"Compositions and methods for treating glioma" US and Japan patent

posted Mar 18, 2019, 5:26 AM by Kacper Walentynowicz   [ updated Mar 18, 2019, 5:26 AM ]

Prof Kaminska has received a patent for innovative method employing synthetic peptides that block crosstalk between tumor cells and microenvironment for brain tumor therapy. Tumor cells produce various factors that influence surrounding non-tumor cells and transform them into tumor-supporting phenotype. The synthetic peptides target tumor secreting GM-CSF (granulocyte-macrophage colony-stimulating factor) and proteins acting through integrin receptors through RGD motifs. Application of these peptides block tumor invasion and growth in vivo.

The recepiant of the patent are Prof. Bożena Kamińska, Dr Małgorzata Sielska, Dr Paweł Wiśniewski, and Dr Aleksandra Ellert-Miklaszewska with ownership to Glia Sp. z o.o. Patent is also under consideration in Europe, Israel, and Canada.

Our integration/workshop retreat

posted Dec 7, 2018, 4:16 PM by Kacper Walentynowicz   [ updated Dec 7, 2018, 4:18 PM ]

We have visited Uniejów (nearby Łódź) to take part in the lab integration retreat where we also took part in workshop on statistics for biologists.
During the retreat we were also able to visit local castle and thermal waters. On site we participated in beer tasting and food paring sessions. The statistics workshop was led by Dr Jakub Mieczkowski which was followed by a lively discussion on our day-to-day data analysis.

6-7 December 2018, Uniejów

Post-doc position

posted Nov 27, 2018, 3:37 AM by Kacper Walentynowicz   [ updated Nov 27, 2018, 3:38 AM ]

Post-doctoral position is available in Kaminska's laboratory from January 2019 for 19 months for individuals with a good grounding in molecular biology, methods such as CRISPR mediated genome editing, RNA-sequencing and epigenetics. In particular, a position is available for a person with expertise in epigenetics, especially relating to single cell data generation (ATAC-seq, RNA-seq) etc..

Ideal candidates should be intellectually curious, productive, and enjoy working in a committed team effort to make these important projects succeed. The project is well under way due to the efforts of a dedicated group of post-docs, technicians and grad students.

Applications should be submitted to b.kaminska@nencki.gov.pl;
deadline for submission is December 31, 2019.

Karolia Stępniak awarded ETIUDA grant (NCN)

posted Aug 31, 2018, 6:14 AM by Kacper Walentynowicz

Karolina Stępniak has been awarded Etiuda grant from NCN. The purpose of the grant is to provide financial support for excellent PhD students to encourage scientific mobility and international collaboration.

The project is entitled 'Mapping of open chromatin and histone modifications in human gliomas' and aims to create high resolution map of the regulatory regions in DNA in gliomas. Combination of high-throughput methods, advanced bioinformatic analysis and predictive modelling will create comprehensive and detailed interaction maps of the regulatory regions in gliomas. Availability of samples from low and high grade will allow to identify regions responsible for malignant transformation, progression, and thus potentially prognostic markers. Further confirmation of the genome-wide analysis will be performed at the Friedrich Miescher Institute of Biomedical Research, FMI in Basel, Switzerland in Dr Luca Giorgetti laboratory.

Master Student Recruitment (FNP project) - [enrolled]

posted Aug 27, 2018, 6:17 AM by Kacper Walentynowicz   [ updated Oct 24, 2018, 2:06 AM ]

Laboratory of Molecular Neurobiology is seeking a talented Master student to join the FNP TEAM-TECH Core Facility project entitled 'NGS platform for comprehensive diagnostics and personalized therapy in neuro-oncology'.

The candidate should present high motivation to work in science, experience in qPCR, ChIP, Western-Blot, and cell culture. Applicants are expected to have very good English (oral and written).

There is allocated stipend for selected candidate: 1500 PLN/month

Please see attached job description for more details.
Contact: m.maleszewska[at]nencki.gov.pl

HOMING grant for Dr Anna Malik

posted Aug 4, 2018, 4:42 AM by Kacper Walentynowicz   [ updated Aug 4, 2018, 4:42 AM ]

r Anna Malik is joining our group from the Max Delbrück Center for Molecular Medicine, Germany. The HOMING program, financed by The Foundation for Polish Science will allow Dr Malik to work on a project entitled: New proteins important for glia's function: VPS10P-domain containing protein family as a new sorting recepetors in astrocytes and microglia. The main purpose of the HOMING Programme, is to encourage young Polish and foreign researchers working abroad, to develop their careers in Poland.

Dr. Malik will receive a fellowship at the Nencki Institute in the Laboratory of Molecular Neurobiology headed by prof. Bożena Kamińska-Kaczmarek.
The total budget of the project is 801 420 PLN.

