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Dr Chinchu Jayaprakash

I graduated, and received my Ph. D. in Molecular and Cell Biology, from Manipal University, in 2018. My Ph. D. thesis was entitled “Genetic and Epigenetic Studies in Oral Cancer”, and focused on examining differences in
methylation-based effects on the genome of oral cancer-affected and normal individuals using high throughput techniques such as microarray and next-generation sequencing, followed by validation by bisulfite sequencing, and further, to determine the effects of methylation and DNA repair, using oral cancer cell lines as models.

In April 2018, I joined Prof. Kaminska’s lab, at the Nencki Institute of Experimental Biology, as a post doctoral research fellow.

Research Interests:
Epigenetic modulation of genomes, epigenetic characterization of biomarkers, neuroscience, anti-cancer therapy.

Awards:
Recipient of the Dr. T.M.A. Pai Structured Fellowship for PhD, Manipal University, 2012.




Publications:
Peer-reviewed Articles:
• Jayaprakash, C., Radhakrishnan, R., Ray, S., and Satyamoorthy, K. "Promoter Methylation of MGMT in Oral Carcinoma: a Population-Based Study and Meta-Analysis." Archives of Oral Biology (2017).
https://doi.org/10.1016/j.archoralbio.2017.03.024
• Jayaprakash, C., Varghese V. K., Bellampalli, R., Radhakrishnan, R., Ray, S., Kabekkodu, S. P., and Satyamoorthy, K. "Hypermethylation of Death-Associated Protein Kinase (DAPK1) and its Association with Oral Carcinogenesis − An Experimental and Meta-Analysis Study." Archives of Oral Biology (2017).
https://doi.org/10.1016/j.archoralbio.2017.04.006
• Bhat, S., Kabekkodu, S. P., Jayaprakash, C., Radhakrishnan, R., Ray, S., and Satyamoorthy, K. "Gene Promoter-associated CpG Island Hypermethylation in Squamous Cell Carcinoma of the Tongue." Virchows Archiv (2017): 1-10.
https://doi.org/10.1007/s00428-017-2094-2
• Andrade, M. J., Jayaprakash, C., Bhat, S., Evangelatos, N., Brand, A., Satyamoorthy, K. “Antibiotics Induced Obesity: A Mitochondrial Perspective.” Public Health Genomics (2017).
https://doi.org/10.1159/000485095
• Radhakrishnan, R., Upadhya, R., Aithal, A., Bhat, S. P., Bhat, S., Jayaprakash, C., Ray S., Satyamoorthy, K. "DNA Methylation Changes in Clinical Stages of Oral Cancer Progression and Correlation with DOC2B Promoter Hypermethylation." Molecular Cancer Biology 1(1) (2013).

Book Chapter:
• Kotambail, A., Bhat, S., Jayaprakash, C., Fernandes, R. C., Varghese, V. K., and Kapaettu, S. 2017. Epigenetics and Human Diseases. Human Genetics. Edited by Sobti RC. p.59-86. Narendra Publishing House, New Delhi.