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August 2017 Can We Use Diet to Effectively Treat Esophageal Disease? A Review of the Current Literature. "Dietary effects on gastroesophageal reflux disease are less clear, though newer research indicates that increased fiber with reduction in simple sugar intake may improve symptoms. In terms of Barrett's esophagusand esophageal adenocarcinoma, antioxidant intake may affect carcinogenesis, though to an unknown degree. Outcomes data regarding dietary manipulation for the management of esophageal diseases is heterogeneous." (Current Gastroenterology Reports)

21 July 2017 Role of Pepsin and Oropharyngeal pH-Monitoring to Assess the Postoperative Outcome of Patients with Laryngopharyngeal Reflux: Results of a Pilot Trial. "Salivary pepsin could be a marker for treatment success, while oropharyngeal pH-monitoring seems to be inadequate in these terms. However, larger studies are required to reach firm conclusions." (Journal of Laparoendoscopic and Advanced Surgical Techniques)

21 July 2017 Systematic assessment with I-SCAN magnification endoscopy and acetic acid improves dysplasia detection in patients withBarrett's esophagus. "Combining I-SCAN magnification endoscopy with ACA can be used in a step-wise manner resulting in high accuracy, sensitivity, and specificity, and with substantial interobserver agreement." (Endoscopy)

July 2015 The Effect of H2 Receptor Antagonist in Acid Inhibition and Its Clinical Efficacy. "The effectiveness of nighttime dose of H2RA suggests a major role of histamine in nocturnal acid secretion" (Korean journal of Gastroenterology)

July 2017 Surgical Anti-Reflux Options Beyond Fundoplication. "Alternative procedures to fundoplication include magnetic sphincter augmentation, electrical stimulation and Roux-en-Y gastric bypass. The indication for surgical management remains failure of or inability to tolerate medical therapy." (Current Gastroenterology Reports)

19 July 2017 Does pH Matter? The role of water in dental patients' diets "This paper explored research that discussed the differences between an alkaline versus an acidic diet and its effects on overall health." (Dentistry IQ)

18 July 2017 Changes in treatment and outcome of oesophageal cancer in Denmark between 2004 and 2013 "The 30-day mortality rate decreased from 4·5 to 1·7 per cent (RR 0·51, 0·22 to 1·15) and the 90-day mortality rate from 11·0 to 2·9 per cent (RR 0·46, 0·26 to 0·82). There were no statistically significant changes in 2- or 5-year survival rates over time." (British Journal of Surgery)

16 July 2017 Gastroesophageal Reflux Disease. "Barrett's esophagus is the only complication of GERD with malignant potential. Patients are typically middle-aged Caucasian males. In patient's with Barrett's esophagus, surveillance for dysplasia is warranted." 

15 July 2017 Gastric Hyperplastic Polyps Associated with Proton Pump Inhibitor Use in a Case without a History of Helicobacter pylori Infection. "administration of proton pump inhibitors may be a risk factor for the development of GHP independent of H. pylori infection" (Internal Medicine)

15 July 2017 Nitrous oxide cryotherapy for treatment of esophageal squamous cell neoplasia: initial multicenter international experience with a novel portable cryoballoon ablation system  "We report the first application of nitrous cryoballoon ablation for curative treatment of early primary or recurrent, ESCN. Our initial experience suggests that efficacy is high and safety profile is reasonable." (Gastrointestinal Endoscopy)

14 July 2017 The evolving genomic landscape of Barrett's esophagus and esophageal adenocarcinoma. "Newer, cost-effective technologies create opportunities to rapidly translate the analysis of DNA into tools that can identify patients with BE at high risk for cancer" (Gastroenterology)

14 July 2017 Additionof Alginate-antacid (Gaviscon Double Action) to Proton Pump InhibitorTherapy in Patients With Breakthrough Symptoms "Adding Gaviscon to PPI reduced breakthrough GERD symptoms but a nearly equal response was observed for placebo. Response to intervention may vary according to whether symptoms are functional in origin." (Alimentary Pharmacology & Therapeutics)

13 July 2017 Patterns of reoperation after failed fundoplication: an analysis of 9462 patients. "Fundoplication has a low reoperation rate within a mean 8.3 years of follow-up. Redo fundoplication is more commonly performed and at an earlier point than conversion to RYGB. Younger age, female gender, and chronic pulmonary disease are associated with reoperation after fundoplication." (Surgical Endoscopy)

