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Curriculum Vitae

Baskaran Thyagarajan, M. Pharm, Ph.D.,

Associate Professor of Pharmaceutics and Neuroscience

College of Health Sciences, School of Pharmacy, University of Wyoming

1000 East University Avenue, Laramie, WY 82071

Phone: (307) 766 6482; Fax: (307) 766 2953; Email: bthyagar@uwyo.edu

Web: http://www.britebaskilab.com

 

ATTRIBUTES


    Exhibit leadership skills to direct a productive team in drug discovery and development research for pain, obesity, and fatty liver disease therapeutics

    Efficiently manage research laboratory, project administration, basic, applied and social scientists and timeline conscious

    Two decades of experience in ion channel pharmacology of Transient Receptor Potential (TRP) proteins and their implications in physiology and pathology of human diseases

    Creative and independent thinker with a strong capability to lead internal and external collaborations   

    Proficiency in Accreditation Council for Pharmacy Education (ACPE), Institutional curricular assessment, development and improvement as per the ACPE guidelines

    Excellent verbal and written communication skills

 

EDUCATION


Doctorate in Pharmacy (Molecular Pharmacology and Physiology)

University of Graz, Austria

August 1998 to September 2001


Master's in Pharmaceutics - Novel Drug Delivery Systems

Banaras Hindu University Varanasi, India

August 1994 to July 1996

 

Bachelors in Pharmaceutical Sciences

Madras Medical College - Chennai, Tamilnadu, India

October 1989 to March 1994

 

D. Pharm in Pharmaceutical Sciences

Madras College of Pharmacy - Chennai, India

June 1988 to September 1989

 

Diploma in Medical Laboratory Technology in Medical Laboratory Sciences

Christian Institute of Clinical Technology - Chennai, Tamil Nadu, India

July 1987 to July1988

 

PROFESSIONAL EXPERIENCE

Associate Professor of Pharmaceutics and Neuroscience (Tenured)

University of Wyoming, Laramie, WY (Aug 2011 to Present)

­   Lead a research team consisting of a senior scientist, graduate, masters, and Undergraduate students

Secured grant funding (over a million $) for drug discovery and  

    development research - Pain and obesity therapeutics development

Curriculum development and teach Biopharmaceutics and

    Pharmacokinetics, Neuroscience (Synaptic Transmission)       and Adipose

   Biology to doctoral, graduate and Undergraduate students

Mentor and guide researcher associates and students, and publish and

    patent new drug/drug delivery system discoveries s for pain, obesity and

    fatty liver disease therapeutic development

Participate in product and market development initiatives, horizon scanning, identifying

     opportunities, writing proposals, networking, and partnership building for

     SBIR/STTR grant initiative

      Generate, identify and capture intellectual property on innovative technology for biotherapeutic development

       Alternate delegate for United States Pharmacopoeial Convention for the School of Pharmacy


Research Assistant Professor

University of Rochester School of Medicine, Rochester, NY (Oct. 2010 to July 2011)

­   Elucidate the mechanism of regulation of IP3 receptor calcium signaling in rhythmic motor programming

 

Research Associate

Rutgers New Jersey Medical School, Newark, NJ (Aug. 2005 to Sept.2010)

­   Analyze mechanisms of regulation of transient receptor potential (TRP) by inositol phosphates and phosphatases in neuronal and skeletal muscle functions

­   Therapeutic development to counteract the effect of biological toxins on

     neuromuscular functions

 

Group Leader - Safety Pharmacology

Ranbaxy Laboratories Limited, Gurgaon, India /    (Jan. 2004 to Aug.  2005)

­   Established and carried out Good Laboratory Practice (GLP) compliant safety pharmacological assays for screening new chemical entities (NCEs) and HITS for hERG inhibition and prolongation of action potential duration

­   Developed reporter gene assays and intracellular Ca2+ measurement assays for primary screening of NCEs against inflammatory and respiratory disease targets

­   Well versed in GLP protocols, Metabolism and Pharmacokinetic Studies, High throughput Ca2+ assays (FLIPR)

 

Assistant Professor

National Institute of Pharmaceutical Education and ResearchPunjab India (Oct. 2002 Dec. 2003)

­   Streptozotocin-induced diabetic rat model and vascular (thoracic aorta) and non-vascular (vas deferens) smooth muscles

­   Coordinated graduate courses on Ion Channels in Drug Discovery, Fluorescent Probes in Cell Signaling, and Metabolism and Toxicity

 

Postdoctoral Fellow

Johns Hopkins University, Baltimore, MD (Sept. 2001 to Sept. 2002)

­   Delineate mechanisms of redox regulation TRP channel proteins

­   Drosophila genetics & Electroretinogram (EMG)- Intracellular as well as extracellular EMG recordings of wild type, trp, trpl, norpA mutant flies

 

Lecturer of Pharmaceutics

University of Pune, India (Aug 1997 to July 1998)

­   Taught Pharmaceutics, Pharmacokinetics, Pharmaceutical Biotechnology and Medicinal Pharmaceutics to Bachelor of Pharmacy students

­   Performed research on the analysis of peptidomimetics and peptide derivatives on rat models of chemical-induced pain

 

Senior Research Fellow of Council for Scientific and Industrial Research

Dept. of Biotechnology, Central Leather Research Institute, Chennai, India

­   Peptide conjugates of non-steroidal anti-inflammatory agent (arginyl diclofenac) and their effects on arthritic pain in rats

 

Community Retail Pharmacist

Swamy Raaj Medicals, Chennai, India (Jan 1990 – Dec 1993)

­   DIspensing chemist, retail pharmacist, medication filling/refilling, dispense compounded preparations (ointments, creams, gels, lotions, liniments, and solutions)

 

AWARDS AND HONORS

­ Special invitee for Governor Mead’s Technology Summit held in Jackson Hole, WY in

    Sept. 2017.

­ Received Gordon Research Conference Fellowship to attend the 2017 Organellar Channels & Transporters meeting held in Mount Snow, Vermont in July 2017.

­ Received UWYO International Travel Award in April 2017

­ Received the Outstanding Researcher award of the College of Health Sciences,

   UWYO in 2017.

­ Awarded Research Associate status at the University of Medicine and Dentistry of

   New Jersey and supported by a contract grant from the Defense Threat Reduction    

   Agency, Department of Defense to investigate the development of botulinum

   neurotoxin therapeutics (2007 -2010)

­ National Institute of Neurological Disorders and Stroke Travel Award for attending

   conference of Keystone Symposium on The Transient Receptor Potential Ion

   Superfamily held in Breckenridge, Colorado, Sept. 18-23, 2007

­ Federation of American Societies for Experimental Biology travel award for FASEB

   conference held at Snowmass, Colorado, June 2007

­ Received Dept. of Science and Technology, Govt. of India research grant in 2004

­ Received Dept. of Biotechnology, Govt. of India research grant in 2004.

­ Postdoctoral fellowship from Johns Hopkins University, Baltimore, Maryland, USA

­ Austrian Academic Exchange Scholarship for Ph. D research study in Austria (1998-

   2001)

­ Senior Research Fellowship from Council for Scientific and Industrial Research, India

   during 1996-1997

­ Junior Research Fellowship from University Grants Commission, India during M.

   Pharm (1994-1996)

­ Indian Drug Manufacturers’ Associations’ G.P. Nair Award for securing University I

   rank in B. Pharm (1994)

­ Received Brihad Bharathiya Samaj, Gujarath, Merit Scholarship during B. Pharm

  (1989-1994)

 

PRESS RELEASES (Selected representative press releases)

 Antiobesity drug derived from chili peppers shows promise in animal trials. Eureka Alert Science AAS

  (press release from 26th Annual Meeting of the Society for the Study of Ingestive behavior

­ Recognition by the scientific community for an invention – “CAPSAICIN TRIGGERS  

   BROWNING OF WHITE FAT TO COMBAT OBESITY”

­ Baskilab featured on the first-page main article of the Laramie newspaper

   (Boomerang) for research on capsaicin triggering browning of white fat cells to prevent

   obesity

­http://www.laramieboomerang.com/articles/2015/02/24/news/doc54ec117ba0a1b715311959.txt

­ Baskilab presented chili pepper research during the 59th Annual Meeting of the  

   Biophysical Society, where CBS news and science AAAS EUREKA alert captured the

   news

a.     http://www.eurekalert.org/pub_releases/2015-02/bs-wni020415.php 

b.     https://www.yahoo.com/health/the-next-big-diet-ingredient-is-red-hot-110553693452.html

­ News video was up on K2 TV on Feb. 12:

­ https://www.youtube.com/watch?v=8A4XIefnNSA&feature=youtu.be

 

RESEARCH AND SCHOLARSHIP

Current support

1.     2017 - 2019

Role: Project leader for one of the UWYO COBRE pillar projects (Thyagarajan, B)

Status: Ongoing

Source: NIGMS COBRE

Title: Modulation of Pain Signaling Mechanisms by Botulinum Neurotoxin A

            Aggregate amount: $988, 280.00

2.    2019-2020

Role: Sub-award Consortium PI

Status: Awaiting Notice of Award

Source: NIH SBIR Phase 1

Title: Development and Evaluation of a polymer coated proprietary cream formulation of resiniferatoxin nanoparticles for the Treatment of Pain Associated with Diabetic Peripheral Neuropathy

Aggregate amount: $217,232.00


Pending support

1.    2019-2024

Role: PI (Thyagarajan. B)

           Status: Under review

           Source: National Institutes of Health

           Title: Modulation of TRP Channel Functions by Cholesterol

          Aggregate amount: $1,837,595.00

2.    2019-2021

Role: PI (Thyagarajan. B)

            Status: Under review

            Source: National Institutes of Health

           Title: Mechanisms of TRP Channel Protein Functions in Exercise Endurance

           Aggregate amount: $388,667.00

3.    2019-2020

Role: PI (Thyagarajan. B)

            Status: Under review

            Source: College of Health Sciences

Title: Analysis of synergism between exercise and TRPV1 activation in exercise endurance and skeletal muscle functions

Aggregate amount: $7,500.00 

PAST / COMPLETED RESEARCH GRANTS

1.2015 - 2016

Role: PI (Thyagarajan, B)

Status: Competed

Source: American Heart Association 

Title: Analysis of effects of dietary capsaicin on brown fat thermogenesis

Aggregate Amount: $154,000.00

2.2015-2017

Role: Thematic Project PI (Thyagarajan B)

Status: Completed

Source: NIH NIGMS INBRE Thematic Research Project

Title: TRPV1 activation prevents from high fat diet-induced non-alcoholic fatty liver disease Aggregate amount: $216,000.00

3.2015-2017

Role: Collaborative Project PI (Thyagarajan B)

Status: Completed

Source: NIH NIGMS INBRE – UWYO_WCC_Collaborative Grant

Title: Analyses of mechanisms by which TRP protein activation protects from vascular dysfunctions in metabolic syndrome

Aggregate amount: $61, 600.00

4.2015 – 2016

Role: PI (Thyagarajan, B)

Status: Completed

Source: UWYO Faculty Grant in Aid

Title: Analyses of mechanisms by which TRPV1 activation stimulates sirtuin-1 to trigger browning of white adipocytes to counteract obesity

Aggregate amount: $5,000.00

5.2015 – 2016

Role: PI (Thyagarajan, B)

Status: Completed

Source: WY NASA Faculty Research Initiation Grant

Title: Sirtuin-1 Emerges as A Potential Target to Defy Accelerated Aging

Aggregate amount: $10,000.00

6.2013 – 2015

Role: WY PI for the collaborative project (Thyagarajan, B)

Status: Completed

Source: Wyoming INBRE- CSU HPCRL Collaborative Project

Title: TRPV1 regulates brown fat thermogenesis: Novel therapeutic potential for obesity. Aggregate amount: $100,000.00

7.2013 - 2014

Role: PI (Thyagarajan, B)

Status: Completed

Source: Wyoming INBRE Bioinformatics Supplemental Program

Title: TRPV1: A spicy target against obesity.

