Dopamine Receptors

Cross references:   Dopamine      Receptors     Ligands 
G-Protein Coupled Receptors
     Ventral Tegmental Area  
Nucleus Accumbens Septi        Limbic System   

Dopamine receptor (Wiki)   
    "Dopamine receptors are a class of metabotropic G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. "  
    "
There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5.  
    The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 receptors are members of the D2-like family.
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    "
D1-like family 
    Activation of D1-like family receptors is coupled to the G protein Gαs, which subsequently activates adenylyl cyclase, increasing the intracellular concentration of the second messenger cyclic adenosine monophosphate (cAMP)."  

    "D2-like family
    Activation of D2-like family receptors is coupled to the G protein Gαi, which directly inhibits the formation of cAMP by inhibiting the enzyme adenylate cyclase.[4]"  
My comment
    To be completely clear, this means that when
Dopamine binds to a D1 family receptor, the cell on which the receptor resides is excited and becomes more active.  When dopamine binds to a D2 family receptor, the cell on which the receptor resides is inhibited and becomes less active.     



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