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October 2018 Surgical results of laparoscopic Toupet fundoplication for gastroesophageal reflux disease with special reference to recurrence. "Laparoscopic Toupet fundoplication for GERD could be performed safely, with a response rate as good as 85%. Compared with non-recurrent cases, preoperative clinical conditions such as esophageal hiatal hernia, reflux esophagitis, and acid reflux time were all advanced in recurrent cases" (Esophagus)

October 2018 Impact of reflux esophagitis on the esophageal function before and after laparoscopic fundoplication. "Regardless of the presence of RE, cardiac function and LES function were improved following laparoscopic Toupet fundoplication, but no changes were observed in esophageal body motor function." (Esophagus)

September 2018 Smokeless Tobacco and Cigar and/or Pipe Are Risk Factors for Barrett Esophagus in Male Patients With Gastroesophageal Reflux Disease. "This study suggests that there is indeed an association between CS and BE. We believe that this is the first time that ST and CP were associated with an even higher odds of developing BE. Further studies are needed to investigate whether the use of ST and CP is also associated with an increased risk of developing BE-associated adenocarcinoma." (Mayo Clinical Proceedings)

13 September 2018 Chronic kidney disease (CKD) patients are exposed to more proton pump inhibitor (PPI)s compared to non-CKD patients. "Chronic kidney disease patients are taking proton pump inhibitors for a much longer duration compared to non-chronic kidney disease patients. Physicians should pay careful attention when prescribing proton pump inhibitors to high risk groups." (PLoS one)

13 September 2018 AssociationBetween Proton Pump Inhibitors and the Risk of Hepatocellular Carcinoma (full text) "This observational study demonstrated that PPIs might increase the risk of HCC." (Alimentary Pharmacology & Therpeutics)"

12 September 2018 Association between proton pump inhibitor use and the risk of pancreatic cancer: A Korean nationwide cohort study. (full text ) "Subgroup analyses revealed that a significant association existed between PPI use and pancreatic cancer in low risk groups including individuals who were female, engaged in healthy lifestyle habits, and had no history of diabetes or chronic pancreatitis." (PLoS one)

12 September 2018 Impact of Toupet Versus Nissen Fundoplication on Dysphagia in Patients With Gastroesophageal Reflux Disease and Associated Preoperative Esophageal Dysmotility: A Systematic Review and Meta-Analysis. "TF may be associated with significantly lower postoperative dysphagia than NF in patients with GORD and associated preoperative esophageal dysmotility. However, no definite conclusions can be drawn as the best available evidence comes mainly from a limited number of heterogeneous randomized controlled trials. Future studies are encouraged to include patients with similar preoperative dysphagia status and report the outcomes with respect to recurrence of acid reflux symptoms." (Surgical Innovations)

11 September 2018 Impact of Gastroesophageal Reflux Disease on Mucosal Immunity and Atopic Disorders. "The relationship of GERD to allergic rhinitis and chronic sinusitis is weak; however, studies support the concept that treatment of frequent episodes of GERD can have a positive effect on rhinitis and sinusitis overall." (Clinical Reviews in allergy & immunology)

10 September 2018 Helicobacter pylori and nonmalignant upper gastrointestinal diseases. (full text) "there is no evidence indicating that H. pylori eradication could worsen the symptoms or the course of GERD" (Helicobacter)

6 September 2018 Endoscopic augmentation of gastroesophageal junction using a full-thickness endoscopic suturing device. "The use of a novel endoscopic suturing technique for the treatment of GERD is feasible and safe. The procedure resulted in short-term GERD symptom improvement." (Endoscopy International Open)

6 September 2018 Low Prevalence of Suspected Barrett's Esophagus in Gastroesophageal Reflux Disease Without Alarm Symptoms. "We found that 73,535 EGDs (13.5%) were performed for a primary indication of GERD without alarm symptom: only 4122 patients (5.6%) had sBE, and of these, 24.2% had sLSBE." (Clinical Gastroenterology & Hepatology)

6 September 2018 Identificationof prognostic phenotypes of esophageal adenocarcinoma in twoindependent cohorts "Two types of esophageal adenocarcinoma can be characterized based on the presence or absence of Barrett’s epithelium. These findings have implications for understanding the etiology of EAC and determining prognosis as well as for development of optimal clinical strategies to identify patients at risk." (Gastroenterology)

5 September 2018 Polymorphisms of Genes Related to Function and Metabolism of Vitamin D in Esophageal Adenocarcinoma. "Specific polymorphisms in vitamin D metabolism-related genes are associated with the likelihood of reflux-BE-EAC progression. Identifying such polymorphisms may aid in development of better surveillance and diagnostic and therapeutic protocols." (Journal of Gastrointestinal Cancer)

5 September 2018 Prospective Single Arm Study on the Effect of Ilaprazole in Patients with Heartburn but No RefluxEsophagitis. (full text) "Daily ilaprazole (20 mg) is efficacious in improving symptom scores, histopathologic findings, and inflammatory biomarkers in patients with heartburn but no reflux esophagitis." (Yonsei Medical Journal)

4 September 2018 Convenient Method of Measuring Baseline Impedance for Distinguishing Patients with Functional Heartburn from those with Proton Pump Inhibitor-Resistant Endoscopic Negative Reflux Disease. "Measuring the simple MBI is a quick method and is useful for distinguishing patients with FH from those in a cohort with PPI-refractory NERD." (Digestion)

4 September 2018 Alcohol Consumption and the Risk of Gastroesophageal RefluxDisease: A Systematic Review and Meta-analysis. "This meta-analysis provides evidence for a potential association between alcohol drinking and the risk of GERD. The increase in alcohol consumption and frequency showed a stronger association with GERD." (Alcohol & Alcoholism)

4 September 2018 Systematic review with meta-analysis: risk of adverse cardiovascular events with proton pump inhibitors independent of clopidogrel. "There is no clear evidence of an association between PPI monotherapy and increased cardiovascular risk." (Alimentary Pharmacology & Therapeutics)

