pircher J, Baaten CC, Wülling M, Kuijpers MJ, Köhler R, Poole AW, Schreiber R, Vortkamp A, Collins PW, Nieswandt B, Kunzelmann K, Cosemans JM, Heemskerk JW.

FASEB J2016 Feb;30(2):727-37. doi: 10.1096/fj.15-280446. Epub 2015 Oct 19.


A comprehensive high-throughput sequencing test for the diagnosis of inherited bleeding, thrombotic and platelet disorders.

Simeoni I, Stephens JC, Hu F, Deevi SV, Megy K, Bariana TK, Lentaigne C, Schulman S, Sivapalaratnam S, Vries MJ, Westbury SK, Greene D, Papadia S, Alessi MC, Attwood AP, Ballmaier M, Baynam G, Bermejo E, Bertoli M, Bray PF, Bury L, Cattaneo M, Collins P, Daugherty LC, Favier R, French DL, Furie B, Gattens M, Germeshausen M, Ghevaert C, Goodeve A, Guerrero J, Hampshire DJ, Hart DP, Heemskerk JW, Henskens YM, Hill M, Hogg N, Jolley JD, Kahr WH, Kelly AM, Kerr R, Kostadima M, Kunishima S, Lambert MP, Liesner R, Lopez J, Mapeta RP, Mathias M, Millar CM, Nathwani A, Neerman-Arbez M, Nurden AT, Nurden P, Othman M, Peerlinck K, Perry DJ, Poudel P, Reitsma P, Rondina M, Smethurst PA, Stevenson W, Szkotak A, Tuna S, van Geet C, Whitehorn D, Wilcox DA, Zhang B, Revel-Vilk S, Gresele P, Bellissimo D, Penkett CJ, Laffan MA, Mumford AD, Rendon A, Gomez K, Freson K, Ouwehand WH, Turro E.

Blood2016 Apr 15. pii: blood-2015-12-688267. [Epub ahead of print]


Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases.

Crescente M, Pluthero FG, Li L, Lo RW, Walsh TG, Louriero S, Ali MS, Vaiyapuri S, Schenk MP, Holbrook LM, Falet H, Jones IM, Poole AW, Kahr WH, Gibbins JM.

Arterioscler Thromb Vasc Biol2016 Apr 14. pii: ATVBAHA.116.307461. [Epub ahead of print]


Protease-Activated Receptor 4 Variant p.Tyr157Cys Reduces Platelet Functional Responses and Alters Receptor Trafficking.

Norman JE, Cunningham MR, Jones ML, Walker ME, Westbury SK, Sessions RB, Mundell SJMumford AD.

Arterioscler Thromb Vasc Biol2016 May;36(5):952-60. doi: 10.1161/ATVBAHA.115.307102. Epub 2016 Mar 10.


A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.

Turro E, Greene D, Wijgaerts A, Thys C, Lentaigne C, Bariana TK, Westbury SK, Kelly AM, Selleslag D, Stephens JC, Papadia S, Simeoni I, Penkett CJ, Ashford S, Attwood A, Austin S, Bakchoul T, Collins P, Deevi SV, Favier R, Kostadima M, Lambert MP, Mathias M, Millar CM, Peerlinck K, Perry DJ, Schulman S, Whitehorn D, Wittevrongel C; BRIDGE-BPD Consortium, De Maeyer M, Rendon A, Gomez K, Erber WN, Mumford AD, Nurden P, Stirrups K, Bradley JR, Lucy Raymond F, Laffan MA, Van Geet C, Richardson S, Freson K, Ouwehand WH.

Sci Transl Med2016 Mar 2;8(328):328ra30. doi: 10.1126/scitranslmed.aad7666. Epub 2016 Mar 2.


A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss.

Stritt S, Nurden P, Turro E, Greene D, Jansen SB, Westbury SK, Petersen R, Astle WJ, Marlin S, Bariana TK, Kostadima M, Lentaigne C, Maiwald S, Papadia S, Kelly AM, Stephens JC, Penkett CJ, Ashford S, Tuna S, Austin S, Bakchoul T, Collins P, Favier R, Lambert MP, Mathias M, Millar CM, Mapeta R, Perry DJ, Schulman S, Simeoni I, Thys C, Consortium BB, Gomez K, Erber WN, Stirrups K, Rendon A, Bradley JR, van Geet C, Raymond FL, Laffan MA, Nurden AT, Nieswandt B, Richardson S, Freson K, Ouwehand WH, Mumford AD.

Blood2016 Feb 24. pii: blood-2015-10-675629. [Epub ahead of print]


2015


Identification of roles for the SNARE-associated protein, SNAP29, in mouse platelets.

Williams CM, Savage JS, Harper MT, Moore SF, Hers I, Poole AW.

Platelets. 2015 Nov 20:1-9.


Leukemia-associated Rho guanine-nucleotide exchange factor is not critical for RhoA regulation, yet is important for platelet activation and thrombosis in mice.

Williams CM, Harper MT, Goggs R, Walsh TG, Offermanns S, Poole AW.

J Thromb Haemost. 2015 Nov;13(11):2102-7. Epub 2015 Oct 20.


EO Agbani, MT van den Bosch, E Brown, CM Williams, NJ Mattheij, JM Cosemans, PW Collins, JW Heemskerk, I Hers, AW Poole.
Circulation. 2015 Sep 1. Published online ahead of print. 

Blair TA, Moore SF, Hers I.

J Thromb Haemost. 2015 Aug;13(8):1479-93.


Harper MT, van den Bosch MT, Hers I, Poole AW.

Blood. 2015 May 7;125(19):3034-6. 


Use of next-generation sequencing and candidate gene analysis to identify underlying defects in patients with inherited platelet function disorders.

Leo VC, Morgan NV, Bem D, Jones ML, Lowe GC, Lordkipanidzé M, Drake S, Simpson MA, Gissen P, Mumford A, Watson SP, Daly ME; UK GAPP Study Group.

J Thromb Haemost. 2015 Apr;13(4):643-50.


A review of platelet secretion assays for the diagnosis of inherited platelet secretion disorders.

Mumford AD, Frelinger Iii AL, Gachet C, Gresele P, Noris P, Harrison P, Mezzano D.

Thromb Haemost. 2015 Apr 16;114(20150416).


Platelet Rho GTPases-a focus on novel players, roles and relationships.

Goggs R, Williams CM, Mellor H, Poole AW.

Biochem J. 2015 Mar 15;466(3):431-42. 


Diversity and impact of rare variants in genes encoding the platelet G protein-coupled receptors.

Jones ML, Norman JE, Morgan NV, Mundell SJ, Lordkipanidzé M, Lowe GC, Daly ME, Simpson MA, Drake S, Watson SP, Mumford AD; UK GAPP study group.

Thromb Haemost. 2015 Mar 30;113(4):826-37. 


Diagnosis of inherited platelet function disorders: guidance from the SSC of the ISTH.

Gresele P; Subcommittee on Platelet Physiology.

J Thromb Haemost. 2015 Feb;13(2):314-22.


Syntaxin 8 regulates platelet dense granule secretion, aggregation, and thrombus stability.

Golebiewska EM, Harper MT, Williams CM, Savage JS, Goggs R, Fischer von Mollard G, Poole AW.

J Biol Chem. 2015 Jan 16;290(3):1536-45.


SDF-1α is a novel autocrine activator of platelets operating through its receptor CXCR4.

Walsh TG, Harper MT, Poole AW.

Cell Signal. 2015 Jan;27(1):37-46. 


Kelly E, Mundell SJ, Sava A, Roth AL, Felici A, Maltby K, Nathan PJ, Bullmore ET, Henderson G.
Psychopharmacology (Berl). 2015 Jan;232(1):305-14. 


2014


Platelet secretion: From haemostasis to wound healing and beyond.

Golebiewska EM, Poole AW.