Aggregate amount: $5,000.00

8.2012 – 2014

Role: PI for the Thematic project (Thyagarajan, B)

Status: Completed

Source: WY INBRE

Title: TRPV1: A spicy treat to counteract metabolic syndrome

Aggregate amount: $100,000.00

9.2013 – 2014

Role: Co-PI for the translational collaborative pilot project (Thyagarajan, B)

Status: Completed

Source: Colorado Clinical and Translational Sciences Institute (CCTSI)

Title: TRPV1 channel: A potential therapeutic target to treat early-life seizures.

Aggregate amount: 30,000.00

10. 2013 – 2014

Role: PI for the New Investigator Award (Thyagarajan, B)

Status: Completed

Source: American Association of Colleges of Pharmacy

Title: Capsaicin antagonizes botulinum neurotoxin A at the motor nerve terminals

Aggregate amount: $10,000.00

11. 2012 – 2013

Role: PI for the Pilot Project (Thyagarajan, B)

Status: Completed

Source: UW Neuroscience Center/NIH P30 Center Core

Title: Lipid microdomains modulate synaptic functions at the neuromuscular junctions

Aggregate amount: $100,000.00

12. 2012 – 2013

Role: PI (Thyagarajan, B)

Status: Completed

Source: University of Wyoming College of Health Sciences Faculty Research Grant

Title: TRPV1: A potential Target against Epilepsy

Aggregate amount: $7500.00

13. Prior to appointment at the University of Wyoming

a.     2002 – 2003

Role: PI (Thyagarajan, B)

Status: Completed

Source: Dept. of Biotechnology, Govt. of India 

Title: Analysis of the role of TRPC channels in hyperglycemia –Research project Funded by    

Aggregate amount: $50,000.00

b.    2002 – 2003

Role: PI (Thyagarajan, B)

Status: Completed

Source: Dept. of Science and Technology, Govt. of India

Title: Modulation of vascular and non-vascular smooth muscle contraction by oxidative stress Aggregate amount: $2,000.00

 

TRAVEL AWARDS

­ 2018

Source: University of Wyoming, College of Health Sciences Travel Award

Amount: $750.00

­ 2017

Source: University of Wyoming International Travel Award

Amount: $2500.00

­ 2016

Source: School of Pharmacy Faculty Mini-Grant 

Purpose: Attend the 60th annual meeting of Biophysical Society in Los Angeles, CA and present research based poster presentation

Amount: $2,115.00

­ 2015

Source: Mountain West Clinical Translational Research - Infrastructure Network

Purpose: Attend the II annual meeting in UNLV, Las Vegas, NV and present research based podium presentation

Amount: $1,500.00

­2015

Source: University of Wyoming College of Health Sciences

Purpose: Attend the ATVB 2015 annual meeting, San Francisco, CA and present a research based podium presentation

Amount: $750.00

­ 2014

Source: American Association of Colleges of Pharmacy (AACP)

Purpose: Attend the annual meeting of AACP, Grapevine, TX and present a research based poster presentation. 

Amount: $1,000.00

­ 2014

Source: Mountain West Clinical Translational Research - Infrastructure Network

Purpose: Attend the I annual meeting in UNLV, Las Vegas, NV and present research based podium presentation

Amount: $1,200.00

­ 2012

Source: Wyoming Geriatric Education Center

Purpose: Attend the Alzheimer’s Workshop on Insight into Alzheimer’s and Other Memory Disorders, Jackson Hole, WY

Amount: $250.00


PUBLICATIONS (PEER-REVIEWED JOURNAL ARTICLES)


1.       (Data based) Baskaran, P, K Covington, J Bennis, A Mohandass, T E Lehmann and B Thyagarajan. Binding Efficacy and Thermogenic Efficiency of Pungent and Nonpungent Analogs of Capsaicin. Molecules 2018, 23 (12), 3199.

2.      (Data based) Krishnan, V, Baskaran, P and B Thyagarajan. Troglitazone activates TRPV1 and causes deacetylation of PPAR gamma in 3T3-L1 cells. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2019, 1865 (2), 445-453

3.      (Data based) Agarwal, S, J Fox, B Thyagarajan and JH Fox. Brain mitochondrial iron accumulates in Huntington's disease, mediates mitochodnrial dysfunction and can be remlved pharmacologically. Free Radic Biol Med 2018 May 20; 120:317-329.

4.       (Data based) Baskaran, P and B Thyagarajan. Measurement of Basal and Forskolin-simulated Lipolysis in Inguinal Adipose Fat Pads. J. Vis. Exp. 2017 Jul 21; 125.

5.       (Data based) Thyagarajan, B and MT Foster. Beiging of white adipose tissue as a therapeutic target for weight loss in humans. Horm. Mol. Biol. Clin. Investig. 2017. Jun 23; 31(2).

6.       (Data based) Thyagarajan, B, JG Potian, JJ McArdle and P Baskaran. Perturbation to Cholesterol at the Neuromuscular Junction confers botulinum neurotoxin A sensitivity to neonatal mice. Toxicol. Sci. 2017 Sep 1; 159 (1):179-188.

7.       (Data based) Social and Administrative Pharmacy Data based) Singh, R, L Staubach, J Frantz and B Thyagarajan.  BAOJ Pharm Sci. 2017, 3:2 3:034.  

8.       (Data based) Baskaran, M, P Baskaran, N Arulsamy and B Thyagarajan. Preparation and Evaluation of PLGA-Coated Capsaicin Magnetic Nanoparticles. Pharm. Res. 2017 Jun; 34(6):1255-1263.

9.       (Data based) Baskaran, P, V Krishnan, K Fettel, P, Gao, Z Ahu, J Ren and B Thyagarajan. TRPV1 activation counters diet-induced obesity through sirtuin-1 activation and PRDM-16 deacetylation in brown adipose tissue. Int. J Obes (Lond). 2017 May 41(5):739-749.

10.     (Data based) Capsaicin induces browning of white adipose tissue to Prevent Obesity. Baskaran, P, V Krishnan, J Ren and B Thyagarajan. Br. J. Pharmacol. 2016 Aug; 173(15):2369-89.

11.     (Review) Baskaran P, Krishnan V and Thyagarajan, B.  Implications of Obesity on Neuromuscular Functions-The Known and Unknown BAOJ Obe Weight Manage 2015, 1:1 1: 003

12.    (Data based) The TRPM8 Protein is a Testosterone Receptor. Part II: Functional Evidence for an Ionotropic Effect of Testosterone on TRPM8. Asuthkar S, Demirkhanyan L, Sun X, Elustondo P, Krishnan V, Baskaran P, Velpula KK, Thyagarajan B, Pavlov E, Zakharian E. J Biol Chem. 2015 Jan 30; 290 (5):2670-88. doi: 10. 1074/jbc.M114.610873.

13.  (Data based) The TRPM8 Protein is a Testosterone Receptor. Part I: Biochemical Evidence for Direct TRPM8-Testosterone Interactions. Asuthkar S, Elustondo PA, Demirkhanyan L, Sun X, Baskaran P, Velpula KK, Thyagarajan B, Pavlov, E, Zakharian E. J Biol Chem. 2015. Jan 30; 290 (5): 2659-69. doi: 10. 1016/jbc.M114.610824.

14. (Data based) Capsaicin modulates acetylcholine release at myoneuroal junction. Thyagarajan, B, JG Potian, P Baskaran and JJ McArdle. Eur. J. Pharmacol. 2014 Dec 5;744:211-9. doi: 10.1016/j.ejphar.2014.09.044. Epub 2014 Oct 23.

15. (Data based) Acute and chronic effects of botulinum neurotoxin A in mammalian neuromuscular junction. Padmamalini Baskaran and Baskaran Thyagarajan. Muscle and Nerve. 2013 Nov 12.

16. (Review) Cotrimoxazole and Neonatal Kernicterus: A Review. Drug Chem Toxicol. Thyagarajan, B and SS Deshpande. 2013 Oct 7.

17.     (Data based) Effects of Enzymatically Inactive Recombinant Botulinum Neurotoxin Type A at the Mouse Neuromuscular Junctions. Baskaran, P, TE Lehmann, E Topchiy, N Thirunavukkarasu, S Deshpande, BR Singh and B Thyagarajan. Toxicon 2013 Jun 25. pii: S0041-0101(13) 00228-6.

18.     (Data based) Acetylcholinesteras downregulation contributes to neuromuscular junction dysfunction in experimental type I diabetic neuropathy. Garcia CC, JG Potian, K Högnason, B Thyagarajan, L. G. Sultatos, VH Routh, and JJ McArdle. Am. J. Physiol. 2012.

19.     (Review) The Inositol 1,4,5-Trisphosphate Receptor in C. elegans. Allman E, B Thyagarajan and KW Nehrke. WIREs Membrane Transport and Signaling. 2012.

20.     (Data based) Recombinant Botulinum Neurotoxin A Heavy Chain-based Delivery Vehicles for Neuronal Cell Targeting. Ho, M, LH Chang, M Pires-Alves, B Thyagarajan, JE Bloom, Z Gu, KK Aberle, SA Teymorian, Y Bannai, JJ McArdle and BA Wilson. Protein Eng Des Sel. 2011 Mar;24(3):247-53

21.     (Data based) The inveterate botulinum neurotoxin A ushers in exoendocytic crypts. Potian JG, Vishwendra Patel, JJ McArdle and B Thyagarajan. The Botulinum J. 2010. 1(4). 418-430.

