BoolSpace

Evolution and Controllability of Cancer Networks: a Boolean Perspective

Sriganesh Srihari 1, Venkatesh Raman2, Hon Wai Leong3 and Mark A. Ragan1

1 Institute for Molecular Bioscience, The University of Queensland, QLD 4072, Australia.
2
The Institute of Mathematical Sciences, CIT Campus Taramani, Chennai 600113, India.
3
Department of Computer Science, National University of Singapore, Singapore 117590. 

Keywords: Controllability of cancer networks; Evolution of cancer networks; Fixed-parameter tractability; Cancer state space


(a) BoolSpace: Boolean modeling of the cancer state space; (b) An illustration of the gene-flipping problem





Publications:
Srihari S, Raman V, Leong HW & Ragan MA (2014). Evolution and controllability of cancer networks: a Boolean perspective, IEEE/ACM Transactions on Computational Biology & Bioinformatics, 11(1):83-94. [PDF]

Srihari S (2013). Evolution and controllability of cancer networks: a Boolean perspective. Cold Spring Harbor Asia - Frontiers in Computational Biology (poster), Suzhou (China), September 2013. [PDF]

Srihari S (2012). Controllability of cancer networks: a Boolean perspective, BioinfoSummer (poster), Adelaide, Australia, December 2012. [PDF]



Supplementary materials

Download source codes and datasets for BoolSpaceV1 here.



Acknowledgements: Australian NHMRC funding to MAR and Dr Peter T. Simpson. visitor statistics