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24 April 2017 Cryoablation in the management of Barrett's esophagus. "The concept of cryotherapy is appealing. By preserving the extracellular matrix and inducing anesthetic effects, cryotherapy has the potential to enable deeper ablations with less pain and a lower rate of stricture formation than radiofrequency ablation. To date, however, these potential benefits remain unproved." (Current Opinion in Gastroenterology)

21 April 2017 Outcome for Patients With Pathological Esophageal Acid Exposure After Laparoscopic Fundoplication. "Pathological acid exposure demonstrated by routine postoperative pH-monitoring was not associated with worse symptomatic outcome in terms of reflux control and satisfaction. A possible explanation for this finding is that laparoscopic fundoplication reduces the patients' ability to perceive reflux." (Annals of Surgery)

21 April 2017 Utility of esophageal mucosal impedance as a diagnostic test for esophageal disease. "MI can differentiate esophageal disorders instantly during endoscopy, and can monitor treatment responses in GERD and eosinophilic esophagitis." (Current Opinion in Gastroenterology)

21 April 2017 Lower Esophageal Sphincter Augmentation forGastroesophageal Reflux Disease: The Safety of a Modern Implant. "During a 4-year period in more than 3000 patients, no unanticipated MSAD complications have emerged, ...  MSAD is considered safe for the widespread treatment of GERD." (Journal of laparoendoscopic and advanced surgical techniques)

20 April 2017 A Review of the Novel Application and Potential Adverse Effects of Proton Pump Inhibitors.  "Long-term use of PPIs may lead to potential adverse effects, such as osteoporotic fracture, renal damage, infection (pneumonia and clostridium difficile infection), rhabdomyolysis, nutritional deficiencies (vitamin B12, magnesium and iron), anemia and thrombocytopenia." (Advances in Therapy)

20 April 2017 Endoscopic diagnosis of subsquamous invasion of adenocarcinoma in short-segment Barrett's esophagus "Endoscopic observations of change of coloration, abnormal vessels, and small holes are effective for the diagnosis of subsquamous invasion. Almost all cases with subsquamous invasion could be diagnosed." (Digestive Endoscopy)

20 April 2017 Considering the esophagogastric junction as a 'zone'. "no studies have elucidated the differences between cancer arising from short-segmentBarrett's esophagus and cancer of the gastric cardia. Thus, there is currently no clinical relevance to subdivision of adenocarcinoma in the EGJ zone into above or below the EGJ line." (Digestive Endoscopy)

20 April 2017 Endoscopic gastric mucosal atrophy distinguishes the characteristics of superficial esophagogastric junction adenocarcinoma. "Two distinct types of EGJ cancer were identified, with and without endoscopic gastric mucosal atrophy. These types were associated with different tumor locations." (Digestive Endoscopy)

19 April 2017 Prevalence of Gastroesophageal Reflux in Cats During Anesthesia and Effect of Omeprazole on Gastric pH. "[Omeprazole] as associated with a significant increase in gastric and esophageal pH within 24 hours, but was not associated with a significant increase in serum gastrin concentration." (Journal of Veterinary Internal Medicine)

18 April 2017 Analysis of 2-Week Data from Two Randomized, Controlled Trials Conducted in Subjects with Frequent Heartburn Treated with Esomeprazole 20 mg. "The results of this study demonstrate that once-daily treatment with esomeprazole 20 mg for 2 weeks effectively resolved subjects׳ heartburn compared with placebo, beginning on day 1." (Clinical Therapeutics)

18 April 2017 Squamous Cellular Carcinoma Antigen Serum Determination as a Biomarker of Barrett Esophagus and Esophageal Cancer: A Phase III Study. "Serum SCCA-IgM determination allows the identification of patients at risk for BE/EAC and the stratification of BE patients in subgroups with different cancer risk. " (Journal of Clinical Gastroenterology)

18 April 2017 Quality Indicators in Endoscopic Ablation for Barrett's Esophagus. "The effectiveness of [Endoscopic Eradication Therapy] has been demonstrated in multiple studies and contemporary management includes a combination of endoscopic mucosal resection (EMR) of all visible lesions followed by eradication of the remaining BE using ablative techniques of which radiofrequency ablation (RFA) has the best evidence supporting effectiveness and safety." (Current Treatment OPtions in Gastroenterology)

April 2017 A microbiota-centric view of diseases of the upper gastrointestinal tract. " The composition of gastric microbiota is highly dynamic, and is influenced by acid suppression, gastric inflammation, and Helicobacter pylori. " (Lancet Gastroenterology & Hepatology)

2017 Risk stratification of Barrett's oesophagus using a non-endoscopic sampling method coupled with a biomarker panel: a cohort study. "A combination of biomarker assays from a single Cytosponge sample can be used to determine a group of patients at low risk of progression, for whom endoscopy could be avoided." (Lancet Gastroenterology & Hepatology)

2017 A non-endoscopic device to sample the oesophageal microbiota: a case-control study. "Alterations in microbial communities occur in the lower oesophagus inBarrett's carcinogenesis, which can be detected at the pre-invasive stage of high-grade dysplasia with the novel Cytosponge device. Our findings are potentially applicable to early disease detection, and future test development should focus on longitudinal sampling of the microbiota to monitor for changes in microbial diversity in a larger cohort of patients." (Lancet Gastroenterology & Hepatology)

