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OPUS 13 for Dr Aleksandra Ellert-Miklaszewska

posted Nov 24, 2017, 1:43 AM by Kacper Walentynowicz   [ updated Nov 24, 2017, 2:00 AM ]
We are pleased to inform that Dr Aleksandra Ellert-Miklaszewska has received NCN flagship OPUS 13 grant (1 mln PLN) from the National Centre for Polish Science.

The project entitled 'Reprogramming antitumor innate immunity in gliomas with osteopontin/Spp1 interfering peptides and nanovehicles-delivered siRNA/shRNA' will investigate the interaction between tumor cells and components of its microenvironment. We have recently showed that tumor-derived protein, called osteopontin,contributes to tumor progression by attracting brain resident microglia and macrophages (GAMs) and shaping immune response in glioblastomas–the most malignat brain tumors. This 'bad education' of GAMs and other innate immune cells to tumor-supporting cells is not permanent and could be reversed bringing back antitumor immunity.Recent data suggest that high amounts of osteopontin detected inthe tumors may be derived notonly from the tumor cells but also from the host cells.Therefore, the main objective of the current project is to analyse the antitumor and immunomodulatory potency of systemic elimination of osteopontin either by genetic tools or using a peptide, which will block osteopontin action.