How & Why we behave?

We are design to behave all the time.  The goal of our laboratory is to unravel the brain mechanism that coordinates optimal behaviors. Recently, we are focusing on the thalamus that integrates sensory and motor information and relays it to the cortex. In many neurological conditions, from depression to Parkinson’s disease, this thalamic function is abnormally activated or inhibited to induce severe behavioral symptoms. By using pysiological and genetic technologies, we have revealed principles on the thalamus-dependent behavioral control with hoping that our study opens up promising new avenues for alleviating patients the suffering of patients.

How the brain encourage us to explore the world every day? Since 2014, we have continued another research project on the motivation of exploration, supported by The Samsung Science & Technology Foundation. Inspired by that animals show explorative behaviors when they see small objects, we are trying to identify the target neurons involving object exploration and acquisition in mice.

Selected publications
-Kim, J., Kim Y., Nakajima, R., Shin, A., Jeong M., Park AH., Jeong, Y., Yang, S., Park, H., Cho, S-H., Cho, K., Chung JH., Paik S-B., Auguestine, G., Kim D. (2017) Inhibitory basal ganglia inputs induce excitatory motor signals in the thalamus. Neuron,  http://dx.doi.org/10.1016/j.neuron.2017.08.028 (IF=14)

-Park, A. H.*, Lee, S. H.*, Lee, C., Kim, J., Lee, H. E., Paik, S.-B., Lee, K. J.*, Kim, D.* (2016). Optogenetic Mapping of Functional Connectivity in Freely Moving Mice via Insertable Wrapping Electrode Array Beneath the Skull. ACS Nano, doi: 10.1021/acsnano.5b07889 (IF=14)

-Kyung, T. *, Lee, S. *, Kim, J. E., Kim, S., Jeong, Y.-M., Kim, D., Woo, D., Park, H., Kim, J., Kim, N. Y., Chae, S., Kim, C.-H., Han, Y.-M. *, Kim, D. * and Heo, W. D. * (2015) Optogenetic control of endogenous Ca2+ channels in vivo. Nature Biotechnology (IF=41.5)

-Kim, Y., Kim, S. H., Kim, K., H., Chae, S., Kim, C., Kim, J., Shin, H.-S., Lee, M.-S.*, Kim, D.* (2015). Age-dependent gait abnormalities in mice lacking the Rnf170 gene linked to human autosomal-dominant sensory ataxia. Human Molecular Genetics, doi:10.1093/hmg/ddv417

-Hwang, G.-T*., Kim, Y.*, Lee, J.-H., Oh, SK., Jeong, C. K., Park, D. Y., Ryu, J., Kwon, HS., Lee, S.-G., Joung, B., Kim, D.* and Lee, K. J.* (2015). Self-powered deep brain stimulation via a flexible PIMNT energy harvester. Energy & Environmental Science, doi: 10.1039/C5EE01593F (IF=20)

-Jo, S.*, Yarishkin, O.*, Hwang, YJ., Chun, YE., Park, M., Woo, DH., Bae, JY., Kim, T., Lee, J., Chun, H., Park, HJ., Lee, DY., Hong, J., Kim, HY., Oh, S. J., Park, SJ., Lee, H., Yoon, BE., Kim, Y., Jeong, Y., Shim, I., Bae, YC., Cho, J., Kowall, NW., Ryu, H., Hwang, E., Kim, D.*, Lee, CJ.* (2014). GABA from reactive astrocytes impairs memory in mouse models of Alzheimer’s disease. Nature Medicine, doi:10.1038/nm.3639 (IF=27.3)

-Kim, J., Woo, J., Park, YG., Chae, S., Jo, S., Choi, JW., Jun, HY., Yeom, YI., Park, SH., Kim, KH., Shin, HS. and Kim D. (2011). Thalamic T-type Ca2+ channels mediate frontal lobe dysfunctions caused by a hypoxia-like damage in the prefrontal cortex.  Journal of Neuroscience, 31:4063-4073 (IF=6.3)

-Park, Y., Park, H., Lee, C., Choi, S., Jo, S., Choi, H., Kim, Y., Shin, H., Llinas, R.R., Kim, D. (2010) CaV3.1 is a tremor rhythm pacemaker in the inferior olive. PNAS, 8;107(23):10731-6 (IF=9.6)

-Kim, D., Park, D., Choi, S., Lee, S., Sun, M., Kim, C., Shin, HS. (2003). "Thalamic control of visceral nociception mediated by T-type Ca2+ channels." Science, 302(5642): 117-119. (IF=33.6)

-Kim, D., Song, I., Keum, S., Lee, T., Jeong, MJ., Kim, SS., McEnery, M. W., Shin, HS. (2001). Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca2+ channels.  Neuron, 31(1): 35-45. (IF=15)

-Kim, D., Jun, KS., Lee, SB., Kang, NG., Min, DS., Kim, YH., Ryu, SH., Suh, PG., Shin, HS. (1997). Phospholipase C isozymes selectively couple to specific neurotransmitter receptors. Nature, 389(6648): 290-293. (IF=41.4)