12 April 2017 AntAcid Therapy and Disease Progression in Patients with Idiopathic Pulmonary Fibrosis Who Received Pirfenidone. "AAT and pirfenidone had outcomes comparable to those of pirfenidone alone in patients with IPF, underscoring the need for prospective trials to elucidate the role of AAT with or without antifibrotic drugs as a treatment for IPF." (Respiration)

11 April 2017 Volumetric laser endomicroscopy in the management ofBarrett's esophagus. "VLE is a new advanced imaging platform for Barrett's esophagus with considerable promise to target Barrett's esophagus-associated neoplasia." (Current Opinion in Gastroenterology)

11 April 2017 Dedicated Barrett's surveillance sessions managed by trained endoscopists improve dysplasia detection rate. "This study demonstrated that a group of trained endoscopists undertaking Barrett's surveillance on dedicated lists had significantly higher [Dysplasia Detection Rate] than a nonspecialist cohort. These findings support the introduction of dedicated Barrett's surveillance lists." (Endoscopy)

11 April 2017 The cost-effectiveness of radiofrequency ablation for Barrett's esophagus with low-grade dysplasia: results from a randomized controlled trial (SURF trial). "Ablation for patients with confirmed BE-LGD is more effective and more expensive than endoscopic surveillance in reducing the risk of progression to high-grade dysplasia/EAC. The increase in costs of ablation can be justified to avoid a serious event such as neoplastic progression." (Gastrointestinal Endoscopy)

7 April 2017 Revised British Society of Gastroenterology recommendation on the diagnosis and management of Barrett's oesophagus with low-grade dysplasia. "Patients with LGD should have a repeat endoscopy in 6 months' time. If LGD is found in any of the follow-up oesophagogastroduodenoscopy and is confirmed by an expert GI pathologist in at least two sets of biopsies, the patient should be offered endoscopic ablation therapy, preferably with RFA, after review by the specialist MDT. If ablation is not undertaken, 6-monthly surveillance is recommended." (Gut)

7 April 2017 Laparoscopic redo fundoplication improves disease-specific and global quality of life following failed laparoscopic or open fundoplication. "laparoscopic redo fundoplication produces a durable improvement in reflux symptoms and disease-specific quality of life. These procedures also improve global quality of life in the short term and are associated with high patient satisfaction" (Surgical Endoscopy)

May 2017 Alginate therapy is effective treatment for GERD symptoms: a systematic review and meta-analysis. " Compared to PPIs or H2RAs, alginates appear less effective .... Alginates are more effective than placebo or antacids for treating GERD symptoms." (Diseases of the Esophagus)

May 2017 The effect of increased chewing strokes on the DeMeester score. "increased chewing strokes lead to a decrease in the number of long refluxepisodes. Though there is a decrease in the DeMeester score and its other individual components, larger randomized controlled studies are required to reach statistical significance." (Diseases of the Esophagus)

April 2017 Factors predicting outcomes of laparoscopic Nissen fundoplication for gastroesophageal reflux disease: experience at a single institution in Korea. "Patients who exhibited a good response to proton pump inhibitor therapy had a significantly greater rate of complete symptom control" (Annals of Surgical Treatment and Research)

5 April 2017 Interim Report of a Prospective Trial on the Clinical Efficiency of a New Full-thickness Endoscopic Plication Device for Patients With GERD: Impact of Changed Suture Material. "28 patients underwent the procedure so far. Mean Gastrointestinal Quality of Life Index scores, DeMeester scores, and general and reflux-specific scores improved (P<0.01). Three of 6 patients, who were treated with converted sutures, experienced postoperative complications" (Surgical Laparoscopy, Endoscopy & Percutaneous Techniques)

4 April 2017 Disease Progression in Barrett's Low-Grade Dysplasia With Radiofrequency Ablation Compared With Surveillance: Systematic Review and Meta-Analysis. "RFA results in a significant reduction risk of disease progression to high-grade dysplasia/EAC among patients with BE with low-grade dysplasia" (American Journal of Gastroenterology)

4 April 2017 The Impact of a Prior Diagnosis of Barrett's Esophagus on Esophageal Adenocarcinoma Survival. "Among 4,978 SEER [Surveillance, Epidemiology & End Results] patients identified with EAC, 577 (12%) had preexisting BE; 4,401 (88%) did not. BE patients had overall lower stage (28.5% stage I vs. 12.8% stage IV) than those without preexisting BE (16.4% stage I vs. 30.6% stage IV). Overall survival was better among patients in the BE group" (American Journal of Gastroenterology)

4 April 2017 Predictors of Progression in Barrett's Esophagus with Low-Grade Dysplasia: Results from a Multicenter Prospective BE Registry. "In this large BE-LGD cohort, progression risk increased substantially when an additional panel of two expert GI pathologists re-confirmed a LGD diagnosis. These BE subjects may be candidates for endoscopic therapy. LGD was a marker of prevalent HGD/EAC in 18% of patients." (American Journal of Gastroenterology)