Blood Rev. 2014 Oct 31. pii: S0268-960X(14)00085-X.


Hers I, Poole AW.
Blood. 2014 Aug 14;124(7):992-3.

Galea GL, Meakin LB, Williams CM, Hulin-Curtis SL, Lanyon LE, Poole AW, Price JS.
J Biol Chem. 2014 Sep 12;289(37):25509-22.

Blair TA, Moore SF, Williams CM, Poole AW, Vanhaesebroeck B, Hers I
Arterioscler Thromb Vasc Biol 2014; first published on June 5 2014


Discrepancy in von Willebrand factor activity determined by ristocetin cofactor and immunotubidometric assays.

Reilly-Stitt C, Coppell J, Mumford AD.

Haemophilia 2014 


How should we test for nonsevere heritable platelet function disorders?

Norman JE, Westbury SK, Jones ML, Mumford AD.

Int J Lab Hematol 2014 


A multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery: Study protocol.

Brierley RC, Pike K, Miles A, Wordsworth S, Stokes EA, Mumford AD, Cohen A, Angelini GD, Murphy GJ, Rogers CA, Reeves BC.

Transfus Apher Sci 2014



Secrets of platelet exocytosis - what do we really know about platelet secretion mechanisms?

Golebiewska EM, Poole AW.

Br J Haematol 2014


Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.

Cooke AE, Oldfield S, Krasel C, Mundell SJ, Henderson G, Kelly E.

Br J Pharmacol 2014


Patel YM, Lordkipanidzé M, Lowe GC, Nisar SP, Garner K, Stockley J, Daly ME, Mitchell M, Watson SP, Austin SK, Mundell SJ. 
J Thromb Haemost 2014

Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay.

Lordkipanidzé M, Lowe GC, Kirkby NS, Chan MV, Lundberg MH, Morgan NV, Bem D, Nisar SP, Leo VC, Jones ML, Mundell SJ, Daly ME, Mumford AD, Warner TD, Watson SP.

Blood 2014


A novel thromboxane A2 receptor N42S variant results in reduced surface expression and platelet dysfunction.

Nisar SP, Lordkipanidzé M, Jones ML, Dawood B, Murden S, Cunningham MR, Mumford AD, Wilde JT, Watson SP, Mundell SJ, Lowe GC; on behalf of the UK GAPP study group.

Thromb Haemost 2014



2013


Transient receptor potential channels function as a coincidence signal detector mediating phosphatidylserine exposure

Harper MT, Londoño JEC, Quick K, Londoño JC, Flockerzi V, Philipp SE, Birnbaumer L, Freichel M, Poole AW.

Sci Signal. 2013, 6: ra50.



RhoG protein regulates platelet granule secretion and thrombus formation in mice.

Goggs R, Harper MT, Pope RJ, Savage JS, Williams CM, Mundell SJ, Heesom KJ, Bass M, Mellor H, Poole AW.

J Biol Chem 2013; 288: 34217-29.



Vincent EE, Elder DJ, Curwen J, Kilgour E, Hers I, Tavaré JM.
PLoS One 2013; 8: e66963. 

Hale LJ, Welsh GI, Perks CM, Hurcombe JA, Moore S, Hers I, Saleem MA, Mathieson PW, Murphy AJ, Jeansson M, Holly JM, Hardouin SN, Coward RJ.
J Pathol. 2013, 230: 95-106.


Partial deletion of the αC-domain in the Fibrinogen Perth variant is associated with thrombosis, increased clot strength and delayed fibrinolysis.

Westbury SK, Duval C, Philippou H, Brown R, Lee KR, Murden SL, Phillips E, Reilly-Stitt C, Whalley D, Ariëns RA, Mumford AD.

Thromb Haemost 2013; 110: 1135-44.

High haematocrit in cyanotic congenital heart disease affects how fibrinogen activity is determined by rotational thromboelastometry.

Westbury SK, Lee K, Reilly-Stitt C, Tulloh R, Mumford AD.

Thromb Res 2013; 132: e145-51. 


Disruption of AP3B1 by a chromosome 5 inversion: a new disease mechanism in Hermansky-Pudlak syndrome type 2

Jones ML, Murden SL, Brooks C, Maloney V, Manning RA, Gilmour KC, Bharadwaj V, de la Fuente J, Chakravorty S, Mumford AD.

BMC Med Genet. 2013, 14: 42.


Dysfunction of the PI3 kinase/Rap1/integrin αIIbβ3 pathway underlies ex vivo platelet hypoactivity in essential thrombocythemia

Moore SF, Hunter RW, Harper MT, Savage JS, Siddiq S, Westbury SK, Poole AW, Mumford AD, Hers I.
Blood. 2013, 121: 1209-19.

The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2.

Jessen B, Bode SF, Ammann S, Chakravorty S, Davies G, Diestelhorst J, Frei-Jones M, Gahl WA, Gochuico BR, Griese M, Griffiths G, Janka G, Klein C, Kögl T, Kurnik K, Lehmberg K, Maul-Pavicic A, Mumford AD, Pace D, Parvaneh N, Rezaei N, de Saint Basile G, Schmitt-Graeff A, Schwarz K, Karasu GT, Zieger B, Zur Stadt U, Aichele P, Ehl S.

Blood. 2013, Feb 12.


PKCα negatively regulates in vitro proplatelet formation and in vivo platelet production in mice
Williams CM, Harper MT, Poole AW.
Platelets. 2013, 

Differential endosomal sorting of a novel P2Y(12) purinoreceptor mutant
Cunningham MR, Nisar SP, Cooke AE, Emery ED, Mundell SJ.
Traffic. 2013 Feb 6. doi: 10.1111/tra.12054

Molecular mechanisms of platelet P2Y12 receptor regulation
Cunningham MR, Nisar SP, Mundell SJ
Biochem Soc Trans. 2013, 41: 225-30

The Small GTPase Rif Is Dispensable for Platelet Filopodia Generation in Mice.
Robert Goggs, Joshua S. Savage, Harry Mellor, Alastair W. Poole
PLoS One 2013; 8: e54663.

Munc13-4 is critical for thrombosis through regulating release of ADP from platelets.
Savage JS, Williams CM, Konopatskaya O, Hers I, Harper MT, Poole AW.
J Thromb Haemost. 2013, 11: 771-5.

Absence of Platelet Phenotype in Mice Lacking the Motor Protein Myosin Va.
Harper MT, van den Bosch MTJ, Hers I, Poole AW.
PLOS ONE2013, 8: e53239.

Guideline on the management of bleeding in patients on antithrombotic agents.

Makris M, Van Veen JJ, Tait CR, Mumford AD, Laffan M; British Committee for Standards in Haematology.

Br J Haematol. 2013, 160: 35-46.


Clinical phenotype, laboratory features and genotype of 35 patients with heritable dysfibrinogenaemia.

Shapiro SE, Phillips E, Manning RA, Morse CV, Murden SL, Laffan MA, Mumford AD.

Br J Haematol. 2013, 160: 220-7.


RhoG protein regulates platelet granule secretion and thrombus formation in mice.

Goggs R, Harper MT, Pope RJ, Savage JS, Williams CM, Mundell SJ, Heesom KJ, Bass M, Mellor H, Poole AW.

J Biol Chem 2013; 288: 34217-29.


Platelet dysfunction associated with the novel Trp29Cys thromboxane A(2) receptor variant.

Mumford A, Nisar S, Darnige L, Jones M, Bachelot-Loza C, Gandrille S, Zinzindoue F, Fischer AM, Mundell S, Gaussem P; The UK GAPP study group.

J Thromb Haemost 2013; 11: 547-554.



2012


Dawood BB, Lowe GC, Lordkipanidzé M, Bem D, Daly ME, Makris M, Mumford A, Wilde JT, Watson SP.

Blood. 2012 Dec 13;120(25):5041-9. doi: 10.1182/blood-2012-07-444281. Epub 2012 Sep 21.