2 September 2018 Proton Pump Inhibitors and Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B or C. "We observed no relationship between dose-dependent effect of PPI use and HCC risk. Subgroup analysis also confirmed PPI use was not correlated to an increased HCC risk. Conclusions Based on a retrospective, nationwide population-based cohort study in Taiwan, where the prescription of PPI is tightly regulated, PPI use is not associated with the risk of developing HCC among patients with chronic HBV or HCV infections." (Hepatology)

1 September 2018 Association of Vitamin D and Parathyroid Hormone With Barrett's Esophagus. "Contrary to our hypothesis, we found a strong inverse association between Barrett's esophagus and hyperparathyroidism (odds ratio=0.516; 95% confidence interval=0.265, 1.01), and a trend toward an inverse association with vitamin D deficiency. We found no association between vitamin D deficiency or hyperparathyroidism with GERD symptoms or erosive esophagitis." (Journal of Clinical Gastroenterology)

26 June 2018 Columnar-Lined Esophagus Develops via Wound Repair in a Surgical Model of RefluxEsophagitis. (full text) "After esophagojejunostomy in rats, metaplastic columnar-lined esophagus develops via a wound healing process that does not appear to involve cellular reprogramming of progenitor cells. This process involves EMT-associated migration of jejunal cells into the esophagus, where they likely have a competitive advantage over squamous cells in the setting of ongoing gastroesophageal reflux disease." (Cellular & Molecular Gastroenterology & Hepatology)

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August 2918 A single-step sizing and radiofrequency ablation catheter for circumferential ablation of Barrett's esophagus: Results of a pilot study. (full text) "This study shows that circumferential RFA using the 360 Express may shorten procedure time, while maintaining efficacy compared to standard circumferential RFA." (United European Gastroenterology Journal)

31 August 2018 Spotlight on the Linx™ Reflux Management System for the treatment of gastroesophageal reflux disease: evidence and research. (full text) "After several years of clinical application, the Linx device has been shown to not only be effective for the management of GERD but also be as effective as fundoplication. With respect to safety, the most common complication of MSA is dysphagia. This often resolved without intervention, but esophageal dilation or device explanation are occasionally necessary. Not fully appreciated in earlier reviews, erosion of the device into the esophagus appears to be the most significant complication of the device after extended follow-up. While very rare, the potentially severe consequences of this phenomenon suggest that the device should be used with some restraint and that patients should be made aware of this potential morbidity." (Medical Devices)

31 August 2018 Persistent dysphagia is a rare problem after laparoscopic Nissen fundoplication. (full text) "After a median follow-up of 4 years, persistent dysphagia (PD) after LNF was observed in 8 (2%) patients, while postoperative gas-bloat syndrome in 45 (12.7%) cases. Endoscopic dilatation was needed in 7 (2%) patients due to dysphagia, and 19 (5%) patients underwent revision surgery due to recurrence of GERD. The postoperative GERD-HRQL total score was significantly reduced (2 (IQR 0-4.3) vs. 19 (IQR 17-32); p < 0.000) and the median AS [Alimentary Satisfaction] was 9/10. Heartburn relief was achieved in 83% of patients. Eighty-three percent of patients were free of PPI intake after follow-up, whereas 13% and 4% of the patients reported daily and irregular PPI use, respectively.." (Surgical Endoscopy)

30 August 2018 The2018 ISDE achalasia guidelines "patients typically present with dysphagia, regurgitation and occasionally chest pain, pulmonary complication and malnutrition. New diagnostic methodologies and therapeutic techniques have been recently added to the armamentarium for treating achalasia. ... The guidelines were prepared according the Appraisal of Guidelines for Research and Evaluation (AGREE-REX) tool, accredited for guideline production by NICE UK" (Diseases of the Esophagus)

30 August 2018 Evaluation of resection of the gastroesophageal junction and jejunal interposition (Merendino procedure) as a rescue procedure in patients with a failed redo antireflux procedure. A single-center experience. (full text) "In our experience, the Merendino procedure seems to be an unsuitable surgical option for patients who require an alternative surgical reconstruction due to a failed fundoplication. However, the small number of patients included in this study as well as the small number of participants who completed the postoperative workout limits this study." (BMC Surgery)

30 August 2018 Comparative efficacy of various anti-ulcer medications after gastric endoscopic submucosal dissection: a systematic review and network meta-analysis. "A combination therapy of PPI and muco-protective agent was superior to PPIalone for ulcer healing at 4 weeks after ESD. In the ulcer healing effect at 8 weeks after ESD, vonoprazan was superior to PPI." (Surgical Endoscopy)

29 August 2018 Long term time trends in use of medications associated with risk of developing osteoporosis: Nationwide data for Denmark from 1999 to 2016. "We found a trend of increasing use from 1999 to 2016 of most medications with a potential for causing osteoporosis, often most pronounced in fracture risk groups (postmenopausal women and/or in the elderly). This may play a clinically relevant role in both current and future causality of osteoporosis." (Bone)

29 August 2018 Proton pump inhibitors' use and risk of hip fracture: a systematic review and meta-analysis. "This meta-analysis suggests that PPI user have a 26% increased risk of hip fracture as compared to non-PPI user. Physicians should take caution in prescribing PPI to patients who are at increased risk of hip fracture." (Rheumatology International)

28 August 2018 Inappropriate Prescription of Proton Pump Inhibitors in a Community Setting. "These findings suggest that inappropriate prescribing of PPIs remains problematic in the community setting in the province of Quebec." (Canadian Journal of Hospital Pharmacy)