12 July 2017 The prevalence of gastric heterotopia of the proximal esophagusis underestimated, but preneoplasia is rare - correlation withBarrett's esophagus.  "The prevalence of IP [Inlet Patch] seems to be underestimated, but preneoplasia within IP is rare, which does not support the recommendation to regularly obtain biopsies for histopathology. Biopsies should be targeted to any irregularities within the heterotopic mucosa. The correlation of IP with Barrett's esophagus hints to a partly common pathogenesis." (Gastroenterology)

12 July 2017 Gastroesophageal Reflux Disease and Pulmonary Diseases Associated with Aspergillosis: Is There a Connection? "Clinicians caring for patients with gastroesophageal reflux disease presenting with elevated Aspergillus IgG or IgE antibodies should maintain a high index of suspicion for this association and proceed to appropriate evaluations, including laryngoscopy and endoscopy, initiating specific PPI-directed therapy when indicated." (Mycopathologia)

10 July 2017 Mucin Expression in the Esophageal Malignant and Premalignant States: A Systematic Review and Meta-analysis. "Increased expression of certain mucin genes in esophageal mucosa may be further studied as a potential diagnostic tool, and this may add important information in the surveillance of Barrett's esophagus."  (Journal of Gastrointestinal Cancer)

10 July 2017 Systematic Review and Meta-analysis: Use of Statins Is Associated with a Reduced Incidence of Oesophageal Adenocarcinoma. "Statin use is associated with a significantly lower incidence of oesophageal adenocarcinoma. This is seen in both Barrett's cohorts and general populations." (Journal of Gastrointestinal Cancer)

August 2017 The Role of Esophageal Hypersensitivity in Functional Heartburn. "the cause of such hypersensitivity is an interesting topic in itself, and psychological factors, such as stress followed by increasing esophageal permeability are gaining attention as factors that can potentially influence this condition." (Jpurnal of Clinical Gastroenterology)

7 July 2017 Associations between obstructive sleep apnea severity and endoscopically proven gastroesophageal reflux disease.  "Endoscopically proven GERD was associated with more severe OSA.GERD symptoms were also associated with deteriorated sleep quality." (Sleep & Breathing)

7 July 2017 Effect and Safety of Peroral Endoscopic Cardial Constriction forGastroesophageal Reflux Disease. "In summary, PECC is a new endoscopic treatment for GERD. It is easy to perform and could achieve satisfactory curative effect and has low incidence of complication. However, more prospective studies are needed to confirm this conclusion." (Chinese Medical Journal)

5 July 2017 Primary and Redo Antireflux Surgery: Outcomes and Lessons Learned. "Complications and patient-reported outcomes worsen with each reoperative ARS." (Journal of gastrointestinal Surgery)

4 July 2017 Subsquamous intestinal metaplasia is common in treatment-naïve Barrett's esophagus.  "This cross-sectional study found a surprisingly high proportion of SSIM in treatment-naïve patients proximal to the SCJ. These findings raise questions regarding BE management and the prevalence of SSIM in normal-appearing esophagus." (Gastrointestinal Endoscopy)

4 July 2017 Prevalence of Barrett's esophagus: An observational study from a gastroenterology clinic.  "The overall prevalence of Barrett's esophagus was 1.8% in our population, with a prevalence of 7.2% in patients that had symptoms of gastroesophageal reflux." (Revista de Gastroenterologia de Mexico)

4 July 2017 Risk of death among users of Proton Pump Inhibitors: a longitudinal observational cohort study of United States veterans "The results suggest excess risk of death among PPI users; risk is also increased among those without gastrointestinal conditions and with prolonged duration of use. Limiting PPI use and duration to instances where it is medically indicated may be warranted." (BMJ Open)

3 July 2017 Bidirectional Association between Fibromyalgia andGastroesophageal Reflux Disease: Two Population-Based Retrospective Cohort Analysis. "The present study suggests a bidirectional relationship between FM and GERD. There is a greater risk of developingGERD for FM patients than developing FM for GERD patients." (Pain)

June 2017 Oesophageal Adenocarcinoma: A Patient and Physician's Perspective.  "This article is co-authored by a patient with oesophageal adenocarcinoma and his physician, who performed oesophagectomy. The patient relates his pre-operative preparation and post-operative experience. The physician comments on the alarming increase in the incidence of this cancer, risk factors, and treatment." (Oncology & Therapy)

