Summer placement at our laboratory

posted Aug 21, 2017, 2:39 AM by Kacper Walentynowicz   [ updated Aug 21, 2017, 2:39 AM ]

We are pleased to have welcomed international students at our laboratory over the summer break. We hope you have learnt a lot and the time spent at the Laboratory of Molecular Neurobiology was not only fruitful in acquiring new skills and knowledge but also showed you a day-today life of scientists at different stages of their carrier. Obtained skills in molecular and cell biology will give you best head-start in your future research projects.  Nevertheless, we hope that in the future, you will look back with a smile at the time spent at the Nencki Institute.

Best of luck with your future plans!

Students were part of:
University of Nottingham, UK
Columbia University, USA
University of Portsmouth, UK
Medical University of Łódź, PL

NCN POLONEZ Grant for Dr Jakub Mieczkowski

posted Jun 4, 2017, 9:57 AM by Kacper Walentynowicz   [ updated Jun 4, 2017, 10:05 AM ]

We are proud to announce that Dr Jakub Mieczkowski has received a grant from the National Science Centre called 'POLONEZ' (eng. Polonaise). This grant is directed towards researchers of Polish origin coming back to Poland after long research career abroad.
The funding for the project entitled 'Identification of epigenetic mechanisms contributing to glioma drug resistance' reaches almost 1 MILION PLN.

'The aim of this project is to identify epigenetic characteristics of glioblastoma stem-like cells and regulatory networks that contribute to tumor drug resistance and reoccurrence. First, epigenetic characteristics and gene expression levels will be profiled in glioblastoma stem-like cells and differentiated cells derived from them'

Further description of the project can be found in the pdf file attached.

We have celebrated this great news by having a small pizza party! Congratulations to Dr Mieczkowski and we wish fruitful results!

Brain Tumor 2017 Berlin Meeting

posted May 24, 2017, 7:07 AM by Kacper Walentynowicz   [ updated May 30, 2017, 12:51 AM ]

Our lab has visited our collaborators in Berlin at the The Max Delbrück Center for Molecular Medicine to attend the Brain Tumor Meeting 2017.

At the conference, we had a chance to present our recent data on minocycline and its potential therapeutic effect in rat glioma model. The presentation was given by Dr Anna Gieryng who leads the project on potential minocycline therapy.

We were also selected to present 4 posters at the poster session that included many researchers from around the world.
Posters were presented by:
* Dr Iwona Ciechomska 'Exploring glioma heterogeneity using immunoblotting and immunohistochemistry.'
* Dr Aleksandra Ellert-Miklaszewska 'Expression and function of NFAT nuclear factor of activated T cells transcription factors in human gliomas.'
* Karolina Stępniak 'Open chromatin and epigenetic landscape of human benign and malignant gliomas.'
* Bartłomiej Gielniewski 'The impact of IDH1/2 mutations on SOCS gene methylation and deregulation of STAT signalling in gliomas.'

FNP funded project TEAM TECH - recruiting Post doc and 3 PhD students

posted May 9, 2017, 6:39 AM by Kacper Walentynowicz   [ updated May 23, 2017, 1:49 AM ]

We are seeking candidates for postdoc  and 3 PhD students to participate in TEAM TECH Core Facility project entitled 'Dissecting pathobiology of pediatric brain tumors' (supported by FNP).

Researchers will participate in cutting-edge biomedical research using DNA sequencing, DNA methylation profiling, high-throughput screening techniques, and cell- and animal-based models. The project takes 3 years, starting from June 1, 2017.

Detailed information is enclosed in the attachment (pdf file below).

Deadline for the application is 27 May 2017 (PhD students) 25 June 2017 (post-doc).

Please send your CV to Prof Bozena Kaminska (b.kaminska@nencki.gov.pl) and any enquires regarding the posts and laboratory.

