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The
BioFiReaDy project aims at investigating mechanical dysfunction and airway clearance efficiency (or lack thereof) of the respiratory system, by a quantitative analysis of mucus motion. A large part of the project is dedicated to healthy configuration, cystic fibrosis (mucoviscidosis) and epithelium dysfunction consequent to consumption of cilia inhibiting drugs (eg nicotine) or recurrent virus and/or bacteria attack. Nevertheless, a large class of diseases is concerned by alteration of mucus mobility.

Mucus is a visco-elastic fluid secreted by the respiratory epithelium that protects tracheo-bronchial tree mucosa from dehydration and traps inhaled particles (allergens, carcinogens, dust, micro-organisms, and inflammatory debris) that come into contact with it. Ciliary motions that are associated with mucus propulsion in the human respiratory tract cleans airways, as it flows from either the tracheo-bronchial tree or upper airways toward the pharynx, where it is swallowed (or expectorated).

Strong mucus mobility is necessary to provide satisfying airway clearance and healthy behaviour of respiratory system. Otherwise either proliferation of pathogen agents is observed in stagnant mucus, either lack of mucoïd film let pathogens slip through pulmonary membrane. Its motion can be altered by its rheometry, thickness, geometry, epithelium vibration features (cilia motion) or respiration cycle alterations.

The material used for this project is mainly computer simulation of biological 3D flows, followed by clinical validation. The mucus layer itself is in the micrometre scale, while the cilia of epithelium cells is close to nanometre, and air circulation and pulmonary tree goes from millimetre to centimetre. The project will also focus on the efficient coupling of these different scales.

Messages

  • Travaux de synthèse de BioFiReaDy invités à publier un chapitre dans le livre Microscale Transport in Biological Processes (Elsevier), à paraître en 2016.
    Posted Nov 26, 2015, 5:33 AM by Philippe Poncet
  • 7ème réunion BioFiReaDy prévue les 2 et 3 novembre 2015 à Toulouse.
    Posted Nov 26, 2015, 5:30 AM by Philippe Poncet
  • 6ème réunion BioFiReaDy La 6ème réunion BioFiReaDy a eu lieu le 30 avril 2015 à l'INSA Toulouse, afin de définir les axes de recherche futurs du projet, ainsi que les futures sources ...
    Posted May 5, 2015, 7:58 AM by Philippe Poncet
  • Article  de méthodologie numérique publié dans le Journal of Computational physics. Ce travail s'intéresse à la simulation des corps déformables en mouvement dans un fluide très visqueux, utilisant moins de ...
    Posted May 23, 2014, 1:48 AM by Philippe Poncet
  • 5ème réunion BioFiReaDy La 5ème réunion BioFiReaDy aura lieu le mardi 17 juin 2014 à l'INSA. Au programme : valorisation des travaux de prélèvement/rhéologie/simulation non newtonienne, et préparation d'un article ...
    Posted May 23, 2014, 1:43 AM by Philippe Poncet
  • Sondage pour la 4ème réunion BioFiReaDy. Le sondage est disponible ici : http://doodle.com/zkg7dchdmd7pyvfw pour que nous arrivions à trouver une date commune.
    Posted Oct 2, 2013, 3:02 AM by Philippe Poncet
  • La simulation numérique des cellules épithéliales dans un fluide à viscosité variable a été publiée en septembre 2013 dans la revue SIAM Journal of Scientific Computing. Voir la section Publications !
    Posted Oct 2, 2013, 3:01 AM by Philippe Poncet
  • Fanny Dardalhon rejoint le projet Pour la dernière année de BioFiReaDy, Fanny Dardalhon rejoint le projet sur un support post-doctoral. Elle prendra en charge les aspects supercalculateurs, apprentissage machine et plateforme de démonstration.
    Posted Jul 3, 2013, 2:14 AM by Philippe Poncet
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