29 June 2017 Factors influencing the outcome of magnetic sphincter augmentation for chronicgastroesophageal reflux disease. "Magnetic sphincter augmentation results in excellent/good outcomes in most patients but a higher BMI, structurally defective sphincter, and elevated LES residual pressure may prevent this goal." (Surgical Endospcopy)

27 June 2017 Treatment of laryngopharyngeal reflux using a sleep positioning device: A prospective cohort study. [MedCline] "In patients with LPR, SPD treatment significantly improves self-reported symptoms of nocturnal reflux as well as symptoms specific to LPR. These results support the therapeutic efficacy of a SPD for patients with LPR." (American Journal of Otolaryngology)

21 June 2017 Diagnostic value of alarm symptoms for upper GI malignancy in patients referred to GI clinic: A 7 years cross sectional study. "We recommend to do an early endoscopy for any patient with UGI symptoms and to take multiple biopsies from any rudeness or suspicious lesion, especially for male gender older than 50, dysphagia, or weight loss." (Journal of Research in Medical Sciences)

16 June 2017 New Approaches to Gastroesophageal Reflux Disease.  "laparoscopic Nissen fundoplication is the preferred surgical technique for treatment of this disease with concomitant hiatal hernia repair when present" (Journal of gastrointestinal surgery)

14 June 2017 Total diet, individual meals, and their association with gastroesophageal reflux disease.  "Amount of fat consumed at lunch is positively associated with GERD, whereas the percentage of energy from total protein and amount of protein intake at evening snack are more likely to be inversely associated with GERD." (Health Promotion Perspectives)

13 June 2017 Modeling Esophagitis Using Human Three-Dimensional Organotypic Culture System. "The acute inflammatory environment induced in the OTC [organotypic tissue culture] significantly affected the overlying epithelium, inducing a regenerative response marked by increased cell proliferation and epithelial hyperplasia. " (American Journal of Pathology)

July 2017 Endoscopic ablation of low-grade dysplasia inBarrett's esophagus: Have all the boxes been checked for us to move on? "there is compelling evidence from the SURF trial that ablation for LGD has clinical and cost effectiveness for managing BE, and the next challenge is nondysplastic BE." (Gastrointestinal Endoscopy)

12 June 2017 A long-term evaluation of the quality of life after laparoscopic Nissen-Rossetti anti-reflux surgery. "Many data suggest a possible recurrence of the symptoms after surgery in a long follow-up period. Our data seem to demonstrate a slight but significant trend in symptoms relapse after surgery." (Journal of Minimal Access Surgery)

9 June 2017 The Utility of the Reflux Symptom Index for Diagnosis of Laryngopharyngeal Reflux in an Allergy Patient Population.  "The optimal RSI score cutoff was determined to be 19. An abbreviated questionnaire was also generated using 6 of the RSI questions found to be significantly different between patients with and without LPR." (Journal of Allergy & Clinical Immunology in Practice)

9 June 2017 Patients are well served by Collis gastroplasty when indicated. "Patients who require a Collis gastroplasty to address a true short esophagus during laparoscopic antireflux operation have comparable operative and quality of life benefits as non-Collis patients, without added morbidity or mortality." (Surgery)

9 June 2017  Study finds no link between PPIs, dementia, Alzheimer’s risk "Researchers found no association between the use of proton pump inhibitors and the risk for mild cognitive impairment, dementia and Alzheimer’s disease in a recent observational, longitudinal study." (Gastroenterology)
7 June 2017 Proton Pump Inhibitors and Risk of Mild Cognitive Impairment and Dementia "Proton pump inhibitors were not associated with greater risk of dementia or of AD" (Journal of the American Geriatrics Society)

July 2017 Barrett's Stem Cells as a Unique and Targetable Entity. "We favor one of these deficient hypotheses, that Barrett's arises from a distinct lineage of junctional cells present in all normal individuals, and discuss efforts to shore it up." (Cellular & Molecular Gastroenterology & Hepatology)

July 2017 The Esophageal Squamous Epithelial Cell-Still a Reasonable Candidate for the Barrett's Esophagus Cell of Origin?  "One possible source is a fully differentiated squamous epithelial cell or a squamous epithelial progenitor or stem cell native to theesophagus that, through molecular reprogramming, either transdifferentiation or transcommitment, could give rise to an intestinalized columnar cell." (Cellular & Molecular Gastroenterology & Hepatology)