Dual regulation of Glycogen Synthase Kinase 3 (GSK3)α/β by Protein Kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets.
Moore SF, van den Bosch MT, Hunter RW, Sakamoto K, Poole AW, Hers I.
J Biol Chem. 2012 Dec 13.


ARF6-Dependent Regulation of P2Y Receptor Traffic and Function in Human Platelets.

Kanamarlapudi V, Owens SE, Saha K, Pope RJ, Mundell SJ.

PLoS One. 2012;7(8):e43532. Epub 2012 Aug 16.


WNT-3a modulates platelet function by regulating small GTPase activity.

Steele BM, Harper MT, Smolenski AP, Alkazemi N, Poole AW, Fitzgerald DJ, Maguire PB.

FEBS Lett. 2012 Jul 30;586(16):2267-72. Epub 2012 Jun 13.


Arrestin scaffolds NHERF1 to the P2Y12 receptor to regulate receptor internalization.

Nisar SP, Cunningham M, Saxena K, Pope RJ, Kelly E, Mundell SJ.

J Biol Chem. 2012 May 18.


Bcl-xL-inhibitory BH3 mimetic ABT-737 depletes platelet calcium stores.

Harper MT, Poole AW.

Blood. 2012 May 3;119(18):4337-8.


Platelet signaling-A primer.

Goggs R, Poole AW.

J Vet Emerg Crit Care (San Antonio). 2012 Feb 3. doi: 10.1111/j.1476-4431.2011.00704.x.


Evaluation of multiple electrode aggregometry in whole blood using Multiplate® Mini Test cells.

Lee KR, Verheyden VJ, Mumford AD.

Thromb Res. 2012 Apr;129(4):e59-64. Epub 2012 Jan 26.


Rapid genetic diagnosis of heritable platelet function disorders with next-generation sequencing: proof-of-principle with Hermansky-Pudlak syndrome.

Jones ML, Murden SL, Bem D, Mundell SJ, Gissen P, Daly ME, Watson SP, Mumford AD; UK GAPP study group.

J Thromb Haemost. 2012 Feb;10(2):306-9. doi: 10.1111/j.1538-7836.2011.04569.x.



2011


Rapid Genetic Diagnosis of Heritable Platelet Function Disorders Using Next Generation Sequencing: Proof-of-Principle With Hermansky-Pudlak Syndrome.

Jones ML, Murden SL, Bem D, Mundell SJ, Gissen P, Daly ME, Watson SP, Mumford AD; on behalf of the UK GAPP study group.

J Thromb Haemost. 2011 Nov 24. doi: 10.1111/j.1538-7836.2011.04569.x.


Pkcα and Pkcβ are Positive Regulators of Thrombus Formation in vivo in a Zebrafish (Danio Rerio) Model of Thrombosis.

Williams CM, Feng Y, Martin P, Poole AW.

J Thromb Haemost. 2011 Sep 27. doi: 10.1111/j.1538-7836.2011.04520.x.


An intact PDZ-motif is essential for correct P2Y12 purinoceptor traffic in human platelets.
Nisar S, Daly ME, Federici AB, Artoni A, Mumford AD, Watson SP, Mundell SJ.
Blood. 2011 Sep 21.


Hyperferritinemia without iron overload in patients with bilateral cataracts: a case series.
Kroger A, Bachli EB, Mumford A, Gubler C.
J Med Case Reports. 2011 Sep 21;5(1):471.

Guidelines for the laboratory investigation of heritable disorders of platelet function.
Harrison P, Mackie I, Mumford A, Briggs C, Liesner R, Winter M, Machin S; British Committee for Standards in Haematology.
Br J Haematol
. 2011 Jul 26. doi: 10.1111/j.1365-2141.2011.08793.x.
PMID:21790527

On-demand treatment of bleeds in haemophilia patients with inhibitors: strategies for securing and maintaining predictable efficacy with recombinant activated factor VII.
Sørensen B, Dargaud Y, Kenet G, Lusher J, Mumford A, Pipe S, Tiede A.
Haemophilia
. 2011 Jul 19. doi: 10.1111/j.1365-2516.2011.02612.x.
PMID:21771206

Akt signalling in health and disease.
Hers I, Vincent EE, Tavaré JM.
Cell Signal
. 2011 Oct;23(10):1515-27. Epub 2011 May 17.
PMID: 21620960

p.Tyr365Cys change in factor VIII: haemophilia A, but not as we know it.

Bowyer AE, Goodeve A, Liesner R, Mumford AD, Kitchen S, Makris M.
Br J Haematol. 2011 Sep;154(5):618-25. doi: 10.1111/j.1365-2141.2011.08688.x. Epub 2011 Jul 14.


Unravelling the different functions of protein kinase C isoforms in platelets.

Heemskerk JW, Harper MT, Cosemans JM, Poole AW.

FEBS Lett. 2011 Jun 23;585(12):1711-6. Epub 2011 May 13.

Moore SF, Hunter RW, Hers I.
J Biol Chem. 2011 May 18.
PMID: 21592956
Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2.
Konopatskaya O, Matthews SA, Harper MT, Gilio K, Cosemans JM, Williams CM, Navarro MN, Carter DA, Heemskerk JW, Leitges M, Cantrell D, Poole AW.
Blood. 2011 Apr 28. PMID: 21527521

A systematic review of the management and outcomes of pregnancy in Glanzmann thrombasthenia.
Siddiq S, Clark A, Mumford A.

Haemophilia. 2011 Apr 4. doi: 10.1111/j.1365-2516.2011.02516.x.

PMID:
 
21457404

Marked discrepancy between coagulometric Protein C activity assays with the pro-thrombotic Protein C Asn2Ile substitution.
Cooper PC, Siddiq S, Morse C, Nightingale J, Mumford AD.

Int J Lab Hematol. 2011 Mar 21. doi: 10.1111/j.1751-553X.2011.01311.x.

PMID:
 
21418542

More on: endoplasmic reticulum loop VKORC1 substitutions cause warfarin resistance but do not diminish gamma-carboxylation of the vitamin K-dependent coagulation factors.

Harrington DJ, Siddiq S, Allford SL, Shearer MJ, Mumford AD.

J Thromb Haemost. 2011 Mar 1. doi: 10.1111/j.1538-7836.2011.04249.x.

PMID:
 
21362126

Platelet Syk is a HIT target.

Poole AW.

Blood. 2011 Feb 17;117(7):2083-4. No abstract available.

PMID:
 
21330480

Purpura fulminans: recognition, diagnosis and management.

Chalmers E, Cooper P, Forman K, Grimley C, Khair K, Minford A, Morgan M, Mumford A.

Arch Dis Child. 2011 Jan 12.

PMID:
 
21233082



Protein kinase C alpha enhances sodium-calcium exchange during store-operated calcium entry in mouse platelets.

Harper MT, Molkentin JD, Poole AW.

Cell Calcium. 2010 Dec;48(6):333-40. Epub 2010 Nov 20.


Src family kinases are essential for primary aggregation by G(i) -coupled receptors.

Nash CA, Séverin S, Dawood BB, Makris M, Mumford A, Wilde J, Senis YA, Watson SP.

J Thromb Haemost. 2010 Oct;8(10):2273-82.


F8 and F9 mutations fail to co-segregate in a family with co-incident haemophilia A and B.

Siddiq S, Morse C, Goodeve A, Panayi M, Tait RC, Mumford A.

Haemophilia. 2010 Sep 22. doi: 10.1111/j.1365-2516.2010.02396.x.PMID: 20860608


Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen.

Gilio K, Harper MT, Cosemans JM, Konopatskaya O, Munnix IC, Prinzen L, Leitges M, Liu Q, Molkentin JD, Heemskerk JW, Poole AW.