3 April 2017 Gastroesophageal reflux disease-related symptom recurrence in patients discontinuing proton pump inhibitors for Bravo esophageal wireless pH monitoring study. "Symptom exacerbation following PPI cessation for at least 7 days correlated with acid reflux severity assessed by Bravo testing. Patients off PPIs for 7 days had a higher likelihood of experiencing worsening symptoms, compared with those off PPIs for more than 7 days. These findings suggest that when PPIs are held for 7 days or less prior to Bravo testing, acute worsening of upper GI symptoms due to the abrupt discontinuation of therapy may influence the Bravo results. The etiology of this may be related to rebound acid hypersecretion and needs to be further elucidated in future studies." (Revista de Gastroenterologia de Mexico)

3 April 2017 Delineation of disease phenotypes associated with esophageal adenocarcinoma by MALDI-IMS-MS analysis of serum N-linked glycans.
 "Although applied to a limited number of blind samples, this methodology appears promising as a means of discovering molecules from serum that may have capabilities as markers of disease." (Abstract)

April 2017 Low Risk of High-Grade Dysplasia or Esophageal Adenocarcinoma Among Patients With Barrett's Esophagus Less Than 1 cm (Irregular Z Line) Within 5 Years of Index Endoscopy "In a prospective, multicenter cohort study, we found that patients with irregular Z line do not develop HGD or esophageal cancer within 5 years after index endoscopy." (Gastroenterology)

March 2017 Clinical Spotlight Review: Endoluminal Treatments for Gastroesophageal Reflux Disease (GERD) Society of American Gastrointestinal and Endoscopic Surgeons review statements on TIF and STRETTA procedures.

31 March 2017 Cross-talkamong metabolic parameters, esophageal microbiota, and host geneexpression following chronic exposure to an obesogenic diet "Our data indicates that unhealthy diets can significantly alter the esophageal microbiota, and enrich for bacterial species previously associated with chronic gastrointestinal diseases." (Scientific Reports)


31 March 2017 Ambulatory reflux monitoring for diagnosis of gastro-esophageal reflux disease: Update of the Porto consensus and recommendations from an international consensus group. "The consensus group determined that grade C or D esophagitis, peptic stricture, histology proven Barrett's mucosa >1 cm, and esophageal acid exposure greater >6% are sufficient to define pathological GERD." (Neurogastroenterology and motility)

30 March 2017 Esophageal sensitivity to acid in patients with Barrett's esophagus is not related to preserved esophageal mucosal integrity. "Esophageal hypersensitivity to acid is less pronounced in BE patients than in GERD patients without Barrett. However, mucosal integrity of the squamous epithelium is equally impaired in GERD patients with and without Barrett" (Neurogastroenterology and motility)

28 March 2017 Current Concepts in Treatment of Barrett's Esophagus With and Without Dysplasia. "Patients with BE without dysplasia should undergo endoscopic surveillance every 3-5 years. Endoscopic ablative therapy (RFA) is the preferred treatment modality for dysplastic BE. Patients with T1a adenocarcinoma should be treated with EMR followed by ablative therapy. Low-risk T1b tumors may be suitable for endoscopic resection." (Journal of Intestinal Surgery)

A Systematic Review and Meta-analysis  "Meta-analyses of observational studies suggest that patients who receive gastric acid suppressants may be at increased risk for recurrent CDI. These data should be interpreted with caution because they may be confounded owing to the observational design of the individual studies." (JAMA Internal Medicine)


25 March 2017 "The missing LINX" for gastroesophageal reflux disease: Operative techniques video for the Linx magnetic sphincter augmentation procedure. "Our experience has revealed that the LINX device can be placed safely in patients with normal or significantly altered anatomy but requires adherence to several key principles and technical points" (American Journal of Surgery)

25 March 2017 The Effect of Ineffective Esophageal Motility onGastroesophageal Reflux Disease. "There is no association between IEM and GERD." (Digestion)

24 March 2017 Chronic microaspiration of bile acids induces lung fibrosis through multiple mechanisms in rats. "Our findings suggest that microaspiration of bile acids could promote the development of pulmonary fibrosis in vivo" (Clinical Science)

24 March 2017 Endoscopic mucosal resection versus esophagectomy for intramucosal adenocarcinoma in the setting of barrett's esophagus "EMR was successful in eradicating IMC in 10/11 patients with similar long-term recurrence and mortality to esophagectomy patients. Patients with IMC may benefit from EMR as initial therapy by obviating the need for a complex and morbid operation." (Surgical Endoscopy)

January to March 2017 Helicobacter pylori and Barrett’s esophagus: a protective factor or a real cause? "H. pylori infection could pose a risk for the onset ofgastroesophageal reflux disease (GERD), which could in turn trigger BE, a precancerous lesion, and subsequently cause cancer. By analyzing the current available data, this article tries to verify that H. pylori infection is the underlying cause of esophageal cancer." (Journal of Biological Regulators & Homeostatic Agents)

2017 Characteristics and Outcomes of Laparoscopic Surgery in Patients with Gastroesophageal Reflux and Related Disease: A Single Center Experience. "The characteristics of the patients who underwent LARS at our hospital differed according to pathophysiology and from those in western countries. Satisfactory outcomes depended on the pathophysiology of individual patients." (Journal of Nippon Medical School)