28 August 2018 Model to Select On-Therapy vs Off-Therapy Tests for Patients with Refractory Esophageal or Extra-Esophageal Symptoms. "Abnormal pH (more than 5.5% of time spent at pH <4) was found in 56% of patients with heartburn and 63% of patients with EER [Extra-Esophageal Reflux] (P=.15). Within EER groups, abnormal pH was detected in a significantly higher proportion (80%) of patients with asthma than patients with cough (60%) or hoarseness (51%) (P<.01). Factors significantly associated with abnormal pH in patients with heartburn were presence of hiatal hernia and body mass index >25." (Gastroenterology)

28 August 2018 Correlation of sleep-disordered breathing and laryngopharyngeal reflux: a two-channel triple-sensor pHmetry catheter study. "The prevalence of GER and LPR is found to be high in patients with sleep-disordered breathing. There is no significant relationship between OSAS severity and GER and LPR grade or respiratory events and reflux episodes with regard to timing." (European Archives of otorhinolaryngology)

28 August 2018 Effect of proton pump inhibitors on sympathetic hyperinnervation in infarcted rats: Role of magnesium. (full text) "Our results indicate that the long-term administration of PPIs was associated with reduced tissue magnesium content and increased myocardial superoxide production, which exacerbated ventricular arrhythmias after infarction. Magnesium may be a potential target for PPI-related arrhythmias after infarction." (PLoS one)

28 August 2018 Feasibility Trial of the Newly Introduced Optical Enhancement Technology in Patients with Gastroesophageal Reflux Disease. (full text) "The newly introduced OE technology significantly improves the diagnosis of GERD compared to HD-WLE. The results should be confirmed in a multicenter trial." (Digestive Disease)

27 August 2018 Long-term reported outcomes of transoral incisionless fundoplication: an 8-year cohort study. "This study demonstrates that TIF can produce durable improvements in disease-specific quality of life in some patients with symptomatic GERD. The majority of patients resumed daily PPI therapy during the study period, but with significantly improved GERD-HRQL scores compared to baseline and increased satisfaction with their medical condition." (Surgical Endoscopy)

27 August 2018 Use of proton pump inhibitors and risk of ischemic events in the general population. "In primary care setting, PPI use was independently associated with increased risk of first-time cardiovascular event, consistent with the evidence that PPIs adversely impact vascular function, underlying the need to promote appropriate prescribing of these drugs." (Atherosclerosis)

27 August 2018 Proton Pump Inhibitor Use and Risk of Developing Alzheimer's Disease or Vascular Dementia: A Case-Control Analysis. "In this large, case-control analysis, we did not find any evidence for an increased risk of either AD or VaD related to PPI or H2RA use." (Drug Safety)

25 August 2018 Associations of proton pump inhibitors and hospitalization due to hyponatremia: A population-based case-control study. "With the exception of lansoprazole, this study suggests an association between any newly initiated PPI-treatment and hospitalization due to hyponatremia. Ongoing PPI use was not associated with an increased risk." (European Journal of Internal medicine)

25 August 2018 Circumferential distribution and clinical characteristics of esophageal cancer in lower esophagus: differences related to histological subtype. "Our results showed no circumferential predilection for ESCC in the lower esophagus, suggesting that development of this type of lesion may be less affected by gastroesophageal reflux. In addition, EAC at the EGJ was frequently found on the right-anterior wall irrespective of BE length." (Esophagus)

24 August 2018 Gastroesophageal reflux disease: from heartburn to Barrett esophagus, and beyond. Patients with gastroesophageal reflux disease (GERD) may present with a variety of symptoms, including heartburn, regurgitation, dysphagia, chronic cough, laryngitis, or even asthma. ... Once a proper diagnosis of GERD is achieved, anti-reflux surgery is an excellent option for patients with partial control of symptoms with medication,” (Updates in Surgery)

24 August 2018 Gastroesophageal reflux disease and morbid obesity: evaluation and treatment. "Even though sleeve gastrectomy has emerged as a suitable treatment option for morbid obesity, it has been related to development of de novo GERD or worsening the pre-existing one. Conversely, results after Roux-en-Y gastric bypass have been encouraging in this aspect, and it seems to be the best option for patients who suffer both diseases" (Updates in Surgery)

23 August 2018 Use of proton pump inhibitor and risk of iron deficiency: a population-based case-control study. "Chronic PPI use increases the risk of ID. Physicians should consider this when balancing the risks and benefits of chronic PPI prescription." (Journal of Internal Medicine)

23 August 2018 Riskof Esophageal Adenocarcinoma After Antireflux Surgery in PatientsWith Gastroesophageal Reflux Disease in the Nordic Countries (full text) "Medical and surgical treatment of GERD were associated with a similar reduced esophageal adenocarcinoma risk, with the risk decreasing to the same level as that in the background population over time, supporting the hypothesis that effective treatment of GERD might prevent esophageal adenocarcinoma." (JAMA Oncology)

22 August 2018 Laryngopharyngeal Reflux. (full text) " In healthy individuals, there are four barriers to reflux encroaching on the larynx. The lower esophageal sphincter, upper esophageal sphincter, esophageal peristalsis, and epithelial resistance factors with any dysfunction will lead to symptoms of laryngopharyngeal reflux" (StatPearls)

22 August 2018 Carditis: a relevant marker of gastroesophageal reflux disease. Data from a prospective central European multicenter study on histological and endoscopic diagnosis of esophagitis (histoGERD trial). "chronic carditis appears to be the immediate consequence of GERD, correlating with patients' symptoms and endoscopic diagnosis. These results are valid in individuals with nonerosive reflux disease, which indicates a higher sensitivity of histological diagnosis. Our findings may impact the routine assessment of reflux patients." (Diseases of the Esophagus)

22 August 2018 Irrational use of proton pump inhibitors in general practise. "Irrational prescribing of PPIs continues both in hospital and in general practise. It is imperative that the side-effects of these medicines are weighed against the benefit and cost effectiveness, especially in the elderly population where polypharmacy remains a substantial concern." (Irish Journal of Medical Science)