J Biol Chem. 2010 Jul 23;285(30):23410-9. Epub 2010 May 17.PMID: 20479008 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text

Investigation of human haemotropic Mycoplasma infections using a novel generic haemoplasma qPCR assay on blood samples and blood smears.

Tasker S, Peters IR, Mumford AD, Day MJ, Gruffydd-Jones TJ, Day S, Pretorius AM, Birtles RJ, Helps CR, Neimark H.

J Med Microbiol. 2010 Jul 22. [Epub ahead of print]PMID: 20651038 [PubMed - as supplied by publisher]

Protein kinase Ctheta negatively regulates store-independent Ca2+ entry and phosphatidylserine exposure downstream of glycoprotein VI in platelets.

Harper MT, Poole AW.

J Biol Chem. 2010 Jun 25;285(26):19865-73. Epub 2010 Apr 13.PMID: 20388711 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text

Cerebral palsy in siblings caused by compound heterozygous mutations in the gene encoding protein C.

Fong CY, Mumford AD, Likeman MJ, Jardine PE.

Dev Med Child Neurol. 2010 May;52(5):489-93. Epub 2010 Feb 19.PMID: 20187890 [PubMed - indexed for MEDLINE]

Regulation of P2Y1 receptor traffic by sorting Nexin 1 is retromer independent.

Nisar S, Kelly E, Cullen PJ, Mundell SJ.

Traffic. 2010 Apr;11(4):508-19. Epub 2010 Jan 8.PMID: 20070609 [PubMed - indexed for MEDLINE]

Heavy chain myosin 9-related disease (MYH9 -RD): neutrophil inclusions of myosin-9 as a pathognomonic sign of the disorder.

Savoia A, De Rocco D, Panza E, Bozzi V, Scandellari R, Loffredo G, Mumford A, Heller PG, Noris P, De Groot MR, Giani M, Freddi P, Scognamiglio F, Riondino S, Pujol-Moix N, Fabris F, Seri M, Balduini CL, Pecci A.

Thromb Haemost. 2010 Mar 31;103(4):826-32. Epub 2010 Feb 19.PMID: 20174760 [PubMed - indexed for MEDLINE]

Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation.

Harper MT, Poole AW.

J Thromb Haemost. 2010 Mar;8(3):454-62. Epub 2009 Dec 11. Review.PMID: 20002545 [PubMed - indexed for MEDLINE]

RGD-ligand mimetic antagonists of integrin alphaIIbbeta3 paradoxically enhance GPVI-induced human platelet activation.

Jones ML, Harper MT, Aitken EW, Williams CM, Poole AW.

J Thromb Haemost. 2010 Mar;8(3):567-76. Epub 2009 Dec 11.PMID: 20002543 [PubMed - indexed for MEDLINE]

Deletion of the distal COOH-terminus of the A2B adenosine receptor switches internalization to an arrestin- and clathrin-independent pathway and inhibits recycling.

Mundell SJ, Matharu AL, Nisar S, Palmer TM, Benovic JL, Kelly E.

Br J Pharmacol. 2010 Feb 1;159(3):518-33. Epub 2010 Jan 28.PMID: 20128803 [PubMed - indexed for MEDLINE]

Two patients with Hermansky Pudlak syndrome type 2 and novel mutations in AP3B1.

Wenham M, Grieve S, Cummins M, Jones ML, Booth S, Kilner R, Ancliff PJ, Griffiths GM, Mumford AD.

Haematologica. 2010 Feb;95(2):333-7. Epub 2009 Aug 13.PMID: 19679886 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text

A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis.

Mumford AD, Dawood BB, Daly ME, Murden SL, Williams MD, Protty MB, Spalton JC, Wheatley M, Mundell SJ, Watson SP.

Blood. 2010 Jan 14;115(2):363-9. Epub 2009 Oct 14.PMID: 19828703 [PubMed - indexed for MEDLINE]

Protein kinase Calpha: disease regulator and therapeutic target.

Konopatskaya O, Poole AW.

Trends Pharmacol Sci. 2010 Jan;31(1):8-14. Epub 2009 Dec 5. Review.PMID: 19969380 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text

Phenotypic approaches to gene mapping in platelet function disorders - identification of new variant of P2Y12, TxA2 and GPVI receptors.

Watson S, Daly M, Dawood B, Gissen P, Makris M, Mundell S, Wilde J, Mumford A.

Hamostaseologie. 2010 Jan;30(1):29-38. Review.PMID: 20162250 [PubMed - indexed for MEDLINE]



Insulin/IGF-1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet function.

Hunter RW, Hers I.

J Thromb Haemost. 2009 Dec;7(12):2123-30. Epub 2009 Oct 8.PMID: 19817984 [PubMed - indexed for MEDLINE]Related citations

Canonical Wnt signaling negatively regulates platelet function.

Steele BM, Harper MT, Macaulay IC, Morrell CN, Perez-Tamayo A, Foy M, Habas R, Poole AW, Fitzgerald DJ, Maguire PB.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19836-41. Epub 2009 Nov 9.PMID: 19901330 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Cracking the platelet WIP.

Poole AW.

Blood. 2009 Nov 19;114(21):4611-2. No abstract available.PMID: 19965714 [PubMed]Related citations

Characterization of a novel focal adhesion kinase inhibitor in human platelets.

Jones ML, Shawe-Taylor AJ, Williams CM, Poole AW.

Biochem Biophys Res Commun. 2009 Nov 6;389(1):198-203. Epub 2009 Aug 28.PMID: 19716803 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

PKCtheta in platelet activation.

Harper MT, Poole AW.

Blood. 2009 Jul 9;114(2):489-91; author reply 491-2. No abstract available.PMID: 19589937 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP levels in human platelets.

Hunter RW, Mackintosh C, Hers I.

J Biol Chem. 2009 May 1;284(18):12339-48. Epub 2009 Mar 4.PMID: 19261611 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Identification and characterization of a novel P2Y 12 variant in a patient diagnosed with type 1 von Willebrand disease in the European MCMDM-1VWD study.

Daly ME, Dawood BB, Lester WA, Peake IR, Rodeghiero F, Goodeve AC, Makris M, Wilde JT, Mumford AD, Watson SP, Mundell SJ.

Blood. 2009 Apr 23;113(17):4110-3. Epub 2009 Feb 23.PMID: 19237732 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

How useful is light transmission platelet aggregometry for the diagnosis of bleeding disorders?

Mumford AD.

J Thromb Haemost. 2009 Apr;7(4):673-5. Epub 2009 Jan 7. No abstract available.PMID: 19143932 [PubMed - indexed for MEDLINE]Related citations

The protein C omega-loop substitution Asn2Ile is associated with reduced protein C anticoagulant activity.

Preston RJ, Morse C, Murden SL, Brady SK, O'Donnell JS, Mumford AD.

Br J Haematol. 2009 Mar;144(6):946-53. Epub 2008 Dec 26.PMID: 19133979 [PubMed - indexed for MEDLINE]Related citations

PKCalpha regulates platelet granule secretion and thrombus formation in mice.

Konopatskaya O, Gilio K, Harper MT, Zhao Y, Cosemans JM, Karim ZA, Whiteheart SW, Molkentin JD, Verkade P, Watson SP, Heemskerk JW, Poole AW.

J Clin Invest. 2009 Feb;119(2):399-407. doi: 10.1172/JCI34665. Epub 2009 Jan 19.PMID: 19147982 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Familial multiple coagulation factor deficiencies - chance associations and distinct clinical disorders.

Robson PJ, Mumford AD.

Haemophilia. 2009 Jan;15(1):11-9. Review.PMID: 19149846 [PubMed - indexed for MEDLINE]Related citations



Understanding the therapeutic action of recombinant factor VIIa in platelet disorders.

Hers I, Mumford A.

Platelets. 2008 Dec;19(8):571-81. Review.PMID: 19012175 [PubMed - indexed for MEDLINE]Related citations

The PKB inhibitor Akti-1/2 potentiates PAR-1-mediated platelet function independently of its ability to block PKB.