22.     (Data based) Investigation of “CRATKML” derived peptides against botulinum neurotoxin A poisoning in vivo and in vitro. Potian, JG, B Thyagarajan, K Hognason, F Lebeda, JJ Schmidt and JJ McArdle. The Botulinum J. 2010. 1(4). 407- 417.

23.     (Data based) Effects of hydroxamate metalloendoprotease inhibitors on botulinum neurotoxin A poisoned mouse neuromuscular junctions.  Thyagarajan, B, JG Potian, CC Garcia, K Högnason, K Čapková, ST Moe, AR Jacobson, KD Janda & JJ McArdle. Neuropharmacology. 2010. March 10

24.     (Data based) Capsaicin protects functions of mouse neuromuscular junctions from the paralytic effects of botulinum neurotoxin A. Thyagarajan, B, N Krivitskaya, K Högnason, JG Potian, CC Garcia and JJ McArdle. J. Pharmacol. Exp. Ther. 2009; Nov; 331(2):361-71

25.     (Data based) Mechanisms of potentiation of Angiotensin II-induced contractile response of isolated rat aorta by hydrogen peroxide and tert-butyryl hydroperoxide. Patel, RJ, PD Patel, MM Patel, NJ Patel and B Thyagarajan. Ind. J. Pharmacol. 2009; 41(3): 140-143

26.     (Data based) Inorganic polyphosphate modulates TRPM8 channels. Zakharian, E, B Thyagarajan, RJ French, E Pavlov and T Rohacs. PLoS ONE. 2009;4(4): e5404

27.     (Data based) Phospholipase C mediated regulation of TRPV6 channels: implications in active intestinal Ca2+ transport. Thyagarajan, B, B Benn, S Christakos and T Rohacs. Mol Pharmacol. 2009. 75(3):608-16

28.     (Data based) Phospholipase C mediated modulation of TRPV1 channels. Rohacs, T, B Thyagarajan and V Lukacs. Mol Neurobiol. 2008 Apr-Jun;37(2-3):153-63

29.     (Data based) Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels. Thyagarajan, B, V Lukacs and T Rohacs. J. Biol Chem. 2008. 283(22):14980-7.

30.     (Data based) TRPV1 – Regulation by phosphoinositides. Lukacs, V, Thyagarajan, B, A Balla, T Balla and T Rohacs. The J. Neurosci, June 27, 2007 26 (26): 7070-7080 (First two authors contributed equally)

31.     (Data based) Rapidly inducible changes in phosphatidyl inositol 4,5-bisphosphate levels to study multiple regulatory functions of the lipid in intact living cells. Varnai, P, B Thyagarajan, T Rohacs and T Balla. J Cell Biol. 2006 Nov  6;175(3):377-82

32.     (Review) Intermittent claudication: An overview. Meru, AV, S Mittra, B Thyagarajan and A Chugh. Atherosclerosis 2006 Aug;187(2):221-37

33.     (Data based) Nitric oxide inhibits capacitative Ca2+ entry by suppression of mitochondrial Ca2+ handling. Baskaran, T, R Malli, K Schmidt, WF Graier and K Groschner. Br. J. Pharmacol. 2002. 137(6):821-30

34.     (Data based) Expression of Trp3 determines sensitivity of capacitative Ca2+ entry to nitric oxide and mitochondrial Ca2+ handling. Thyagarajan, B, M Poteser, C Romanin, H Kahr, MX Zhu and K Groschner. J. Biol. Chem. 2001. 276 (51). 48149-48158

35.     (Data based) Coassembly of Trp 1 and Trp 3 proteins generates diacylglycerol- and Ca2+-sensitive cation channels. Lintshinger, B, MB Geldsetzer, T Baskaran, WF Graier, C Romanin, MX Zhu and K Groschner. J. Biol. Chem. 2000 Sep 8; 275 (36). 27799-27805

36.     (Data based) Enhancement of bioavailability of griseofulvin by its complexation with beta-Cyclodextrin. Dhanaraju, MD, KS Kumaran, T Baskaran and MS Moorthy. Drug Dev. Ind. Pharm. 1998.  24(6). 583-587


             My bibliography list

https://www.ncbi.nlm.nih.gov/myncbi/browse/collection

 

PUBLICATIONS (REFEREED BOOK AND MONOGRAPH CHAPTERS)

1. 2018. Baskaran Thyagarajan. Intechopen's Capsaicin and its Human Therapeutic Development: Chapter on Capsaicin and metabolic diseases: A mini-review on preclinical mechanisms and clinical efficacy.

2. 2015. Baskaran Thyagarajan. Springer’s Handbook of Toxinology: Biological Toxins and Bioterrorism. Authored a chapter on Botulinum neurotoxin antidotes (INVITED REVIEW).

3. 2010. Baskaran Thyagarajan and Joseph McArdle Guest Editor of a special issue of The Botulinum Journal that focused on the trafficking and metabolic stability in vivo of botulinum neurotoxins

 

ABSTRACTS PUBLISHED IN SPECIAL ISSUES OF JOURNALS

 

1.     Mechanisms by which Botulinum Neurotoxin A Suppresses Pain. Baskaran Thyagarajan, Louis Premkumar and Padmamalini Baskaran. 2391 PosB407 DOI:https://doi.org/ 10.1016/j.bpj.2017. 11.2656. Vol. 114, ISSUE 3, Suppl. 1, 483A, FEB 02, 2018

2.      Sub-Chronic Oral Safety Analysis of MetabocinTM. Padmamalini Baskaran, Laurel Markert, Liesl Zimmerman, Jane Bennis, Baskaran Thyagarajan. 2392. pos B4 08 DOI:https://doi.org/10.1016/j.bpj.2017.11.2657. Vol. 114 (3) Suppl. 3, 484A FEB 02, 2018

3. Regulation of TRPV1 Expression in Non-Neuronal Tissues by BDNF, Sp1, and Sp4. Padmamalini Baskaran and Baskaran Thyagarajan. 2389 pos B405 DOI:https://doi.org/10.1016/j.bpj.2017. 11. 2654. VOLUME 114, ISSUE 3, SUPPLEMENT 1, 483A, FEBRUARY 02, 2018   

4.      Evidence for the Role of CaMKinase II and Synapsin I in the Restoration of Neurotransmission in Botulinum Neurotoxin A Intoxicated Nerve Terminals. Padmamalini Baskaran, Baskaran Thyagarajan, Biophysical Journal, Vol. 106, Issue 2, p337a. January 28, 2014.

5.      Botulinum neurotoxin A inhibits acetylcholine exocytosis independent of SNAP-25 cleavage. Baskaran, P, JG Potian, JJ McArdle and B Thyagarajan. Toxicon 2012 68 page 100.

6.      Capsaicin: A novel antidote against botulinum neurotoxin A. Thyagarajan, B., S Schreiner Capsaicin: A novel antidote against botulinum neurotoxin A. Thyagarajan, B., S Schreiner and P Baskaran. Toxicon 60 (2) 2012.

7.      Role of Calbindin-D9k as a Facilitator of Calcium Entry via TRPV6. Rohacs T, Dhawan P, Yudin Y, Thyagarajan B, Christakos S. Journal of Bone and Mineral Research 01/2012; 27(Suppl. 1): SA0435.

 

PRESENTATIONS (REFEREED NATIONAL AND INTERNATIONAL ABSTRACTS)

 

1.  (Data based) Heather Townsend, Padmamalini Baskaran, Jun Ren, and Baskaran Thyagarajan. TRPV1 activation enhances exercise endurance, mitochondrial biogenesis and fatty acid oxidation in skeletal muscle. 63rd Annual Meeting of Biophysical Society, Baltimore, MD. March 2-6, 2019.

2.   (Data based) Adithya Mohandass, Hanna Ahuja, Padmamalini Baskaran, Eleonora Zakharian and Baskaran Thyagarajan. Atorvastatin-induced Pain: Evidence for the role of TRPV1-dependent signaling. 63rd Annual Meeting of Biophysical Society, Baltimore, MD. March 2-6, 2019.

3.     (Teaching based) Myran L, Mann A, Onysko M, Nguyen TN, Singh R, Hilaire ML, Thyagarajan B, Oung AB, Zarbock SD, Linn BS, Hornecker JR. Collaborative approaches to enhancing student education. Poster Presentation, American Association of Colleges of Pharmacy; Boston, Massachusetts. July 2018.

4.    (Data based) Heather Townsend, Vivek Krishnan, Enette Larsen-Meyer, Jun Ren, Padmamalini Baskaran, and Baskaran Thyagarajan. Analysis of synergism between exercise and TRPV1 activation to enhance metabolic activity. Society for the Study of Ingestive Behavior, 26th Annual Meeting, Porto, Bonita Spring, July 17 - 21, 2018.

5.    (Data based) Baskaran Thyagarajan, Laurel Markert, Jane Bennis, Liesl Zimmermann, Jonathan Fox and Padmamalini Baskaran. Pharmacological and safety analysis of subchronic oral MetabocinTM feeding in mice. Society for the Study of Ingestive Behavior, 26th Annual Meeting, Porto, Bonita Spring, July 17 - 21, 2018.

6.  (Data based) Padmamalini Baskaran and Baskaran Thyagarajan. Role of BMP8b in TRPV1-mediated thermogenic mechanisms. Society for the Study of Ingestive Behavior, 26th Annual Meeting, Porto, Bonita Spring, July 17 - 21, 2018.

7.   (Data based) Baskaran Thyagarajan, Louis Premkumar and Padmamalini Baskaran. Mechanisms by which Botulinum Neurotoxin A Suppresses Pain. 62nd Annual Meeting of Biophysical Society, San Francisco, CA, Feb 2-7, 2018.

8. (Data based) Padmamalini Baskaran, Laurel Markert, Liesl Zimmerman, Jane Bennis, Baskaran Thyagarajan. Sub-Chronic Oral Safety Analysis of MetabocinTM. 62nd Annual Meeting of Biophysical Society, San Francisco, CA, Feb 2-7, 2018.

9. (Data based) Padmamalini Baskaran and Baskaran Thyagarajan. Regulation of TRPV1 Expression in Non-Neuronal Tissues by BDNF, Sp1, and Sp4. 62nd  Annual Meeting of Biophysical Society, San Francisco, CA, Feb 2-7, 2018.

10. (Data based) Thyagarajan, B and P Baskaran. TRPV1 expression in adipose tissues determines metabolic activity and energy expenditure to counter diet-induced obesity. 61st Annual Meeting of Biophysical Society, New Orleans, LA; Feb 11 – 15, 2017.