21 August 2018 [EndoStim® treatment-a new minimally invasive technology in antireflux surgery]. "Electrical neuromodulation is a technique that successfully provides patients with GERD with control of their reflux symptoms. The technique requires interdisciplinary patient selection, comprehensive patient education, and comprehensive surgical training. The method is not free of postoperative problems. The electrical neuromodulation of the LES should therefore be used especially in centers with high expertise in reflux therapy." (Der Chirurg)

18 August 2018 Prediagnostic circulating markers of inflammation and risk of oesophageal adenocarcinoma: a study within the National Cancer Institute Cohort Consortium "This prospective study provides evidence of a link between systemic inflammation and oesophageal adenocarcinoma risk. In addition, this study provides the first evidence that indirect effects of excess adiposity and cigarette smoking, via systemic inflammation, increase the risk of oesophageal adenocarcinoma." (Gut)

16 August 2018 Risk factors for gastroesophageal reflux disease and analysis of genetic contributors. (ful text) "GERD has proven to be a multivariate disorder, including abnormal anatomical structures and co-morbidities, affected by environmental and genetic factors. The latter has been also found in several studies and in a newly published GWAS, although none of them has established specific genetic loci with certainty. Further investigation on the mentioned risk genes is needed, in order to evaluate their exact function and role, to probably use them as screening tools or biomarkers and to demonstrate new therapeutic approaches to this increasingly common disease." (World Journal of Clinical Cases)

16 August 2018 Acid suppressant medications and the risk of allergic diseases. "There is a growing body of evidence to support that exposure to acid suppressant medications increases the risk of developing allergic diseases. Further research is needed to not only clarify this relationship but to define the potential mechanism of action." (Expert Review of Clinical Immunology)

16 August 2018 Effect of Acid Suppression on Peripheral T-Lymphocyte Subsets and Immunohistochemical Esophageal Mucosal Changes in Patients With Gastroesophageal Reflux Disease. "Acid-induced T-cell-related cytokine production plays an important role in inflammation occurring in patients with GERD. Mucosal and peripheral inflammation reduces with PPI use." (Journal of Clinical Gastroenterology)

15 August 2018 Nissen Fundoplication (Anti-reflux Procedure). (full text) "Surgical management typically involves laparoscopic anti-reflux surgeries (LARS) and the repair of any existing hiatal hernia. Anti-reflux surgery generally includes a fundoplication, which is a technique to recreate lower esophageal sphincter pressure by wrapping the fundus of the stomach around the esophagus in the abdomen. There are many techniques of LARS, and this article will focus on the popular Nissen fundoplication." (StatPearls)

15 August 2018 Meta-Analysis of Gastroesophageal Reflux Disease and Idiopathic Pulmonary Fibrosis."GERD and IPF may be related but this association is most likely confounded, especially by smoking" (Chest)

13 August 2018 The added value of magnifying endoscopy in diagnosing patients with certain gastroesophageal reflux disease. "Magnifying endoscopy reveals abnormalities that can be used as additional endoscopic diagnostic criteria of gastroesophageal reflux disease." (Advances in Medical Sciences)

12 August 2018 On-Demand Therapy with Proton Pump Inhibitors for Maintenance Treatment of Nonerosive Reflux Disease or Mild Erosive Esophagitis: A Systematic Review and Meta-Analysis. (full text) "On-demand PPI treatment is effective for many patients with NERD or mild EE. Although not FDA-approved, it may be adequate for those patients whose symptoms are controlled to their satisfaction" (Gastroenterology Research & practice)

10 August 2018 Evaluation of serum glycoprotein biomarker candidates for detection of esophageal adenocarcinoma and surveillance of Barrett's esophagus. "The results confirm alteration of complement pathway glycoproteins during BE-EAC pathogenesis. Further prospective clinical validation of the confirmed biomarker candidates in a large cohort is warranted, prior to development of a first-line BE surveillance blood test." (Molecular & cellular proteomics)

9 August 2018 Adverse effects of proton pump inhibitors: fact or fake news?  "Most of the recent highly publicized serious adverse effects ascribed to proton pump inhibitors are not based on demonstrable evidence. Nevertheless, when proton pump inhibitors are prescribed long-term, they should be used at the lowest effective dose and the need for their use periodically reassessed." (Current Opinion in Gastroenterology)

9 August 2018 Optimal Omeprazole Dosing and Symptom Control: A Randomized Controlled Trial (OSCAR Trial). "Initially designed to be taken 30 min before the first daily meal, these agents are commonly used suboptimally, which adversely affects symptom relief." "Low-cost efforts to promote commonly recommended PPI dosing can dramatically reduce GERD symptoms and related economic costs." (Digestive Diseases & Sciences)

9 August 2018 Sleep Disturbances Are Commonly Reported Among Patients Presenting to a Gastroenterology Clinic. "Patients presenting to a tertiary care GI clinic report poorer sleep than healthy controls." (Digestive Diseases and Sciences)

9 August 2018 Laparoscopicanti-reflux surgery for the treatment of idiopathic pulmonaryfibrosis (WRAP-IPF): a multicentre, randomised, controlled phase 2trial (full text) "the results of this trial show that laparoscopic anti-reflux surgery in patients with IPF and abnormal acid GER is safe and well tolerated" (Lancet)

August 2018 [Analysis of proton pump inhibitors anti-ulcer drugs use in the Araba district primary care area]. "PPIs prescription should be done with caution since their unjustified high use in the prevention of gastropathy increases the risk of inappropriate prescriptions." (Revista espanola de salud publica)

8 August 2018 Outcome of hospital outpatient treatment of functional gastrointestinal disorders. "One year after attending a specialist GI clinic a minority of patients with FGIDs were symptomatically improved. Failure to benefit by many patients may relate to the nature of patients and conditions being treated or the limited nature and range of treatments offered. Different models of care, including more diverse multi-disciplinary models, should be explored." (Internal Medicine Journal)