July 2017 Origin of Barrett's Epithelium: Esophageal Submucosal Glands.  "Increased proliferation in ESMGs and ducts in response to injury also has been noted in human beings and animals." (Cellular & Molecular Gastroenterology & Hepatology)

July 2017 Columnar Metaplasia in Three Types of Surgical Mouse Models of Esophageal Reflux.  "duodenal contents alone can induce columnar metaplasia and dysplasia; however, the combination of gastric acid with duodenal content reflux can cause metaplasia and dysplasia more efficiently." (Cellular & Molecular Gastroenterology & Hepatology)

July 2017 Emerging Gastrointestinal and Liver Diseases in Asia Pacific: Implications to Health Care in the Region (World Gastroenterology Organization: Asian Pacific Association of Gastroenterology Distinguished Global Lecture 2015). "These emerging diseases reflect the continued fast-paced socioeconomic development in the region with marked lifestyle changes and increasing affluence." (Journal of Clinical Gastroenterology)


7 June 2017 Letter: should Barrett's oesophagus be considered a potential cardiovascular risk factor?  "In summary, increased [Visceral Adipose Tissue] may be the key factor for understanding the pathophysiology of increased [CardioVascular Disease] events in BO patients." (Alimentary Pharmacology & Therapeutics)

6 June 2017 Esophageal Penetration of the Magnetic Sphincter Augmentation Device: History Repeats Itself. "Judging from the literature, MSAD implantation may be an effective way to control GERD, but the method can carry major complications, such as migration of the device into the esophagus" (Journal of Laparoendoscopic and Advanced Surgical techniques)

5 June 2017 Heritability and genetic correlation between GERD symptoms severity, metabolic syndrome, and inflammation markers in families living in Mexico City. "Genetic factors substantially explain the phenotypic variance of the severity of some GERD symptoms, metabolic syndrome components and inflammation markers. Observed genetic correlations suggest that these phenotypes share common genes." (PLoS one)

4 June 2017 Gastroesophageal Reflux and Idiopathic Pulmonary Fibrosis. "Medical therapy with acid-reducing medications controls the production of acid and has some benefit. However, reflux and aspiraion of weakly acidic or alkaline gastric contents can still occur. Better results have been reported after laparoscopic anti-reflux surgery, as this form of therapy re-establishes the competence of the lower esophageal sphincter, therefore stopping any type of reflux." (World Jouranl of Surgery)

July 2017 Esophagectomy for Superficial Esophageal Neoplasia. "The managing physician must remain cognizant of the limitations of endoscopic approaches and consider surgical resection when they are exceeded."  (Gastrointestinal Endoscopy Clinics of North America)

July 2017 Care of the Postablation Patient: Surveillance, Acid Suppression, and Treatment of Recurrence. " Identified risk factors for recurrence include age and length of BE before treatment and may also include presence of a large hiatal hernia, higher grade of dysplasia before treatment, and history of smoking." (Gastrointestinal Endoscopy Clinics of North America)

July 2017 Cryotherapy for Barrett's Esophagus. "he mechanism of cryotherapy ablative effects includes immediate injury as well as coagulation necrosis occurring over several hours and days, unlike heat-based thermal ablation." (Gastrointestinal Endoscopy Clinics of North America)

July 2017 Radiofrequency Ablation of Barrett's Esophagus: Efficacy, Complications, and Durability. "Although most patients achieve eradication of neoplasia and intestinal metaplasia, in the long-term a substantial portion of patients develop recurrent disease." (Gastrointestinal Endoscopy Clinics of North America)

July 2017 Radiofrequency Ablation of Barrett's Esophagus: Patient Selection, Preparation, and Performance. "The ease of performance of the procedure along with its efficacy and low rate of adverse events have established RFA as a reliable technique for endoscopic management of dysplastic BE." (Gastrointestinal Endoscopy Clinics of North America)

July 2017 The Role of Endoscopic Ultrasound in the Management of Patients with Barrett's Esophagus and Superficial Neoplasia. "The utility of EUS in the evaluation of Barrett esophagus patients is controversial. This is a review of the evidence using EUS in BE patients" (Gastrointestinal Endoscopy Clinics of North America)

July 2017 Management of Nodular Neoplasia in Barrett's Esophagus: Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection.  "Treatment of early Barrett's neoplasia should be centralized and limited to expert centers with a high-volume load and sufficient expertise in the detection and treatment of esophageal neoplasia." (Gastrointestinal Endoscopy Clinics of North America)