April 2017 Endoscopic mucosal resection for high-grade dysplasia and intramucosal carcinoma: a Canadian experience. "Our experience supports the safety of EMR as a first-line treatment for patients with BE with dysplasia and IMC in early short-term follow-up." (Canadian Journal of Surgery)

23 March 2017 Barrett's Metaplasia Develops from Cellular Reprograming of Esophageal Squamous Epithelium due to Gastroesophageal Reflux. "This study provides evidence that chronic exposure to physiological components of gastric refluxate led to repression of the discernable squamous transcriptional factors and activation of latent columnar transcriptional factors. This reflects the alteration in lineage commitment of the precursor-like bi-phenotypic, NES-B10T cells in response to A+B exposure as the possible origin of BM from the resident NES cells." [NES = Normal Esophageal Squamous, A+B = Acid + Bile, BM = Barrett's Metaplasia] (Americn Journal of Physiology - Gastrointestinal & Liver)

April 2017 Risk of oesophageal adenocarcinoma in individuals with Barrett's oesophagus "This population-based study indicates that OAC is primarily diagnosed during the first months following an initial diagnosis of BO. This could justify a changed surveillance strategy of BO with a repeated thorough endoscopy shortly after initial BO diagnosis to identify prevalent early OAC or HGD." (European journal of Cancer)

April 2017 The Development, Application and Analysis of an Enhanced Recovery Programme for Major Oesophagogastric Resection "Enhanced recovery is feasible and safe after major upper gastrointestinal surgery." (Journal of gastrointestinal Surgery)

March 2017 Novel Calculator to Estimate Overall Survival Benefit from Neoadjuvant Chemoradiation in Patients with Esophageal Adenocarcinoma "A novel OS calculator was developed for esophageal adenocarcinoma that reasonably predicts which patients are expected to derive OS benefit from nCRT. This tool can be helpful in determining OS benefit from nCRT to assist with treatment decision making." (Journal of American College of Surgeons)

21 March 2017 Factors associated with residual gastroesophageal refluxdisease symptoms in patients receiving proton pump inhibitor maintenance therapy. "Approximately half of the GERD patients receiving maintenance PPI therapy had residual symptoms associated with a lower quality of life, and the CYP2C19 genotype appeared to be associated with these residual symptoms." (World Journal of Gastroenterology)

21 March 2017 The dynamics of the oesophageal squamous epithelium 'normalisation' process in patients with gastro-oesophagealreflux disease treated with long-term acid suppression or anti-reflux surgery. "Five years of treatment is generally required before squamous epithelial cell morphology and proliferation are 'normalised' in patients with chronic GERD, despite endoscopic and symptomatic disease control. Control of the acid component of the refluxate seems to play the predominant role in restoring tissue morphology." (Alimentary Pharmacology & Therapeutics)

20 March 2017 Medical Treatment of Gastroesophageal Reflux Disease. " Long-term medical therapy for GERD should be tailored to each patient to provide symptomatic control and maintain esophageal mucosal healing." (World Journal of Surgery)

20 March 2017 Risk of acute myocardial infarction in patients withgastroesophageal reflux disease: A nationwide population-based study. "This large population-based study demonstrates an association betweenGERD and future development of AMI, however, PPIs use only achieved marginal significance in reducing the occurrence of AMI in GERD patients." (PLoS One)

20 March 2017 Diagnosis of gastro-oesophageal reflux disease is enhanced by adding oesophageal histology and excluding epigastric pain. "Histology increases diagnosis of GERD and should be performed when clinical suspicion is high and endoscopy is negative. Excluding patients with epigastric pain enhances sensitivity for the diagnosis of GERD."  (Alimentary Pharmacology & Therapeutics)

20 March 2017 Recent advances in diagnostic testing for gastroesophageal reflux disease . "Recent advances in endoscopic assessment of esophageal epithelial integrity via mucosal impedance measurement is questioning the paradigm of prolonged ambulatory testing for GERD." (Expert Review of Gastroenterology & Hepatology)                                    

18 March 2017 HLA-DR expression in tumor epithelium is an independent prognostic indicator in esophageal adenocarcinoma patients. "In summary, we show that high HLA-DR expression in the EAC tumor epithelium is an independent favorable prognostic indicator of prolonged patient survival, and screening for HLA-DR may be a useful addition to the growing number of prognostic immune-based tests." (Cancer Immunology, Immunotherapy)

16 March 2017 Computer-aided detection of early Barrett's neoplasia using volumetric laser endomicroscopy  ."This study suggests that an automatic detection algorithm has the potential to assist endoscopists to detect early neoplasia on VLE" (Gastrointestinal Endoscopy)

16 March 2017 Feasibility of liquid nitrogen cryotherapy after failed radiofrequency ablation for Barrett's esophagus. "Cryospray ablation is feasible and safe for achieving CE-D and CE-IM after RFA failure. The CE-D rates are high with cryotherapy in this population." (Digestive Endoscopy)

16 March 2017 Deprescribing versus continuation of chronic proton pump inhibitor use in adults. "We found that deprescribing methods led to worse symptoms control while considerably reducing pill use. Deprescribing PPIs may lead to side effects such as inflammation of the esophagus. Very few data were available to make a conclusion regarding long-term benefits and harms of PPI reduction or discontinuation." (Cochrane)