11. (Data based) Baskaran, P, ZJ Zhang, B Thyagarajan. TRPV1 activation stimulates brown adipose tissue activation and enhances mitochondrial biogenesis to counter diet-induced obesity. 61st Annual Meeting of Biophysical Society, New Orleans, LA; Feb 11 – 15, 2017.

12. (Data based) Krishnan, V, P Baskaran and B Thyagarajan. Analysis of role of TRPV1 exercise, energy intake and obesity. 61st Annual Meeting of Biophysical Society, New Orleans, LA; Feb 11 – 15, 2017.

13. (Data based) Thyagarajan, B, B. Kimberley, R. H. Eckel and P Baskaran. Transient Receptor Potential Vanilloid subfamily 1 (TRPV1) activation stimulates SiRT-1PPARa interaction and PGC-1a upregulation in the liver and counters NAFLD. Kern Lipid Conference 2017, Vail, CO.

14. (Data based) Thyagarajan, B and P Baskaran. TRPV1 activation restores mitochondrial quality control to counter non-alcoholic fatty liver disease. Gordon Research Conference on Organellar Channels & Transporters meeting held in Mount Snow, Vermont in July 2017.

15.  (Data based; Community College Students and University of WY undergraduate students’ joint presentation) TRPV1 activation counters vascular dysfunctions by increasing PPARs, SiRT-1, PGC-1a and UCP-1 expression in thoracic aorta. Schilling, K, L Markert, K Nazminia, J Bennis, S McAllister, P Baskaran and B Thyagarajan. Undergraduate Research Day, April 29, 2017.

16.  (Data based; Graduate student presentation) Exercise and Dietary Capsaicin – Two Prong Approach to Combat Obesity. Krishnan, V, A Hoover, Y Limon, P Baskaran and B Thyagarajan. College of Health Sciences Annual Research Day April 14, 2017.

17.  (Data based; Graduate student presentation) TRPV1 activation induces mitophagy to prevent non-alcoholic fatty liver disease in high fat diet-induced obese mice. Chakraborty, S, P Baskaran, and B Thyagarajan. College of Health Sciences Annual Research Day April 14, 2017.

18.     (Data based; undergraduate student presentation). Oral Sub-chronic Safety Studies of Capsaicin. Markert, L, L Zimmerman, J Bennis, J Frantz, P Baskaran and B Thyagarajan. College of Health Sciences Annual Research Day April 14, 2017.

19.     (Data based; Graduate student presentation) TRPV1 Protein Expression in Adipose Tissues Determines Metabolic Activity and Energy Expenditure. Krishnan, V, P Baskaran and B Thyagarajan. College of Health Sciences Annual Research Day April 14, 2017.

20.     (Data based) Thyagarajan, B and P Baskaran. TRPV1 expression in adipose tissues determines metabolic activity and energy expenditure to counter diet-induced obesity. 61st Annual Meeting of Biophysical Society, New Orleans, LA; Feb 11 – 15, 2017.

21.     (Data based) Baskaran, P, ZJ Zhang, B Thyagarajan. TRPV1 activation stimulates brown adipose tissue activation and enhances mitochondrial biogenesis to counter diet-induced obesity. 61st Annual Meeting of Biophysical Society, New Orleans, LA; Feb 11 – 15, 2017.

22.     (Data based) Krishnan, V, P Baskaran and B Thyagarajan. Analysis of role of TRPV1 exercise, energy intake and obesity. 61st Annual Meeting of Biophysical Society, New Orleans, LA; Feb 11 – 15, 2017.

23.     (Data based) Thyagarajan, B, V Krishnan, J Ren and P Baskaran. TRPV1 activation triggers browning of white adipose tissue and counters obesity. Society for the Study of Ingestive Behavior, 24th Annual Meeting, Porto, Portugal, July 12-17, 2016.

24.     (Data based) Thyagarajan B, Cook R and Baskaran P. MetabolcinTM increases lipolytic pathways to counter high fat induced non-alcoholic fatty liver disease. ATVB Annual Meeting, Nashville, Tennessee, May 5-7, 2016.

25.     (Data based; Pharm D student author) Lai, B, Lai, MB and Thyagarajan B. Analyses of mechanisms of aspirin resistance by bioinformatics approach. 60th Annual Meeting of Biophysical Society, Los Angeles, CA; Feb 27 – March 02, 2016.

26.     (Data based) Thyagarajan B, Krishnan V, Ren J and Baskaran P. Capsaicin activates TRPV1-CaMKII-AMPK-SiRT-1-dependent mechanism to trigger browning of white adipocytes to antagonize diet-induced obesity. American Heart Association Conference, Orlando, FL, November 2015.

27.     (Data based; Pharm D student author) Lai B, Lai MB and Thyagarajan B. Aspirin-mediated acetylation and protein glycation as a novel hypothesis on the mechanism of action of aspirin resistance. Wyoming INBRE Research Network Retreat, Sept. 10-12, 2015, Grand Teton National Park, WY.

28.     (Data based; Undergraduate student author) Cisneros S, Cook R, Baskaran P and Thyagarajan B. TRPV1emerges as a novel target to prevent hepatic steatosis. Wyoming INBRE Research Network Retreat, Sept. 10-12, 2015, Grand Teton National Park, WY.

29.     (Data based; Graduate student author) Krishnan V, Baskaran P and Thyagarajan B. Exercise prevents diet-induced obesity via mechanisms regulated by transient receptor potential vanilloid 1 protein. Wyoming INBRE Research Network Retreat, Sept. 10-12, 2015, Grand Teton National Park, WY.

30.     (Data based; Undergraduate student author) Favela F, Watkins J, Schiiling K, Williams A, Graham R, Hepp A, Tighe R, Horyza E, McAllister S, Baskaran P and Thyagarajan B. Investigating the role of SiRT-1 in hepatocyte lipoautophagy. Wyoming INBRE Research Network Retreat, Sept. 10-12, 2015, Grand Teton National Park, WY.

31.     (Data based; Undergraduate student author) Favela F, Schiiling K, Williams A, Graham R, Tighe R, Watkins J, Hepp A, McAllister S, Baskaran P and Thyagarajan B. Analysis of effect of TRPV1 activation on triglyceride and cholesterol levels in an obese mouse model. UWYO Undergraduate Research Day. April 30, 2016.

32.     (Data based) Analysis of Mechanisms by which Marine Toxin Modulates TRPV1. Padmamalini Baskaran and Baskaran Thyagarajan. Annual Meeting of the Rocky Mountain Regional Neuroscience Group. Anschutz Medical Campus, UCD, May 15, 2015 (Third best poster award)

33.     (Data based; Undergraduate student author) Investigating the role of SiRT-1 in hepatocyte lipoautophagy. Rebecca Iacovette, Philip Gard, Rachel Graham, Joy Watkins, Jana Favela, Rachel Tighe, Erik Horyza, Kaylan Schilling, Anna Hepp, Steven McAllister and Baskaran Thyagarajan. UWyo Undergraduate Research Day, May 02, 2015.

34.     (Data based; Pharm D student author) TRPV1 Activation Suppresses High Fat Diet-Induced Non-Alcoholic Fatty Liver Disease. Justine Frantz, Yair Limon, Sara Cisneros, Padmamalini Baskaran, Steven McAllister and Baskaran Thyagarajan. UWyo Undergraduate Research Day, May 02, 2015.

35.     (Data based; Undergraduate student author) Haploinsufficiency of Synaptojanin-1 Exacerbates Metabolic Syndrome. Wyatt Fabrizio, Padmamalini Baskaran and Baskaran Thyagarajan. UWyo Undergraduate Research Day, May 02, 2015.

36.     (Data based; High School student author) Preparation and evaluation of capsaicin magnetic nanoparticles for target site-specific pain therapy. Mrudhula Baskaran and Baskaran Thyagarajan. 59th Annual Meeting of Biophysical Society, Baltimore, MD Feb 07-12, 2015.

37.     (Data based) The BRITE side of TRPV1: Novel Role in Browning of white Adipocytes. Padmamalini Baskaran, Vivek Krishnan, Kevin Fettel and Baskaran Thyagarajan. 59th Annual Meeting of Biophysical Society, Baltimore, MD Feb 07-12, 2015.

38.     (Data based) TRPV1 activation modulates acetylcholine release at the myoneural junctions. Baskaran Thyagarajan, Joseph Potian, Joseph McArdle, Padmamalini Baskaran. 59th Annual Meeting of Biophysical Society, Baltimore, MD Feb 07-12, 2015.

39.     (Data based; Graduate student author) Dietary capsaicin and exercise: Analysis of a two-pronged approach to counteract obesity. Vivek Krishnan and Baskaran Thyagarajan. 59th Annual Meeting of Biophysical Society, Baltimore, MD Feb 07-12, 2015.

40.     (Data based) Capsaicin Antagonizes Botulinum Neurotoxin A at the Motor Nerve Terminals. Baskaran Thyagarajan, Charlotte A Nutt and Padmamalini Baskaran. American Association of Colleges of Pharmacy Annual Meeting, July 26-30 2014, Grapevine, TX.

41.     (Teaching based; Pharm D student authors) Drug Interactions: Type Drug-Drug interactions Meloxicam and Cholestyramine. Aitor Andikoetxea, Linzi Barton, Jordan Calmes, Heather Dickson, Holly Green, Timothy Hunzie, Jessica Martin, Choong Sung Park and Baskaran Thyagarajan. College of Health Sciences Research day April 11, 2014.

42.     (Teaching based; Pharm D student authors) Drug Interactions: Type Drug-Drug interactions Phenytoin and Oral contraceptive(s). Kaylyn Bahnson, Austin Baker, Samantha Holmes, Michael Mullin, Lindsey Snyder, Jennifer Voltmer, Abagail Ward and Baskaran Thyagarajan. College of Health Sciences Research day April 11, 2014.

43.     (Teaching based; Pharm D student authors) Drug Interactions: Type Drug-Food Theophylline and Caffeine interaction. Taylor Gardner, Lynlee Gerk, Julia Min, Lauren Pulley, Alec Richard, Taler Steir, Gail Whitecotton and Baskaran Thyagarajan. College of Health Sciences Research day April 11, 2014.

44.     (Teaching based; Pharm D student authors) Drug Interactions: Type Drug-Food Griseofulvin and Fatty/greasy food. Becky Boschee, Jaime Cantu, Kailey McGrail, Christy Mortimer, Kendra Siebigteroth, Brandon Tritle, Chelsea White and Baskaran Thyagarajan. College of Health Sciences Research day April 11, 2014.