July 2017 Beyond Dysplasia Grade: The Role of Biomarkers in Stratifying Risk. "This review highlights the challenges of using dysplasia to stratify cancer risk and addresses the development and use of molecular biomarkers and in vivo molecular imaging to detect early neoplasia in Barrett's esophagus." (Gastrointestinal Endoscopy Clinics of North America)

July 2017 Alternatives to Traditional Per-Oral Endoscopy for Screening. "a number of alternative methods are currently being investigated: transnasal and video capsule endoscopy, endomicroscopy, cell collection devices like the cytosponge and biomarkers" (Gastrointestinal Endoscopy Clinics of North America)

July 2017 Who Deserves Endoscopic Screening for Esophageal Neoplasia? "the incidence and mortality from esophageal adenocarcinoma (EAC) have continued to increase. This likely stems from the large population of patients that develop EAC outside of a BE screening and surveillance program" (Gastrointestinal Endoscopy Clinics of North America)

2 June 2017 Dietary inflammatory index and risk of reflux oesophagitis,Barrett's oesophagus and oesophageal adenocarcinoma: a population-based case-control study. "a pro-inflammatory diet may exacerbate the risk of the inflammation-metaplasia-adenocarcinoma pathway in oesophageal carcinogenesis." (British Journal of Nutrition)

1 June 2017 Pictograms to Provide a Better Understanding ofGastroesophageal Reflux Symptoms in Chinese Subjects. "Pictograms could help ordinary people who do not have medical education to understand reflux symptoms more accurately in China. Compared with abstract terms, pictograms could be useful for epidemiological studies and diagnosis ofGERD in the community." (Gastroenterology Research and Practice)

1 June 2017 Late Recurrence of Barrett's Esophagus After Complete Eradication of Intestinal Metaplasia is Rare: Final Report From Ablation in Intestinal Metaplasia Containing Dysplasia Trial. "In this analysis of prospective cohort data from the AIM dysplasia trial, we found BE to recur after CEIM by RFA in almost one-third of patients with baseline dysplastic disease; most recurrences occurred during the first year after CEIM. However, patients who achieved CEIM and remained BE free at 1 year after RFA had a low risk of BE recurrence. Studies are needed to determine when surveillance can be decreased or discontinued; our study did not identify any BE or dysplasia recurrence after 4 years of surveillance." (Gastroenterology)


31 May 2017 Endoscopic Accessories Used for More Advanced Endoluminal Therapeutic Procedures.  "endoscopic management has been receiving increasing attention. In this article, I review endoscopic and/or endoluminal devices used for the treatment of GERD and obesity" (Clinical Endoscopy)

31 May 2017 Omeprazole-Domperidone Fixed Dose Combination vs Omeprazole Monotherapy: A Phase 4, Open-Label, Comparative, Parallel Randomized Controlled Study in Mild to Moderate Gastroesophageal Reflux Disease "Omeprazole-domperidone combination was more effective than omeprazole alone in providing complete cupping of reflux symptoms and healing of esophagitis in patients with GERD. Both the treatments were well tolerated with few reports of adverse events." (Clinical Medical Insights, Gastroenterology)

31 May 2017 Recurrence of intestinal metaplasia and early neoplasia after endoscopic eradication therapy for Barrett's esophagus: a systematic review and meta-analysis. "The results of this study demonstrate that the incidence rates of overall, IM, and dysplasia recurrence rates post-EET are not inconsiderable and reinforce the importance of close surveillance after achieving CE-IM." (Endoscopy International Open)

31 May 2017 Characteristics of children and adolescents first prescribed proton pump inhibitors or histamine-2-receptor antagonists: an observational cohort study. "Pediatric patients receiving PPIs and those receiving H2RAs may represent different patient populations. PPIs may be more commonly prescribed than H2RAs among patients with respiratory diseases." (Current Medicl Research & Opinion)

30 May 2017 Psychosocial Factors Are Associated with Quality of Life After Laparoscopic Antireflux Surgery. "Strong social support and psychiatric well-being appear to be important predictors of a higher QoL following LARS. Optimizing social support and treating depression preoperatively and postoperatively may improve QoL outcomes for LARS patients." (Journal of Laparoendoscopic and Advanced Surgical Techniques)

28 May 2017 [Study on lifestyle in patients with gastroesophageal  reflux disease]. "Conclusion: The elderly people are at high risk for GERD, and unhealthy habits like fast-eating, over-eating, too tight belt, and hot-eating is closely related to GERD. The lifestyles such as chewing food thoroughly, splitting the meals up, warm and cool diet, keeping patients out of the too tight belt are necessary for GERD patients." (Zhong nan da xue xue bao Yixue ban)