Dr Ciechomska seminar at the Department of Biochemistry

posted Mar 14, 2017, 1:31 AM by Kacper Walentynowicz   [ updated Mar 14, 2017, 1:32 AM ]

Today, Dr Iwona Ciechomska presented her recently published paper at the Departmental seminar. The paper entitled 'BIX01294, an inhibitor of histone methyltransferase, induces autophagy-dependent differentiation of glioma stem-like cells.' published in Scientific Reports (IF 5.5) shed a light on BIX01294 mechanism in sensitization of glioma stem-like cells to temozolomide (currently a first-line therapeutic).
BIX01294 is an inhibitor of G9a histone methyltransferase (introducing H3K9me2 and H3K27me3 repressive marks) triggering autophagy in human glioma cells. This preliminary work can have a potential therapeutic application in GBM patients.

For more information see: Ciechomska et al. (2016) BIX01294, an inhibitor of histone methyltransferase, induces autophagy-dependent differentiation of glioma stem-like cells. Sci Rep [ PubMed ]

Masters thesis in our lab!

posted Dec 5, 2016, 5:45 AM by Kacper Walentynowicz   [ updated Dec 5, 2016, 5:45 AM ]

We are seeking highly motivated MSc students to complete their research projects in one of our subjects:

Histopathology of rat gliomas following experimental therapies.

DNA methylation as a diagnostic biomarker.
Epigenetic changes in glioma cancer stem cells.
Whole genome open chromatin analysis of differentiating glioma cancer stem cells.

You are required to have very good written and spoken English.

Please send your CV and covering letter to:
Prof. Bozena Kaminska

Joined PhD Position Available

posted Jun 7, 2016, 4:14 AM by Kacper Walentynowicz   [ updated Jun 7, 2016, 4:14 AM ]

We are pleased to start a new application for the joined PhD project with the University of Groningen (Dr Eggen).

Please see attached description of the project and send your application to: b.kaminska@nencki.gvo.pl

Appointed PhD student will spent 2 years in Warsaw and two years in Groningen. The student will acquire training in bioinformatics  to analyze the data and build regulatory gene networks that describe microglia heterogeneity and how these networks are affected by neurodegenerative disease.

Congratulations to our PhD student Sylwia K Krol!

posted Jun 5, 2016, 2:40 AM by Kacper Walentynowicz   [ updated Jun 5, 2016, 2:40 AM ]

We are pleased to announce that our PhD student secured the National Centre of Science grant (NCN - 'PRELUDIUM') to study RecQ helicases in GCM samples. This would employ our biobank of freshly-frozen patient GBM samples that we have been collecting from around the country. The project holds a great promise for novel targeted therapeutic strategy and better stratification of GBM patients.

The PRELUDIUM grants are available to pre-doctoral early-stage researchers. The selection criteria on which the grant is awarded include scientific excellence and innovative nature of the project.  They are highly competitive national grants ranging from
50 000 - 150 000 PLN (12 000 - 35 000 EUR).

We are very proud and wish Sylwia all the best in her work!

Neurobiology Center Seminar by Shamba Mondal

posted May 13, 2016, 1:05 AM by Kacper Walentynowicz   [ updated May 13, 2016, 1:06 AM ]

We would like to invite everyone for today's Neurobiology Seminar by our PhD student, speaking about open chromatin landscape in classical and alternative microglia activation. The seminar will be presented in English followed by a discussion.

Presentation will be given at the Neurobiology Center Lecture Theatre on the 1 floor at Nencki Institute at 12:00.

Post-Doc position - (APPOINTED)

posted May 12, 2016, 2:10 AM by Kacper Walentynowicz   [ updated Jun 7, 2016, 1:00 AM ]

We are currently recruiting a post-doc for a 2-year post in neuroimmunology and experimental neurooncology. You are invited to join a research team focusing on the molecular and cellular mechanisms of microglia-glioma interactions in rodents and immunotherapy for gliomas. We are seeking a postdoctoral fellow with experience in neuroanatomy, neuroinflammation, pharmacology, brain tumor models in vivo, and strong interest in neuroimmunology and immunotherapy of brain tumors.

Please send your applications to: b.kaminska@nencki.gov.pl

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