45.     (Teaching based; Pharm D student authors) Drug Interactions: Type Drug-Disease interactions Metformin and Renal disease. Luke Aust, Nicolas Cadman, Lyndie Gore, Adrianna Hotchkiss, Marissa McIntyre, Paige Nelson, Jessica Papke, Katrina Roberts and Baskaran Thyagarajan. College of Health Sciences Research day April 11, 2014.

46.     (Teaching based; Pharm D student authors) Drug Interactions: Type Drug-Disease interactions Ca2+ channel blockers and Congestive heart failure. Sean Baker, Keith Bennett, Ross Davidson, Wenyang Donehue, Amber Hull, Jennifer McCarthy, Erica Turechek and Baskaran Thyagarajan. College of Health Sciences Research day April 11, 2014.

47.     (Data based) Dietary Capsaicin Triggers Browning of White Adipocytes: A novel mechanism to antagonize obesity. Padmamalini Baskaran and Baskaran Thyagarajan. College of Health Sciences Research day April 11, 2014.

48.     (Data based) Capsaicin combats obesity by increasing energy homeostasis and locomotor activity. Padmamalini Baskaran, Jun Ren and Baskaran Thyagarajan. College of Health Sciences Research day April 11, 2014.

49.      (Data based; Graduate student author) Analysis of Role of TRPV1 in Kainic Acid Mediated Toxicities: Evidence for a Novel Therapeutic Intervention Against Epilepsy. Bayasgalan Thyagarajan, Padmamalini Baskaran and Baskaran Thyagarajan. College of Health Sciences Research day April 11, 2014.

50.      (Data based; Graduate student author) TRPV1 transcriptionally regulates adipogenesis and obesity. Vivek Krishnan, Padmamalini Baskaran, Kevin Fettel and Baskaran Thyagarajan. College of Health Sciences Research day April 11, 2014.

51.     (Data based) Evidence for the role of CaMKinase II and Synapsin I in the restoration of neurotransmission in botulinum neurotoxin A intoxicated nerve terminals. Baskaran Thyagarajan and Padmamalini Baskaran. Biophysical Society 58th Annual meeting, San Francisco, CA February 2014.

52.     (Data based) New Heat for the Cold Receptor: the TRPM8 channel is an Ionotropic Testosterone Receptor. Swapna Asuthkar, Lusine Demirkhanyan, Xiaohui Sun, Pia Elustondo, Kiran Velpula, Baskaran Thyagarajan, Evgeny Pavlov, Eleonora Zakharian. Biophysical Society 58th Annual meeting, San Francisco, CA February 2014.

53.     (Data based; Graduate student author) Kainic acid activates TRPV1 via PLC-dependent mechanisms. Bayasgalan Surenkhuu, Padmamalini Baskaran and Baskaran Thyagarajan. Biophysical Society 58th Annual meeting, San Francisco, CA February 2014.

54.     (Data based; Graduate student author) TRPV1 is a novel target for Ca2+-mediated toxicities of kainic acid. Surenkhuu B, P Baskaran, and B Thyagarajan. Front Range Neuroscience Group Annual Meeting, Dec. 04, 2013, Fort Collins, CO.

55.     (Data based) Cholesterol depletion differentially regulates heat and cold-activated TRP channels. Baskaran Thyagarajan, BayasgalanSurenkhuu, and Padmamalini Baskaran. Rocky Mountain Regional Neuroscience Group Annual Meeting, Aurora CO, May 16, 2013.

56.     (Data based; Graduate student author) Cholesterol-rich lipid microdomains modulate the activation of TRP channel proteins. Bayasgalan Surenkhuu, Padmamalini Baskaran and Baskaran Thyagarajan. College of Health Sciences, 19th Annual Research Day, April 12, 2013.

57.     (Data based) Toxicity profiles of deactivated recombinant botulinum neurotoxin at the mammalian neuromuscular junction. Baskaran Thyagarajan, Teresa Lehmann, Elena Topchiy, Nagarajan Thirunavukkarasu, Sharad Deshpande, Shuowei Cai, Bal Ram Singh and Padmamalini Baskaran. College of Health Sciences, 19th Annual Research Day, April 12, 2013.

58.     (Data based) Capsaicin – A novel therapeutic drug to counteract obesity. Padmamalini Baskaran, Kormakur Hognason, Jun Ren and Baskaran Thyagarajan. College of Health Sciences, 19th Annual Research Day, April 12, 2013.

59.     (Data based; Undergraduate student author) Botulinum neurotoxin A inhibits pain via TRPV1-Protein kinase C dependent mechanisms. Kenneth Brenneman, Padmamalini Baskaran, and Baskaran Thyagarajan Biophysical Society 57th Annual Meeting, Philadephia, PA Feb 2013.

60.     (Data based) Cholesterol depletion differentially regulates heat and cold-activated TRP channels. Baskaran Thyagarajan, Bayasgalan Surenkhuu, and Padmamalini Baskaran. Biophysical Society 57th Annual Meeting, Philadelphia, PA Feb 2013.

61.     (Data based) Effects of enzymatically inactive recombinant botulinum neurotoxin type A at the mouse neuromuscular junctions. Padmamalini Baskaran, Teresa Lehmann, Elena Topchiy, Nagarajan Thirunavukkarasu, Sharad Deshpande, Shuowei Cai, Bal Ram Singh and Baskaran Thyagarajan. Front Range Neuroscience Group Annual Meeting, Nov. 28, 2012, Fort Collins, CO.

62.     (Data based; Graduate student author) Cholesterol depletion activates TRPV1.Bayasgalan Surenkhuu, Padmamalini Baskaran, Suzanne Clark, Bruce Culver, and Baskaran Thyagarajan. Front Range Neuroscience Group Annual Meeting, Nov. 28, 2012, Fort Collins, CO.

63.     (Data based) Lipid microdomains regulate neuronal endocytic mechanisms during development. Padmamalini Baskaran, Xianshi Tang, Joseph Potian, Joseph McArdle and Baskaran Thyagarajan. Front Range Neuroscience Group Annual Meeting, Nov. 28, 2012, Fort Collins, CO.

64.     (Data based) Phosphoinositide regulation of TRPV1. Lukacs, V, B Thyagarajan and T Rohacs. Biophysical Society 56th Annual Meeting, San Diego, CA Feb 2012.

65.     (Data based) Botulinum neurotoxin A inhibits acetylcholine exocytosis independent of SNAP-25 cleavage. Baskaran P, JG Potian, JJ McArdle and B Thyagarajan. 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (TOXINS 2011), Santa Fe, NM, October 2011

66.     (Data based) Analysis of molecular mechanisms that integrate sensory perception of nutrient with rhythmic motor output. Thyagarajan B and KW Nehrke, 18th International C. elegans Meeting, Los Angeles, CA. June 2011.

67.     (Data based) Complex regulation of TRPV1 by phosphoinositides. Lukacs, V, B Thyagarajan and T Rohacs. Biophysical Society 55th Annual Meeting, Baltimore, MD March 2011

68.     (Data based) Cholesterol depletion sensitizes and enhances the uptake and inhibitory actions of botulinum neurotoxin A during development. Thyagarajan, B, JG Potian, V Patel and JJ McArdle. Society for Neuroscience annual meeting, San Diego, CA, 2010, Nov 13-17

69.     (Data based) Characterization of an experimental model of myasthenia gravis with musk antibodies. Patel, V, JG Potian, B Thyagarajan, J Michaels and JJ McArdle. Society for Neuroscience annual meeting, San Diego, CA, Nov. 2010.

70.     (Data based) Differential sensitivity of fast and slow twitch muscles to botulinum neurotoxin A. Potian, JG, B Thyagarajan and JJ McArdle. 17th Biennial Medical Defense Bioscience Review Hunt Valley, MD May 2010

71.     (Data based) 2,3-butanedione monoxime enhances acetylcholine release from botulinum neurotoxin A poisoned motor nerve terminals. Patel, V, JG Potian, B Thyagarajan, and JJ McArdle. 17th Biennial Medical Defense Bioscience Review Hunt Valley, MD May 2010

72.     (Data based) Capsaicin interacts with clathrin-coated pit dependent mechanisms to protect motor nerve terminals against botulinum neurotoxin A. Thyagarajan, B, JG Potian and JJ McArdle. Experimental Biology 2010, Anaheim Convention Center, Anaheim, CA. April 2010.

73.     (Data based) Complex regulation of TRPV1 by phosphoinositides. Lukacs, V, B. Thyagarajan and T Rohacs. 54th annual meeting of the Biophysical Society, San Francisco, CA, Feb 2009

74.     (Data based) TRPV1 modulates acetylcholine release from motor nerve terminals. Thyagarajan B, JG Potian, V Patel, CC Garcia, and JJ McArdle. 54th annual meeting of the Biophysical Society, San Francisco, CA, Feb 2009.

75.     (Data based) Sensitivity to botulinum neurotoxin A differs for fast and slow twitch muscles. Potian J.G., B Thyagarajan, CC Garcia, K Hognason and JJ McArdle. 46th Interagency Botulism Research Coordinating Committee, October 2009; Alexandria, VA

76.     (Data based) Dysfunction of the peripheral neuromuscular system during experimental diabetic neuropathy. Garcia, CC, JG Potian, B Thyagarajan, N Krivitskaya, VH Routh and JJ McArdle. Abstract at American Diabetes Association, June 2009; New Orleans, LO.

77.     (Data based) Capsaicin protects mouse neuromuscular junctions from the paralytic effects of botulinum neurotoxin A. Thyagarajan, B, N Krivitskaya, K Hognason, JG Potian, and JJ McArdle. Biophysical Journal, Volume 96, Issue 3, Supplement 1, February 2009, Page 268a

78.     (Data based) The role of phospholipase C in the Ca2+-induced inactivation of TRPV6.
Thyagarajan, B, V Lukacs, B Benn, S Christakos and T Rohacs Biophysical Journal, Volume 96, Issue 3, Supplement 1, February 2009, Page 265a

79.     (Data based) Enhancement of neurotransmitter release from botulinum neurotoxin a (BoNT/A) poisoned motor nerve terminals by 2,3-butanedione monoxime (BDM). Högnason, K, B Thyagarajan, JG Potian, and JJ McArdle. 16th Biennial Medical Chemical Defense Bioscience Review, Hunt Valley, MD, June 2008

80.     (Data based) CRATKML peptide derivatives - novel therapeutic tools to treat botulinum neurotoxin A poisoning. Högnason, K, B Thyagarajan, JG Potian, F Lebeda, JJ Schmidt, and JJ McArdle. 16th Biennial Medical Chemical Defense Bioscience Review,  Hunt Valley, MD, June 2008

81.   (Data based) Small molecule zn metallo-endoprotease inhibitors restore neurally-evoked acetylcholine release and mechanical activity to botulinum neurotoxin A  poisoned muscle. McArdle, JJ, B Thyagarajan, CC Garcia, N Krivitskaya, K. Högnason, A R Jacobson, S T Moe, K Capkova and KD Janda. 16th Biennial Medical Chemical Defense Bioscience Review, Hunt Valley, MD, June 2008

82.     (Data based) Cholesterol depletion enhances botulinum neurotoxin A potency at developing mouse neuromuscular junctions. Potian, JG, B Thyagarajan, N Krivitskaya, K Hognason, and JJ McArdle. 16th Biennial Medical Chemical Defense Bioscience Review, Hunt Valley, MD 21031, June 2008

83.     (Data based) Capsaicin protects the mouse neuromuscular junction against the paralytic effects of botulinum neurotoxin A. Thyagarajan, B, N Krivitskaya, JG Potian, K Hognason, N Souayah, and JJ McArdle. 16th Biennial Medical Chemical Defense Bioscience Review 2008 held at Baltimore Marriott Hunt Valley Inn, Hunt Valley, MD 21031 from 01 to 06 of June 2008.