Recruiting Post-doc! - CLOSED

posted Jul 2, 2018, 7:37 AM by Kacper Walentynowicz   [ updated Aug 13, 2018, 11:59 AM ]

The successful candidate will apply and optimize genome- and transcriptome-wide approaches (MNase-/ChIP-/RNA-sequencing,) to study chromatin accessibility and gene regulation using mammalian systems (primary cancer cell lines), carry out validation experiments involving biochemical and molecular biological tools, and participate in the general duties of the team. They will take a strong lead in the project management, as well as data generation, analyses and interpretation, collaborating with other team members. The applicant is expected to report scientific results, by writing scientific papers, attending scientific meetings, and effective communication with peers.

Applicants should have a PhD in a relevant field (up to 7 years after the award), hands-on expertise in molecular and cell biology techniques (e.g. DNA/RNA isolation, PCR, Real-Time PCR, Cloning, Western blotting, immunoprecipitation), as well as in handling primary cells cultures and at least one first author article. The applicant is expected to be able to organize herself/himself, to plan experiments and work independently, but also to feel comfortable as part of a team. Understanding of genome-wide bioinformatics analysis would be an advantage.

The role with commence between September and December 2018. We offer a full-time employment contract for the duration of the project (until September 2021). The position is paid according to the National Cancer Centre salary scheme, which amounts to a monthly net salary ~5,800 PLN. There are no teaching obligations. Possible benefits include a reduced-rate medical care package, and membership in the MultiSport programme. To improve her/his skills on MNase titration series, the successful candidate is expected to take an internship at the laboratory located in Boston (USA).

The closing date for applicants is 10th of August 2018, with possible recruitment decisions being made earlier, depending on the submission of suitable applications.

The application must be in English and should include a 1 page cover letter, CV, a list of publications, and contact information for two references.

Applications should be sent as a single pdf file to u.dziewulska@nencki.gov.pl.

Putting '[post-doc]' into the subject line of the email will ensure that it will be received in the correct email folder.

>> details <<

Congratulations to one of our Erasmus Students!

posted Jun 27, 2018, 2:25 AM by Kacper Walentynowicz   [ updated Jun 28, 2018, 1:26 AM ]

We are thrilled to share that Georgia Simmons has secured First Class Degree in Biomedical Science from the University of Portsmouth. Georgia did her final research project at the Laboratory of Molecular Neurobiology under supervision of Dr Helen Filmore (Univeristy of Portsmouth) and Kamil Wojnicki and Kacper Walentynowicz. Her project entitled 'Characterisation of functional parameters observed within activation of microglia in response to glioblastoma' has received the highest mark in the year group and will be used as an example for future students.

We are proud and happy with Georgia's success, and wish her all the best in future research career!

Prof Bozena Kaminska at the 'Polish Science Towards EMBL'

posted Jun 19, 2018, 11:26 AM by Kacper Walentynowicz   [ updated Jun 19, 2018, 11:30 AM ]

The objective of the conference is to celebrate Poland's way towards accession to the European Molecular Biology Laboratory (EMBL) and to enrich this process with the scientific symposium bringing together Polish and world’s leading experts and researchers in the field of biomedical research.

Prof Kaminska presented recent data on how microenvironment shapes glioma progression in the talk entitled: Tumor-derived molecules shape tumor microenvironment: from biology to therapy. She was one of the speakers selected to represent Nencki's biomedical research along with Dr Ewelina Knapska.

The conference was supported by Nencki Institute, EMBL, and Ministry of Science and Higher Education.

More information: http://embl.nencki.gov.pl/

2,000,000 PLN boost for research! OPUS14

posted May 25, 2018, 7:30 AM by Kacper Walentynowicz   [ updated May 25, 2018, 7:30 AM ]

We are thrilled to share that we have received 2mln PLN for research into molecular mechanisms of microglia in different experimental glioma models. The grant is provided by National Science Centre (OPUS 14) and has been ranked as the top 1st best project.

OPUS and PRELUDIUM are the two flagship calls of the National Science Centre, and they continue to attract the greatest interest among all available funding opportunities. The expert panels of the 14th edition have awarded a total of € 92,208,782 to the submitted research projects. In all, 3122 applications were received for both calls, 669 of which were recommended for funding, setting the success rate at 21%

The project entitled 'Epigenetic mechanisms determining the defective innate immunity responses in malignant gliomas' will analyse molecular profiles of GAMs in two animal models and correlate the data acquired from the clinical samples. We will show how local tumor microenvironment likely contributes to shaping chromatin openness and active transcription in brain macrophages and evokes 'trained immune memory'.

Principal Investigator: Prof. dr hab. Bożena Kamińska-Kaczmarek

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