Welcome to Kim's Lab

Dec. 14, 2017   
A new paper on "Medial preoptic nuclei induces hunting-like behavior to target objects and prey" by Seguen Park et. al is accepted in Nature Neuroscience

Aug. 31, 2017   
A new paper on "Thalamic mechanism of Parkinson disease" is published in Neuron: http://dx.doi.org/10.1016/j.neuron.2017.08.028

Sep. 20.2017   Shinjeong Lee won 'the Global Ph.D. Scholarship' from the National Research Foundation (NRF)

May. 5. 2017   Dr. Youngsoo Kim won 'Travel award' from the International Beahvioral and Neural Genetics Society (IBANGS)
Mar. 1, 2017   Prof. Daesoo Kim won 'the 2017 Samil Prize of Science' from the Samil Foundation, http://31cf.or.kr/

Feb.27.2017   Yongcheol Jeong won 'the Medytox scholarship' from Medytox Inc.

Oct.20.2016   Anna Shin won 'the Global Ph.D. Scholarship' from the National Research Foundation (NRF)

Jan. 20, 2016,  Prof. Daesoo Kim talked on "A Neural Switch for Being Happy with Less on a Crowded Planet" at  the World Econimic Forum 2016 (DAVOS, swiss)



How the brain seek resources?

Animals continuously search and acquire useful resources for their survival. It has been unknown as to how the brain yields this motivation and orchestrates related behaviors. Researchers at KAIST reveal that a specific group of neurons in the medial preoptic area (MPA) mediates hunting-like behavior to acquire target objects and prey. Photostimulation of these neurons induces chasing, holding, biting, and retrieving target objects and prey. Inhibition of them decreases interest of mice of targets. Using this phenomenon, researchers developed a new technology called by MIDAS (MPA-induced drive assisted steering) and applied it for controlling behavior of mice. The MIDAS mice navigate pathways along the programmed route in a complex maze with avoiding obstacles. This finding and technology will be useful for understanding and modulating of foraging behaviors and related human phenomena and disorders such as object hoarding disorders and shopping addiction (Nature Neuroscience in press).

A new theory of Parkinson’s disease

Thalamic mechanism of Parkinson disease

Parkinson’s disease (PD) is a debilitating movement disorder that affects more than 10 million people worldwide. Although it is known that PD is caused by a lack of the brain neuromodulator dopamine, it is unknown how this disease causes the debilitating motor abnormalities, such as tremor and loss of voluntary movement, that plague PD patients. Research published in the journal Neuron on 30 August, by a research team led by Dr. Daesoo Kim of the Department of Biological Sciences at Korea Advanced Science & Technology (KAIST) has identified a new mechanism that underlies Parkinson disease. 

This discovery may help to alleviate the motor problems suffered by Parkinson patients. The basal ganglia are a brain structure that controls complex movements. During low dopamine states, such as PD, the basal ganglia more strongly inhibit their target neurons. For the past three decades, scientists have assumed that this stronger inhibition caused the motor problems of PD patients. To test this assumption, the researchers used optogenetic technology to directly activate basal ganglia inhibitory output and then examined the response of target neurons in the thalamus, a part of the brain also involved in movement. Surprisingly, the target neurons in the thalamus exhibited a paradoxical increase in activity in response to the inhibition. This rebound excitation produced aberrant muscular rigidity and tremor that is very similar to the symptoms of PD patients. Eliminating this rebound firing caused the motor symptoms to be completed cured in an animal model of PD, proving that the rebound firing causes the motor problems experienced by PD patients. 

Dr. Daesoo Kim said: "This study overturns three decades of consensus on the provenance of Parkinsonian symptoms.” Dr. Jeongjin Kim, the lead researcher on the project, remarked: “The therapeutic implications of this study for treatment of Parkinsonian symptoms are profound. It may soon become possible to remedy movement disorders without using dopamine.” Dr. George Augustine at NTU added “Our findings are a breakthrough, both for understanding how the brain normally controls movement of our body and for understanding how this control goes awry during PD and related dopamine-deficiency disorders. Most importantly, our work opens up promising new avenues for alleviating the suffering of PD patients”. (Neuron, 2017)

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