15 March 2017 Determinants of reflux-induced chronic cough. "The presence of a larger volume of refluxate and oesophageal exposure to reflux for a longer period of time seems to play an important role in inducing cough, while the acidity of the refluxate seems to be less relevant. This helps explain the observation that most patients with chronic cough tend not to benefit from acid inhibitory treatment." (Gut)

April 2017 Meta-analysis of biomarkers predicting risk of malignant progression in Barrett's oesophagus.  "Loss and mutation of p53, and raised level of Ki-67 predicted malignant progression in Barrett's oesophagus." (British Journal of Surgery)

15 March 2017 Treating GERD May Reduce Nasal Symptoms "This study "provides the strongest evidence to date for a causative role for LPR in nasal obstruction symptoms and thus provides novel insights for the clinical investigation and potential treatment of patients presenting with nasal obstruction,"" (JAMA)

15 March 2017 Efficacy of Psychotropic Drugs in Functional Dyspepsia "Psychotropic drugs may be an effective treatment for FD, but the effect appears to be limited to antipsychotics and tricyclic antidepressants with fewer trials for other agents" (Gut)

14 March 2017 Endoscopic Fundoplication: Effectiveness for Controlling Symptoms of Gastroesophageal Reflux Disease. "At a mean follow-up of 24 months, TIF is effective. Although symptoms and satisfaction improved significantly, many patients continued to take PPIs." (Innovations - Philadelphia)

10 March 2017 Gastro-Oesophageal Reflux Disease - How to Manage if PPI are not Sufficiently Effective, not Tolerated, or not Wished? "The standard treatment for GERD with PPI is less effective than thought: At least 30% of patients have persistent symptoms and lesions (treatment gap). With persistent symptoms or request an alternative treatment, a stratified diagnosis is required. Alginates and new surgical procedures expand the therapeutic options." (German Medical Weekly Review)

April 2017 Endoscopic Management of Early Esophagogastric Cancer. "Endoscopic management techniques, such as endoscopic mucosal resection and endoscopic submucosal dissection, have consistently demonstrated excellent outcomes in the management of these lesions. These techniques are associated with a lower risk of morbidity and mortality when compared with traditional surgical management." (Surgical Oncology Clinics of N. Ameica)

April 2017 Screening and Preventive Strategies in Esophagogastric Cancer. "For esophageal adenocarcinoma, work is needed to develop efficient and effective techniques in mass screening programs. For most Western populations, current screening is not cost effective." (Surgical Oncology Clinics of N. Ameica)

8 March 2017 Endoscopic Treatment of High-Grade Dysplasia and Early Esophageal Cancer. "Patients with BE and HGD should undergo endoscopic ablative therapy. Patients with T1a adenocarcinoma should be treated with EMR and subsequent ablation of the entire BE segment. Low-risk T1b tumors may be suitable for endoscopic resection." (World Journal of Surgery)

7 March 2017 Risk factors associated with gastroesophageal reflux disease relapse in primary care patients successfully treated with a proton pump inhibitor. "The relapse rate after short-term treatment with omeprazole was high. The consumption of citrus fruits and NSAIDs increased the possibility of GERD relapse." (Revista de Gastroenterologia de Mexico)

7 March 2017 Complexity and diversity of GERD phenotypes. "patients with GERD can be clinically subdivided into two distinct syndromes: patients with esophageal and extraesophageal symptoms. The diagnosis of NERD should be supported by the evidence that symptoms are due to reflux episodes" (

Minerva Gastroenterologica e Dietologica)

6 March 2017 A Multicenter Study of a Fluorescence In Situ Hybridization Probe Set for Diagnosing High-Grade Dysplasia and Adenocarcinoma in Barrett's Esophagus. "This study demonstrates that using FISH to determine the percentage of cells with polysomy can accurately and objectively aid in the diagnosis of HGD/EA in BE specimens." (Digestive Diseases & Sciences)

3 March 2017 Abdominal Compression by Waist Belt Aggravates Gastroesophageal Reflux, primarily by Impairing Esophageal Clearance. "The most marked effect of the belt was impaired esophageal clearance of refluxed acid (median values of 23.0 seconds without belt vs 81.1 seconds with belt) (P=.008). The pattern of impaired clearance was that of rapid re-reflux after peristaltic clearance." (Gastroenterology)

3 March 2017 Extra-esophageal presentation of GERD: new understanding in a new era. "Associations of gastroesophageal reflux disease (GERD) with extraesophageal manifestations, such as chronic cough, asthma, and laryngitis, are reported frequently, and there is a strong evidence of biological plausibility in support of this relationship." (Minerva Gastroenetrologica e dietologica)

3 March 2017 Gastroesophageal Reflux and Idiopathic Pulmonary Fibrosis. "A phase II NIH study is currently in progress in the USA to determine the role of antireflux surgery in patients with GERD and IPF. The hope is that this simple operations might alter the natural history of IPF, avoiding progression and the need for lung transplantation." (World Journal of Surgery)