27 May 2017 The Validity of a New Structured Assessment of Gastrointestinal Symptoms Scale (SAGIS) for Evaluating Symptoms in the Clinical Setting. "The SAGIS instrument has excellent psychometric properties and supports the clinical assessment of and symptom-based categorization of patients with a wide spectrum of gastrointestinal symptoms." (Digestive Diseases & Sciences)

May 2017 Risk of progression of Barrett's esophagus in patients with cirrhosis. "Cirrhotics with worsening liver function are at increased risk of progression of BE. More frequent endoscopic surveillance might be warranted in such patients." (world Journal of Gastroenterology)

26 May 2017 Early Barrett esophagus-related neoplasia in segments 1 cm or longer is always associated with intestinal metaplasia. "Barrett neoplasia is always associated with intestinal metaplasia; absence of intestinal metaplasia is attributable to sampling error or obliteration of residual intestinal metaplasia by neoplasia and those with segments less than 1 cm show atypical features for Barrett-related disease (absent intestinal metaplasia and female gender)" (Modern Pathology)

25 May 2017 Cost-effectiveness analysis of endoscopic eradication therapy for treatment of high-grade dysplasia in Barrett's esophagus. "EET is likely to be a cost-effective treatment strategy compared with surveillance alone in patients with HGD arising in Barrett's esophagus in the UK." (Journal of Comparative Effectiveness Research)

25 May 2017 Current and future treatment options for esophageal cancer in the elderly. "Clinical evaluation of comorbidity is necessary to make treatment decisions. Therapeutic options for early carcinomas are endoscopic or surgical resection. For elderly patients with advanced carcinomas, preoperative chemoradiation or chemotherapy should be discussed." (Expert opinion on Pharmacotherapy)

April - June 2017 Gastroesophageal reflux disease prevalence among school teachers of Saudi Arabia and its impact on their daily life activities. "This study revealed a prevalence of GERD symptoms among 58% of school teachers. 7 point 8% of GERD participants reported symptoms which affected their daily life activities." (International Journal of Health Sciences)

24 May 2017 Endoluminal Sphincter Augmentation with the MUSE™ System and GERDX™ System in the Treatment of Gastroesophageal RefluxDisease: A New Impact? "most early devices [for endoluminal sphincter augmentationhave proven to be unsafe or failed to provide long-term symptom relief ... While the currently available literature has proven their [MUSE & GERDX] effectiveness in principle, long-term results are lacking" (Surgical Technology International)

21 May 2017 Nissen fundoplication vs proton pump inhibitors for laryngopharyngeal reflux based on pH-monitoring and symptom-scale. "LNF achieves better improvement than PPIs for LPR with type I hiatal hernia." (World Journal of Gastroenterology)

18 May 2017 Central Obesity as a Risk Factor for Non-Erosive Reflux Disease. "Central obesity appears to be an independent risk factor for NERD. This result supports the presence of an association between GERD and central obesity, even in the absence of esophageal erosion (NERD)." (Yonsei Medical journal)

16 May 2017 What Factors Associate With Symptom Recurrence After Anti-reflux Surgery for GERD?   "Symptom recurrence after anti-reflux surgery was associated with having primarily extraesophageal symptoms and poor preoperative response to acid-suppression therapy." (AGA Journals)

15 May 2017 Fundoplication in Patients with Esophageal Atresia: Patient Selection, Indications, and Outcomes. "In short term, fundoplication alleviates symptoms in most patients but recurrences are common occurring in at least one third of the patients. Patients with fundoplication wrap failure often require redo surgery, which may be complicated and associated with significant morbidity. A safe option in a subset of patients with failed anti-reflux surgery appears to be long-term medical treatment with proton pump inhibitors." (Frontline in Pediatrics)

15 May 2017 Food and Gastroesophageal Reflux Disease. " there is few data about the type of diet and gastroesophageal reflux. Mediterranean diet and a very low carbohydrate diet protect against reflux. Regarding diet-related practices, consistent data showed that a "short-meal-to-sleep interval" favorsreflux episodes," (Current Medicinal Chemistry)