Hunter RW, Harper MT, Hers I.

J Thromb Haemost. 2008 Nov;6(11):1923-32. Epub 2008 Aug 28.PMID: 18761726 [PubMed - indexed for MEDLINE]Related citations

Pharmacodynamic resistance to warfarin is associated with nucleotide substitutions in VKORC1.

Harrington DJ, Gorska R, Wheeler R, Davidson S, Murden S, Morse C, Shearer MJ, Mumford AD.

J Thromb Haemost. 2008 Oct;6(10):1663-70. Epub 2008 Aug 1.PMID: 18680536 [PubMed - indexed for MEDLINE]Related citations

Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation.

Hall KJ, Harper MT, Gilio K, Cosemans JM, Heemskerk JW, Poole AW.

PLoS One. 2008 Sep 25;3(9):e3277.PMID: 18815612 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Rapid resensitization of purinergic receptor function in human platelets.

Mundell SJ, Barton JF, Mayo-Martin MB, Hardy AR, Poole AW.

J Thromb Haemost. 2008 Aug;6(8):1393-404. Epub 2008 May 28.PMID: 18513210 [PubMed - indexed for MEDLINE]Related citations

Critical roles for the actin cytoskeleton and cdc42 in regulating platelet integrin alpha2beta1.

Pula G, Poole AW.

Platelets. 2008 May;19(3):199-210.PMID: 18432521 [PubMed - indexed for MEDLINE]Related citations

Reciprocal regulation of platelet responses to P2Y and thromboxane receptor activation.

Barton JF, Hardy AR, Poole AW, Mundell SJ.

J Thromb Haemost. 2008 Mar;6(3):534-43. Epub 2007 Dec 10.PMID: 18088343 [PubMed - indexed for MEDLINE]Related citation

Antithrombin alfa in hereditary antithrombin deficient patients: A phase 3 study of prophylactic intravenous administration in high risk situations.

Tiede A, Tait RC, Shaffer DW, Baudo F, Boneu B, Dempfle CE, Horellou MH, Klamroth R, Lazarchick J, Mumford AD, Schulman S, Shiach C, Bonfiglio LJ, Frieling JT, Conard J, von Depka M.

Thromb Haemost. 2008 Mar;99(3):616-22.PMID: 18327412 [PubMed - indexed for MEDLINE]Related citations



Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway.

Hers I.

Blood. 2007 Dec 15;110(13):4243-52. Epub 2007 Sep 7.PMID: 17827393 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Isoform-specific functions of protein kinase C: the platelet paradigm.

Harper MT, Poole AW.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1005-8. Review.PMID: 17956264 [PubMed - indexed for MEDLINE]Related citations

Coincident regulation of PKCdelta in human platelets by phosphorylation of Tyr311 and Tyr565 and phospholipase C signalling.

Hall KJ, Jones ML, Poole AW.

Biochem J. 2007 Sep 15;406(3):501-9.PMID: 17570831 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Effects of abiotic factors on the phylogenetic diversity of bacterial communities in acidic thermal springs.

Mathur J, Bizzoco RW, Ellis DG, Lipson DA, Poole AW, Levine R, Kelley ST.

Appl Environ Microbiol. 2007 Apr;73(8):2612-23. Epub 2007 Jan 12.PMID: 17220248 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Developing oligodendrocytes express functional GABA(B) receptors that stimulate cell proliferation and migration.

Luyt K, Slade TP, Dorward JJ, Durant CF, Wu Y, Shigemoto R, Mundell SJ, Váradi A, Molnár E.

J Neurochem. 2007 Feb;100(3):822-40. Epub 2006 Nov 27.PMID: 17144904 [PubMed - indexed for MEDLINE]Related citations


PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation.

Pula G, Schuh K, Nakayama K, Nakayama KI, Walter U, Poole AW.

Blood. 2006 Dec 15;108(13):4035-44. Epub 2006 Aug 29.PMID: 16940418 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

A review of inherited platelet disorders with guidelines for their management on behalf of the UKHCDO.

Bolton-Maggs PH, Chalmers EA, Collins PW, Harrison P, Kitchen S, Liesner RJ, Minford A, Mumford AD, Parapia LA, Perry DJ, Watson SP, Wilde JT, Williams MD; UKHCDO.

Br J Haematol. 2006 Dec;135(5):603-33. Review.PMID: 17107346 [PubMed - indexed for MEDLINE]Related citations

Distinct clathrin-coated pits sort different G protein-coupled receptor cargo.

Mundell SJ, Luo J, Benovic JL, Conley PB, Poole AW.

Traffic. 2006 Oct;7(10):1420-31. Epub 2006 Aug 10.PMID: 16899088 [PubMed - indexed for MEDLINE]Related citations

Combined deficiency of factors VII and X: clinical description of two cases and management of spinal surgery.

Chilcott JL, Russell G, Mumford AD.

Haemophilia. 2006 Sep;12(5):555-8. No abstract available.PMID: 16919090 [PubMed - indexed for MEDLINE]Related citations

Distinct roles for protein kinase C isoforms in regulating platelet purinergic receptor function.

Mundell SJ, Jones ML, Hardy AR, Barton JF, Beaucourt SM, Conley PB, Poole AW.

Mol Pharmacol. 2006 Sep;70(3):1132-42. Epub 2006 Jun 27.PMID: 16804093 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Management of anticoagulation for coronary artery bypass surgery in a patient with severe prekallikrein deficiency.

Oram MP, Mumford AD, Morse C, Underwood S.

J Cardiothorac Vasc Anesth. 2006 Aug;20(4):580-2. Epub 2006 Feb 2. No abstract available.PMID: 16884995 [PubMed - indexed for MEDLINE]Related citations

Agonist-selective mechanisms of mu-opioid receptor desensitization in human embryonic kidney 293 cells.

Johnson EA, Oldfield S, Braksator E, Gonzalez-Cuello A, Couch D, Hall KJ, Mundell SJ, Bailey CP, Kelly E, Henderson G.

Mol Pharmacol. 2006 Aug;70(2):676-85. Epub 2006 May 8.PMID: 16682505 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Regulation of small GTP-binding proteins by insulin.

Welsh GI, Hers I, Wherlock M, Tavaré JM.

Biochem Soc Trans. 2006 Apr;34(Pt 2):209-12. Review.PMID: 16545078 [PubMed - indexed for MEDLINE]Related citations

Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells.

Hers I, Wherlock M, Homma Y, Yagisawa H, Tavaré JM.

J Biol Chem. 2006 Feb 24;281(8):4762-70. Epub 2005 Dec 6.PMID: 16338927 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Internalization and desensitization of the oxytocin receptor is inhibited by Dynamin and clathrin mutants in human embryonic kidney 293 cells.

Smith MP, Ayad VJ, Mundell SJ, McArdle CA, Kelly E, López Bernal A.

Mol Endocrinol. 2006 Feb;20(2):379-88. Epub 2005 Sep 22.PMID: 16179383 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Vasodilator-stimulated phosphoprotein (VASP) is phosphorylated on Ser157 by protein kinase C-dependent and -independent mechanisms in thrombin-stimulated human platelets.

Wentworth JK, Pula G, Poole AW.

Biochem J. 2006 Jan 15;393(Pt 2):555-64.PMID: 16197368 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Hereditary hyperferritinemia cataract syndrome: ocular, genetic, and biochemical findings.

Ismail AR, Lachlan KL, Mumford AD, Temple IK, Hodgkins PR.

Eur J Ophthalmol. 2006 Jan-Feb;16(1):153-60.PMID: 16496261 [PubMed - indexed for MEDLINE]Related citations


A SHPing tale: perspectives on the regulation of SHP-1 and SHP-2 tyrosine phosphatases by the C-terminal tail.

Poole AW, Jones ML.

