Evolution and Controllability of Cancer Networks: a Boolean Perspective

Sriganesh Srihari 1, Venkatesh Raman2, Hon Wai Leong3 and Mark A. Ragan1

1 Institute for Molecular Bioscience, The University of Queensland, QLD 4072, Australia.
The Institute of Mathematical Sciences, CIT Campus Taramani, Chennai 600113, India.
Department of Computer Science, National University of Singapore, Singapore 117590. 

Keywords: Controllability of cancer networks; Evolution of cancer networks; Fixed-parameter tractability; Cancer state space

(a) BoolSpace: Boolean modeling of the cancer state space; (b) An illustration of the gene-flipping problem

Srihari S, Raman V, Leong HW & Ragan MA (2014). Evolution and controllability of cancer networks: a Boolean perspective, IEEE/ACM Transactions on Computational Biology & Bioinformatics, 11(1):83-94. [PDF]

Srihari S (2013). Evolution and controllability of cancer networks: a Boolean perspective. Cold Spring Harbor Asia - Frontiers in Computational Biology (poster), Suzhou (China), September 2013. [PDF]

Srihari S (2012). Controllability of cancer networks: a Boolean perspective, BioinfoSummer (poster), Adelaide, Australia, December 2012. [PDF]

Supplementary materials

Download source codes and datasets for BoolSpaceV1 here.

Acknowledgements: Australian NHMRC funding to MAR and Dr Peter T. Simpson. visitor statistics