15 May 2017 Linx more effective than PPIs for treating regurgitation in GERD “This study at least in preliminary analysis has demonstrated superiority of the magnetic sphincter augmentation procedure using the Linx device compared with twice daily PPI therapy in control of regurgitation, control of heartburn and control of gastroesophageal reflux measured objectively,” (Healio Gastroenterology)

15 May 2017 Therapeutic Response to Twice-daily Rabeprazole on Health-related Quality of Life and Symptoms in Patients with RefractoryReflux Esophagitis: A Multicenter Observational Study. "Twice-daily treatment with rabeprazole improved the subjective symptoms and health-related quality of life in patients with refractory refluxesophagitis more effectively than the standard once-daily dose." (Internal Medicine)

May 2017 [Esophageal complications of gastroesophageal reflux disease: consequences or defensive reactions?] " In Barrett's esophagus, which can be unambigously considered as a complication of gastroesophageal reflux disease, reflux symptoms ruining the quality of life may significantly improve, since the metaplastic Barrett epithelium is much more resistent to gastric acid, than the normal epithelial lining of the esophagusFurthermore, the motility disorders (hypertensive lower esophageal sphincter, achalasia, cricopharyngeal achalasia) and structural changes (Schatzki's ring, esophageal stricture, subglottic trachea stenosis), which develop as a complication of reflux may help to prevent aspiration that can cause new complaints and may lead to further complications. " (Orvosi Hetilap)

13 May 2017 Automated cytological detection of Barrett's neoplasia with infrared spectroscopy. "Analysis of esophageal cell samples can be performed with FTIR [Fourier transform infrared] spectroscopy with reasonable sensitivity for Barrett's neoplasia, but with poor specificity with the current technique." (Journal of Gastroenterology)

June 2017 Barrett Esophagus and Intramucosal Esophageal Adenocarcinoma. "Recent data point to at least 2 carcinogenic pathways operating in EAC. The use of p53 overexpression and high-risk human papillomavirus may represent the best chance to detect progressors. Genome-wide technology may provide molecular signatures to aid diagnosis and risk stratification in BE." (Hematology/Oncology clinics of North America)

May 2017 Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline. "This guideline recommends deprescribing PPIs (reducing dose, stopping, or using "on-demand" dosing) in adults who have completed a minimum of 4 weeks of PPI treatment for heartburn or mild to moderate gastroesophageal reflux disease or esophagitis, and whose symptoms are resolved. The recommendations do not apply to those who have or have had Barrett esophagus, severe esophagitis grade C or D, or documented history of bleeding gastrointestinal ulcers." (Canadian Family Physician)

12 May 2017 Alteration in the gastric microbiota and its restoration by probiotics in patients with functional dyspepsia "Reflux of the small intestinal contents, including bile acid and intestinal bacteria, to the stomach was suggested to induce a bacterial composition change and be involved in the pathophysiology underlying FD. Probiotics appear effective in the treatment of FD through the normalisation of gastric microbiota." (BMJ Open Gastroenterology)

10 May 2017 Two-Stage Explantation of a Magnetic Lower Esophageal Sphincter Augmentation Device Due to Esophageal Erosion. "We present the first account of LINX explantation for esophageal erosion in the United States. We demonstrated that a staged laparoendoscopic approach to LINX removal in these cases is feasible with minimal morbidity." (Journal of laparoendoscopic & Advanced Surgical techniques)

10 May 2017 Association between coffee or tea drinking and Barrett's esophagus or esophagitis: an Italian study. "Our data were suggestive of a reduced risk of BE and E with tea intake. An adverse effect of coffee was found among BE patients who had stopped drinking coffee. Coffee or tea intakes could be indicative of other lifestyle habits with protective or adverse impact on esophageal mucosa." (European Journal of Clinical Nutrition

May 2017 Endoscopic screening for Barrett's esophagus: while we're in, do we also need to see the stomach and the duodenum? "The current study published in Endoscopy International Open expands upon the previous findings and concludes that the overall quality and gastroesophageal junction visualization of uTNE and sEGD are comparable." (Endoscopy International Open)

May 2017 Comparative quality assessment of esophageal examination with transnasal and sedated endoscopy. "Esophageal assessment with TNE or EGD was comparable in overall quality and GEJ visualization. TNE quality was not affected by procedure location. TNE is a feasible option for endoscopic assessment of reflux complications." (Endoscopy International Open)