Cell Signal. 2005 Nov;17(11):1323-32. Review.PMID: 16084691 [PubMed - indexed for MEDLINE]Related citations

Evidence that the purinergic receptor P2Y12 potentiates platelet shape change by a Rho kinase-dependent mechanism.

Hardy AR, Hill DJ, Poole AW.

Platelets. 2005 Nov;16(7):415-29.PMID: 16236603 [PubMed - indexed for MEDLINE]Related citations

Rapid detection of the prothrombin C20209T transition by Light Cycler analysis.

Clench T, Standen GR, Ryan E, Chilcott JL, Mumford AD.

Thromb Haemost. 2005 Nov;94(5):1114-5. No abstract available.PMID: 16363262 [PubMed - indexed for MEDLINE]Related citations

Protein activation of a ribozyme: the role of bacterial RNase P protein.

Buck AH, Dalby AB, Poole AW, Kazantsev AV, Pace NR.

EMBO J. 2005 Oct 5;24(19):3360-8. Epub 2005 Sep 15.PMID: 16163391 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Analysis of mGluR1a constitutive internalization using a pulse-chase enzyme-linked immuno-sorbant assay (ELISA).

Pula G, Mundell SJ, Roberts PJ, Kelly E.

J Biochem Biophys Methods. 2005 Sep 30;64(3):167-81.PMID: 16112201 [PubMed - indexed for MEDLINE]Related citations

A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome.

Albrecht C, McVey JH, Elliott JI, Sardini A, Kasza I, Mumford AD, Naoumova RP, Tuddenham EG, Szabo K, Higgins CF.

Blood. 2005 Jul 15;106(2):542-9. Epub 2005 Mar 24.PMID: 15790791 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes.

Hers I, Tavaré JM.

Biochem J. 2005 Jun 1;388(Pt 2):713-20.PMID: 15713122 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Centaurin-alpha 1, an ADP-ribosylation factor 6 GTPase activating protein, inhibits beta 2-adrenoceptor internalization.

Lawrence J, Mundell SJ, Yun H, Kelly E, Venkateswarlu K.

Mol Pharmacol. 2005 Jun;67(6):1822-8. Epub 2005 Mar 18.PMID: 15778454 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms.

Hardy AR, Conley PB, Luo J, Benovic JL, Poole AW, Mundell SJ.

Blood. 2005 May 1;105(9):3552-60. Epub 2005 Jan 21.PMID: 15665114 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Role of protein kinase B in insulin-regulated glucose uptake.

Welsh GI, Hers I, Berwick DC, Dell G, Wherlock M, Birkin R, Leney S, Tavaré JM.

Biochem Soc Trans. 2005 Apr;33(Pt 2):346-9. Review.PMID: 15787603 [PubMed - indexed for MEDLINE]Related citations

Functional interaction of protein kinase Calpha with the tyrosine kinases Syk and Src in human platelets.

Pula G, Crosby D, Baker J, Poole AW.

J Biol Chem. 2005 Feb 25;280(8):7194-205. Epub 2004 Dec 6.PMID: 15583006 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Generation of a polyclonal rabbit anti-mouse tissue factor antibody by nucleic acid immunisation.

Mumford AD, Chen D, Dorling A, Kemball-Cook G, McVey JH.

Thromb Haemost. 2005 Jan;93(1):160-4.PMID: 15630507 [PubMed - indexed for MEDLINE]Related citations

Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1.

Harrington DJ, Underwood S, Morse C, Shearer MJ, Tuddenham EG, Mumford AD.

Thromb Haemost. 2005 Jan;93(1):23-6.PMID: 15630486 [PubMed - indexed for MEDLINE]Related citations


Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles.

Berwick DC, Dell GC, Welsh GI, Heesom KJ, Hers I, Fletcher LM, Cooke FT, Tavaré JM.

J Cell Sci. 2004 Dec 1;117(Pt 25):5985-93. Epub 2004 Nov 16.PMID: 15546921 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Severe prekallikrein deficiency associated with homozygosity for an Arg94Stop nonsense mutation.

Wynne Jones D, Russell G, Allford SL, Burdon K, Hawkins GA, Bowden DW, Minaee S, Mumford AD.

Br J Haematol. 2004 Oct;127(2):220-3.PMID: 15461630 [PubMed - indexed for MEDLINE]Related citations

Clinical features and molecular analysis of seven British kindreds with hereditary hyperferritinaemia cataract syndrome.

Lachlan KL, Temple IK, Mumford AD.

Eur J Hum Genet. 2004 Oct;12(10):790-6.PMID: 15280904 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

PKC-interacting proteins: from function to pharmacology.

Poole AW, Pula G, Hers I, Crosby D, Jones ML.

Trends Pharmacol Sci. 2004 Oct;25(10):528-35. Review.PMID: 15380937 [PubMed - indexed for MEDLINE]Related citations

Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus.

Jones ML, Craik JD, Gibbins JM, Poole AW.

J Biol Chem. 2004 Sep 24;279(39):40475-83. Epub 2004 Jul 21.PMID: 15269224 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Reciprocal cross-talk between P2Y1 and P2Y12 receptors at the level of calcium signaling in human platelets.

Hardy AR, Jones ML, Mundell SJ, Poole AW.

Blood. 2004 Sep 15;104(6):1745-52. Epub 2004 Jun 8.PMID: 15187029 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

The rare coagulation disorders--review with guidelines for management from the United Kingdom Haemophilia Centre Doctors' Organisation.

Bolton-Maggs PH, Perry DJ, Chalmers EA, Parapia LA, Wilde JT, Williams MD, Collins PW, Kitchen S, Dolan G, Mumford AD.

Haemophilia. 2004 Sep;10(5):593-628. Review.PMID: 15357789 [PubMed - indexed for MEDLINE]Related citations

Antibody cross-linking of human platelet P-selectin induces calcium entry by a mechanism dependent upon Fcgamma receptor IIA.

Sathish JG, Falati S, Croce K, Crump C, Furie BC, Furie B, Poole AW.

Thromb Haemost. 2004 Sep;92(3):598-605.PMID: 15351857 [PubMed - indexed for MEDLINE]Related citations

Evaluation of soil gas sampling and analysis techniques at a former petrochemical plant site.

Hers I, Li L, Hannam S.

Environ Technol. 2004 Jul;25(7):847-60.PMID: 15346867 [PubMed - indexed for MEDLINE]Related citations

Desensitization and internalization of metabotropic glutamate receptor 1a following activation of heterologous Gq/11-coupled receptors.

Mundell SJ, Pula G, McIlhinney RA, Roberts PJ, Kelly E.

Biochemistry. 2004 Jun 15;43(23):7541-51.PMID: 15182196 [PubMed - indexed for MEDLINE]Related citations

Activation of cyclic AMP-dependent protein kinase inhibits the desensitization and internalization of metabotropic glutamate receptors 1a and 1b.

Mundell SJ, Pula G, More JC, Jane DE, Roberts PJ, Kelly E.

Mol Pharmacol. 2004 Jun;65(6):1507-16.PMID: 15155843 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

GPIb potentiates GPVI-induced responses in human platelets.

Baker J, Griggs RK, Falati S, Poole AW.

Platelets. 2004 Jun;15(4):207-14.PMID: 15203711 [PubMed - indexed for MEDLINE]Related citations

Agonist-independent internalization of metabotropic glutamate receptor 1a is arrestin- and clathrin-dependent and is suppressed by receptor inverse agonists.

Pula G, Mundell SJ, Roberts PJ, Kelly E.

J Neurochem. 2004 May;89(4):1009-20.PMID: 15140199 [PubMed - indexed for MEDLINE]Related citations

Characterisation of lymphocyte responses to Ca2+ in Scott syndrome.

Elliott JI, Mumford AD, Albrecht C, Collins PW, Giddings JC, Higgins CF, Tuddenham EG, McVey JH.