7 August 2018 [Reconsidering on the drug therapy of adult laryngopharyngeal reflux disease]. "PPI therapy, while seeming logical, is less useful in patients with reflux hypersensitivity" (Chinese Journal of otorhinolaryngology)

7 August 2018 Relationship between extralaryngeal endoscopic findings, proton pump inhibitor (PPI) response, and pH measures in suspected laryngopharyngeal reflux. "endoscopic scores of laryngeal and extralaryngeal findings did not predict PPI response or oropharyngeal acid exposure in suspected LPR." (Diseases of the Esophagus)

6 August 2018 THE ROLE OF THE TRANSDIAPHRAGMATIC PRESSURE GRADIENT IN THE PATHOPHYSIOLOGY OF GASTROESOPHAGEAL REFLUX DISEASE. (full text) "This review shows that TPG is an important contributor to GERD even when an intact esophagogastric barrier is present in the setting of obesity and pulmonary diseases." (Arquivos de gastroenterologi)

6 August 2018 Bidirectional association between gastroesophageal reflux disease and depression: Two different nested case-control studies using a national sample cohort. (full text) "reflux symptom itself could result in depression if patients are constantly feeling upset about their condition. Depression might also increase the risk of GERD. First, the fear of reflux symptoms might increase the individual’s perception of reflux symptoms" "GERD and depression displayed bidirectional associations" (Scientific Reports)

August 2018 Gastroesophageal reflux disease (GERD) in children. "Unless there are warning features such as failure to thrive, haematemesis, abnormal posturing, choking/gagging or coughing while feeding, regurgitation in infancy need not be investigated. In older children and adolescents with typical reflux symptoms, empirical PPI therapy is justified" (Paediatrics & international child health)

August 2018 Antireflux surgery is equally beneficial in nonerosive and erosive gastroesophageal reflux disease. (full text) "Laparoscopic Nissen fundoplication is equally beneficial to patients with NERD and ERD. Antireflux surgery should not be avoided for GERD patients without mucosal breaks on endoscopy as the evidence of erosive esophagitis." (Annals of surgical treatment & research)

September 2018 Endoscopic techniques for treating gastroesophageal reflux. "In this review, we describe the four endoscopic antireflux devices on market and summarize the current data in the literature. The short and long-term data demonstrate durable symptom improvement and favorable safety profile" (Current Opinion in Gastroenterology)

2 August 2018 Proton Pump Inhibitors: Risks and Rewards and Emerging Consequences to the Gut Microbiome. "current data suggest that PPI use is not associated with an increased risk of bone fractures, community-acquired pneumonia, cardiovascular events, hypocalcemia, and gastric malignancies. A mild increased risk of vitamin B12 deficiency and chronic kidney disease, and a moderate increase in the risk of rebound hypersecretion, small intestinal bacterial overgrowth, and enteric infections, including Clostridium difficile, has been noted with PPI therapy" (Nutrition in Clinical Practice)

2 August 2018 ProtonPump Inhibitor and Histamine–2 Receptor Antagonist Use and Risk ofLiver Cancer in Two Population–Based Studies (full text) "We found some evidence that PPI use was associated with liver cancer. Whether this association is causal or reflects residual confounding or reverse causation requires additional research." (Alimentary Pharmacology & Therapeutics)

1 August 2018 The Esophageal Microbiome in Health and Disease. "Understanding changes in the esophageal microbiome could affect our understanding of the natural history of diseases of the esophagus and present potential therapeutic approaches." (Current Gastroenterology reports)

1 August 2018 Clinical relevance of low androgen to gastroesophageal reflux symptoms. (full text pdf) "Although GERD symptoms are generally not considered to be typical symptoms of LOH [late onset hypogonadism], our study indicates that those symptoms might be clues for the detection of LOH. (Endocrine Journal)

August 2018 New insights in the diagnosis of chronic refractory cough. "Among patients referred to a specialty respiratory center with CRC multiple concomitant diagnoses for cough were common. Certain diagnoses such as OSA and TBM have not been reported in cough guidelines but in this study are commonly associated diagnoses. Targeted therapy for each recognized diagnosis improves patient response." (Respiratory Medicine)

31 July 2018 Metoclopramide (full text)  "Metoclopramide has been approved by the FDA specifically to treat nausea and vomiting in patients with gastroesophageal reflux disease or diabetic gastroparesis by increasing gastric motility" (StatPearls)

July 2018 Critical appraisal of guidelines for screening and surveillance of Barrett's esophagus. (full textThe main problem of all guidelines is the level of evidence of the statements and recommendations proposed. In a systematic analysis ... it was found that most of the recommendations for BE guideline were of level B or C for quality evidence... Although the new guidelines are more convergent that the previous ones, there are still many studies to be carried out evaluating the correct management of BE concerning the best technique to be used and avoiding the over or the under-treatment of the patients” (Annals of Translational Medicine)

July 2018 Alcohol accumulation promotes esophagitis via pyroptosis activation. "Our study clarified that alcohol accumulation could aggravate the progress of esophagitis by inducing pyroptosis" (International Journal of Biological Sciences)

July 2018 Prevalence and the risk factors of gastro-esophageal reflux disease in medical students. "Prevalence of symptoms of GERD in medical students is 25%, majority had mild symptoms. Associated dyspeptic symptoms were present in 38.6%. Factors predisposing to GERD in them are higher BMI, final years of MBBS course, use of NSAID, inadequate sleep, sleeping within one hour of taking dinner, missing breakfast on regular basis and quick eating." (Medical journal, Armed forces, India)

July 2018 Detection of Mutations in Barrett's Esophagus Before Progression to High-Grade Dysplasia or Adenocarcinoma. (full text) "In genomic analyses of BE tissues from patients with or without later progression to HGD or EAC, we found significantly higher numbers of TP53 mutations in BE from patients with subsequent progression. These mutations were frequently detected before the onset of dysplasia or substantial changes in copy number." (Gastroenterology)

30 July 2018 Gaviscon® Advance alone versus co-prescription of Gaviscon® Advance and proton pump inhibitors in the treatment of laryngopharyngeal reflux. "Gaviscon® Advance alone is effective in treating symptoms of LPR, while co-prescription with a high-dose PPI offers no additional benefit." (European archives of oto-rhino-laryngology)

July 2018 The relationship between eosinophilic esophagitis and esophageal cancer. (full text) "We found no significant difference or increased risk in the rate of EC in the EoE group (P = 0.575) when compared to the control population. In this largest study, we found no association between esophageal cancer and EoE. Further long-term prospective studies are needed to better characterize the relationship between EoE and esophageal malignancy."

