Course Outline

I. Evolution
        1) Phylogenies
            "Branches springing from one root"
(The Tragedy of King Richard the Second)
        2) Major Transitions in Vertebrate Evolution
"Half a fish and half a monster"

(The Tempest)

        3) Plant and Animal Domestication

            “Conformable as other household Kates”

(The Taming of the Shrew)

II. Genetics
        4) Genotype and Phenotype
“To hide the sparks of nature"

Hybrids and Mendelian Genetics

             “We will unite the white rose and the red”

(The Tragedy of King Richard the Third)

III. Reproduction and Development
        6) Mating Rituals
“The honor of your bed”
(Two Noble Kinsmen)

        7) Hermaphroditism

"I am all the daughters of my father’s house and all the brothers too"

(Twelfth Night)

        8) Embryonic Development

"From that womb where you imprison'd were"

(Titus Andronicus)       
        9) Offspring Dispersal
             "Where chance may nurse or end it"

(The Winter's Tale)

        10) Metamorphosis

  "There is differency between a grub and a butterfly"


IV. Leaves and Flowers

        11) Plant Pigments

              “Shall dye your white rose in a bloody red”

              (The First Part of King Henry the Sixth)

        12) Plant Senescence

              "It must needs wither"


V. Survival Strategies

        13) Camouflage

              “So may the outward shows be least themselves”

(The Merchant of Venice)

        14) Hibernation and Suspended Animation

              "In this borrowed likeness of shrunk death"

(Romeo and Juliet)

        15) Parasitism

              “So many dip their meat in one man's blood”

              (Timon of Athens)

VI. Matter and Energy

        16) Nutrient Cycles

              "A man may fish with the worm that hath eat of a king"


        17) Enzymes

              "May I be so converted"

              (Much Ado about Nothing)

        18) ATP and Energy Production

              "Nothing will come of nothing"

(King Lear)

        19) Photosynthesis

              "Take up the rays o' the beneficial sun"

              (The Life of King Henry the Eighth)

VII. DNA, RNA, and Protein

        20) Replication

              "The one so like the other"

              (The Comedy of Errors)

        21) The Central Dogma, Part 1: DNA

              "The bill that writes them all alike"

        22) The Central Dogma, Part 2: RNA

              “The voice of the recorded law"
              (Measure for Measure)
        23) The Central Dogma, Part 3: Protein
              “Thy rude hand to act the deed"
              (The Life and Death of King John)
        24) Protein Trafficking
              "What shipping and what lading's in our haven"
        25) Protein Turnover
              "Thus have I, Wall, my part discharged so; And, being done, thus Wall away doth go"
              (A Midsummer Night's Dream)
VIII. Structure and Transport
        26) Skeletons: Endo-, Exo-, and Cyto-

              “How would thy guts fall about thy knees!”

              (The First Part of King Henry the Fourth)

        27) Membrane Transport

              “Furnish you fairly for this interchange”

              (Troilus and Cressida)

IX. Signal Integration

        28) Signaling Cascades

              "Go, bear thou this letter"

              (The Merry Wives of Windsor)

        29) Pheromones

              “As if you snuffed up love by smelling love”

              (Love's Labour's Lost)

        30) Circadian Clocks

              “Who Time trots withal”

              (As You Like It)

X. Cell Growth

        31) Telomeres and Cellular Senescence

              "Blasted with antiquity"

              (The Second Part of King Henry the Fourth)

        32) Apoptosis

              "I have slain myself"

              (Antony and Cleopatra)

        33) Cancer

              “By devilish policy art thou grown great”

              (The Second Part of King Henry the Sixth)

XI. Immunity

        34) Antigen Presentation

              “Set it on York gates”

              (The Third Part of King Henry the Sixth)

        35) Autoimmune Disease

              "Myself have to mine own turn'd enemy"

               (Julius Caesar)

XII. Laboratory Methods

        36) Protein Purification

              “Observingly distil it out”

              (The Life of King Henry the Fifth)

        37) Gene Insertion

              “So it stead you, I will write”

              (Two Gentlemen of Verona)

        38) Plasmids

              “That gem, conferred by testament to the sequent issue”

                  (All's Well that Ends Well)