Thromb Haemost. 2004 Feb;91(2):412-5. Review. No abstract available.PMID: 14961172 [PubMed - indexed for MEDLINE]Related citations

Tissue factor in the myocardium: evidence of roles in haemostasis and inflammation.

Mumford AD, McVey JH.

Dis Markers. 2004;20(6):353-8. Review.PMID: 15665396 [PubMed - indexed for MEDLINE]Related citations

Protein tyrosine phosphatases.

Jones ML, Poole AW.

Methods Mol Biol. 2004;273:169-78. No abstract available.PMID: 15308801 [PubMed - indexed for MEDLINE]Related citations

Platelet dense-granule secretion: the [3H]-5-HT secretion assay.

Crosby D, Poole AW.

Methods Mol Biol. 2004;272:95-6. No abstract available.PMID: 15226537 [PubMed - indexed for MEDLINE]Related citations



Inhibition of Escherichia coli RNase P by oligonucleotide directed misfolding of RNA.

Childs JL, Poole AW, Turner DH.

RNA. 2003 Dec;9(12):1437-45.PMID: 14624000 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Factor V I359T: a novel mutation associated with thrombosis and resistance to activated protein C.

Mumford AD, McVey JH, Morse CV, Gomez K, Steen M, Norstrom EA, Tuddenham EG, Dahlback B, Bolton-Maggs PH.

Br J Haematol. 2003 Nov;123(3):496-501.PMID: 14617013 [PubMed - indexed for MEDLINE]Related citations

Physical and functional interaction between protein kinase C delta and Fyn tyrosine kinase in human platelets.

Crosby D, Poole AW.

J Biol Chem. 2003 Jul 4;278(27):24533-41. Epub 2003 Apr 29.PMID: 12721299 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Agonist-induced internalization of metabotropic glutamate receptor 1A: structural determinants for protein kinase C- and G protein-coupled receptor kinase-mediated internalization.

Mundell SJ, Pula G, Carswell K, Roberts PJ, Kelly E.

J Neurochem. 2003 Jan;84(2):294-304.PMID: 12558992 [PubMed - indexed for MEDLINE]Related citations



Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes.

Hers I, Bell CJ, Poole AW, Jiang D, Denton RM, Schaefer E, Tavaré JM.

Biochem J. 2002 Dec 15;368(Pt 3):875-84.PMID: 12220227 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes.

Berwick DC, Hers I, Heesom KJ, Moule SK, Tavare JM.

J Biol Chem. 2002 Sep 13;277(37):33895-900. Epub 2002 Jul 9.PMID: 12107176 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

A Tyr346-->Cys substitution in the interdomain acidic region a1 of factor VIII in an individual with factor VIII:C assay discrepancy.

Mumford AD, Laffan M, O'Donnell J, McVey JH, Johnson DJ, Manning RA, Kemball-Cook G.

Br J Haematol. 2002 Aug;118(2):589-94.PMID: 12139751 [PubMed - indexed for MEDLINE]Related citations

Metabotropic glutamate receptor 1 internalization induced by muscarinic acetylcholine receptor activation: differential dependency of internalization of splice variants on nonvisual arrestins.

Mundell SJ, Matharu AL, Pula G, Holman D, Roberts PJ, Kelly E.

Mol Pharmacol. 2002 May;61(5):1114-23.PMID: 11961129 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinases.

Crosby D, Poole AW.

J Biol Chem. 2002 Mar 22;277(12):9958-65. Epub 2002 Jan 11.PMID: 11788586 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Characterization of arrestin expression and function.

Mundell SJ, Orsini MJ, Benovic JL.

Methods Enzymol. 2002;343:600-11. No abstract available.PMID: 11665594 [PubMed - indexed for MEDLINE]Related citation


Marked elevation of thrombin generation in patients with elevated FVIII:C and venous thromboembolism.

O'Donnell J, Mumford AD, Manning RA, Laffan MA.

Br J Haematol. 2001 Dec;115(3):687-91.PMID: 11736955 [PubMed - indexed for MEDLINE]Related citations

Arrestin specificity for G protein-coupled receptors in human airway smooth muscle.

Penn RB, Pascual RM, Kim YM, Mundell SJ, Krymskaya VP, Panettieri RA Jr, Benovic JL.

J Biol Chem. 2001 Aug 31;276(35):32648-56. Epub 2001 Jun 20.PMID: 11418617 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Rapid agonist-induced desensitization and internalization of the A(2B) adenosine receptor is mediated by a serine residue close to the COOH terminus.

Matharu AL, Mundell SJ, Benovic JL, Kelly E.

J Biol Chem. 2001 Aug 10;276(32):30199-207. Epub 2001 May 1.PMID: 11333255 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Agonist-induced internalization of the metabotropic glutamate receptor 1a is arrestin- and dynamin-dependent.

Mundell SJ, Matharu AL, Pula G, Roberts PJ, Kelly E.

J Neurochem. 2001 Aug;78(3):546-51.PMID: 11483657 [PubMed - indexed for MEDLINE]Related citations

The snake venom toxin alboaggregin-A activates glycoprotein VI.

Asazuma N, Marshall SJ, Berlanga O, Snell D, Poole AW, Berndt MC, Andrews RK, Watson SP.

Blood. 2001 Jun 15;97(12):3989-91.PMID: 11389045 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Regulation of G protein-coupled receptor-adenylyl cyclase responsiveness in human airway smooth muscle by exogenous and autocrine adenosine.

Mundell SJ, Olah ME, Panettieri RA, Benovic JL, Penn RB.

Am J Respir Cell Mol Biol. 2001 Feb;24(2):155-63.PMID: 11159049 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Factor VII deficiency and the FVII mutation database.

McVey JH, Boswell E, Mumford AD, Kemball-Cook G, Tuddenham EG.

Hum Mutat. 2001;17(1):3-17. Review.PMID: 11139238 [PubMed - indexed for MEDLINE]Related citations


Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway.

Quek LS, Pasquet JM, Hers I, Cornall R, Knight G, Barnes M, Hibbs ML, Dunn AR, Lowell CA, Watson SP.

Blood. 2000 Dec 15;96(13):4246-53.PMID: 11110698 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Arrestin isoforms dictate differential kinetics of A2B adenosine receptor trafficking.

Mundell SJ, Matharu AL, Kelly E, Benovic JL.

Biochemistry. 2000 Oct 24;39(42):12828-36.PMID: 11041847 [PubMed - indexed for MEDLINE]Related citations

Molecular analysis of the genotype-phenotype relationship in factor VII deficiency.

Millar DS, Kemball-Cook G, McVey JH, Tuddenham EG, Mumford AD, Attock GB, Reverter JC, Lanir N, Parapia LA, Reynaud J, Meili E, von Felton A, Martinowitz U, Prangnell DR, Krawczak M, Cooper DN.

Hum Genet. 2000 Oct;107(4):327-42.PMID: 11129332 [PubMed - indexed for MEDLINE]Related citations

Evidence of a role for SHP-1 in platelet activation by the collagen receptor glycoprotein VI.

Pasquet JM, Quek L, Pasquet S, Poole A, Matthews JR, Lowell C, Watson SP.

J Biol Chem. 2000 Sep 15;275(37):28526-31.PMID: 10871605 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Trafficking of the HIV coreceptor CXCR4: role of arrestins and identification of residues in the C-terminal tail that mediate receptor internalization

Orsini MJ, Parent JL, Mundell SJ, Marchese A, Benovic JL.

J Biol Chem. 2000 Aug 18;275(33):25876. No abstract available.PMID: 10940318 [PubMed - as supplied by publisher]Free ArticleRelated citations

Bleeding symptoms and coagulation abnormalities in 337 patients with AL-amyloidosis.

Mumford AD, O'Donnell J, Gillmore JD, Manning RA, Hawkins PN, Laffan M.