26 July 2018 Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial. (full text) "High-dose PPI and aspirin chemoprevention therapy, especially in combination, significantly and safely improved outcomes in patients with Barrett's oesophagus." (Lancet)

26 July 2018 RecentAdvances In Surveillance of Patients With Barrett’s Esophagus (full text article from Gastroscopy & Endoscopy News)

25 July 2018 Identification of prognostic risk factors for esophageal adenocarcinoma using bioinformatics analysis. (full text) "These prognosis-related genes and differentially expressed miRNA have provided potential biomarkers for EAC diagnosis and treatment." (Onco Targets & Therapy)

25 July 2018 Regression of intestinal metaplasia following magnetic sphincter augmentation device placement. "Fundoplication has been shown to lead to regression of disease. Magnetic sphincter augmentation is an alternative to fundoplication that effectively treats reflux disease. Initially, patients with intestinal metaplasia were not considered candidates for device placement, so outcomes in these patients are unknown."  "Magnetic sphincter augmentation is effective in achieving regression of intestinal metaplasia. Longer-term follow-up is needed to assess durability of effect and make meaningful comparisons to fundoplication." (Surgical endocopsy)

24 July 2018 The Influence of Antireflux Surgery on Esophageal Cancer Risk in England: National Population-based Cohort Study. "Antireflux surgery may be associated with a reduced risk of esophageal cancer risk, however it remains primarily an operation for symptomatic relief." (Annals of Surgery)

23 July 2018 Safety and efficacy of a minimally invasive cell sampling device ('Cytosponge') in the diagnosis of esophageal pathology: a systematic review. "the device yielded overall impressive results against the endoscopy/biopsy gold standard. Patient acceptability was high. If these promising early results are validated by other investigators in other populations, the Cytosponge represents an important new advance in the detection of esophageal pathology that could potentially decrease the burden of endoscopic esophageal sampling." (European Journal of Gastroenterology & Hepatology)

July 2018 Extraesophageal Symptoms and Diseases Attributed to GERD: Where is the Pendulum Swinging Now? (full text) "Best Practice Advice 9: Fundoplication should only be considered in those with a mechanical defect (e.g., hiatal hernia), moderate to severe reflux at baseline off PPI therapy who have continued reflux despite PPI therapy and have failed more conservative non-GI treatments." (Clinical Gastroenterology & hepatology)

23 July 2018 Significantassociation between the use of different proton pump inhibitors andmicroscopic colitis: a nationwide Danish case‐control study (full text) "We found a strong association between microscopic colitis and ongoing use of proton pump inhibitors, especially lansoprazole." (Alimentary Pharmacology & Therapeutics)

23 July 2018 Evaluation of gastroesophageal reflux disease. "Once a proper diagnosis of GERD is achieved, antireflux surgery is an excellent option for patients with partial control of symptoms with medication, for patients who do not want to be on long-term medical treatment (compliance/cost), or when complications of medical treatment occur." (Updates in Surgery)

23 July 2018 Pathophysiology of gastroesophageal reflux disease: how an antireflux procedure works (or does not work).  "Hiatal approximation and fundoplication determine excellent outcomes in patients in whom the abnormal reflux is mostly due to the valve mechanism. In patients with altered intra-abdominal pressure due to obesity, a bariatric procedure such as a Roux-en-Y gastric bypass is probably more appropriate" (Updates in Surgery)

23 July 2018 Gastroesophageal reflux and Barrett's esophagus: a pathway to esophageal adenocarcinoma. "Approximately 10-15% of patients with GERD will develop Barrett's esophagus (BE). This metaplastic transformation is due to the chronic injury produced by repeated reflux episodes and involves genetic mutations that can lead to a malignant transformation." (Updates in Surgery)

23 July 2018 The role of laparoscopic Nissen, Hill, and Nissen-Hill hybrid repairs for uncomplicated gastroesophageal reflux disease. " data strongly suggest that the anchoring of GE junction with Hill sutures reduces the axial stresses on the Nissen wrap to maintain its integrity. The laparoscopic Nissen, and laparoscopic Hill procedures have been proven to have excellent results for the treatment of GERD" (Minerva Chirurgica)

23 July 2018 A safety review of proton pump inhibitors to treat acid-related digestive diseases. "adverse drug reactions cannot be assessed by means of randomized clinical trials due to the high costs, ethical reasons, and difficulties in performing prospective observational studies. So far, assessment of retrospective observational investigations remains the only method to evaluate adverse events with any drug in general" (Expert Opinion on Drug Safety)

20 July 2018 Reflux and Belching after Laparoscopic 270 degree Posterior Versus 180 degree Anterior Partial Fundoplication. "LTF and LAF provide similar reflux control, with a comparable effect on acidic, liquid, and gas reflux. Both procedures equally reduced the number of belches and supragastric belches." (Journal of Gastrointestinal Surgery)
19 July 2018 Comparison of the outcome of laparoscopic procedures for GERD. "a magnetic sphincter augmentation with the LINX Reflux Management System (Torax Medical) and the lower esophageal sphincter Electrical Stimulation (EndoStim) have been developed, seeking for a durable and effective minimally invasive alternative to laparoscopic fundoplication for the treatment of reflux. Both devices seem to be promising" (Updates in surgery)