84.     (Data based) The activity of a mutant δ2 ionotropic glutamate receptor is modulated by phosphatidylinositol 4,5- bisphospate (PIP2). Petrou, V. I, B Thyagarajan, T Rohacs, F Selimi, N Heintz and DE Logothetis. Joint meeting of the Biophysical Society 52nd Annual meeting and 16th International Biophysics Congress February 2-6, 2008, Long Beach, California

85.     (Data based) Transient receptor potential channel TRPM8 is associated with polyphosphate and polyhydroxybutyrate. Zakharian, E, B Thyagarajan, E Pavlov, RJ French and T Rohacs. Joint meeting of the Biophysical Society 52nd Annual meeting and 16th International Biophysics Congress February 2-6, 2008, Long Beach, California

86.     (Data based) Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6. Thyagarajan, B, V Lukacs and T Rohacs. Joint meeting of the Biophysical Society 52nd Annual meeting and 16th International Biophysics Congress February 2-6, 2008, Long Beach, California

87.     (Data based) Rapid pip2 depletion inhibits menthol-induced currents through both wild type and mutant TRPM8 channels in Xenopus oocyte expression system. Louise Gil Mast, S, B Thyagarajan, V Lukacs and T Rohacs. FASEB Summer Research Conferences: ION CHANNEL REGULATION June 9 – 14, 2007, Snowmass Colorado

88.     (Data based) Regulation of TRPV1 by phosphatidylinositol 4,5-bisphosphate. Lukacs, V, B Thyagarajan, A Balla, P Varnai, T Balla and T Rohacs. FASEB Summer Research Conferences: ION CHANNEL REGULATION June 9 – 14, 2007, Snowmass Colorado

89.     (Data based) Phosphatidylinositol 4,5-bisphosphate activates TRPV6 channels: a novel mechanism for Ca2+-induced inhibition of TRPV6 currents. Thyagarajan, B*, V Lukacs and T Rohacs. Keystone Symposia on The Transient Receptor Potential Ion Channel Superfamily September 18 - 23, 2007, Beaver Run Resort, Breckenridge, Colorado. *NINDS Scholar.

90.     (Data based) Phosphatidylinositol 4,5-bisphosphate activates TRPV6 channels: a novel mechanism for Ca2+-induced inhibition of TRPV6 currents. Thyagarajan, B, V Lukacs and T Rohacs. FASEB Summer Research Conferences: Ion Channel Regulation June 9 – 14, 2007, Snowmass Colorado

91.   (Data based) Dual regulation of TRPV1 by phosphatidylinositol 4,5-bisphosphate. Lukacs,V, B Thyagarajan, A Balla, P Varnai, T Balla and T Rohacs. Biophys. J. (Annual Meeting Abstracts) 2007: 290a (First two authors contributed equally)

92.   (Data based; Graduate student author) Augmentation of hydrogen peroxide responses in thoracic aorta of streptozotocin induced diabetic rats: role of tyrosine kinases. Patel, RJ and B Thyagarajan. Second Annual World Congress on Insulin Resistance Syndrome” held at Los Angeles, California, U.S.A. November 18-20, 2004

93.   (Data based; Graduate student author) Mechanisms underlying modulation of contractile responses to angiotensin II by reactive oxygen species in rat thoracic aorta. Patel, RJ and B Thyagarajan. International Symposium on Recent Advances in Pharmacology, New Delhi, India in January 2004

94.  (Data based) Enhanced H2O2 responses in thoracic aorta of hyperglycemic rats: evidence of tyrosine kinases as drug targets. Patel, RJ, and B Thyagarajan. Indian Pharmacological Society Conference held at New Delhi, India. December 2003

95.  (Data based) Ca2+ channel function of TRP3 requires targeting to cholesterol-rich membrane domains. Balzer-Geldsetzer, M, B Thyagarajan, I Wakabayashi and K Groschner. Biophys. J. (Annual Meeting Abstracts) 2002: 623d.

96.     (Data based) The c-terminal domain of TRP is an essential determinant of PLC-dependent regulation and subcellular localization. Groschner, K, B Thyagarajan and M Balzer-Geldsetzer. Biophys. J. (Annual Meeting Abstracts) 2002:21d

97.     (Data based) Analysis of the role of subcellular localization of TRP proteins for Ca2+ signaling in HEK293 cells. Balzer-Geldsetzer, M, EM Rath, T  Baskaran and K Groschner. Biophys. J. (Annual Meeting Abstracts) 2001: 205a

98.     (Data based) Differential modulation of capacitative and TRP3-mediated ca2+ entry into HEK293 cells by nitric oxide donors. Thyagarajan, B, C Romanin, MX Zhu and K Groschner. Biophys. J. (Annual Meeting Abstracts) 2001: 202e

99.     (Data based) Expression of Trp3 modulates the capacitative calcium entry into HEK293 cells. Baskaran T, M Balzer-Geldsetzer and K Groschner. Naunyn-Schmiedebergs Archives of Pharmacology Volume: 363 Issue:Pages: R69-R69 2000. 

100.  (Data based) ACE inhibitors – Market survey and performance. Padmamalini, B, Mittal S. and B Thyagarajan. Joint congress of Federation of Asian Pharmaceutical Association and Indian Pharmaceutical Association (1998) - Best poster award

 

INVITED TALKS AND PRESENTATIONS

 

1.              (Data based) Novel target site-specific magnetic particles based drug delivery to suppress noxious pain. Baskaran Thyagarajan. Research Conference, Dept. of Anesthesiology, University of Colorado, Denver. January 15, 2019.

2.             (Data based) Botulinum Neurotoxin A magnetic microspheres for target site-specific pain therapeutics. Baskaran Thyagarajan. Wyoming Sensory Biology Symposium, UW NPS Station, Grand Teton, WY, Aug 31 - Sept 1, 2018

3.             (Data based; Student presentation). MetabocinTM and Exercise: A Two Prong Approach to Combat Diet-induced Obesity. Heather Townsend and Baskaran Thyagarajan. College of Health Sciences Research Seminar (Fall Seminar Series), Sept. 2018.

4.             (Data based) Targeted Drug Delivery in Pain Therapeutics. Baskaran Thyagarajan. College of Health Sciences Research Seminar (Fall Seminar Series), Sept. 2018.

5.             (Data based) Mechanisms of pain inhibition by magnetic particles of botulinum neurotoxin A. Chemistry and Pharmacology of Drug Abuse Conference, Northeastern University, August 2-3, 2018.

6.             (Data based) Target Site-Specific Therapeutics to Treat Noxious Pain. Baskaran Thyagarajan. NISBRE, Washington DC, June 26, 2018

7.             (Data based) A TR(i)P beyond pain and pleasure: TRPV1 browns the WAT and Heats the BAT. Baskaran Thyagarajan. Dept. of Cancer Biology and Pharmacology, the University of Illinois at Peoria, IL. June 15, 2018.

8.             (Data based) Nanotechnology-based strategies for targeting TRPV1 in obesity and pain. Baskaran Thyagarajan Dept. of Pharmacology, Southern Illinois University, Springfield, IL, June 13, 2018.

9.             (Data based; Pharm D student presentation) Novel Strategy to Treat Noxious Pain. Menglan Wang and Baskaran Thyagarajan. College of Health Sciences Annual Research Day. April 2018.

10.          (Data based) Emergence of capsaicin as a novel dietary supplement to combat obesity and metabolic dysfunctions. B Thyagarajan. Invited research talk at the Sunrise Rotary Club, Laramie, WY in Sept. 2017

11.           (Data based) Mechanisms of Browning of White Adipose Tissue – Implications in obesity management. Baskaran, P and B Thyagarajan. Invited research talk at Avinashilingam University, Coimbatore, India in August 2017.

12.          (Data based) TRPV1 sets the heat in fat – A novel strategy to combat metabolic dysfunctions. B Thyagarajan. Invited research talk at SRM University, Chennai, India in August 2017.

13.          (Data based) Novel Strategy to Counter Obesity: A Target, a Drug, and a Delivery System. B Thyagarajan. Invited research talk at Amritanandamayi Vishwa Vidyapeetam, Cochin, India in August 2017.

14.          (Data based) TRPV1 activation orchestrates Sirtuin-1-Dependent Browning of WAT to Counter Diet-Induced Obesity. B Thyagarajan. Invited research talk at the Institute of Science Nirma University, Ahmedabad, India in August 2017.

15.          (Data based) Hot capsaicin puts a chill on obesity. B Thyagarajan. Invited research talk at the Rotary Club of Laramie, WY in June 2017.

16.          (Data based) TRPV1 Puts a Heat in Wat: A BRITE Approach to Counter Obesity. B Thyagarajan. Invited research talk at Endocrinology Research Conference, Anschutz Medical Campus, University of Colorado, Denver, CO in June 2017.

17.          (Data based; Undergraduate student presentation) Liesl Zimmerman. Undergraduate Research Day April 29, 2017.

18.          (Data Based) Baskaran Thyagarajan. WY INBRE Annual meeting 2017. TRPV1 activation prevents high fat diet-induced non-alcoholic fatty liver disease in obesity via SiRT-1-dependent mechanisms. Laramie WY April 27-28, 2017

19.          (Data Based) Baskaran Thyagarajan. WY INBRE Annual meeting 2017. Analyses of Mechanisms by which TRP protein activation protects from vascular dysfunction in metabolic syndrome. Laramie, WY April 27-28, 2017.