Br J Haematol. 2000 Aug;110(2):454-60.PMID: 10971408 [PubMed - indexed for MEDLINE]Related citations

The lens in hereditary hyperferritinaemia cataract syndrome contains crystalline deposits of L-ferritin.

Mumford AD, Cree IA, Arnold JD, Hagan MC, Rixon KC, Harding JJ.

Br J Ophthalmol. 2000 Jul;84(7):697-700.PMID: 10873976 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Inhibition of platelet integrin alpha(IIb)beta(3) by peptides that interfere with protein kinases and the beta(3) tail.

Hers I, Donath J, Litjens PE, van Willigen G, Akkerman JW.

Arterioscler Thromb Vasc Biol. 2000 Jun;20(6):1651-60.PMID: 10845885 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Selective regulation of endogenous G protein-coupled receptors by arrestins in HEK293 cells.

Mundell SJ, Benovic JL.

J Biol Chem. 2000 Apr 28;275(17):12900-8.PMID: 10777589 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Evidence against a direct role of the integrin alpha2beta1 in collagen-induced tyrosine phosphorylation in human platelets.

Hers I, Berlanga O, Tiekstra MJ, Kamiguti AS, Theakston RD, Watson SP.

Eur J Biochem. 2000 Apr;267(7):2088-97.PMID: 10727949 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Elevation of FVIII: C in venous thromboembolism is persistent and independent of the acute phase response.

O'Donnell J, Mumford AD, Manning RA, Laffan M.

Thromb Haemost. 2000 Jan;83(1):10-3.PMID: 10669146 [PubMed - indexed for MEDLINE]Related citations

Inflammatory and contractile agents sensitize specific adenylyl cyclase isoforms in human airway smooth muscle.

Billington CK, Hall IP, Mundell SJ, Parent JL, Panettieri RA Jr, Benovic JL, Penn RB.

Am J Respir Cell Mol Biol. 1999 Nov;21(5):597-606.PMID: 10536119 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization.

Orsini MJ, Parent JL, Mundell SJ, Marchese A, Benovic JL.

J Biol Chem. 1999 Oct 22;274(43):31076-86. Erratum in: J Biol Chem 2000 Aug 18;275(33):25876. Marchese, Adriano [added].PMID: 10521508 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Thrombin-induced association of SHP-2 with multiple tyrosine-phosphorylated proteins in human platelets.

Edmead CE, Crosby DA, Southcott M, Poole AW.

FEBS Lett. 1999 Oct 1;459(1):27-32.PMID: 10508911 [PubMed - indexed for MEDLINE]Related citations

Characterization of G protein-coupled receptor regulation in antisense mRNA-expressing cells with reduced arrestin levels.

Mundell SJ, Loudon RP, Benovic JL.

Biochemistry. 1999 Jul 6;38(27):8723-32.PMID: 10393547 [PubMed - indexed for MEDLINE]Related citations

Delays by patients in seeking treatment for acute chest pain: implications for achieving earlier thrombolysis.

Mumford AD, Warr KV, Owen SJ, Fraser AG.

Postgrad Med J. 1999 Feb;75(880):90-5.PMID: 10448469 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

The effect of inhibitors of receptor internalization on the desensitization and resensitization of three Gs-coupled receptor responses.

Mundell SJ, Kelly E.

Br J Pharmacol. 1998 Dec;125(7):1594-600.PMID: 9884089 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Enhanced expression of G protein-coupled receptor kinase 2 selectively increases the sensitivity of A2A adenosine receptors to agonist-induced desensitization.

Mundell SJ, Luty JS, Willets J, Benovic JL, Kelly E.

Br J Pharmacol. 1998 Sep;125(2):347-56.PMID: 9786508 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Differential involvement of tyrosine and serine/threonine kinases in platelet integrin alphaIIbbeta3 exposure.

Hers I, Donath J, van Willigen G, Akkerman JW.

Arterioscler Thromb Vasc Biol. 1998 Mar;18(3):404-14.PMID: 9514409 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Evidence for co-expression and desensitization of A2a and A2b adenosine receptors in NG108-15 cells.

Mundell SJ, Kelly E.

Biochem Pharmacol. 1998 Mar 1;55(5):595-603.PMID: 9515570 [PubMed - indexed for MEDLINE]Related citations

Hereditary hyperferritinemia-cataract syndrome: two novel mutations in the L-ferritin iron-responsive element.

Mumford AD, Vulliamy T, Lindsay J, Watson A.

Blood. 1998 Jan 1;91(1):367-8. No abstract available.PMID: 9414313 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Hyperferritinaemia in the absence of iron overload.

Arnold JD, Mumford AD, Lindsay JO, Hegde U, Hagan M, Hawkins JR.

Gut. 1997 Sep;41(3):408-10.PMID: 9378401 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Minimising delays to thrombolysis in patients developing acute myocardial infarction in hospital.

Mumford AD, Banning AP.

Postgrad Med J. 1997 Aug;73(862):491-5.PMID: 9307741 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

A dominant negative mutant of the G protein-coupled receptor kinase 2 selectively attenuates adenosine A2 receptor desensitization.

Mundell SJ, Benovic JL, Kelly E.

Mol Pharmacol. 1997 Jun;51(6):991-8.PMID: 9187265 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen.

Poole A, Gibbins JM, Turner M, van Vugt MJ, van de Winkel JG, Saito T, Tybulewicz VL, Watson SP.

EMBO J. 1997 May 1;16(9):2333-41.PMID: 9171347 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Clinically significant pulmonary barotrauma after inflation of party balloons.

Mumford AD, Ashkan K, Elborn S.

BMJ. 1996 Dec 21-28;313(7072):1619. No abstract available.PMID: 8991010 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Exposure of ligand-binding sites on platelet integrin alpha IIB/beta 3 by phosphorylation of the beta 3 subunit.

van Willigen G, Hers I, Gorter G, Akkerman JW.

Biochem J. 1996 Mar 15;314 ( Pt 3):769-79.PMID: 8615768 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Regulation of cytosolic calcium by collagen in single human platelets.

Poole AW, Watson SP.

Br J Pharmacol. 1995 May;115(1):101-6.PMID: 7647963 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

The effects of aspirin and paracetamol on the aggregation of equine blood platelets.

Heath MF, Evans RJ, Poole AW, Hayes LJ, McEvoy RJ, Littler RM.

J Vet Pharmacol Ther. 1994 Oct;17(5):374-8.PMID: 7853463 [PubMed - indexed for MEDLINE]Related citations

Hamartomas of the breast: six novel diagnostic features in three-dimensional thick sections.

Davies JD, Kulka J, Mumford AD, Armstrong JS, Wells CA.

Histopathology. 1994 Feb;24(2):161-8.PMID: 8181810 [PubMed - indexed for MEDLINE]Related citations

ADP induces desensitisation of equine platelet aggregation responses: studies using ADP beta S, a stable analogue of ADP.

Poole AW, Heath MF, Evans RJ.

Res Vet Sci. 1993 Mar;54(2):235-43.PMID: 8460266 [PubMed - indexed for MEDLINE]Related citations

A method for loading equine platelets with the fluorescent calcium indicator Fura-2: ADP induces a rise in the cytosolic free calcium ion concentration.

Poole AW, Heath MF, Sage SO, Evans RJ.

Equine Vet J. 1993 Jan;25(1):45-8.PMID: 8422884 [PubMed - indexed for MEDLINE]Related citations

Porcine relaxin affects the release of luteinizing hormone in rats.

Summerlee AJ, Mumford AD, Smith MS.

J Neuroendocrinol. 1991 Apr 1;3(2):133-8.PMID: 19215513 [PubMed - in process]Related citations

Lesion of the subfornical organ affects the haemotensive response to centrally administered relaxin in anaesthetized rats.

Mumford AD, Parry LJ, Summerlee AJ.

J Endocrinol. 1989 Sep;122(3):747-55.PMID: 2809482 [PubMed - indexed for MEDLINE]Related citations