3 March 2017 Pathophysiology of Gastroesophageal Reflux Disease. "occurs most commonly due to the presence of a hiatal hernia, esophageal dysmotility, a rise in abdominal pressure (obesity), and decrease in thoracic pressure (chronic lung diseases)."  (World Journal of Surgery)

3 March 2017 Does Nissen Fundoplication Provide Lifelong Reflux Control? Symptomatic Outcome After 31-33 Years. "Patients in the present study used PPIs less frequently than what has been reported in previous long-term follow-up studies. Our results indicate that successful surgery may provide lifelong relief of GERD symptoms and normalize the health-related quality of life in GERD patients."  (World Journal of Surgery)

3 March 2017 From Heartburn to Barrett's Esophagus, and Beyond. "Patients with BE without dysplasia require endoscopic surveillance, while those with low- or high-grade dysplasia should have consideration of endoscopic eradication therapy followed by surveillance." (World Journal of Surgery)

3 March 2017 Surgical Treatment of High-Grade Dysplasia and Early Esophageal Cancer. "We recommend that esophageal tumors that have invaded into the submucosa (T1b) or beyond should be treated with an esophagectomy" (World Journal of Surgery)

March 2017 The Risks and Benefits of Long-term Use of Proton Pump Inhibitors: Expert Review and Best Practice Advice From the American Gastroenterological Association. "Best Practice Advice 3: Patients with Barrett's esophagus and symptomatic GERD should take a long-term PPI. Best Practice Advice 4: Asymptomatic patients with Barrett's esophagus should consider a long-term PPI." (Gastrenterology)

March 2017 Acceptability of the Cytosponge procedure for detecting Barrett's oesophagus: a qualitative study. "data suggest the Cytosponge was acceptable to the majority of participants with risk factors for BE, and could be used as a first-line test to investigate GERD symptoms" (BMJ Open)

2 March 2017 Diet and Gastroesophageal Reflux Disease: Role in Pathogenesis and Management   "Although anecdotal evidence has suggested associations with certain foods (fats, nonvegetarian, fried foods, and beverages) with reflux symptoms, objective evidence based data in this field remain unclear. Recent evidence points to the increasing importance of lifestyle in disease development as well." (Current Opinion in Gastroenterology)

1 March 2017 PPI-refractory GERD: current diagnosis and management. "Currently, laparoscopic fundoplication in experienced hands represents a treatment modality of documented efficacy in patients with PPI-refractory GERD." (Minerva Gastroenetrologica e dietologica)

1 March 2017 Comparison of laparoscopic Nissen and Toupet fundoplication using a propensity score matching analysis. "Although there was no marked difference in the recurrence rate between the two procedures, postoperative dysphagia was observed at a higher frequency with the Nissen method than the Toupet method." (Surgery Today)

28 February 2017 TGR5 expression in benign, preneoplastic and neoplastic lesions of Barrett's esophagus: Case series and findings. "TGR5 might be a potential marker for the progression from BE to high-grade dysplasia and EA" (World Journal Gastroenterology)

28 February 2017 Intestinal Metaplasia of the Esophagus in Children with Esophageal Atresia. "IM occurs in EA-TEF patients, some as young as 2 years. Therefore, early endoscopic surveillance should be considered in this GER-prone population." (Journal of Pediatric Gastroenterology & Nutrition)

28 February 2017 The Annual Risk of Esophageal Adenocarcinoma Does Not Decrease Over Time in Patients With Barrett's Esophagus. "Persistence of non-neoplastic BE on multiple consecutive endoscopies was not associated with lower EAC risk. These findings argue against discontinuation of endoscopic surveillance in patients with persistent nondysplastic BE after multiple negative endoscopies." (American Journal of Gastroenterology)

27 February 2017 Advances in the Diagnosis and Treatment of Barrett's Esophagus and Early Esophageal Cancer; Summary  "Patients with BE have a 30- to 40-fold increased risk of EAC. In the past 20 years, there have been dramatic advances in our understanding of the incidence and natural history of BE. Endoscopic treatment of BE is evolving. Even early EAC has been treated without esophagectomy and good oncologic results in the modern era." (Journal of Gastrointestinal Surgery)

27 February 2017 Sex steroid hormones in relation to Barrett's esophagus: an analysis of the FINBAR Study. "This study found evidence for associations between circulating sex steroid hormones and Barrett's esophagus in younger men and men with higher waist-to-hip ratios. Further studies are necessary to elucidate whether sex steroid hormones are consistently associated with esophageal adenocarcinogenesis." (Andrology)

24 February 2017 Successful treatment of proton pump inhibitor induced sporadic fundic gland polyps with an argon plasma coagulator in a patient with polycythaemia vera. "Non-respondent FGPs after discontinuation of PPI use may be successfully treated using APC" (International Journal of Surgical case reports)

24 February 2017 Electrical Stimulation of Lower Esophageal Sphincter Quells Refractory GERD "After one year of electrical stimulation therapy (EST), more than 81% of patients were completely off proton pump inhibitors, according to the study." (General Surgery News)

February 2017 Promising Technologies Arise for Diagnosis of Barrett’s Esophagus "Recent and prospective advancements in diagnosing cancer in Barrett’s esophagus may allow for earlier and better detection. But as with most newer technologies, some of these alternatives — ranging from computer analysis to surveillance endoscopy to saliva — have their critics as well." (Gastroenterology)