20.          Hot and Spicy Treats to Counter Obesity. Rotary Club of Cheyenne, WY. April 18, 2017.

21.          TRPV1 Sparks a BRITE Fire in Fat: A Novel Strategy to Counter Obesity. Baskaran Thyagarajan. Department of Food Science and Human Nutrition, Colorado State University, Ft. Collins. April 13, 2017.

22.          (Data based; invited) Baskaran Thyagarajan and Padmamalini Baskaran. TRPV1: An Emerging Target for Metabolic and Degenerative Diseases. TCG Life Sciences, Kolkata, India. August 19, 2016

23.          (Data based; invited) Baskaran Thyagarajan and Padmamalini Baskaran. Triggering Browning of White: A New Paradigm in Anti-Obesity Therapy. Kongunadu Arts and Science College, Coimbatore, India. August 11, 2016

24.     (Data based; Graduate student presentation) Krishnan V, Baskaran P, Nazminia K, Limon Y and Thyagarajan B. Supplementation of dietary capsaicin with exercise to counteract diet-induced obesity. Abstract accepted for presentation at the CTR-IN III Annual Meeting, June 6-8, 2016, Las Vegas, NV.

25.     (Data based) The Yin and Yang of the Crosstalk between seaweed toxin and vanilloid receptor 1. CHS Research Day, University of Wyoming. April 15, 2016, Laramie, WY.

26.     (Data based; Pharm D student presentation) Fabrizio W, Baskaran P and Thyagarajan B. Analysis of Role of Synaptojanin-1 in Diet-Induced Obesity. UWYO Undergraduate Research April 30, 2016

27.     (Data based; Undergraduate student presentation) Nazminia K, Frantz J, Baskaran P and Thyagarajan B. Sirtuin-1 and Regucalcin Emerge as A Potential Target to Defy Redox Stress-Induced Accelerated Aging. UWYO. Undergraduate Research Day April 30, 2016

28.     (Data based; Undergraduate student presentation) Markert L, Limon Y, Baskaran P and Thyagarajan B. MetabocinTM protects mice from high fat diet-induced hyperlipidemia, hyperglycemia and hypertension by activating TRPV1 protein. UWYO Undergraduate Research Day. April 30, 2016.

29.     (Data based) Baskaran P, Cisneros S, Cook R, McAllister S and Thyagarajan B. N-HMME upregulates lipolytic proteins in the liver to counter NAFLD. 60th Annual Meeting of Biophysical Society, Los Angeles, CA, February 27-March 02, 2016

30.     (Data based) Harnessing the potential of chili peppers to prevent fatty liver: TRPV1 activation couples to SiRT-1 to antagonize diet-induced non-alcoholic fatty liver disease. Mountain West Clinical Translational Research - Infrastructure Network 2nd Annual Meeting, UNLV, Las Vegas, NV, June 08-10, 2015.

31.     (Data based) Capsaicin Activates TRPV1-CaMKII-AMPK-SiRT-1-Dependent Mechanism to Trigger Browning of White Adipocytes to Antagonize Diet-Induced Obesity. Annual Meeting of Atherosclerosis, Thrombosis and Vascular Biology, San Francisco, CA, May 08, 2015.

32.     (Data based) Capsaicin Fuels a Fire in Fat: A Novel Approach to Counteract Obesity. American College of Sports Medicine –Rocky Mountain Chapter Annual Meeting, Denver, CO, March 28, 2015.

33.     (Data based) A toxin in need is non-toxic in deed: Anti-nociceptive potential of botulinum neurotoxin A. Tamil Nadu Veterinary and Animal Sciences University, Madras Veterinary College, Chennai, India, June 30, 2014

34.     (Data based) Heal, Pain and Beyond: “Hot and Spicy” TRPV1 emerges as a novel target against obesity. Mountain West Clinical Translational Research - Infrastructure Network 1st Annual Meeting, UNLV, Las Vegas, NV, June 23-25, 2014.

35.     (Data based) Topical formulations – The upcoming marvels. Peak Ed. Denver, CO, May 21, 2014.

36.     (Data based) Targeting TRP channels: A TR(i)P through heat and cold to treat pain and degenerative diseases, Dept. of Neuroscience, University of Colorado School of Medicine, Denver, CO, March 25, 2014.

37.     (Data based) Novel strategy to counteract obesity. Anschutz Medical Campus, University of Colorado-Denver. January 05 2014.

38.     (Data based) Emerging strategies to counteract botulinum neurotoxin intoxication. Defense Threat Reduction Agency, June 05, 2013.

39.     (Data based) TRP channels, degenerative diseases and beyond. INBRE Retreat Jan 26, 2013 at Fort Collins, CO

40.     (Data based) TRP Channel Protein: Truly Remarkable Proteins in Physiology and Disease. BASKILAB Data Blitz, Front Range Neuroscience Group Annual Meeting, Nov. 28, 2012 Fort Collins. CO

41.     (Data based) Botulinum Neuro Toxin, Tool & Therapy: “Take A Shot to Shoot A Frown”. 6th Annual Botulinum Research Symposium, University of Massachusetts, Dartmouth, MA. August 16-17, 2012

42.     (Data based) Capsaicin: A novel Antidote Against Botulinum Neurotoxin A. 17th International Conference of the International Society on Toxinology and Venom Week 2012, Hawaii, July 2012.

43.     (Data based) Therapeutic effects of capsaicin against botulinum neurotoxin A intoxication. 48th Interagency Botulism Research Coordinating Committee, Santa Fe, NM, October 2011.

44.     (Data based) Multi-Drug Approach for Botulism Therapeutics, Webinar, Advinus Therapeutics Limited, TATA Group, Pune, India, February 2011.

45.     (Data based) “Endocytic pits disassembly hits BoNT/A uptake”: Novel mechanistic insight into BoNT/A prophylaxis. 4th Annual Botulinum Research Symposium, University of Massachusetts, Dartmouth, MA. August 19-20, 2010.

46.     (Data based) TRPV1-Lipid Microdomains - BoNT/A: A cross-talk that modulates neuronal exoendocytosis. National Brain Research Center, Manesar, India. July 2010.

47.     (Data based) TRPV1-Botulinum Neurotoxin A Crosstalk: An Emerging Prophylactic/Therapeutic Intervention. Albany College of Pharmacy, Vermont, VT. May 2010.

48.     (Data based) Botulinum Neurotoxin A Therapeutics: Rationale for a multi-drug approach, 17th Biennial Medical Defense Bioscience review, Hunt Valley, MD, May 2010.

49.     (Data based) Cholesterol depletion sensitizes mouse neuromuscular junctions to the neuroparalytic effects of botulinum neurotoxin A, Interagency for Botulism Research Coordinating Committee 46th Annual meeting, Alexandria, VA, Oct 2009.

50.     (Data based) TRP Traps BoNT: An Emerging Crosstalk, 3rd Annual Botulinum Research Symposium, University of Massachusetts, Dartmouth, MA. August 20-21, 2009.

51.     (Data based) “Hot” chili pepper keeps neuromuscular junction “Cool”: Capsaicin preserves mouse neuromuscular junction functions from the paralytic effects of botulinum neurotoxin A, 2nd Annual Botulinum Research Symposium held at University of Massachusetts, Dartmouth. August 21-22, 2008.

52.     (Data based) TRP-NO-mitochondria – a cross talk, Birla Institute of Technology and Science, Pilani, India in August 2002.

53.     (Data based) TRP channels in cellular calcium signaling, National Institute of Pharmaceutical Education and Research, Mohali, India, in July 2002.


PATENT

1.         Thyagarajan, B and Baskaran, P. Novel Target Site-Specific Pain Therapy with Botulinum Magnetic Aggregates (Provision application no. 62/689.107 submitted on 23rd June 2018)

2.         Thyagarajan, B and Baskaran, P. TRPV1 knock-in method for TRPV1 mice for Adipose Tissue Modulation (UWYO/0012US). Non-provisional submitted in June 2018.

3.         Thyagarajan, B and Baskaran, P. Nanoparticle delivery system for targeted anti-obesity treatment. US patent number 9,320,749 issued on April 26, 2016.

4.         Thyagarajan, B. TRPV1 Knock-In Method and TRPV1 Mice for Adipose Tissue Modulation. US Provisional Patent Serial Number 62/351,131 filed on 06/16/2016.

5.         Baskaran, P and Thyagarajan, B. Capsaicin upregulation of lipolytic proteins for the treatment of nonalcoholic Fatty liver disease. Provisional patent application serial number 62/235,829 filed on October 01, 2015.

6.        Thyagarajan, B and JJ McArdle.  "Methods for Attenuating the Effects of Botulinum Toxin". BaskarUSPTO Application # 20100303932.

 

UNDERGRADUATE AND GRADUATE STUDENT RESEARCH SUPERVISION (SUPERVISOR, COMMITTEE CHAIR/CO-CHAIR/MEMBER

Current

Course

No of advisees

Pharm D students

20

Ph. D. (chair)

1

Undergraduate research students

7

Prepharmacy Research students

2

Ph. D thesis committee (member)

3

Master Thesis committee

1

 

CURRENT (2018-2019) GRADUATE (PH. D), MASTERS (M.S.) AND UNDERGRADUATE STUDENTS CURRENTLY TRAINED IN BASKILAB, MOLECULAR SIGNALING LABORATORY, UNIVERSITY OF WYOMING [UNDERGRADUATE (U), MASTER (M), GRADUATE (G)]

 

Student

Role

Fellowship

Research Project

Current status

1. Adithya Mohandass

(G)

 

Advisor

 

BMS program

Neur5980 – 4 Cr.

Cholesterol regulation of TRP proteins

I Year Graduate Student (ph. D) / BMS Program

2.  Rexiati

Maimaiti

(G)

 

Member, Ph. D Thesis Committee

BMS Graduate Assistantship

CardIac dysfunction

II Year Graduate Student (ph. D) / BMS Program

3. Mingming Sun

(G)

 

Member, Ph. D Thesis Committee

BMS Graduate Assistantship

Cardiometabolic diseases

BMS Ph. D Scholar

4. Courtney Sutton

(G)

Member, Ph. D Thesis Committee

BMS Graduate Assistantship

TRPM8 in reproductive functions

BMS Ph. D Scholar

5. Hanna Ahuja

(U)

Advisor

Wyoming Research Scholar Program

TRPV1 and pain signaling

Undergraduate Research Student

6. Heather Townsend

(U)

Advisor

Wyoming Research Scholar Program

AMPK in exercise endurance

Undergraduate Research Student

7. Kyle Biehl

(U)

Advisor

Research Credit

PHCY4160-1 Cr.

