Neural circuit mechanism of hunting behavior


Animals have innate motivation to get useful resources from environment. For hutning a running prey, they chase, attack, and bite it to kill. We are studying on the neural circuit mechanisms that rapidly orchestrate these hutning actions by using cutting-edge technologies including optogenetics, in vivo brain imaging, the brain-machine, and artificial intelligence (AI).


Selected publications

-Park, S.-G. *, Jeong Y.-C. *, Kim, D.-G. *, Lee, M.-H. Lee, Shin A., Park G., Ryoo, J., Hong, J., Bae, S., Kim, C.-H., Lee, P.-S. *, and Kim, D.* (2018) Medial preoptic circuit induces hunting-like actions to target objects and prey. Nature Neuroscience, in press (IF=16)
-Kim, J., Kim Y., Nakajima, R., Shin, A., Jeong M., Park AH., Jeong, Y., Yang, S., Park, H., Cho, SH., Cho, K., Chung J.H., Paik SB., Auguestine, G., Kim D. (2017). Inhibitory basal ganglia inputs induce excitatory motor signals in the thalamus. Neuron,  http://dx.doi.org/10.1016/j.neuron.2017.08.028 (IF=14)

-Park, A. H.*, Lee, S. H.*, Lee, C., Kim, J., Lee, H. E., Paik, SB., Lee, KJ.*, Kim, D.* (2016). Optogenetic mapping of functional connectivity in freely moving mice via insertable wrapping electrode array beneath the skull. ACS Nano, doi: 10.1021/acsnano.5b07889 (IF=14)

-Kyung, T. *, Lee, S. *, Kim, J. E., Kim, S., Jeong, Y.-M., Kim, D., Woo, D., Park, H., Kim, J., Kim, N. Y., Chae, S., Kim, CH., Han, YM. *, Kim, D. * and Heo, W. D. * (2015) Optogenetic control of endogenous Ca2+ channels in vivo. Nature Biotechnology (IF=41.5)

-Kim, Y., Kim, SH., Kim, KH., Chae, S., Kim, C., Kim, J., Shin, HS., Lee, MS.*, Kim, D.* (2015). Age-dependent gait abnormalities in mice lacking the Rnf170 gene linked to human autosomal-dominant sensory ataxia. Human Molecular Genetics, doi:10.1093/hmg/ddv417

-Hwang, G.-T*., Kim, Y.*, Lee, JH., Oh, SK., Jeong, CK., Park, DY., Ryu, J., Kwon, HS., Lee, SG., Joung, B., Kim, D.* and Lee, KJ.* (2015). Self-powered deep brain stimulation via a flexible PIMNT energy harvester. Energy & Environmental Science, doi: 10.1039/C5EE01593F (IF=20)

-Jo, S.*, Yarishkin, O.*, Hwang, YJ., Chun, YE., Park, M., Woo, DH., Bae, JY., Kim, T., Lee, J., Chun, H., Park, HJ., Lee, D.Y., Hong, J., Kim, HY., Oh, SJ., Park, SJ., Lee, H., Yoon, BE., Kim, Y., Jeong, Y., Shim, I., Bae, YC., Cho, J., Kowall, NW., Ryu, H., Hwang, E., Kim, D.*, Lee, CJ.* (2014). GABA from reactive astrocytes impairs memory in mouse models of Alzheimer’s disease. Nature Medicine, doi:10.1038/nm.3639 (IF=27.3)

-Kim, J., Woo, J., Park, YG., Chae, S., Jo, S., Choi, JW., Jun, H.Y., Yeom, YI., Park, SH., Kim, KH., Shin, HS. and Kim D. (2011). Thalamic T-type Ca2+ channels mediate frontal lobe dysfunctions caused by a hypoxia-like damage in the prefrontal cortex.  Journal of Neuroscience, 31:4063-4073 (IF=6.3)

-Park, Y., Park, H., Lee, C., Choi, S., Jo, S., Choi, H., Kim, Y., Shin, HS., Llinas, R.R., Kim, D. (2010) CaV3.1 is a tremor rhythm pacemaker in the inferior olive. PNAS, 8;107(23):10731-6 (IF=9.6)

-Kim, D., Park, D., Choi, S., Lee, S., Sun, M., Kim, C., Shin, HS. (2003). "Thalamic control of visceral nociception mediated by T-type Ca2+ channels." Science, 302: 117-119. (IF=33.6)

-Kim, D., Song, I., Keum, S., Lee, T., Jeong, MJ., Kim, SS., McEnery, M. W., Shin, HS. (2001). Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca2+ channels.  Neuron, 31(1): 35-45. (IF=15)

-Kim, D., Jun, KS., Lee, S.B., Kang, N.G., Min, DS., Kim, YH., Ryu, SH., Suh, PG., Shin, HS. (1997). Phospholipase C isozymes selectively couple to specific neurotransmitter receptors. Nature, 389: 290-293. (IF=41.4)