23 February 2017 Systematic review and meta-analysis of controlled and prospective cohort efficacy studies of endoscopic radiofrequency for treatment of gastroesophageal reflux disease. "The Stretta procedure significantly improves subjective and objective clinical endpoints, except LES basal pressure, and therefore should be considered as a viable alternative in managing GERD." (Surgical Endoscopy)

23 February 2017 Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: a meta-analysis. "The prevalence of gastro-oesophageal reflux symptoms varied strikingly among countries, even when similar definitions were used to define their presence. Prevalence was significantly higher in subjects ≥50 years, smokers, NSAID users and obese individuals, although these associations were modest." (Gut)

23 February 2017 Cost-Effectiveness of Screening Patients with Gastroesophageal Reflux Disease for Barrett's Esophagus With a Minimally Invasive Cell Sampling Device. "In a comparative modeling analysis of screening strategies for BE in patients with GERD, we found cytosponge screening with endoscopic confirmation to be a cost-effective strategy. The greatest benefit was achieved by endoscopic screening, but with an unfavorable cost margin." (Clinical Gastroentorology & Hepatology)

23 February 2017 The Safety of Appropriate Use of Over-the-Counter Proton Pump Inhibitors: An Evidence-Based Review and Delphi Consensus   " based on the available empirical evidence and clinical experience accumulated over nearly 30 years with prescription and OTC PPIs, the panel considers that OTC PPIs are generally safe and effective when used according to the label instructions" (Drugs)


23 February 2017 New Advances in Immediate Release PPI Therapy "delayed-release PPIs are all acid labile, and therefore we have had to develop these complicated enteric coatings to protect them from acid degradation in the stomach" (Medscape sponsored by makers of Zegerid)

22 February 2017 Long-term kidney outcomes among users of proton pump inhibitors without intervening acute kidney injury "Overall, new users of PPIs and H2 blockers had comparable demographic characteristics, but PPI users were more likely to have diabetes, chronic lung disease, hyperlipidemia, and cardiovascular disease" (Kidney International)

22 February 2017 p53 protein accumulation predicts malignant progression in Barrett'smetaplasia: a prospective study of 275 patients. "We conclude that p53 protein accumulation, detected by IHC in aggregates of cells, is a significant predictor of malignant progression in patients with BM " (Histopathology)

21 February 2017 Outcomes after liquid nitrogen spray cryotherapy in Barrett's esophagus-associated high-grade dysplasia and intramucosal adenocarcinoma: 5-year follow-up. "In patients with BE-HGD/IMC, LNSCT is effective in eliminating dysplasia and intestinal metaplasia. Progression to adenocarcinoma was uncommon, and recurrence of dysplasia was successfully treated in most cases. Long-term surveillance is necessary to detect late recurrence of dysplasia." (Gastrointestinal Endoscopy)

21 February 2017 Fewer acute respiratory infection [ARI] episodes among patients receiving treatment for gastroesophageal reflux disease. "The study suggests that GERD treatment with PPIs may help reduce healthcare visits for ARIs" (PLoS one)

21 February 2017 When is proton pump inhibitor use appropriate? "while PPIs are highly efficacious in erosive acid-peptic disorders, efficacy is not equaled in other conditions." (BMC Medicine)

February 2017 Risk of oesophageal adenocarcinoma in individuals with Barrett's oesophagus. "This population-based study indicates that OAC is primarily diagnosed during the first months following an initial diagnosis of BO. This could justify a changed surveillance strategy of BO with a repeated thorough endoscopy shortly after initial BO diagnosis to identify prevalent early OAC or HGD." (European Journal of Cancer)

19 February 2017 The risk of oesophageal adenocarcinoma in a prospectively recruited Barrett's oesophagus cohort.  "Patients with BO had a modest increase in all-cause mortality and a large increase in OAC mortality, particularly if fit for surveillance. Low-grade dysplasia and the length of the BO segment were associated with developing OAC." (United european Gastroenterology Journal)

19 February 2017 Acid reflux and coughing: What's the connection? "A cough associated with other symptoms of acid reflux or LPR should also be seen by a doctor." (Medical News Today)

17 February 2017 Epidemiology and natural history of gastro-esophageal reflux disease. "[Data from medical literature] seem to suggest that both NERD and mild esophagitis tend to remain as such over time and the progression from NERD to ERD, from mild to severe ERD and from ERD to Barrett's esophagus may occur only in a small number of cases, ranging from 0% to 30%, 10%-22% and 1%-13%, respectively." (Minerva Gastroenterologica e Dietologica)

16 February 2017 Past, present and future of Barrett's oesophagus. "endoscopic advances have transformed the management of Barrett's oesophagus from a primarily surgical disease into an endoscopically managed condition" (European Journal of Surgical Endoscopy)

14 February 2017 Body weight trajectories and risk of oesophageal and gastric cardia adenocarcinomas  "Being overweight in early adulthood and weight gain later in life were each associated with increased risks of EA and GCA. This underscores the potential of weight control programs for reducing EA and GCA risk." (BJC)

