Updates‎ > ‎

Dr Ciechomska seminar at the Department of Biochemistry

posted Mar 14, 2017, 1:31 AM by Kacper Walentynowicz   [ updated Mar 14, 2017, 1:32 AM ]
Today, Dr Iwona Ciechomska presented her recently published paper at the Departmental seminar. The paper entitled 'BIX01294, an inhibitor of histone methyltransferase, induces autophagy-dependent differentiation of glioma stem-like cells.' published in Scientific Reports (IF 5.5) shed a light on BIX01294 mechanism in sensitization of glioma stem-like cells to temozolomide (currently a first-line therapeutic).
BIX01294 is an inhibitor of G9a histone methyltransferase (introducing H3K9me2 and H3K27me3 repressive marks) triggering autophagy in human glioma cells. This preliminary work can have a potential therapeutic application in GBM patients.

For more information see: Ciechomska et al. (2016) BIX01294, an inhibitor of histone methyltransferase, induces autophagy-dependent differentiation of glioma stem-like cells. Sci Rep [ PubMed ]
Comments