18 July 2018 Laparoscopic magnetic sphincter augmentation versus double-dose proton pump inhibitors for management of moderate-to-severe regurgitation in GERD: a randomized controlled trial. (full text pdf) "GERD patients with moderate-to-severe regurgitation, especially despite once-daily PPI treatment, should be considered for minimally invasive treatment with magnetic sphincter augmentation rather than increased PPI dosing." (Gastrointestinal Endoscopy)

18 July 2018 Magnetic sphincter augmentation for gastroesophageal reflux disease: review of clinical studies. "Observational cohort studies have shown that MSA compares well with fundoplication in selected patients and has an acceptable safety profile. The device can be easily removed if necessary, thereby preserving the option of fundoplication in the future." (Updates in Surgery)

July 2018 Development of benchmark quality criteria for assessing whole-endoscopy Barrett's esophagusbiopsy cases. (full text) "Expert pathology review of BE requires the scoring of a limited number of IND cases, consistency of assessment and a high agreement with a consensus gold standard diagnosis. These benchmark quality criteria will be used to assess the performance of other pathologists joining our panel." (United European Gastroenterology Journal)

18 July 2018 Laparoscopic magnetic sphincter augmentation versus double-dose proton pumpinhibitors for management of moderate-to-severe regurgitation inGERD: a randomized controlled trial (full text) "GERD patients with moderate-to-severe regurgitation, especially despite once-daily PPI treatment, should be considered for minimally invasive treatment with magnetic sphincter augmentation rather than increased PPI dosing." (Gastrointestinal enoscopy) The study was sponsored by Torax Medical.

17 July 2018 Appropriateness in prescribing PPIs: A position paper of the Italian Society of Gastroenterology (SIGE) - Study section "Digestive Diseases in Primary Care". "In order to re-establish a correct use of these effective drugs in daily clinical practice, the Italian Society of Gastroenterology (SIGE), nominated a panel of experts who reviewed the available clinical literature and produced a series of updated position statements on the use of PPIs in clinical practice." (Digestive & Liver Disease)

17 July 2018 Gastroesophageal reflux symptoms among Italian university students: epidemiology and dietary correlates using automatically recorded transactions. (full text) "The results of our study are in line with the values reported in the literature. Nowadays, GERD is a common problem in our communities, and can potentially lead to serious medical complications; the economic burden involved in the diagnostic and therapeutic management of the disease has a relevant impact on healthcare costs." (BMC Gastroenterology)

16 July 2018 Relationship Between Meal Frequency and Gastroesophageal Reflux Disease (GERD) in Iranian Adults. "The prevalence of GERD in the study population was 23.7%. There was no significant association between meal or snack frequency and GERD symptoms in the whole population. However, after adjustment of all potential confounders, we found that women who consumed 1-2 or 3-5 snacks per day, compared with those who never had snacks, had a 41% and 51% reduced risk of having GERD, respectively." (BMC Gastroenterology)

16 July 2018 Quality Improvement in Gastroenterology: A Systematic Review of Practical Interventions for Clinicians. "Our review of quality improvement literature in gastroenterology revealed common themes of successful programs: Education was frequently used but often insufficient, the EMR may be underutilized in guiding decision making, and patient-reported outcomes were infrequently assessed. Further research may be needed to compare QI strategies directly." (Digestive Diseases & Sciences)

13 July 2018 Melatonin in Prevention of the Sequence from RefluxEsophagitis to Barrett's Esophagus and Esophageal Adenocarcinoma: Experimental and Clinical Perspectives. (full text) "The beneficial influence of melatonin in preventing esophageal injury from acid-pepsin and acid-pepsin-bile exposure in animals as well as the usefulness of melatonin and its precursor, L-tryptophan in prophylactic and supplementary therapy against esophageal disorders in humans, are also discussed." (International Journal of Medical Sciences)

13 July 2018 Minimal versus obligatory dissection of the diaphragmatic hiatus during magnetic sphincter augmentation surgery. "The magnetic sphincter augmentation (MSA) device was initially implanted with minimal hiatal dissection (MHD) at the diaphragmatic hiatus. Due to concern of possible MSA device dysfunction if herniated into an occult or small hiatal hernia, and increased understanding to the role of defective crura in reflux disease, the operative procedure was changed to planned obligatory dissection (OD) of the hiatus at the time of all implantations." "OD of the hiatus with crural closure resulted in less recurrence of reflux symptoms and hiatal hernia, despite an increased proportion of patients with larger hiatal hernia and more complex anatomic disease at the time of operation." (Surgical Endoscopy)

13 July 2018 Gastroesophageal Reflux Disease in Obese Patients. " Obese patients benefit from weight loss by diet to decrease GERD symptoms; however, Roux-en-Y gastric bypass surgery is associated with a higher weight loss and a decrease in GERD symptoms, and is considered the best way to treat both diseases at the same time." (Journal of laparosscopic & advanced surgical techniques)

11 July 2018 Changes in proton pump inhibitor prescribing trend over the past decade and pharmacists' effect on prescribing practice at a tertiary hospital. (ful text) "In outpatient settings, the rate of PPI prescribing remained almost constant, utilization and expenditure increased for the past ten years, dominated by oral formulations and rabeprazole. In contrast, in inpatient settings, the rate of PPI prescribing, utilization and expenditure  increased from 2007 to 2015 and then decreased, dominated by injection formulations and omeprazole." (BMC Health Services Research)

July 2018 [Correlation between severity of gastroesophageal reflux cough and degree of gastroesophageal reflux disease]. "The severity of nocturnal symptoms of gastroesophageal reflux cough is related to the degree of gastroesophageal reflux, to which clinical pediatricians should pay attention." (Zhonghua er ke za zhi)

11 July 2018 Comparison of Esophageal Function Tests to Investigate the Effect of Helicobacter Pylori Infection on Gastroesophageal Reflux Disease (GERD). (downloadable full text) "H. pylori infection improved esophageal peristalsis, enhanced lower esophageal sphincter (LES) pressure, and reduced esophageal acid exposure, which might be protective factors for GERD." (Medical Science Monitor)