14 February 2017 Recurrence of Barrett's Esophagus is Rare Following Endoscopic Eradication Therapy Coupled With Effective Reflux Control. "The current study highlights the importance of reflux control in patients with BE undergoing EET. In this setting, EET has long-term durability with low recurrence rates providing early evidence for extending endoscopic surveillance intervals after EET." (American Journal of Gastroenterology)

March 2017 Candidate serum metabolite biomarkers for differentiating gastroesophageal reflux disease, Barrett's esophagus, and high-grade dysplasia/esophageal adenocarcinoma.  "Serum metabolite differences can be detected between individuals with GERD versus BE, and between those with BE versus HGD/EA, and may help differentiate patients at different stages of progression to EA." (Metabolomics)

13 February 2017 A Double-blind, Randomized, Multicenter Clinical Trial Investigating the Efficacy and Safety of Esomeprazole Single Therapy Versus Mosapride and Esomeprazole Combined Therapy in Patients with EsophagealReflux Disease. "The combination proton pump inhibitor with mosapride showed a tendency for upper abdominal pain, belching, and total GERD symptoms scores to improve more rapidly. This suggests that combination therapy with esomeprazole and mosapride will be useful for rapid improvement of specific GERD symptoms such as upper abdominal pain and belching in ERD patients." (Journal of Neurogastroenterology & Motility)

11 February 2017 Efficacy of Vonoprazan for Proton Pump Inhibitor-Resistant RefluxEsophagitis. "VPZ was effective for most patients with PPI-resistant RE." (Digestion)

11 February 2017 Lack of Incremental Effect of Histamine Receptor Antagonists over Proton Pump Inhibitors on the Risk of Neoplastic Progression in Patients with Barrett's Esophagus: A Cohort Study. "H2RA do not seem to have any chemopreventive role in patients with BE." (Journal of Digestive Diseases)

10 February 2017 Risk of malignant progression in Barrett's esophagus indefinite for dysplasia. "Risk of progression to advanced neoplasia after the first year following IND diagnosis is lower than previously thought and similar to other recent studies. Longer BE segment and smoking history may help predict which IND patients are more likely to progress to HGD/EAC and therefore identify patients who may warrant closer monitoring." (Diseases of the Esophagus)

8 February 2017 [Surgical and interventional procedures for reflux therapy : Endoscopic or laparoscopic?]  "Endoscopic techniques are becoming established more and more between pharmaceutical and surgical therapy instead of replacing them." (Der Chirurg)

7 February 2017 Bile salt receptor TGR5 is highly expressed in esophageal adenocarcinoma and precancerous lesions with significantly worse overall survival and gender differences. "Our findings indicated that TGR5 may play an important role in the development and prognosis of EAC through a bile acid ligand. Gender differences in TGR5 and VDR expression may explain why males have a higher incidence of EAC compared to females." (Clinical & Experimental Gastroenterology)

February 2017 Discordance Among Pathologists in the United States and Europe in Diagnosis of Low-Grade Dysplasia for Patients With Barrett's Esophagus "In an analysis of criteria used in histopathologic diagnosis of LGD, we did not observe improvement in level of agreement among experienced pathologists, even after accounting for inflammation. The level of inter-observer agreement increased with level of pathologist confidence. There was also a difference in reading of histopathology samples of BE tissues between US and European pathologists." (Gastroenterology)

February 2017 Outcomes of Pregnancies for Women Undergoing Endoscopy While They Were Pregnant: A Nationwide Cohort Study "Adverse pregnancy outcomes are rare in women undergoing endoscopy during pregnancy. Potential excess risks, if any, seem minimal and should be weighed against the need for timely investigation and treatment of women where an underlying GI disease may be a more severe threat to pregnancy outcome than the endoscopy." (Gastroenterology)

1 February 2017 Adam, Eve and the reflux enigma: age and sex differences across the gastro-oesophageal reflux spectrum. "Two views may explain our findings. First, women have either milder reflux, or reduced mucosal sensitivity hence reflux remains silent for longer. Alternatively, women genuinely develop reflux later, that is, are more protected and for longer from developing GORD and its complications. Early evidence is emerging that female sex hormones may indeed have a protective role in GORD during the reproductive period."  (European Journal of Gastroenterology & Hepatology)

1 February 2017 Taste and Smell Disturbances in Patients with Gastroparesis and Gastroesophageal Reflux Disease. "Abnormalities in taste and smell are significantly correlated with both gastroparesis and GERD symptom severity." (Journal of Neurogastroenterology & motility)

February 2017 Laparoscopic Anterior Partial Fundoplication is Comparable With Nissen Fundoplication forGastroesophageal Reflux Disease. "LAPF is as effective as LNF for GERD, with less dysphagia" (Surgical Laparoscopy)

February 2017 Etiology and treatment of cough in idiopathic pulmonary fibrosis. "There also may be an overlap between IPF cough and cough due to other common etiologies such as asthma, gastroesophageal reflux disease" (Respiratory Medicine)

February 2017 Surgical Options for the Treatment of Gastroesophageal Reflux Disease What surgical options are currently available for the treatment of gastroesophageal reflux disease? Dr Tom DeMeester,  a paid consultant to Torax Medical and EndoStim BV (Gastreoenterology & Hepatology)