Analyses of thermogenic gene expression in thermoneutrality

Undergraduate Research Student

10. Jane Bennis

(U)

Advisor

Work-study student

 

Animal handling, tissue harvest and project support

Research Student

13. Mark Menghini

(U)

Advisor

Research Credit

PHCY5160-1 Cr.

Food choice and obesity

Research Student

14. Nic Chaves

(U)

Advisor

Research student

PRDM-16 and metabolic dysfunction

Undergraduate Research Student

15. Noah Gustafson

(U)

Advisor

Research student

 

Undergraduate Research Student

 

PAST STUDENTS (RESEARCH TRAINEES IN BASKILAB)

 

1.           Jessica O’Neal. INBRE transition fellow.

2.           Jenni Ebersberger. INBRE transition fellow.

3.           Vivek Krishnan, Neuroscience Graduate Student.

4.           Menglan Wang, Honors research. Pharm D student.

5.           Kara Nazminia, WY NASA fellow and Undergraduate research trainee, Sirtuin-1 in defying aging.

6.           Lara Markret, WY INBRE Undergraduate Research Fellow, Role of TRPV1 activation in vascular dysfunction.

7.           Yair Limon, Undergraduate research fellow

8.       Asa Hover, Undergraduate research student

9.           Liesl Zimmmerman, INBRE Undergraduate Research Fellow (Fall 2016 through Spring 2017)

10.   Samidh Shankar Chakraborty, I year Biomedical Sciences Graduate  Student

11. Kelly Kaliana dos Santos, B Pharm student, Federal University of Ceará, Fortaleza-CE, Brazil, Sumer Research Fellow – Worked on a specific project evaluating the effect of metabolic diseases on mouse mating behavior in the chow and high fat diet-fed wild type, TRPV1-/-, TRPM8-/- mice

12. Wyatt Fabrizio, WY INBRE Transition Fellow

13. Sara Cisneros, WY INBRE Transition Fellow

14. Ross Cook, Undergraduate research trainee

15. Peter Espinola, Work Study Student

16. Amanda Nutt, Second Year Pharm D student. Research Trainee.

17. Kevin Fettel - Work-Study Student. WY INBRE Undergraduate research fellow. Analyses of the effect of Atorvastatin on the restoration of expression and activity of TRPV1 in adipocytes to counteract obesity.

18. Zhen Lu, Ph.D. Student, Neuroscience Program. Molecular mechanisms of Huntington’s Disease (Thesis Committee Member)

19. Justine Frantz, Undergraduate researcher

20. Elena Topchiy, Ph. D., NMR spectroscopy to study small molecules, Ph.D., Department of Molecular Biology, May 2014 (Thesis committee member)

21. Bayasgalan Surenkhuu, Neuroscience Master Graduate Student. Role of transient receptor potential proteins in excitotoxicity. 2014 (Co-chair for M.S.thesis committee.

22. Kenneth Brenneman, Undergraduate research student. Role of TRPM2 in neurodegeneration.

23. Ana Mulinovic, rotation student from Molecular and Cellular Life Sciences program – TRPV1 and ASIC: Modulation by lipid microdomains.

24.        Xianshi Tang, Research Assistant. Role of lipid microdomains in the

regulation of synaptic functions. June 2012-Dec 2012

25.        Shannon Schreiner, Master Graduate Student, Botulinum neurotoxin A

A potential antidote for pain, 2012

26.        Rashwin Patel, Mechanisms of potentiation of Angiotensin II-induced contractile response of isolated rat aorta by hydrogen peroxide and tert-butyryl hydroperoxide, 2003

27.        Kanaiyalal Prajapathy, Redox regulation of vas deferens smooth muscle, 2003

28.        Vikram Sharma, Ph.D student Analysis of role of TRPC3 channel protein expression in diabetes, 2003  (Ph. D Thesis committee member)

29.        Dhanaraj, C-reactive protein – A redox sensor in metabolic diseases, 2004. (Co-Supervisor)

30.        Lead a team of 4 Senior Research Scientists, 2 Research Scientists, 2 Research Associates and 1 Research Technician at Ranbaxy Research laboratory, New Drug Discovery Research, Safety Pharmacology Group, Haryana, India

 

TEACHING

 

Course Number

Course Name

Year

Credit Hours

Number of Students

PHCY 6102

Biopharmaceutics and Pharmacokinetics

2019

4

49

NEUR 5280

Synaptic Transmission (Course coordinator)

2018

3

44

PHCY 6101 (Pharmacy Skills 6160)

Pharmaceutical dosage form design (Laboratory course)

2018

3

47

PHCY 6102

Biopharmaceutics and Pharmacokinetics

2018

4

58

PHCY 6101

Pharmaceutical dosage form design (Laboratory course)

2017

4

58

PHCY 6102

Biopharmaceutics and Pharmacokinetics

2017

4

35

PHCY 6101

Pharmaceutical dosage form design (Laboratory course)

2016

3

35

 

2011 onwards (Variable number of students in some courses)

1.    PHCY 6102-Biopharmaceutics and Pharmacokinetics 4 credits (Spring semester)

2.    PHCY 6101-Pharmaceutical dosage form design (Laboratory course) 3 credits (Fall semester)

3.    PHCY 6550-Advanced Cardiovascular Physiology and Pharmacology 3 Credits. Team taught course (New course) offered in the Spring semester

4.    NEUR 5715-Neuroscience Seminar Course 2 Credits (Spring 2015)

5.    PHCY 4160-Problems in Pharmacy (1 to 3 Credits) in the Spring, Summer, Fall semesters

6.    NEUR 5960-Thesis Research (4 credits) in the Fall and Spring semesters

7.    NEUR 5980-Dissertation Research (1 to 3 credits) in the Summer semester

8.    PHCY 5160-Graduate Problems Course (1 or 2 credits) in the Fall, Spring and Summer semesters

Past:

 

Course

Year

Credit

General Anesthetics

2010

1

Neuromuscular blocking agents

2010

1

Biopharmaceutics and Pharmacokinetics

2010

2

Drug Toxicity

2010

2

Cardiovascular system Physiology

2002

2

Central and Peripheral Nervous System

2002

2

Pharmacological Screening of Drugs

2002

2

Pharmacology I (General Pharmacology)

2003

2

Pharmacology II (CNS, ANS, CVS, Autocoids, Chemotherapeutic agents, Antimicrobials and NSAIDS)

2003

4

Ion channels in drug discovery (Graduate course designed for Ph. D students)

2003

2

Fluorescence probes in cell signaling  (Graduate course designed for M.S. and Ph. D students)

2003

2

Metabolinomics – Metabolism and drug toxicity (Graduate course designed for M.S. and Ph. D students)

2003

4

 

ADVISING

Year

Number of Undergraduate Advisees

Number of Graduate/Resident Advisees

2018

21

1

2017

21

1

2016

21

2

2015

4

11 (10 Pharm. D students)

2014

2

8 (7 Pharm D students)

2013

2

8 (4 Pharm D students)

2012

2

4 (2 Pharm D students)

 

UNIVERSITY SERVICE (LISTING OF COMMITTEE/ADMINISTRATIVE RESPONSIBILITIES)

 

University of Wyoming

1.    Institutional Biosafety Committee, Thyagarajan B, Member

2.    Tenure and Promotion Committee

College of Health Sciences

1.    Research Committee

2.    Diversity and Inclusions Committee (Until Summer 2018)

Division/School of Pharmacy

1.         Safety Committee (Lifetime), Thyagarajan B, Member

2.         Curriculum and Instruction Committee, Thyagarajan B, Member (Until Summer 2018)

3.         School of Pharmacy Tenure and Promotion Committee

4.         School of Pharmacy, Admissions Committee

5.         Chaired the Pharmaceutics Faculty Search Committee in fall 2015 – spring 2016. The search was successful with an offer to be made to shortlisted candidate, but hiring will either be indefinitely delayed or frozen or cancelled due to budget reductions by the University of Wyoming.

 

PROFESSIONAL/COMMUNITY SERVICE

 

·  Community Service Activities

1.         (2016) Organized the visit of the Honorable Governor of WY Mat Mead in Baskilab to share the scientific advancement and projects pursued in Baskilab.

2.         (2015) Hosted a group of high school counselors and described our research goals. This activity significantly enhanced the perceptions on the type and quality of research work conducted in our laboratory in the School of Pharmacy.

3.         (2012 and 2013) Judge for High School Senior Students’ Scientific Projects, Wyoming State Science Fair.

4.         (2010) Congenital Heart Diseases – Eye Opener - An awareness program sponsored by Park Middle School, NJ.

5.         (1992-1994) “Arivoli Iyakkam” (knowledge forum) – Eradication of illiteracy – Program sponsored by the Govt. of India.

6.         (1990-1997) Polio eradication program – Rotary club sponsored activity in villages of southern parts of India.

 

PROFESSIONAL MEMBERSHIPS AND ACTIVITIES (INCLUDING GRANT AND MANUSCRIPT REVIEW)

 

I.              Reviewer for:

1. Journal of Experimental Neurology

2. Journal of Pharmacology and Experimental Therapeutics

3. Journal of Pharmacy and Pharmacology

4. Free Radical Biology and Medicine

5. Indian Journal of Dental Research

6. Frontiers in Neuroscience

7. Journal of Cell Biochemistry and Biophysics

8. PLoS ONE

9. The Botulinum Journal

10. Life Sciences

11. Marine Drugs

12. Journal of Animal Physiology and Animal Nutrition

13. Medicine & Science in Sports & Exercise

14. Canadian Journal of Physiology and Pharmacology

15. Journal of Cell reports

16. Current Drug Targets

17. Scientific Reports

18. British Journal of Pharmacology

19. FASEB Journal

20. Toxins

21. Reviewer for Clinical and Translational Research-Infrastructural Network, research grants

22. Reviewer for grant proposals that are submitted to Institute of Translational Health Sciences (ITHS), University of Washington, USA

23. Reviewer for grant proposals (pre/postdoctoral and transformational project award) for American Heart Association

II. External Examiner for Ph. D thesis

Madras University, India,

Kongunadu Arts and Science College, Coimbatore, India

Tamilnadu Dr. M.G.R. Medical University, India

Ramachandra Medical University, India.

 

Professional memberships (Current)

1.    American Heart Association

2.    Biophysical Society

3.    American Diabetes Association

4.    Association of Pharmaceutical Teachers of India

5.    Society for the Study of Ingestive Behavior

6.    American Association of Colleges of Pharmacy

EEXTRACURRICULAR ACTIVITIE

        Proficiency in

  Star Gazing – Sky exploration

  Singing (Carnatic vocal and light music) and Tabla (Indian Drums)

  Palmistry

  Re-recording, soundtrack mixing and making short films

  Audiovisual aid development

  Photography and video editing

  Baking