11 July 2018 Histology of Barrett's Metaplasia: Do Goblet Cells Matter? "if the answer to the following question, "Would you as a gastroenterologist recommend surveillance for a patient with clear endoscopic evidence of CLE, particularly if it is ≥ 3 cm in length, but in which goblet cells were not reported to be present by the pathologist," is yes, then the US requirement for goblet cells as part of the criteria for "BE" is superfluous." (Digestive Diseases & Sciences)

11 July 2018 Screening for Barrett's Esophagus: Are New High-Volume Methods Feasible? (full text) "As Barrett's esophagus is a low prevalence disease, potential screening tests must be applied to an enriched population to reduce the false-positive rate and improve the cost-effectiveness of the program." (Digestive Diseases & Sciences)

11 July 2018 Gastroesophageal Reflux Disease Might Induce Certain-Supposedly Adaptive-Changes in the Esophagus: A Hypothesis. "We believe that GERD may induce different self-protective reactions in the esophagus that result in reduced acid regurgitation or decreased reflux symptoms." (Digestive Diseases & Sciences)

10 July 2018 Barrett's esophagus in children: what is the evidence? "Although BE is considered a premalignant condition; incidence of carcinoma in pediatric population is low. Long-term follow-up with endoscopies and biopsies seems to be advisable for BE evidence and malignant alterations." (Worls Journal of Pediatrics)

July-August 2018 Salvage endoscopic submucosal dissection for esophageal adenocarcinoma arising during radiofrequency ablation. (full text pdf) "Partial or suboptimal response to radiofrequency ablation or early recurrence of Barrett's mucosa after radiofrequency ablation should raise suspicion for adenocarcinoma and lead to consideration of en bloc resection by endoscopic submucosal dissection." (Annals of Gastroenterology)

10 July 2018 Exposure of Barrett's and esophageal adenocarcinoma cells to bile acids activates EGFR-STAT3 signaling axis via induction of APE1. "In summary, our study provides multiple pieces of evidence supporting a critical role for APE1 induction in activating the EGFR-STAT3 signaling axis in response to acidic bile salts, the main risk factor for Barrett's carcinogenesis." (Oncogene)

9 July 2018 Diagnostic Efficacy of 24-hr Esophageal pH Monitoring in Patients with Refractory Gastroesophageal Reflux Disease. (full text) "Our findings suggested that nearly more than half of the patients with refractory GERD would have a functional disorder in the 24h pH-impedance analysis." (Open access Macedonian journal of medical sciences)

9 July 2018 Prevalence and risk factors of gastro-esophageal reflux disease among undergraduate medical students from a southern Indian medical school: a cross-sectional study. (full text) "Based on the symptom score, a diagnosis of GERD was made in 18 (5.02%) students. Frequent consumption of carbonated drinks (OR = 3.63 [95% CI 1.39-9.5]; P = 0.008) and frequent consumption of tea or coffee (OR = 4.65 [95% CI 1.2-17.96]; P = 0.026) were significantly associated with a diagnosis of GERD." (BMC Research notes)

9 July 2018 The relationship between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease: a meta-analysis. (full text) "The meta-analysis showed that there was a significant correlation between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease." (Sleep & Breathing)

8 July 2018 Proton Pump Inhibitors Diminish Barrett's Esophagus Length: Our Experience. "PPIs achieve a reduction to the length of Barrett's oesophagus, in both types, and the development of squamous islands is commonly associated with their use." (Open Access Macedonia Journal of Medical Sciences)

5 July 2018 Endoscopic submucosal dissection for superficial esophageal cancer. "Continued refinement of ESD technique and innovation will overcome some of the current limitations of ESD and enable curative resection of superficial esophageal cancer as an alternative to invasive surgery." (Diseases of the Esophagus)

5 July 2018 Recent advances in Barrett's esophagus. "Research topics of greatest interest include the mechanism of BE development and transformation to cancer, risk stratification methods to identify individuals who may benefit from ablation of BE, optimization of eradication therapy, and surveillance methods to ensure that remission is maintained after eradication is achieved." (Annals of New York Academy of Sciences)

4 July 2018 Nearinfrared fluorescent peptide nanoparticles for enhancing esophagealcancer therapeutic efficacy (full text) "drug delivery to tumor sites and therapeutic responses could be monitored with near-infrared fluorescence ... This unique nanoparticle system may lead to potential approaches for bioorganic fluorescence-based delivering, imaging, and drug release tracking." (Nature Communications)

3 July 2018 Barrett's Esophagus in Patients with Gastroesophageal Reflux Disease. "Endoscopic surveillance with detailed inspection and systematic biopsies is recommended for most patients with Barrett's esophagus. Esophageal carcinoma if detected should be treated at the earliest." (Journal of Nepal Health Research Council)

2 July 2018 Phenotypes of Jackhammer esophagus in patients with typical symptoms of gastroesophageal reflux disease responsive to proton pump inhibitors. (full text) "The prevalence of JE in patients with typical symptoms of GERD and response to PPI therapy is low. True GERD was diagnosed in less than half of this selected cohort, indicating the need for objective testing to stratify phenotypes of JE" (Scientific Reports)

July 2018 [New possibilities with retroflexed functional endoscopy]. "The advantages of functional endoscopy have an impact not only on the medical staff and patients. Its precise and participatory approach is relevant to healthcare, enlarges the diagnostic horizon, and forms a basis for interdisciplinary collaboration."  (HNO)

July 2018 Chronic Cough Is Associated With Long Breaks in Esophageal Peristaltic Integrity on High-resolution Manometry. "Long breaks in esophageal peristaltic integrity are associated with cough. The presence of long breaks is associated with suboptimal benefit from antireflux therapy." (Journal of Neurogastroenterology & Motility)