8 May 2017 Alcohol consumption pattern and risk of Barrett's oesophagusand erosive oesophagitis: an Italian case-control study. " In conclusion, although often not statistically significant, our data suggested a reduced risk of Barrett's oesophagus and oesophagitis with a low/moderate intake of wine and beer consumption. A non-significant increased risk of Barrett's oesophagus/oesophagitis was observed with a higher intake of any type of heavy alcohol consumption" (British Journal of Nutrition)

8 May 2017 Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca2+ Efflux Channel in the Tubulovesicle "Given the well-established roles of gastric acids in stomach homeostasis and gastric biology (Forte and Zhu, 2010Hersey and Sachs, 1995), our identification of ML1 as the first known TV Ca2+ channel may lead to the development of new therapeutic approaches to treat acid-related gastric diseases." (Developmental Cell)

7 May 2017 Impact of gastroesophageal reflux control through tailored proton pump inhibition therapy or fundoplication in patients with Barrett's esophagus. "This study evaluated the effects of increasing, acid-reflux-adjusted doses of proton pump inhibitors (PPI) on symptoms and histology in Barrett’s esophagus (BE) patients in comparison to BE patients with a clinically successful fundoplication. All patients went through an extensive prospective protocol with symptom assessment, upper endoscopy with biopsies, 24 h pH-monitoring and manometry. In the non-operated group, 42% of patients needed more than the standard PPI dose to reach acid control which then was associated with improvement of symptom scores up to the same levels as after successful fundoplication. In addition, acid reflux control was associated with changes in the esophageal columnar and squamous epithelium, regardless of medical or surgical treatment." (World Journal of gastroenterology)

7 May 2017 Esophagitis and its causes: Who is "guilty" when acid is found "not guilty"? "This manuscript analyzes the esophageal diseases whose etiology is not directly related to abnormal gastro-esophageal reflux episodes. These conditions occur less frequently than gastroesophageal reflux disease, but their diagnosis should always be considered when managing patients with unexplained upper gastrointestinal symptoms." (World Journal of gastroenterology)

5 May 2017 Ineffective esophageal motility: clinical, manometric, and outcome characteristics in patients with and without abnormal esophageal acid exposure. "GER symptoms are not discriminatory in patients with IEM with and without underlying pathologic acid reflux. Clinical response to PPI in such patients depends on the presence of esophageal pathologic acid exposure. Those with IEM and normal acid exposure remain symptomatic and mostly resistant to therapy." (Diseases of the Esophagus)

5 May 2017 Foregut symptoms, somatoform tendencies, and the selection of patients for antireflux surgery. "There is no difference in the risk for somatization between patients with foregut symptoms and those with documented GERD. Therapeutic decision making especially prior to antireflux surgery requires an awareness of mental and emotional challenges." (Diseases of the Esophagus)

5 May 2017 Clinical characteristics and associated factors of Japanese patients with adenocarcinoma of the esophagogastric junction: a multicenter clinicoepidemiological study. "The incidence rate of AEGJ is lower in Japan than in Western countries, but associated factors similar to those in Western patients were detected, including obesity, a hiatal hernia, smoking, and the male sex." (Diseases of the Esophagus)

5 May 2017 CEACAM 6, a novel marker for the diagnosis of Barrett's esophagus. "Our findings highlight the increasing expression of CEACAM6 from CLE to BE with a subsequent decrease to dysplasia and adenocarcinoma. In view of this, we advocate the utilization of this marker for the enhanced diagnosis of BE and for the distinction of BE and dysplasia." (Diseases of the Esophagus)

4 May 2017 The Degree of Disease Knowledge in Patients with Gastroesophageal Reflux Disease: A Multi-center Prospective Study in Korea. "The surveyed Korean patients had relatively low disease knowledge, suggesting that a GERD educational program may be beneficial in Korea. Formulation of a program is underway." (Journal of Neurogastroenterology and Motility)

4 May 2017 Upper esophageal sphincter abnormalities and high-resolution esophageal manometry findings in patients with laryngopharyngeal reflux. "Abnormal UES function was noted in one-third of patients with LPR or GERD. However, there were no abnormalities on esophageal function testing specific for LPR." (Scandinavian Journal of gastroenterology)

2 May 2017 Randomised clinical trial: addition of alginate-antacid (Gaviscon Double Action) to proton pump inhibitor therapy in patients with breakthrough symptoms. "Adding Gaviscon to PPI reduced breakthrough GERD symptoms but a nearly equal response was observed for placebo. Response to intervention may vary according to whether symptoms are functional in origin." (Alimentary Pharmacology & Therapeutics)